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1 Comment on "Hypercholesterolemia with consumption of PFOA-laced Western diets is dependent on strain and sex of mice" by Rebholz S.L. et al. Toxicol. Rep. 2016 (3) 46-54
article 2016    
Author: Princen, H.M.G. · Pouwer, M.G. · Pieterman, E.J.
Keywords: Biology · APOE*3-Leiden.CETP mice · Lipoprotein metabolism · Lipoproteins · Non-HDL-C/HDL-C · Perfluorooctanoate (PFOA) · Plasma cholesterol · Plasma triglycerides · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences

2 Colestilan decreases weight gain by enhanced NEFA incorporation in biliary lipids and fecal lipid excretion
article 2013    
Author: Sugimoto-Kawabata, K. · Shimada, H. · Sakai, K. · Suzuki, K. · Kelder, T. · Pieterman, E.J. · Cohen, L.H. · Havekes, L.M. · Princen, H.M. · Hoek, A.M. van den
Keywords: Biology · Adipose tissue · Bile acid sequestrant · Hyperinsulinemic-euglycemic clamp · Insulin sensitivity · Nonesterified fatty acid · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

3 Dose effects of ammonium perfluorooctanoate on Lipoprotein Metabolism in APOE*3-Leiden.CETP mice
article 2019    
Author: Pouwer, M.G. · Pieterman, E.J. · Chang, S.C. · Olsen, G.W. · Verschuren, L. · Jukema, J.W. · Princen, H.M.G.
Keywords: Health · Cholesterol · Lipoproteins · Non-HDL cholesterol · Perfluorooctanoic acid (PFOA) · Peroxisome proliferator-activated receptor (PPAR)α · Triglycerides · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

4 The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden.CETP mice
article 2017    
Author: Landlinger, C. · Pouwer, M.G. · Juno, C. · Hoorn, J.W.A. van der · Pieterman, E.J. · Jukema, J.W. · Staffler, G. · Princen, H.M.G. · Galabova, G.
Keywords: Health · APOE*3Leiden.CETP mice · Anti-PCSK9 vaccine · Atherosclerosis · Systemic and vascular inflammation · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

5 The BCR-ABL1 Inhibitors Imatinib and Ponatinib Decrease Plasma Cholesterol and Atherosclerosis, and Nilotinib and Ponatinib Activate Coagulation in a Translational Mouse Model
article 2018    
Author: Pouwer, M.G. · Pieterman, E.J. · Verschuren, L. · Caspers, M.P.M. · Kluft, C. · Garcia, R.A. · Aman, J. · Jukema, J.W. · Princen, H.M.G.
Keywords: Biology · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

6 Alirocumab, evinacumab, and atorvastatin triple therapy regresses plaque lesions and improves lesion composition in mice
article 2019    
Author: Pouwer, M.G. · Pieterman, E.J. · Worms, N. · Keijzer, N. · Jukema, J.W. · Gromada, J. · Gusarova, V. · Princen, H.M.G.
Keywords: APOE*3-Leiden.CETP mice · Angiopoietin-like proteins · Antibodies · Apolipoproteins · Atherosclerosis · Cardiovascular disease · Drug therapy/Hypolipidemic drugs · Macrophages / monocytes · PCSK9 · Regression · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

7 Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin
article 2014    
Author: Kühnast, S. · Hoorn, J.W.A. van der · Pieterman, E.J. · Hoek, A.M. van den · Sasiela, W.J. · Gusarova, V. · Peyman, A. · Schäfer, H.L. · Schwahn, U. · Jukema, J.W. · Princen, H.M.G.
Keywords: Biology · 3Leiden.CETP mice · APOE · Atorvastatin · Proprotein convertase subtilisin/kexin type 9 · Alirocumab · Apolipoprotein E · Atorvastatin · Bile acid · Cholesterol · Collagen · Low density lipoprotein receptor · Sterol · Triacylglycerol · Animal experiment · Animal model · Atherosclerosis · Atherosclerotic plaque · Controlled study · Disease severity · Dose response · Drug effect · Drug potentiation · Drug safety · Fat content · Female · Lipid blood level · Monocyte · Monotherapy · Mouse · Nonhuman · Protein degradation · Smooth muscle fiber · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

8 A novel EPO receptor agonist improves glucose tolerance via glucose uptake in skeletal muscle in a mouse model of diabetes
article 2011    
Author: Scully, M.S. · Ort, T.A. · James, I.E. · Bugelski, P.J. · Makropoulos, D.A. · Deutsch, H.A. · Pieterman, E.J. · Hoek, A.M. van den · Havekes, L.M. · Dubell, W.H. · Wertheimer, J.D. · Picha, K.M.
Keywords: Health · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

