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1 Macrophage migration inhibitory factor: critical role in obesity, insulin resistance, and associated comorbidities.
article 2010    
Author: Kleemann, R. · Bucala, R.
Keywords: Biology · glucose · macrophage migration inhibition factor · animal · genetics · human · insulin resistance · metabolism · obesity · physiology · review · Animals · Glucose · Humans · Insulin Resistance · Macrophage Migration-Inhibitory Factors · Obesity
[Abstract]

2 Systems biology approaches to the study of cardiovascular drugs
bookPart 2010    
Author: Nikolsky, Y. · Kleemann, R.
Keywords: Biology · Biological networks · Cardiovascular disease · Drugs · Inflammation · Lipid metabolism · Pathway analysis · Side effects · Signaling pathways · Systems biology
[Abstract]

3 Role of Macrophage Migration Inhibitory Factor in Obesity, Insulin Resistance, Type 2 Diabetes, and Associated Hepatic Co-Morbidities: A Comprehensive Review of Human and Rodent Studies
article 2015    
Author: Morrison, M.C. · Kleemann, R.
Keywords: Health · MIF · Adipose tissue · Insulin resistance · Non-alcoholic fatty liver disease · Obesity · Type 2 diabetes · Macrophage migration inhibition factor · Comorbidity · Correlation analysis · Fatty liver · Glucose homeostasis · Human · Lipid storage · Liver fibrosis · Non insulin dependent diabetes mellitus · Nonalcoholic fatty liver · Nonhuman · Review · Weight reduction · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

4 Cytokines and atherosclerosis: A comprehensive review of studies in mice
article 2008    
Author: Kleemann, R. · Zadelaar, A.S.M. · Kooistra, T.
Keywords: Health · Atherosclerosis · Cytokines · Macrophage · Gamma interferon · Granulocyte colony stimulating factor · Granulocyte macrophage colony stimulating factor · Interleukin 1 · Interleukin 10 · Interleukin 12 · Interleukin 18 · Interleukin 2 · Interleukin 20 · Interleukin 3 · Interleukin 4 · Interleukin 5 · Interleukin 6 · Atherogenesis · Diet · Gene deletion · Gene overexpression · Mouse strain · Nonhuman · Outcome assessment · Protein expression · Review · Sex difference · Animals · Atherosclerosis · Colony-Stimulating Factors · Cytokines · Disease Models, Animal · Inflammation · Interferon-gamma · Interleukins · Macrophage Migration-Inhibitory Factors · Mice · Signal Transduction · Tumor Necrosis Factor-alpha
[Abstract]

5 Systems biology analysis unravels the complementary action of combined rosuvastatin and ezetimibe therapy
article 2012    
Author: Verschuren, L. · Radonjic, M. · Wielinga, P.Y. · Kelder, T. · Kooistra, T. · Ommen, B. van · Kleemann, R.
Keywords: Biology · adverse effect · coamplified · combination therapy · inflammation · mouse model · systems biology · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

6 Exploring pathway interactions in insulin resistant mouse liver
article 2011    
Author: Kelder, T. · Eijssen, L. · Kleemann, R. · Erk, M. van · Kooistra, T. · Evelo, C.
Keywords: Health · Life · MHR - Metabolic Health Research MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[Abstract]

7 Beneficial effects of alternate dietary regimen on liver inflammation, atherosclerosis and renal activation
article 2011    
Author: Wielinga, P.Y. · Yakala, G.K. · Heeringa, P. · Kleemann, R. · Kooistra, T.
Keywords: Health · Diets · Nutrition · Kidneys · Atheriosclerosis · Liver · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

8 Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm doxycycline selectively depletes aortic wall neutrophils and cytotoxic t cells
article 2009    
Author: Lindeman, J.H.N. · Abdul-Hussien, H. · Bockel, J.H. van · Wolterbeek, R. · Kleemann, R.
Keywords: Health · Aneurysm · Immunology · Inflammation · Molecular biology · Trials · Doxycycline · Gelatinase B · Granulocyte colony stimulating factor receptor · Interleukin 13 · Interleukin 6 · Interleukin 8 · Antiinfective agent · CCAAT enhancer binding protein · Enzyme inhibitor · IL6 protein, human · Transcription factor AP 1 · Transcription factor RelA · Abdominal aorta aneurysm · Aged · Cytotoxic T lymphocyte · Drug effect · Drug megadose · Drug tolerability · Enzyme inhibition · Aortic Aneurysm, Abdominal · CCAAT-Enhancer-Binding Proteins · Doxycycline · Enzyme Inhibitors · Matrix Metalloproteinase 9 · Middle Aged · Neutrophils · T-Lymphocytes, Cytotoxic · Vasculitis
[PDF] [Abstract]

