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1 Biological evaluation of Tyr6 and Ser7 modified drosocin analogues
article 2005    
Author: Visser, P.C. de · Hooft, P.A.V. van · Vries, A.-M. de · Jong, A. de · Marel, G.A. van der · Overkleeft, H.S. · Noort, D.
Keywords: Antibiotic agent · Amino acid substitution · Amino terminal sequence · Article · Controlled study · Drug screening · Drug stability · Drug synthesis · Nonhuman · Protein degradation · Amino Acid Sequence · Glycopeptides · Humans · Microbial Sensitivity Tests · Molecular Sequence Data · Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization · Chemicals · Drosocin, 179048-25-0 · Serine, 56-45-1, 6898-95-9 · Tyrosine, 16870-43-2, 55520-40-6, 60-18-4 · Drosocin, 149924-99-2 · Glycopeptides · Serine, 56-45-1 · Tyrosine, 55520-40-6
[Abstract]

2 Approach toward a generic treatment of gram-negative infections: Synthesis of haptens for catalytic antibody mediated cleavage of the interglycosidic bond in lipid A
article 1999    
Author: Berg, R.J.B.H.N. van den · Noort, D. · Milder-Enacache, E.S. · Marel, G.A. van der · Boom, J.H. van · Benschop, H.P.
Keywords: Biology · Azasugars · Catalytic antibodies · Endotoxin · Glycosidases · Immunotherapy · Treatment · Infectious diseases · Antibodies · Immunology · Glycosides · Catalytic converters
[Abstract]

3 Activity-based protein profiling reveals broad activity of the nerve agent sarin
article 2009    
Author: Tuin, A.W. · Mol, M.A.E. · Berg, R.M. van den · Fidder, A. · Marel, G.A. van der · Overkleeft, H.S. · Noort, D.
Keywords: Chemistry · 1 alkyl 2 acetylglycerophosphocholine esterase · Acylamino acid releasing enzyme · Carboxylesterase · Dipeptidyl peptidase · Dipeptidyl peptidase 9 · Fatty acid synthase · Methylphosphonofluoridic acid · Organophosphate · Palmitoyl coenzyme A hydrolase · Prolyl endopeptidase · Sarin · Unclassified drug · Animal cell · Biotinylation · Chemical structure · Controlled study · Human · Human cell · Matrix assisted laser desorption ionization time of flight mass spectrometry · Nonhuman · Protein analysis · Quantitative analysis · Sensitivity analysis · Macaca mulatta
[Abstract]

4 Synthesis of pyrophosphonic acid analogues of farnesyl pyrophosphate
article 1995    
Author: Valentijn, A.R.P.M. · Berg, O. van den · Marel, G.A. van der · Cohen, L.H. · Boom, J.H. van
Keywords: Health · Enzyme inhibitor · Phosphonic acid derivative · Squalene synthase inhibitor · Drug synthesis · Reaction analysis
[Abstract]

5 A novel approach towards the synthesis of pyrophosphate analogues of farnesyl pyrophosphate
article 1994    
Author: Valentijn, A.R.P.M. · Berg, O. van den · Marel, G.A. van der · Cohen, L.H. · Boom, J.H. van
Keywords: Biology
[Abstract]

6 Ring-extended derivatives of gramicidin S with furanoid sugar amino acids in the turn region have enhanced antimicrobial activity
article 2009    
Author: Knijnenburg, A.D. · Spalburg, E. · Neeling, A.J. de · Mars-Groenendijk, R.H. · Noort, D. · Grotenbreg, G.M. · Marel, G.A. van der · Overkleeft, H.S. · Overhand, M.
Keywords: Defence · β turns · Antibiotics · Cyclic peptides · Gramicidin S · Sugar amino acids
[Abstract]

