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1 Effect of low dose atorvastatin versus diet-induced cholesterol lowering on atherosclerotic lesion progression and inflammation in apolipoprotein E*3-Leiden transgenic mice
article 2005    
Author: Verschuren, L. · Kleemann, R. · Offerman, E.H. · Szalai, A.J. · Emeis, S.J. · Princen, H.M.G. · Kooistra, T.
Keywords: Biology · Biomedical Research · Growth factors · Lipids · Lipoprotein metabolism · Pathophysiology · C reactive protein · Cholesterol · Gelatinase B · Macrophage migration inhibition factor · Plasminogen activator inhibitor 1 · Vascular cell adhesion molecule 1 · Animal cell · Animal experiment · animal model · Antiinflammatory activity · Aorta arch · Cholesterol blood level · Cholesterol diet · Controlled study · Dietary intake · Disease activity · Disease course · Disease severity · Inflammation · Lipoprotein metabolism · Low drug dose · Macrophage · Monocyte · Mouse · Nonhuman · Pathophysiology · Protein expression · Smooth muscle fiber · Transgenic mouse · Treatment outcome · Amyloid A protein · Apolipoprotein E3 · Atorvastatin · Animals · Anticholesteremic Agents · Aorta · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Biological Markers · C-Reactive Protein · Cholesterol · Diet · Diet, Atherogenic · Drug Administration Schedule · Female · Heptanoic Acids · Inflammation · Male · Mice · Mice, Transgenic · Pyrroles · Serum Amyloid A Protein
[Abstract]

2 Some characteristics of three ageing rat models for osteopenia with emphasis on effects of PTH
article 1994    
Author: Theuns, H.M. · Offerman, E. · Blauw, B. · Hoven, P.v.d. · Bekker, H. · Roholl, P.J.M.
Keywords: Health · ageing rat models for osteopenia · histomorphometry · postmenopausal osteopenia · senile osteopenia · vitamin D deficiency
[Abstract]

3 A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice
article 1993    
Author: HogenEsch, H. · Gijbels, M.J.J. · Offerman, E. · Hooft, J. van · Bekkum, D.W. van · Zurcher, C.
Keywords: Biology · broxuridine · intercellular adhesion molecule 1 · triamcinolone · epidermis hyperplasia · gene mutation · hematopoietic cell · histopathology · immunohistochemistry · macrophage function · neutrophil · remission · squamous epithelium · Adrenal Cortex Hormones · Animal · Chronic Disease · Cyclosporine · Dermatitis · Disease Models, Animal · Immunohistochemistry · Mast Cells · Mice · Mice, Inbred C57BL · Mutation · Rodent Diseases · Skin
[PDF] [Abstract]

4 Combined analysis of pharmacokinetic and efficacy data of preclinical studies with statins markedly improves translation of drug efficacy to human trialss
article 2013    
Author: Steeg, E. van de · Kleemann, R. · Jansen, H.T. · Duyvenvoorde, W. van · Offerman, E.H. · Wortelboer, H.M. · DeGroot, J.
Keywords: Biology · Biomedical Innovation · Healthy Living · Life · PHS - Pharmacokinetics & Human Studies (tot 2013 daarna KFP) MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

5 Cholesteryl ester transfer protein decreases high-density lipoprotein and severely aggravates atherosclerosis in APOE*3-Leiden mice
article 2006    
Author: Westerterp, M. · Hoogt, C.C. van der · Haan, W. de · Offerman, E.H. · Dallinga-Thie, G.M. · Jukema, J.W. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Health · Biomedical Research · CETP · Cholesterol efflux · Hyperlipidemia · Reverse cholesterol transport · Transgenic mice cholesterol · High density lipoprotein · Low density lipoprotein · Very low density lipoprotein · Animal cell · Animal experiment · Animal model · Animal tissue · Aorta root · Atherosclerosis · Cholesterol blood level · Controlled study · Diet · Mouse · Nonhuman · Plasma · Protein expression · Transgenic mouse · Animals · Antigens, CD36 · Apolipoprotein E3 · Apolipoproteins E · Atherosclerosis · Carrier Proteins · Cell Line, Tumor · Cholesterol · Cholesterol Ester Transfer Proteins · Diet · Female · Glycoproteins · Humans · Lipids · Lipoproteins · Lipoproteins, HDL · Macrophages · Mice · Mice, Transgenic · Rats
[Abstract]