9 LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: Time course and mechanisms
article 2009    
Author: Verschuren, L. · Vries de Weij, J. van der · Zadelaar, A.S.M. · Kleemann, R. · Kooistra, T.
Keywords: Health · Biomedical Research · Atherosclerosis · Inflammation · Liver-X-receptor · Macrophages · ABC transporter A1 · ABC transporter G1 · apolipoprotein E3 · cell adhesion molecule · chemokine receptor CCR7 · cholesterol · endothelial leukocyte adhesion molecule 1 · Hermes antigen · immunoglobulin enhancer binding protein · intercellular adhesion molecule 1 · lipid · liver X receptor agonist · n (2,2,2 trifluoroethyl) n [4 [2,2,2 trifluoro 1 hydroxy 1 (trifluoromethoxy)ethyl]phenyl]benzenesulfonamide · serum amyloid A · triacylglycerol · ABC transporter · ABCG1 protein, mouse · apolipoprotein E3 (Leidein) · cell receptor · DNA binding protein · fluorinated hydrocarbon · hypocholesterolemic agent · lipoprotein · liver X receptor · n (2,2,2 trifluoroethyl) n [4 (2,2,2 trifluoro 1 hydroxy 1 trifluoromethylethyl)phenyl]benzenesulfonamide · sulfonamide · TO-901317 · animal experiment · animal model · atherosclerosis · cell adhesion · cholesterol blood level · cholesterol diet · controlled study · disease course · drug mechanism · drug potency · endothelium · female · immunohistochemistry · macrophage · monocyte · mouse · nonhuman · priority journal · protein expression · remission · triacylglycerol blood level · animal · drug potentiation · genetics · metabolism · pathology · transgenic mouse · Animals · Anticholesteremic Agents · Antigens, CD44 · Apolipoprotein E3 · Atherosclerosis · ATP-Binding Cassette Transporters · DNA-Binding Proteins · E-Selectin · Female · Hydrocarbons, Fluorinated · Intercellular Adhesion Molecule-1 · Lipoproteins · Mice · Mice, Transgenic · Receptors, Cytoplasmic and Nuclear · Serum Amyloid A Protein · Sulfonamides
[PDF] [Abstract]

10 The challenges for molecular nutrition research 3 : Comparative nutrigenomics research as a basis for entering the system level
article 2008    
Author: Daniel, H. · Drevon, C.A. · Klein, U.I. · Kleemann, R. · Ommen, B. van
Keywords: Biomedical Research
[PDF]

11 Surgical removal of inflamed epididymal white adipose tissue attenuates the development of non-alcoholic steatohepatitis in obesity
article 2016    
Author: Mulder, P. · Morrison, M.C. · Wielinga, P.Y. · Duyvenvoorde, W. van · Kooistra, T. · Kleemann, R.
Keywords: Biology · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

12 Beneficial Effects of a Nutritional Composition on Diabetic Risk Factors and Complications in LDLr-/-. Leiden Mice
article 2015    
Author: Schoemaker, M. · Tol, E. van · Kooistra, T. · Kleemann, R. · Wielinga, P.
Keywords: Biology · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

13 Global Suppression of IL-6-induced Acute Phase Response Gene Expression after Chronic in Vivo Treatment with the Peroxisome Proliferator-activated Receptor-α Activator Fenofibrate
article 2004    
Author: Gervois, P. · Kleemann, R. · Pilon, A. · Percevault, F. · Koenig, W. · Staels, B. · Kooistra, T.
Keywords: Biology · Biomedical Research · Biological organs · Enzyme kinetics · Lipids · Metabolism · Patient treatment · Plasmas · Acute phase response (APR) · Gene expression · Genetic engineering · Albumin · Alpha 2 macroglobulin · CCAAT enhancer binding protein · CCAAT enhancer binding protein alpha · CCAAT enhancer binding protein beta · CCAAT enhancer binding protein delta · Fenofibrate · Fibrinogen · Interleukin 6 · peroxisome proliferator activated receptor agonist · peroxisome proliferator activated receptor alpha · serum amyloid A · STAT3 protein · Stress activated protein kinase · Transcription factor · Unclassified drug · Acute phase response · Animal experiment · Animal tissue · Clinical article · Controlled study · Down regulation · Enzyme activation · Fibrinogen blood level · Gene expression regulation · Hyperlipidemia · In vivo study · Knockout mouse · Liver · Long term care · Male · Mouse · Nonhuman · Protein expression · Protein function · Protein phosphorylation · Transcription regulation · Wild type · Acute-Phase Reaction · Animals · Antilipemic Agents · Apolipoproteins · Down-Regulation · Fibrinogen · Haptoglobins · Humans · Interleukin-6 · Mice · Procetofen · Receptors, Cytoplasmic and Nuclear · Serum Amyloid A Protein · Signal Transduction · Transcription Factors · Animalia · Eukaryota
[PDF] [Abstract]