7 Ring-extended gramicidin S analogs Containing cis δ-sugar amino acid turn mimetics with varying ring size
article 2012    
Author: Knijnenburg, A.D. · Spalburg, E. · Neeling, A.J. de · Mars-Groenendijk, R.H. · Noort, D. · Grotenbreg, G.M. · Marel, G.A. van der · Overkleeft, H.S. · Overhand, M.
Keywords: Antimicrobial activity · Conformational analysis · Gramicidin S · Peptides · Anti-microbial activity · Conformational analysis · Gramicidin S · Mimetics · Oxetanes · Protonated · Ring sizes · Side-chains · Sugar amino acids · Peptides · Sugars · Amino acids · Amino acid · Furan derivative · Gramicidin derivative · Gramicidin S · Gramicidin s derivative · Hemolytic agent · Ornithine · Oxetane derivative · Pyran derivative · Unclassified drug · Antibacterial activity · Biomimetics · Controlled study · Drug synthesis · Gram negative bacterium · Gram positive bacterium · Hmolysis · Human · Human cell · Hydrophobicity · Minimum inhibitory concentration · Molecular size · Nonhuman · Priority journal · Proton transport · Structure activity relation · Defence Research · Defence, Safety and Security · Life · CBRN - CBRN Protection · EELS - Earth, Environmental and Life Sciences
[Abstract]

8 Tuning hydrophobicity of highly cationic tetradecameric Gramicidin S analogues using adamantane amino acids
article 2010    
Author: Knijnenburg, A.D. · Kapoerchan, V.V. · Spalburg, E. · Neeling, A.J. de · Mars-Groenendijk, R.H. · Noort, D. · Marel, G.A. van der · Overkleeft, H.S. · Overhand, M.
Keywords: Chemistry · β-Sheet · Amphipathicity · Cationic antimicrobial peptides · Gramicidin S · MRSA
[Abstract]

9 Structural and biological evaluation of some loloatin C analogues
article 2009    
Author: Tuin, A.W. · Grotenbreg, G.M. · Spalburg, E. · Neeling, A.J. de · Mars-Groenendijk, R.H. · Noort, D. · Marel, G.A. van der · Overkleeft, H.S. · Overhand, M.
Keywords: Chemistry · Cationic antimicrobial peptide · Loloatin C · Structure-activity relationship · Sugar amino acid
[Abstract]

10 Inhibitors of protein:farnesyl transferase and protein:geranylgeranyl transferase I : Synthesis of homologous diphosphonate analogs of isoprenylated pyrophosphate
article 1998    
Author: Overhand, M. · Stuivenberg, H.R. · Pieterman, E. · Cohen, L.H. · Leeuwen, R.E.W. van · Valentijn, A.R.P.M. · Overkleeft, H.S. · Marel, G.A. van der · Boom, J.H. van
Keywords: Health · bisphosphonic acid derivative · enzyme inhibitor · geranyltransferase · protein farnesyltransferase · article · enzyme activity · enzyme inhibition · enzyme specificity · phosphate metabolism · priority journal
[Abstract]

11 Exploring the conformational and biological versatility of ß-turn-modified gramicidin s by using sugar amino acid homologues that vary in ring size
article 2011    
Author: Knijnenburg, A.D. · Tuin, A.W. · Spalburg, E. · Neeling, A.J. de · Mars-Groenendijk, R.H. · Noort, D. · Otero, J.M. · Llamas-Saiz, A.L. · Raaij, M.J. van · Marel, G.A. van der · Overkleeft, H.S. · Overhand, M.
Keywords: Chemistry · ß-turn · Amino acids · Antimicrobial peptides · Conformation analysis · Gramicidin S · Life · CBRN - CBRN Protection · EELS - Earth, Environmental and Life Sciences
[Abstract]

12 Synthesis and biological evaluation of novel gramicidin s analogues
article 2009    
Author: Tuin, A.W. · Palachanis, D.K. · Buizert, A. · Grotenbreg, G.M. · Spalburg, E. · Neeling, A.J. de · Mars-Groenendijk, R.H. · Noort, D. · Marel, G.A. van der · Overkleeft, H.S. · Overhand, M.
Keywords: Chemistry · Antibiotics · Conformation analysis · Peptidomimetics · Sugar amino acid
[Abstract]

