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1 GLC-analysis and pharmacokinetics of the four stereoisomers of soman
article 1981    
Author: Benschop, H.P. · Berends, F. · Jong, L.P.A. de
Keywords: Biology · Organophosphorus compound · Soman · Animal · Gas chromatography · Kinetics · Metabolism · Rat · Stereoisomerism · Animal · Chromatography, Gas · Kinetics · Organophosphorus Compounds · Rats · Soman · Stereoisomerism · organophosphorus compound · G agents · Prophylaxis · Therapy · Blood · Skin (anatomy) · GC - Gas chromatography · Reaction kinetics · Stereochemistry · Degradation
[Abstract]

2 Biomonitoring of exposure to lewisite based on adducts to haemoglobin
article 2000    
Author: Fidder, A. · Noort, D. · Hulst, A.G. · Jong, L.P.A.de · Benschop, H.P.
Keywords: Toxicology · Adducts · Electrospray mass spectroscopy · Gas chromatography-mass spectroscopy · Haemoglobin · 2 chlorovinylarsonous acid · Arsenic acid derivative · Beta globin · Dimercaprol · Hemoglobin · Imidazole derivative · Lewisite · Unclassified drug · Animal experiment · Biological monitoring · Chemical warfare · Controlled study · Erythrocyte · Gas chromatography · Guinea pig · Health hazard · Human · Human cell · Male · Mass spectrometry · Nonhuman · Radioactivity · Urinalysis · Animals · Arsenicals · Binding Sites · Carbon Radioisotopes · Chelating Agents · Dimercaprol · Environmental Exposure · Erythrocytes · Gas Chromatography-Mass Spectrometry · Globins · Guinea Pigs · Hemoglobins · Humans · Imidazoles · Male · Protein Binding · Mass spectrometry · Electrospray ionization · 1-(heptafluorobutyryl)imidazole, 32477-35-3 · 2-chlorovinylarsonous acid · Arsenicals · Carbon radioisotopes · Chelating agents · Dimercaprol, 59-52-9 · Globins, 9004-22-2 · Hemoglobins · Imidazoles · Lewisite, 541-25-3
[Abstract]

3 Alkylation of human serum albumin by sulfur mustard in vitro and in vivo : Mass spectrometric analysis of a cysteine adduct as a sensitive biomarker of exposure
article 1999    
Author: Noort, D. · Hulst, A.G. · Jong, L.P.A. de · Benschop, H.P.
Keywords: Carbon 14 · Cysteine 52-90-4 · Mustard gas 505-60-2 · Pronase · Serum albumin · Alkylation · Binding kinetics · Human · Human tissue · In vitro study · Iran · Mass spectrometry · Quantitative assay · Alkylating Agents · Alkylation · Amino acid sequence · Biological markers · Chemical warfare · Chemical warfare agents · High Pressure Liquid Chromatography · Hydrolysis · Molecular sequence data · Protein binding · Serum albumin · Trypsin · Trypsin, EC 3.4.21.4
[Abstract]

4 Diagnosis and dosimetry of exposure to sulfur mustard: Development of a standard operating procedure for mass spectrometric analysis of haemoglobin adducts - Exploratory research on albumin and keratin adducts
article 2000    
Author: Noort, D. · Fidder, A. · Hulst, A.G. · Jong, L.P.A. de · Benschop, H.P.
Keywords: Adducts · Albumin · Dosimetry · Haemoglobin · Keratin · Mass spectrometry · Sulfur mustard · Albuminoid · Carbon · Diagnostic agent · Hemoglobin · Keratin · Mustard gas · Article · Chemistry · Culture technique · Differential diagnosis · Drug effect · Human · Intoxication · Liquid chromatography · Mass spectrometry · Pathology · Reference value · Skin · Albumins · Carbon Radioisotopes · Cell Culture Techniques · Chromatography, Liquid · Diagnosis, Differential · Hemoglobins · Humans · Mass Spectrometry · Poisoning · Reference Values · Skin · Carbon Radioisotopes · Keratins, 68238-35-7 · Mustard Gas, 505-60-2
[Abstract]

5 The bispyridinium-dioxime HLö-7. A potent reactivator for acetylcholinesterase inhibited by the stereoisomers of tabun and soman
article 1989    
Author: Jong, L.P.A.de · Verhagen, M.A.A. · Langenberg, J.P. · Hagedorn, I. · Löffler, M.
Keywords: Biology · Bis(pyridinium oxime) derivative · Enzyme inhibitor · Organophosphorus compound · Radioisotope · Enzyme reactivation · Fish · Human · Nonbiological model · Nonhuman · Normal human · Rat · Stereoisomerism · Acetylcholinesterase 9000-81-1 · Animal · Cholinesterase Reactivators · Eels · Human · In Vitro · Organophosphorus Compounds · Oximes · Phosphoric Acid Esters · Pyridines · Pyridinium Compounds · Stereoisomerism · Structure-Activity Relationship · Organophosphorus compounds · Oximes · Phosphoric acid esters · Pyridines · Pyridinium compounds · Soman, 96-64-0 · Tabun, 77-81-6
[Abstract]