14 Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFκB-C/EBP-β complex formation
article 2003    
Author: Kleemann, R. · Gervois, P.P. · Verschuren, L. · Staels, B. · Princen, H.M.G. · Kooistra, T.
Keywords: Biology · Animals · Antilipemic Agents · Bezafibrate · C-Reactive Protein · CCAAT-Enhancer-Binding Protein-beta · Cell Nucleus · Clofibric Acid · Down-Regulation · Hepatocytes · Humans · Interleukin-1 · Mice · Mice, Knockout · NF-kappa B · NF-kappa B p50 Subunit · Protein Binding · Receptors, Cytoplasmic and Nuclear · Transcription Factors · Transcription, Genetic · Transfection
[Abstract]

15 Extra-Virgin Olive Oil with Natural Phenolic Content Exerts an Anti-Inflammatory Effect in Adipose Tissue and Attenuates the Severity of Atherosclerotic Lesions in Ldlr−/−.Leiden Mice
article 2018    
Author: Luque-Sierra, A. · Alvarez-Amor, L. · Kleemann, R. · Martín, F. · Varela, L.M.
Keywords: Nutrition · Atherosclerosis · Extra-virgin olive oil · High-fat diet · Inflammation · Obesity · Healthy for Life · Healthy Living
[Abstract]

16 Key Inflammatory Processes in Human NASH Are Reflected in Ldlr−/−.Leiden Mice: A Translational Gene Profiling Study
article 2018    
Author: Morrison, M.C. · Kleemann, R. · Koppen, A. van · Hanemaaijer, R. · Verschuren, L.
Keywords: Biology · Liver · NASH, · Inflammation · Molecular · Gene expression · Translational · Mouse · Human · Translational · Cytokine · Growth factor · Transcription factor · Animal experiment · Animal model · Controlled study · Extracellular matrix · Gene expression profiling · Human tissue · Inflammation · Lipid diet · Lipid metabolism · Liver biopsy · Mouse · Nonalcoholic fatty liver · Nonhuman · Transcriptomics · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

17 Apical sodium-dependent bile acid transporter inhibition with volixibat improves metabolic aspects and components of non-alcoholic steatohepatitis in Ldlr-/-.Leiden mice
article 2019    
Author: Salic, K. · Kleemann, R. · Wilkins-Port, C. · McNulty, J. · Verschuren, L. · Palmer, M.
[PDF] [Abstract]

18 Beneficial Effects of an Alternating High- Fat Dietary Regimen on Systemic Insulin Resistance, Hepatic and Renal Inflammation and Renal Function
article 2012    
Author: Yakala, G.K. · Heijden, R. van der · Molema, G. · Schipper, M. · Wielinga, P.Y. · Kleemann, R. · Kooistra, T. · Heeringa, P.
Keywords: Health · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

19 Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models
article 2011    
Author: Kleemann, R. · Verschuren, L. · Morrison, M. · Zadelaar, A.S.M. · Erk, M.J. van · Wielinga, P.Y. · Kooistra, T.
Keywords: Nutrition · Anti-inflammatory · Atherosclerosis · Cholesterol · CRP · Inflammation · Polyphenol · Proliferation · Quercetin · C reactive protein · endothelial leukocyte adhesion molecule 1 · fibrinogen · immunoglobulin enhancer binding protein · quercetin · vascular cell adhesion molecule 1 · animal experiment · animal model · antiinflammatory activity · article · atherosclerosis · cardiovascular risk · controlled study · drug activity · drug blood level · drug effect · endothelium cell · human · human cell · inflammation · liver cell · male · mouse · nonhuman · priority journal · protein expression · risk factor · transgenic mouse · Life · MHR - Metabolic Health Research MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[Abstract]

20 The pathophysiology of abdominal aortic aneurysm growth: Corresponding and discordant inflammatory and proteolytic processes in abdominal aortic and popliteal artery aneurysms
article 2010    
Author: Abdul-Hussien, H. · Hanemaaijer, R. · Kleemann, R. · Verhaaren, B.F.J. · Bockel, J.H. van · Lindeman, J.H.N.
Keywords: Biology
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 100 found. Next | Sort by date