13 Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified d-phenylalanine residues
article 2009    
Author: Knaap, M. van der · Engels, E. · Busscher, H.J. · Otero, J.M. · Llamas-Saiz, A.L. · Raaij, M.J. van · Mars-Groenendijk, R.H. · Noort, D. · Marel, G.A. van der · Overkleeft, H.S. · Overhand, M.
Keywords: Defence · Anti-microbial peptides · Biological profile · Gramicidin S derivatives
[Abstract]

14 Evaluation of readily accessible azoles as mimics of the aromatic ring of D-phenylalanine in the turn region of gramicidin S
article 2011    
Author: Knaap, M. van der · Lageveen, L.T. · Busscher, H.J. · Mars-Groenendijk, R. · Noort, D. · Otero, J.M. · Llamas-Saiz, A.L. · Raaij, M.J. van · Marel, G.A. van der · Overkleeft, H.S. · Overhand, M.
Keywords: Chemistry · Antibacterial activity · Azole · GramicidinS · Hemolytic activity · Peptides · Life · CBRN - CBRN Protection · EELS - Earth, Environmental and Life Sciences
[Abstract]

15 Synthesis and evaluation of strand and turn modified ring-extended gramicidin S derivatives
article 2011    
Author: Knijnenburg, A.D. · Kapoerchan, V.V. · Grotenbreg, G.M. · Spalburg, E. · Neeling, A.J. de · Mars-Groenendijk, R.H. · Noort, D. · Otero, J.M. · Llamas-Saiz, A.L. · Raaij, M.J. van · Ravensbergen, B. · Nibbering, P.H. · Marel, G.A. van der · Overkleeft, H.S. · Overhand, M.
Keywords: Amphipathic peptides · Antibiotics · Cationic antimicrobial peptides · Dipeptide isostere · Gramicidin S, GS14K4 · Secondary structure · Life · CBRN - CBRN Protection · EELS - Earth, Environmental and Life Sciences
[Abstract]

16 Inverted analogs of the antibiotic gramicidin S with an improved biological profile
article 2012    
Author: Kapoerchan, V.V. · Knijnenburg, A.D. · Keizer, P. · Spalburg, E. · Neeling, A.J. de · Mars-Groenendijk, R.H. · Noort, D. · Otero, J.M. · Llamas-Saiz, A.L. · Raaij, M.J. van · Marel, G.A. van der · Overkleeft, H.S. · Overhand, M.
Keywords: Antibiotics · Cyclic peptide · Hemolysis · Improved properties · MRSA · Healthy Living · Life · CBRN - CBRN Protection · EELS - Earth, Environmental and Life Sciences
[Abstract]

17 Gramicidin S derivatives containing cis- and trans-morpholine amino acids (MAAS) as turn mimetics
article 2010    
Author: Kapoerchan, V.V. · Spalburg, E. · Neeling, A.J. de · Mars-Groenendijk, R.H. · Noort, D. · Otero, J.M. de · Ferraces-Casais, P. · Llamas-Saiz, A.L. · Raaij, M.J. van · Doorn, J. van · Marel, G.A. van der · Overkleeft, H.S. · Overhand, M.
Keywords: Chemistry · Antibiotics · Conformation analysis · Gramicidin s · Peptides · Peptidomimetics · Amino acid, 65072-01-7 · Gramicidin, 1405-97-6 · Amino Acids · Anti-Bacterial Agents · Dipeptides · Gramicidin, 1405-97-6 · Morpholines
[Abstract]

18 An adamantyl amino acid containing gramicidin S analogue with broad spectrum antibacterial activity and reduced hemolytic activity
article 2010    
Author: Kapoerchan, V.V. · Knijnenburg, A.D. · Niamat, M. · Spalburg, E. · Neeling, A.J. de · Nibbering, P.H. · Mars-Groenendijk, R.H. · Noort, D. · Otero, J.M. · Llamas-Saiz, A.L. · Raaij, M.J. van · Marel, G.A. van der · Overkleeft, H.S. · Overhand, M.
Keywords: Health · Amino acids · Antibiotics · Gramicidin · Methicillin-resistant Staphylococcus aureus (MRSA) · Peptides
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 18 of 18 found. | Sort by date