6 Characterization of sulfur mustard induced structural modifications in human hemoglobin by liquid chromatography-tandem mass spectrometry
article 1996    
Author: Noort, D. · Verheij, E.R. · Hulst, A.G. · Jong, L.P.A. de · Benschop, H.P.
Keywords: Toxicology · globin · hemoglobin · mustard gas · trypsin · alkylation · article · blood · chemical warfare · human · liquid chromatography · protein modification · tandem mass spectrometry · Alkylation · Amino Acid Sequence · Carcinogens · Chemical Warfare Agents · Chromatography, High Pressure Liquid · Erythrocytes · Gas Chromatography-Mass Spectrometry · Hemoglobins · Humans · Molecular Sequence Data · Mustard Gas · Peptide Fragments · Spectrophotometry, Ultraviolet · Sulfur Radioisotopes · Trypsin
[Abstract]

7 In vitro adduct formation of phosgene with albumin and hemoglobin in human blood
article 2000    
Author: Noort, D. · Hulst, A.G. · Fidder, A. · Gurp, R.A. van · Jong, L.P.A. de · Benschop, H.P.
Keywords: Toxicology · Albumins · Alpha globin · Amino acid sequence · Environmental exposure · Humans · Protein analysis · Protein binding · Protein blood level · Protein determination · Protein synthesis · Radioactivity · Chromatography, High Pressure Liquid · Environmental monitoring · Hemoglobins · Mass Spectrometry · Phosgene · Protein Binding · Hemoglobins · Phosgene, 75-44-5
[Abstract]

8 A physiologically based model for the toxicokinetics of C(±)P(±)-soman in the atropinized guinea pig and marmoset - Effect of scavengers and hydrolytic enzymes promoting elimination
article 2000    
Author: Jong, L.P.A. de · Sweeney, R.E. · Maxwell, D.M. · Langenberg, J.P. · Benschop, H.P.
Keywords: Warfare
[Abstract]

9 Diagnosis and dosimetry of exposure to sulfur mustard: Development of a standard operating procedure for hemoglobin adducts: Exploratory research on albumin and keratin adducts
article 2000    
Author: Noort, D. · Fidder, A. · Jong, L.P.A. de · Schans, G.P. van der · Benschop, H.P.
Keywords: Warfare · Adducts · Albumin · Dosimetry · Hemoglobin · Keratin · Mass spectrometry · Sulfur mustard
[Abstract]

10 Retrospective detection of exposure to organophosphates: analysis in blood of human beings and rhesus monkeys
bookPart 1999    
Author: Polhuijs, M. · Langenberg, J.P. · Noort, D. · Hulst, A.G. · Benschop, H.P. · Jong, L.P.A. de
Keywords: Biology · Nerve agents · Exposure · Blood · Humans · Monkeys
[Abstract]

11 Immunochemical detection of sulfur mustard adducts with keratins in the stratum corneum of human skin
article 2002    
Author: Schans, G.P. van der · Noort, D. · Mars-Groenendijk, R.H. · Fidder, A. · Chau, L.F. · Jong, L.P.A. de · Benschop, H.P.
Keywords: Asparagine · Glutamine · Keratin · Monoclonal antibody · Mustard gas · Article · Chemical warfare · Controlled study · Environmental exposure · Human · Human tissue · Immunochemistry · Immunofluorescence microscopy · Pollutant · Protein binding · Quantitative assay · Skin test · Stratum corneum · Animals · Antibodies, Monoclonal · Antibody Specificity · Enzyme-Linked Immunosorbent Assay · Epidermis · Fluorescent Antibody Technique, Indirect · Haptens · Humans · Immunohistochemistry · Keratins · Mice · Microscopy, Fluorescence · Mustard Gas
[Abstract]

12 Direct determination of the chemical composition of acetylcholinesterase phosphonylation products utilizing electrospray-ionization mass spectrometry
article 1997    
Author: Barak, R. · Ordentlich, A. · Barak, D. · Fischer, M. · Benschop, H.P. · Jong, L.P.A. de · Segall, Y. · Velan, B. · Shafferman, A.
Keywords: Determination · Chemical compounds · Acetylcholinesterase · Electrospray · Mass spectroscopy · Ionization · Aging (biology) · Inhibitors · Organic phosphates · Acetylcholinesterase, EC 3.1.1.7 · Cholinesterase Inhibitors · Organophosphorus Compounds · Recombinant Proteins · Acetylcholinesterase · Aging · ESI-MS · Organophosphonate inhibitor · Enzyme activity · Enzyme phosphorylation · Mass spectrometry · Alkylation · Cholinesterase inhibitors · Humans · Mass spectrometry · Molecular structure · Molecular weight · Organophosphorus compounds · Recombinant proteins
[PDF] [Abstract]