9 Fenofibrate increases very low density lipoprotein triglyceride production despite reducing plasma triglyceride levels in APOE*3-Leiden.CETP mice
article 2010    
Author: Bijland, S. · Pieterman, E.J. · Maas, A.C.E. · Hoorn, J.W.A. van der · Erk, M.J. van · Klinken, J.B. van · Havekes, L.M. · Dijk, K.W. van · Princen, H.M.G. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Apolipoprotein B (apoB) · Emulsion particles · Fenofibrate · Hepatic genes · Kinetic study · Lipoprotein lipase · Lipoprotein metabolism · Male mouse · Mouse models · Palmitic acid · Peroxisome proliferator-activated receptor · Plasma cholesterol · Plasma triglycerides · Production rates · Skeletal muscle · Very low density lipoproteins · White adipose tissues · Acids · Cytology · Emulsification · Fatty acids · Gene expression · Glycerol · Liver · Mammals · Nutrition · Plasmas · Acetyl coenzyme A acetyltransferase · Acyl coenzyme A desaturase 1 · Acyl coenzyme A oxidase · Apolipoprotein A4 · Apolipoprotein B · Apolipoprotein B messenger RNA editing enzyme catalytic polypeptide 1 · Apolipoprotein C1 · Apolipoprotein C2 · Apolipoprotein C3 · Apolipoprotein E3 · Blood clotting factor 5 Leiden · Carnitine palmitoyltransferase I · Cholesterol · Cholesterol ester transfer protein · Diacylglycerol acyltransferase 1 · Diacylglycerol acyltransferase 2 · Fas antigen · Fatty acid · Fatty acid binding protein 2 · Fenofibrate · Lipoprotein lipase · Palmitic acid · Sterol regulatory element binding protein 1a · Sterol regulatory element binding protein 1c · Triacylglycerol · Triolein · Tritium · Animal experiment · Controlled study · Emulsion · Enzyme activity · Esterification · Food intake · Gene expression profiling · Lipid transport · Lipogenesis · Lipoprotein synthesis · Liver parenchyma · Nnhuman · Skeletal muscle · Treatment duration · Treatment outcome · Animals · Apolipoproteins B · Lipid Metabolism · Lipoproteins, HDL · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Transgenic · Procetofen · Triglycerides · Biomedical Innovation · Healthy Living
[PDF] [Abstract]

10 Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE*3Leiden.CETP mice, a translational model for atherosclerosis
article 2014    
Author: Gierman, L.M. · Kühnast, S. · Koudijs, A. · Pieterman, E.J. · Kloppenburg, M. · Osch, G.J.V.M. van · Stojanovic-Susulic, V. · Huizinga, T.W.J. · Princen, H.M.G. · Zuurmond. A.M.
Keywords: Biology · Alanine aminotransferase · Apolipoprotein E · Atorvastatin · Cholesterol ester transfer protein · Endothelial leukocyte adhesion molecule 1 · Etimibe · Monocyte chemotactic protein 1 · Serum amyloid A · Very low density lipoprotein · Animal experiment · Animal model · Animal tissue · Atherosclerosis · Cholesterol blood level · Cholesterol intake · Controlled study · Female · Knee osteoarthritis · Mouse · Nonhuman · Priority journal · Transgenic mouse · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

11 APOE*3Leiden.CETP transgenic mice as model for pharmaceutical treatment of the metabolic syndrome
article 2014    
Author: Hoek, A.M. van den · Hoorn, J.W.A. van der · Maas, A.C. · Hoogen, R.M. van den · Nieuwkoop, A. van · Droog, S. · Offerman, E.H. · Pieterman, E.J. · Havekes, L.M. · Princen, H.M.G.
Keywords: Biology · Diabetic dyslipidemia · Insulin resistance · NAFLD · Obesity · Pharmacological treatment · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

12 Anacetrapib reduces (V)LDL-cholesterol by inhibition of CETP activity and reduction of plasma PCSK9
article 2015    
Author: Tuin, S.J. van der · Kühnast, S. · Berbée, J. · Verschuren, L. · Pieterman, E.J. · Havekes, L.M. · Hoorn, J.W. van der · Rensen, P.C. · Jukema, J.W. · Princen, H.M. · Willems van Dijk, K. · Wang, Y.
Keywords: Health · CETP · Cholesterol · Metabolism · Drug therapy · Hypolipidemic drugs · LDL · Metabolism · Lipids · Lipoproteins · PCSK9 · Anacetrapib · Apolipoprotein B · Cholesterol ester transfer protein · Low density lipoprotein receptor · Proprotein convertase subtilisin kexin type 9 · RNA · Serine proteinase · Sterol regulatory element binding protein 1 · Sterol regulatory element binding protein 2 · Triacylglycerol · Unclassified drug · Very low density lipoprotein cholesterol · Animal experiment · Animal tissue · Atherosclerosis · Cholesterol synthesis · Controlled study · Down regulation · Drug mechanism · Enzyme blood level · Female · Liver · Microarray analysis · Mouse · Nonhuman · Polymerase chain reaction · Protein expression · RNA isolation · Western diet · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

