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1 Global Suppression of IL-6-induced Acute Phase Response Gene Expression after Chronic in Vivo Treatment with the Peroxisome Proliferator-activated Receptor-α Activator Fenofibrate
article 2004    
Author: Gervois, P. · Kleemann, R. · Pilon, A. · Percevault, F. · Koenig, W. · Staels, B. · Kooistra, T.
Keywords: Biology · Biomedical Research · Biological organs · Enzyme kinetics · Lipids · Metabolism · Patient treatment · Plasmas · Acute phase response (APR) · Gene expression · Genetic engineering · Albumin · Alpha 2 macroglobulin · CCAAT enhancer binding protein · CCAAT enhancer binding protein alpha · CCAAT enhancer binding protein beta · CCAAT enhancer binding protein delta · Fenofibrate · Fibrinogen · Interleukin 6 · peroxisome proliferator activated receptor agonist · peroxisome proliferator activated receptor alpha · serum amyloid A · STAT3 protein · Stress activated protein kinase · Transcription factor · Unclassified drug · Acute phase response · Animal experiment · Animal tissue · Clinical article · Controlled study · Down regulation · Enzyme activation · Fibrinogen blood level · Gene expression regulation · Hyperlipidemia · In vivo study · Knockout mouse · Liver · Long term care · Male · Mouse · Nonhuman · Protein expression · Protein function · Protein phosphorylation · Transcription regulation · Wild type · Acute-Phase Reaction · Animals · Antilipemic Agents · Apolipoproteins · Down-Regulation · Fibrinogen · Haptoglobins · Humans · Interleukin-6 · Mice · Procetofen · Receptors, Cytoplasmic and Nuclear · Serum Amyloid A Protein · Signal Transduction · Transcription Factors · Animalia · Eukaryota
[PDF] [Abstract]

2 Fenofibrate reduces atherogenesis in ApoE*3Leiden mice: Evidence for multiple antiatherogenic effects besides lowering plasma cholesterol
article 2006    
Author: Kooistra, T. · Verschuren, L. · Vries de-Weij, J.van der · Koenig, W. · Toet, K. · Princen, H.M.G. · Kleemann, R.
Keywords: Biology · Biomedical Research · Atherosclerosis · Fibrates · Inflammation · Pleiotrop · Reverse cholesterol transport · ABC transporter A1 · Cholesterol · Fenofibrate · Granulocyte macrophage colony stimulating factor · Immunoglobulin enhancer binding protein · Intercellular adhesion molecule 1 · Monocyte chemotactic protein 1 · Serum amyloid A · Vascular cell adhesion molecule 1 · Animal cell · Animal experiment · Animal model · Animal tissue · Aorta atherosclerosis · Atherogenesis · Cholesterol blood level · Cholesterol diet · Cholesterol transport · Controlled study · Disease severity · Drug effect · Macrophage · Mouse · Nonhuman · Protein blood level · Protein expression · Transgenic mouse · Upregulation · Animals · Antilipemic Agents · Aorta · Aortic Valve · Apolipoprotein E3 · Apolipoproteins E · Atherosclerosis · Cholesterol · Female · Inflammation · Lipids · Lipoproteins · Mice · Mice, Transgenic · Procetofen
[Abstract]

3 The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment
article 2004    
Author: Mandard, S. · Zandbergen, F. · Nguan, S.T. · Escher, P. · Patsouris, D. · Koenig, W. · Kleemann, R. · Bakker, A. · Veenman, F. · Wahli, W. · Müller, M. · Kersten, S.
Keywords: Biology · Biomedical Research · Biochemistry · Biological membranes · Blood · Precipitation (chemical) · RNA · Tissue · Adipose tissue · Blood plasma · Fasting induced adipose factors · Immunoprecipitation · Proteins · Cytokine · Fasting induced adipose factor · Fenofibrate · Messenger RNA · Peroxisome proliferator activated receptor alpha · Peroxisome proliferator activated receptor delta · Peroxisome proliferator activated receptor gamma · Unclassified drug · Adiponectin · ANGPTL4 protein, human · cell receptor · protein · RNA · Signal peptide · Transcription factor · Adipocyte · Animal cell · Blood level · Body mass · Cell differentiation · Chromatin · Controlled study · DNA responsive element · Gene control · Hepatoma cell · Human · Human cell · Human tissue · Immunoprecipitation · Intron · Liver · Mouse · Nonhuman · Rat · Transactivation · Upregulation · White adipose tissue · Animal · Blood · C57BL mouse · Cell culture · Cell line · Cell strain 3T3 · Genetic transcription · Metabolism · Molecular genetics · Nucleotide sequence · Reverse transcription polymerase chain reaction · Serodiagnosis · Tumor cell line · Western blotting · Animalia · Eukaryota · 3T3-L1 Cells · Adipocytes · Adiponectin · Adipose Tissue · Animals · Base Sequence · Blotting, Western · Cell Differentiation · Cell Line · Cell Line, Tumor · Cells, Cultured · Chromatin · Cytokines · Humans · Intercellular Signaling Peptides and Proteins · Introns · Liver · Mice · Mice, Inbred C57BL · Molecular Sequence Data · Precipitin Tests · Procetofen · Proteins · Rats · Receptors, Cytoplasmic and Nuclear · Reverse Transcriptase Polymerase Chain Reaction · RNA · RNA, Messenger · Trans-Activation (Genetics) · Transcription Factors · Transcription, Genetic · Up-Regulation
[PDF] [Abstract]

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