13 Low level nose-only exposure to the nerve agent soman: Toxicokinetics of soman stereoisomers and cholinesterase inhibition in atropinized guinea pigs
article 1998    
Author: Benschop, H.P. · Trap, H.C. · Spruit, H.E.T. · Wiel, H.J. van der · Langenberg, J.P. · Jong, L.P.A. de
Keywords: Perception · Atropine · Carboxylesterase · Cholinesterase · Animal cell · Blood level · Enzyme inhibition · Exposure · Guinea pig · Inhalation · Male · Neurotoxicity · Nonhuman · Stereoisomerism · Toxicokinetics · Administration, Inhalation · Animals · Carboxylic ester hydrolases · Chemical warfare agents · Dose-response relationship · Drugs · Erythrocytes · Soman · Stereoisomerism · Time factors · Atropine, 51-55-8 · Carboxylesterase, EC 3.1.1.1 · Carboxylic ester hydrolases, EC 3.1.1.- · Soman, 96-64-0
[Abstract]

14 Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers
article 1999    
Author: Ordentlich, A. · Barak, D. · Kronman, C. · Benschop, H.P. · Jong, L.P.A. de · Ariel, N. · Barak, R. · Segall, Y. · Velan, B. · Shafferman, A.
Keywords: Cholinesterase reactivator · Soman · Binding site · Chirality · Dealkylation · Enzyme activity · Enzyme analysis · Enzyme binding · Enzyme specificity · Enzyme structure · Enzyme substrate · Human cell · Protein expression · Stereochemistry · Stereoisomerism · Alkylation · Amino acid substitution · Binding sites · Cell line · Cholinesterase inhibitors · Humans · Hydrogen Bonding · Kidney · Macromolecular substances · Models, Molecular · Mutagenesis, Site-Directed · Stereoisomerism · Acetylcholinesterase, EC 3.1.1.7 · Alanine, 56-41-7 · Phenylalanine, 63-91-2 · Phosphorus, 7723-14-0 · Soman, 96-64-0
[Abstract]

15 Lessons learned by use of stereomers of soman - An organophosphorus inhibitor with two chiral centers on the functional architecture of human acetylcholinesterase
article 2000    
Author: Ordentlich, A. · Barak, D. · Kronman, C. · Benschop, H.P. · Jong, L.P.A. de · Ariel, N. · Barak, R. · Segall, Y. · Velan, B. · Shafferman, A.
Keywords: Warfare
[Abstract]

16 Immunochemical detection of sulfur mustard-adducts with DNA and proteins: Exploratory research on adducts with proteins
article 2000    
Author: Schans, G.P. van der · Noort, D. · Mars-Groenendijk, R.H. · Dijk-Knijnenburg, H.C.M. van · Fidder, A. · Jong, L.P.A. de · Benschop, H.P.
Keywords: Warfare · Adducts · DNA · Hemoglobin · Keratin · Dosimetry · Immunoassay · Sulfur mustard
[Abstract]

17 Antidotes to organophosphate poisoning. 2. Thiadiazole-5-carboxaldoximes
article 1979    
Author: Benschop, H.P. · Berg, G.R. van den · Hooidonk, C. van · Jong, L.P.A. de · Kientz, C.E. · Berends, F. · Kepner, L.A. · Meeter, E. · Visser, R.P.L.S.
Keywords: Biology · Acetylcholinesterase · Antidote · Atropine · Cholinesterase reactivator · Diacetyl oxime · Enzyme · Obidoxime P · Paraoxon · Sarin · Tri ortho cresyl phosphate · 1,2,3 thiadiazole 5 carboxaldoxime · 2 (hydroximinomethyl) 1 methylpyridinium salt · 2 methyl 1,2,3 thiadiazolium salt carboxaldoxime · 3 methyl 1,2,3 thiadiazolium salt 5 carboxaldoxime · Animal experiment · Blood · Blood and hemopoietic system · Dose response · Drug administration · Drug analysis · Drug blood level · Drug comparison · Drug elimination · Drug half life · Drug interaction · Drug intoxication · Drug metabolism · Drug response · Drug screening · Drug synthesis · Drug tolerance · Drug toxicity · Drug urine level · Goat · Guinea pig · High performance liquid chromatography · Hydroximinoacetone · In vitro study · Intoxication · Intraperitoneal drug administration · Intravenous drug administration · Mouse · Nuclear magnetic resonance · Oral drug administration · Organophosphate intoxication · Pharmacokinetics · Prevention · Prophylaxis · Rabbit · Rat · Subcutaneous drug administration · Theoretical study · Therapy · Thiadiazole 5 carboxaldoxime derivative · Ultraviolet spectrophotometry · Urine · Acetylcholinesterase · Animal · Antidotes · Body Temperature · Cattle · Chemistry · Dose-Response Relationship, Drug · Enzyme Reactivators · Female · Goats · Guinea Pigs · Half-Life · In Vitro · Lethal Dose 50 · Male · Mice · Organophosphorus Compounds · Oximes · Rabbits · Rats · Rats, Inbred Strains · Sarin · Solubility · Structure-Activity Relationship
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 17 of 17 found. | Sort by date