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1 Inhibition of glutathione S-transferase activity in human melanoma cells by alfa, beta-unsaturated carbonyl derivatives : effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal
article 1996    
Author: Iersel, M.L.P.S. van · Ploemen, J.P.H.T.M. · Struik, I. · Amersfoort, C. van · Keyzer, A.E. · Schefferlie, J.G. · Bladeren, P.J. van
Keywords: Health · Cells · Glutathione S-transferases · Inhibition · Ketones · 2 hexenal · Cinnamaldehyde · Citral · Crotonaldehyde · Controlled study · Enzyme activity · Enzyme inhibition · High performance liquid chromatography · Human · Human cell · Melanoma cell · Acrolein · Aldehydes · Chromatography, High Pressure Liquid · Curcumin · Enzyme Inhibitors · Ethacrynic Acid · Glutathione · Glutathione Transferase · Humans · Melanoma · Monoterpenes · Skin Neoplasms · Terpenes · Tumor Cells, Cultured
[Abstract]

2 Irreversible inhibition of cytosolic glutathione S-transferases
article 1996    
Author: Ploemen, J.P.H.T.M. · Ommen, B. van · Iersel, M.L.P.S. van · Rompelberg, C.J.M. · Verhagen, H. · Bladeren, P.J. van
Keywords: Nutrition

3 In vitro inhibition of rat and human glutathione S-transferase isoenzymes by disulfiram and diethyldithiocarbamate
article 1996    
Author: Ploemen, J.-P.H.T.M. · Iersel, M.L.P.S. van · Wormhoudt, L.W. · Commandeur, J.N.M. · Vermeulen, N.P.E. · Bladeren, P.J. van
Keywords: diethyldithiocarbamate · disulfiram · gl utathion e · glutathione S-transferases · in vitro · inhibition · 1 chloro 2,4 dinitrobenzene · 1,2 epoxy 3 (4 nitrophenoxy)propane · aldehyde dehydrogenase inhibitor · diethyldithiocarbamic acid · disulfiram · dithiothreitol · glutathione transferase · isoenzyme · thiol · unclassified drug · article · controlled study · drug metabolism · enzyme inactivation · enzyme inhibition · enzyme purification · enzyme substrate · human · nonhuman · priority journal · rat · reduction · Animals · Disulfiram · Dithiothreitol · Ditiocarb · Glutathione · Glutathione Transferase · Humans · Isoenzymes · Rats · Spectrophotometry, Ultraviolet · Time Factors
[Abstract]

4 Use of physicochemical calculation of pKa and CLogP to predict phospholipidosis-inducing potential: A case study with structurally related piperazines
article 2004    
Author: Ploemen, J.P.H.T.M. · Kelder, J. · Hafmans, T. · Sandt, H. van de · Burgsteden, J.A. van · Salemink, P.J.M. · Esch, E. van
Keywords: Health Physiology · Physiological Sciences · Alveolar histiocystosis · Electron microscopy · Foamy macrophages · Gepirone · Lung · Phospholipidosis · Physicochemical calculated parameters · Piperazines · Sprague-Dawley rats · gepirone · piperazine · animal experiment · animal model · article · cell proliferation · cell type · controlled study · electron microscopy · histiocytosis · lipidosis · lung alveolus epithelium · lung alveolus macrophage · lymphoid tissue · macrophage activation · male · nonhuman · partition coefficient · pKa · prediction · rat · Administration, Oral · Animals · Antidepressive Agents · Chemistry, Physical · Diet · Dose-Response Relationship, Drug · Female · Foam Cells · Humans · Lipidoses · Male · Phospholipids · Pulmonary Alveoli · Pyrimidines · Rats · Rats, Sprague-Dawley · Toxicity Tests · U937 Cells · Animalia
[Abstract]

5 Uniform procedure of 1H NMR analysis of rat urine and toxicometabonomics Part II : Comparison of NMR profiles classification of hepatotoxicity
article 2007    
Author: Schoonen, W.G.E.J. · Kloks, C.P.A.M. · Ploemen, J.-P.H.T.M. · Smit, M.J. · Zandberg, P. · Horbach, G.J. · Mellema, J.-R. · Zuylen, C.T. van · Tas, A.C. · Nesselrooij, J.H.J. van · Vogels, J.T.W.E.
Keywords: Biology · Analytical research · Cholestasis · Hepatotoxicity · Metabonomics · Necrosis · NMR · Steatosis · Urinalysis · 1 naphthyl isothiocyanate · biological marker · bromobenzene · carbon tetrachloride · chlorpromazine · ethinylestradiol · ibuprofen · iproniazid · isoniazid · methyltestosterone · mianserin · paracetamol · phenobarbital · placebo · tetracycline · thioacetamide · animal experiment · animal tissue · article · controlled study · diagnostic accuracy · diagnostic value · drug blood level · drug urine level · early diagnosis · fatty liver · histopathology · intermethod comparison · intrahepatic cholestasis · liver necrosis · liver toxicity · male · nonhuman · pattern recognition · prediction · principal component analysis · proton nuclear magnetic resonance · rat · urinalysis · Animals · Biological Markers · Cholestasis · Fatty Liver · Hepatitis, Toxic · Liver · Magnetic Resonance Spectroscopy · Male · Necrosis · Pattern Recognition, Automated · Principal Component Analysis · Rats · Rats, Wistar · Urine · Animalia · Rattus
[Abstract]

6 Sensitivity of 1H NMR analysis of rat urine in relation to toxicometabonomics. Part I: Dose-dependent toxic fffects of Bromobenzene and paracetamol
article 2007    
Author: Schoonen, W.G.E.J. · Kloks, C.P.A.M. · Ploemen, J.P.H.T.M. · Horbach, G.J. · Smit, M.J. · Zandberg, P. · Mellema, J.R. · Zuylen, C.T. van · Tas, A.C. · Nesselrooij, J.H.J. van · Vogels, J.T.W.E.
Keywords: Biology · Analytical research · Biomarkers · Bromobenzene · Hepatotoxicity · Metabonomics · Necrosis · Paracetamol · Urinalysis · alanine aminotransferase · aspartate aminotransferase · biological marker · bromobenzene · paracetamol · alanine aminotransferase blood level · animal experiment · animal tissue · article · aspartate aminotransferase blood level · clinical chemistry · controlled study · diagnostic accuracy · diagnostic value · dose response · drug blood level · drug urine level · early diagnosis · histopathology · intermethod comparison · liver dysfunction · liver necrosis · liver toxicity · male · non invasive measurement · nonhuman · pattern recognition · principal component analysis · proton nuclear magnetic resonance · rat · sensitivity analysis · spectrometer · urinalysis · Acetaminophen · Alanine Transaminase · Analgesics, Non-Narcotic · Animals · Aspartate Aminotransferases · Bromobenzenes · Dose-Response Relationship, Drug · Hepatitis, Toxic · Kidney · Liver · Magnetic Resonance Spectroscopy · Necrosis · Principal Component Analysis · Rats · Rattus
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 6 of 6 found. | Sort by date