13 The APOE∗3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis
article 2019    
Author: Pouwer, M.G. · Heinonen, S.E. · Behrendt, M. · Andréasson, A.M. · Koppen A. van · Menke, A.L. · Pieterman, E.J. · Hoek, A.M. van den · Jukema, J.W. · Leighton, B. · Jonsson-Rylander, A.M. · Princen, H.M.G.
Keywords: Health · Inflammatory diseases · Diabetes · Atherosclerosis · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

14 Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3
article 2003    
Author: Laan, W.H. van der · Quax, P.H.A. · Seemayer, C.A. · Huisman, L.G.M. · Pieterman, E.J. · Grimbergen, J.M. · Verheijen, J.H. · Breedveld, F.C. · Gay, R.E. · Gay, S. · Huizinga, T.W.J. · Pap, T.
Keywords: Adenoviridae · Animals · Arthritis, Rheumatoid · Cartilage, Articular · Cell Division · Fibroblasts · Gene Expression · Gene Therapy · Genetic Vectors · Humans · Matrix Metalloproteinases · Mice · Mice, SCID · Synovial Membrane · Tissue Inhibitor of Metalloproteinase-1 · Tissue Inhibitor of Metalloproteinase-3 · Transduction, Genetic · Adenoviridae · Animalia
[Abstract]

15 PCSK9 inhibition fails to alter hepatic LDLR, circulating cholesterol, and atherosclerosis in the absence of ApoE
article 2014    
Author: Ason, B. · Hoorn, J.W.A. van der · Chan, J. · Lee, E. · Pieterman, E.J. · Nguyen, K.K. · Di, M. · Shetterly, S. · Tang, J. · Yeh, W.C. · Schwarz, M. · Jukema, J.W. · Scott, R. · Wasserman, S.M. · Princen, H.M.G. · Jackson, S.
Keywords: Biology · Anti-proprotein convertase subtilisin/kexin type 9 antibody · Apolipoprotein E · Low density lipoprotein receptor · Proprotein convertase subtilisin/kexin type 9 · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

16 Niacin Reduces Atherosclerosis Development in APOE*3Leiden.CETP Mice Mainly by Reducing NonHDL-Cholesterol
article 2013    
Author: Kühnast, S. · Louwe, M.C. · Heemskerk, M.M. · Pieterman, E.J. · Klinken, J.B. van · Berg, S.A.A. van den · Smit, J.W.A. · Havekes, L.M. · Rensen, P.C.N. · Hoorn, J.W.A. van der · Princen, H.M.G. · Jukema, J.W.
Keywords: Biology · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

17 Perfluoroalkyl sulfonates cause alkyl chain length-dependent hepatic steatosis and hypolipidemia mainly by impairing lipoprotein production in APOE*3-leiden CETP mice
article 2011    
Author: Bijland, S. · Rensen, P.C.N. · Pieterman, E.J. · Maas, A.C.E. · Hoorn, J.W. van der · Erk, M.J. van · Havekes, L.M. · Dijk, K.W. van · Chang, S.C. · Ehresman, D.J. · Butenhoff, J.L. · Princen, H.M.G.
Keywords: Health · Cholesterol · Lipoprotein · Perfluorooctane sulfonate · PPARa · PXR · Triglyceride · Life · MSB - Microbiology and Systems Biology MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

18 Variable cartilage degradation in mice with diet-induced metabolic dysfunction: food for thought
article 2018    
Author: Kozijn, A.E. · Gierman, L.M. · Ham, F. van der · Mulder, P. · Morrison, M.C. · Kühnast, S. · Heijden, R.A. van der · Stavro, P.M. · Koppen, A. van · Pieterman, E.J. · Hoek, A.M. van den · Kleemann, R. · Princen, H.M.G. · Mastbergen, S.C. · Lafeber, F.P.J.G. · Zuurmond, A.M. · Bobeldijk, I. · Weinans, H. · Stoop, R.
Keywords: Biology · Osteoarthritis · Metabolic dysfunction · High-fat diet · Obesity · Mouse model · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

19 Oncostatin M reduces atherosclerosis development in APOE*3Leiden.CETP mice and is associated with increased survival probability in humans
article 2019    
Author: Keulen, D. van · Pouwer, M.G. · Emilsson, V. · Matic LP · Pieterman, E.J. · Hedin, U. · Gudnason, V. · Jennings, L.L. · Holmstrøm, K. · Nielsen, B.S. · Pasterkamp, G. · Lindeman, J.H.N. · Gool, A.J. van · Sollewijn Gelpke, M.D. · Princen, H.M.G. · Tempel, D.
Keywords: Atherosclerosis · Oncostatin M · Biomedical Innovation · Healthy Living · Life Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 19 of 19 found. | Sort by date