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Showing 1 to 10 of 10 found. | Sort by date

1 A category approach to predicting the developmental (neuro) toxicity of organotin compounds: The value of the zebrafish (Danio rerio) embryotoxicity test (ZET)
article 2013    
Author: Beker van Woudenberg, A. · Wolterbeek, A. · Brake, L. te · Snel, C. · Menke, A. · Rubingh, C. · Groot, D. de · Kroese, D.
Keywords: Health · Alternative model · Biological verification · Developmental (neuro) toxicity · Grouping · Organotins · Read across · Zebrafish embryotoxicity test (ZET) · Biomedical Innovation · Healthy Living · Life Triskelion BV · QS - Quality & Safety TARA - Toxicology and Risk Assessment · EELS - Earth, Environmental and Life Sciences
[Abstract]

2 Potentially increased sensitivity of pregnant and lactating female rats to immunotoxic agents
article 2012    
Author: Menke, A. · Wolterbeek, A. · Snel, C. · Bruijntjes, J. · Groot, D.D. · Oostrum, L.V. · Waalkens, I. · Kuper, C.F.
Keywords: Biology · DOTC · immunotoxicity · lactation · pregnancy · sensitive periods · thymus · Healthy for Life · Healthy Living · Life Triskelion · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences TNO Bedrijven
[Abstract]

3 Zebrafish embryotoxicity test for developmental (neuro)toxicity: Demo case of an integrated screening approach system using anti-epileptic drugs
article 2014    
Author: Beker van Woudenberg, A. · Snel, C. · Rijkmans, E. · Groot, D. de · Bouma, M. · Hermsen, S. · Piersma, A. · Menke, A. · Wolterbeek, A.
Keywords: Biology · Antiepileptic drugs · Behavior · Developmental (neuro)toxicity · Gene expression · Histopathology · Integrated test strategy · Kinetics · Zebrafish embryotoxicity test (ZET) · Anticonvulsive agent · Carbamazepine · Cytochrome P450 26A1 · Ethosuximide · Etiracetam · Valproic acid · ALDH1A2 gene · Animal cell · Animal experiment · Animal model · Animal tissue · Case study · Cell vacuole · Concentration (parameters) · Controlled study · CYP26A1 gene · Demo case study · Developmental toxicity · Edema · Embryo · Embryotoxicity · Experimental design · Female · Gene · Gene expression · Histopathology · In situ hybridization · Larva · Liver cell · Male · Morphology · Motor activity · Nerve degeneration · Neurotoxicity · Nonhuman · Nucleotide sequence · Pericardial disease · Pericardial edema · Phenotype · Predictive value · Sensitivity analysis · Swimming · Toxicity testing · Toxicokinetics · Whole mount in situ hybridization · Zebra fish · Zebrafish embryotoxicity test · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

4 Metabolically induced liver inflammation leads to NASH and differs from LPS-or IL-1β-induced chronic inflammation
article 2014    
Author: Liang, W. · Lindeman, J.H. · Menke, A.L. · Koonen, D.P. · Morrison, M. · Havekes, L.M. · Hoek, A.M. van den · Kleemann, R.
Keywords: Biology · human NASH · inflammation · neutrophils · NF-κB · steatosis · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

5 Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates?
article 2015    
Author: Mesens, N. · Crawfordb, A.D. · Menke, A. · Hung, P.D. · Goethem, F. van · Nuyts, R. · Hansen, E. · Wolterbeek, A. · Gompel, J. van · Witte, P. de · Esguerra, C.V.
Keywords: Nutrition · Zebrafish larvae · Screening assay · Lfabp10a · Hepatotoxicity · DILI · Alpidem · Amiodarone · Bosentan · Buspirone · Diclofenac · Fatty acid binding protein · Fatty acid binding protein 10a · Glycogen · Ketorolac · Nefazodone · Paracetamol · Reactive oxygen metabolite · Rosiglitazone · Tacrine · Tamoxifen · Tetracycline · Troglitazone · Unclassified drug · Zolpidem · Adult · Animal tissue · Cell vacuole · Cholestasis · Circulation · Concentration response · Controlled study · Drug safety · Female · Glycogen analysis · Heart rate · Histology · Histopathology · In situ hybridization · Larval stage · Liver cell · Liver level · Liver size · Liver toxicity · Male · Mitochondrial membrane · Mitochondrial toxicity · Molecular cloning · Nonhuman · Protein expression · Steatosis · Toxicity testing · Zebra fish · Danio rerio · Food and Nutrition · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

6 Intervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis (NASH) and hepatic fibrosis in LDLR-/-.Leiden mice
article 2016    
Author: Morrison, M.C. · Mulder, P. · Salic, K. · Verheij, J. · Liang, W. · Duyvenvoorde, W. van · Menke, A. · Kooistra, T. · Kleemann, R. · Wielinga, P.Y.
Keywords: Biology · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

7 Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology
article 2014    
Author: Liang, W. · Menke, A.L. · Driessen, A. · Koek, G.H. · Lindeman, J.H. · Stoop, R. · Havekes, L.M. · Kleemann., R. · Hoek, A.M. van den
Keywords: Biology · Adult · Animal experiment · Animal model · Clinical article · Controlled study · Female · Hepatitis · Histopathology · Human · Human tissue · Human versus animal comparison · Liver biopsy · Liver fibrosis · Liver hypertrophy · Macrovesicular steatosis · Male · Microvesicular steatosis · Nonalcoholic fatty liver · Nonhuman · Process development · Reproducibility · Scoring system · Steatosis · Validation process · Rodentia · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

8 The APOE∗3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis
article 2019    
Author: Pouwer, M.G. · Heinonen, S.E. · Behrendt, M. · Andréasson, A.M. · Koppen A. van · Menke, A.L. · Pieterman, E.J. · Hoek, A.M. van den · Jukema, J.W. · Leighton, B. · Jonsson-Rylander, A.M. · Princen, H.M.G.
Keywords: Health · Inflammatory diseases · Diabetes · Atherosclerosis · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

9 Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death
article 2015    
Author: Keatinge, M. · Bui, H. · Menke, A. · Chen, Y.C. · Sokol, A.M. · Bai, Q. · Ellett, F. · Costa, M. da · Burke, D. · Gegg, M. · Trollope, L. · Payne, T. · McTighe, A. · Mortiboys, H. · Jager, S. de · Nuthall, H. · Kuo, M.S. · Fleming, A. · Schapira, A.H.V. · Renshaw, S.A. · Highley, J.R. · Chacinska, A. · Panula, P. · Burton, E.A. · O'Neill, M.J. · Bandmann, O.
Keywords: Health · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

10 Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr-/-.Leiden Mice
article 2018    
Author: Morrison, M.C. · Verschuren, L. · Salic, K. · Verhij, J. · Menke, A. · Wielinga, P.Y. · Iruarrizaga-Lejarretts, M. · Gole, L. · Yu, W.M. · Turner, S. · Caspers, M.P.M. · Martinez-Arranz, I. · Pieterman, E. · Stoop, R. · Koppen, A. van · Hoek, A.M. van den · Mato, J.M. · Hanemaaijer, R. · Alonso, C. · Kleemann, R.
Keywords: Biology · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 10 of 10 found. | Sort by date