6 Apolipoprotein CI aggravates atherosclerosis development in ApoE-knockout mice despite mediating cholesterol efflux from macrophages
article 2007    
Author: Westerterp, M. · Eck, M. van · Haan, W. de · Offerman, E.H. · Berkel, T.J.C. van · Havekes, L.M. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · ApoCI · Cholesterol efflux · Hyperlipidemia · Macrophages · Transgenic mice · Triacylglycerol · Adipose tissue · Aorta root · Artery wall · Atherosclerosis · Protein expression · Statistical significance · Triacylglycerol blood level · Animals · Apolipoprotein C-I · Apolipoproteins E · Atherosclerosis · Bone Marrow Cells · Bone Marrow Transplantation · Cholesterol · Female · Gene Expression Regulation · Liver · Macrophages · Male · Mice · Mice, Knockout · Mice, Transgenic
[Abstract]

7 No effect of C-reactive protein on early atherosclerosis development in apolipoprotein E*3-Leiden/human C-reactive protein transgenic mice
article 2005    
Author: Trion, A. · Maat, M.P.M. de · Jukema, J.W. · Laarse, A. van der · Maas, M.C. · Offerman, E.H. · Havekes, L.M. · Szalai, A.J. · Princen, H.M.G. · Emeis, J.J.
Keywords: Biology · Biomedical Research · Atherosclerosis · C-reactive protein · Inflammation · Mouse · Transgene · Acute phase protein · Apolipoprotein E3 Leiden · Biological marker · C reactive protein · Cholesterol · Unclassified drug · Animal experiment · Animal model · Animal tissue · Atherogenesis · Blood sampling · Cardiovascular risk · Cholesterol blood level · Cholesterol diet · Controlled study · Enzyme linked immunosorbent assay · Experimental model · Histopathology · Hypercholesterolemia · Immunohistochemistry · Inflammation · Mouse strain · Nonhuman · Pathophysiology · Protein blood level · Protein expression · Protein function · Transgenic mouse · Animals · Apolipoprotein E3 · Apolipoproteins E · Atherosclerosis · Biological Markers · Body Weight · C-Reactive Protein · Cholesterol · Early Diagnosis · Eating · Endothelium, Vascular · Female · Humans · Hypercholesterolemia · Male · Mice · Mice, Transgenic · Monocytes · Risk Factors · Severity of Illness Index
[Abstract]

8 Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification
article 2007    
Author: Westerterp, M. · Berbée, J.F.P. · Delsing, D.J.M. · Jong, M.C. · Gijbels, M.J.J. · Dahlmans, V.E.H. · Offerman, E.H. · Romijn, J.A. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Lipoprotein · Lipoprotein lipase · Skin · Triglyceride · very low density lipoprotein · animal cell · animal experiment · animal tissue · controlled study · electricity · esterification · female · in vitro study · mouse · nonhuman · phenotype · skin transplantation · wild type · Animals · Apolipoprotein C-I · Cells, Cultured · Enzyme-Linked Immunosorbent Assay · Esterification · Fatty Acids, Nonesterified · Female · Humans · Lipoproteins, VLDL · Macrophages · Male · Mice · Mice, Inbred C57BL · Mice, Knockout · Mice, Transgenic · Oleic Acid · Phenotype · Protein Binding · Skin · Skin Abnormalities · Skin Transplantation
[PDF] [Abstract]

9 Acyl-CoA:Cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE*3-leiden mice
article 2001    
Author: Delsing, D.J.M. · Offerman, E.H. · Duyvenvoorde, W. van · Boom, H. van der · Wit, E.C.M. de · Gijbels, M.J.J. · Laarse, A. van der · Jukema, J.W. · Havekes, L.M. · Princen, H.M.G.
Keywords: Biology · Acetates · Animals · Anticholesteremic Agents · Aortic Valve · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Body Weight · Cell Adhesion · Cell Line · Cholesterol · Diet, Atherogenic · Disease Models, Animal · Eating · Endothelium, Vascular · Female · Heterozygote · Lipoproteins · Macrophages · Mice · Mice, Transgenic · Sterol O-Acyltransferase · Sulfonic Acids
[Abstract]

10 APOE*3Leiden.CETP transgenic mice as model for pharmaceutical treatment of the metabolic syndrome
article 2014    
Author: Hoek, A.M. van den · Hoorn, J.W.A. van der · Maas, A.C. · Hoogen, R.M. van den · Nieuwkoop, A. van · Droog, S. · Offerman, E.H. · Pieterman, E.J. · Havekes, L.M. · Princen, H.M.G.
Keywords: Biology · Diabetic dyslipidemia · Insulin resistance · NAFLD · Obesity · Pharmacological treatment · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 10 of 10 found. | Sort by date