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Showing 1 to 15 of 15 found. | Sort by date

1 Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms
article 2000    
Author: Renwick, A.B. · Surry, D. · Price, R.J. · Lake, B.G. · Evans, D.C.

2 Lack of effect of coumarin on unscheduled DNA synthesis in the in vivo rat hepatocyte DNA repair assay
article 2000    
Author: Edwards, A.J. · Price, R.J. · Renwick, A.B. · Lake, B.G.
Keywords: In vivo DNA repair · Rat hepatocytes · Unscheduled DNA synthesis · dimethylnitrosamine · n (2 fluorenyl)acetamide · animal cell · chromosome aberration · controlled study · liver cell · liver toxicity · nonhuman · sister chromatid exchange · unscheduled DNA synthesis · 2-Acetylaminofluorene · Animals · Anticoagulants · Cell Separation · Cells, Cultured · Coumarins · Dimethylnitrosamine · DNA · DNA Repair · DNA Replication · Liver · Male · Mutagens · Rats · Rats, Sprague-Dawley · Animalia · Zea mays
[Abstract]

3 Metabolism of zaleplon by human liver : evidence for involvement of aldehyde oxidase
article 2002    
Author: Lake, B.G. · Ball, S.E. · Kao, J. · Renwick, A.B. · Price, R.J. · Scatina, J.A.
Keywords: Nutrition

4 CYP isoform induction screening in 96-well plates : use of 7-benzyloxy-4-trifluoromethylcoumarin as a substrate for studies with rat hepatocytes
article 2000    
Author: Price, R.J. · Surry, D. · Renwick, A.B. · Meneses-Lorente, G. · Lake, B.G. · Evans, D.C.
Keywords: Medicine · Geneeskunde · Pharmacology · Toxicology

5 Metabolism of a novel phosphodiesterase-IV inhibitor (V11294) by human hepatic cytochrome P450 forms
article 2002    
Author: Subrahmanyam, V. · Renwick, A.B. · Waters, D.G. · Price, R.J. · Tonelli, A.P. · Lake, B.G.
Keywords: Nutrition

6 Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes
article 2001    
Author: Subrahmanyam, V. · Renwick, A.B. · Walters, D.G. · Young, P.J. · Price, R.J. · Tonelli, A.P. · Lake, B.G.
Keywords: Nutrition

7 Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices
article 2000    
Author: Renwick, A.B. · Watts, P.S. · Edwards, R.J. · Barton, P.T. · Guyonnet, I. · Price, R.J. · Tredger, J.M. · Pelkonen, O. · Boobis, A.R. · Lake, B.G.
Keywords: Biology · Biochemistry

8 Use of a quantitative real-time reverse transcription-polymerase chain reaction method to study the induction of CYPIA, CYP2B and CYP4A forms in precision-cut rat liver slices
article 2002    
Author: Pan, J. · Xiang, Q. · Renwick, A.B. · Price, R.J. · Ball, S.E. · Kao, J. · Scatina, J.A. · Lake, B.G.
Keywords: Nutrition

9 Inhibition of zaleplon metabolism by cimetidine in the human liver : in vitro studies with subcellular fractions and precision-cut liver slices
article 2002    
Author: Renwick, A.B. · Ball, S.E. · Tredger, J.M. · Price, R.J. · Walters, D.G. · Kao, J. · Scatina, J.A. · Lake, B.G.
Keywords: Nutrition · Aldehyde oxidase · Cimetidine · Cytochrome P450 3A · Reduced nicotinamide adenine dinucleotide phosphate · Zaleplon · Cell fractionation · Drug inhibition · Drug metabolism · Human · Human cell · Human tissue · In vitro study · Liver metabolism · Liver microsome · Liver slice · Acetamides · Cimetidine · Cytosol · Dose-Response Relationship, Drug · Drug Interactions · Enzyme Inhibitors · Humans · Hypnotics and Sedatives · Inhibitory Concentration 50 · Kinetics · Liver · Models, Chemical · Pyrimidines · Subcellular Fractions · Staphylococcus phage 3A
[Abstract]

10 Evaluation of 7-benzyloxy-4-trifluoromethyl-coumarin, some other 7-hydroxy-4-trifluoro-methylcoumarin derivatives and 7-benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450 enzymes
article 2001    
Author: Renwick, A.B. · Lavignette, G. · Worboys, P.D. · Williams, B. · Surry, D. · Lewis, D.F.V. · Price, R.J. · Lake, B.G. · Evans, D.C.
Keywords: Nutrition

11 Lack of effect of furfural on unscheduled DNA synthesis in the in vivo rat and mouse hepatocyte DNA repair assays and in precision-cut human liver slices
article 2001    
Author: Lake, B.G. · Edwards, A.J. · Price, R.J. · Phillips, B.J. · Renwick, A.B. · Beamand, J.A. · Adams, T.B.
Keywords: Nutrition

12 Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices
article 2000    
Author: Renwick, A.B. · Watts, P.S. · Edwards, R.J. · Barton, P.T. · Guyonnet, I. · Price, R.J. · Tredger, J.M. · Pelkonen, O. · Boobis, A.R. · Lake, B.G.
Keywords: Nutrition · Apoprotein · Cytochrome P450 · Cytochrome p450 2a6 · Cytochrome P450 2B6 · Cytochrome P450 2C19 · Cytochrome p450 2c8 · Cytochrome P450 2C9 · Cytochrome P450 3A4 · Cytochrome P450 3A5 · Debrisoquine 4 hydroxylase · Dimethylnitrosamine demethylase · Ethoxyresorufin · O Deethylase · Peptide antibody · Phenacetin o deethylase · Tolbutamide methylhydroxylase · Unclassified drug · Enzyme activity · Enzyme metabolism · Human tissue · Liver cell culture · Liver slice · Protein stability · School child · Xenobiotic metabolism · Adolescent · Adult · Aged · Child · Child, Preschool · Culture Media · Culture Techniques · Cytochrome P-450 Enzyme System · Enzyme Stability · Female · Humans · Immunoblotting · Isoenzymes · Liver · Male · Microsomes, Liver · Middle Aged
[Abstract]

13 Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-trifluoromethyl- coumarin by human hepatic CYP isoforms : evidence for selectivity towards CYP3A4
article 2001    
Author: Renwick, A.B. · Lewis, D.F.V. · Fulfords, S. · Surry, D. · Williams, B. · Worboys, P.D. · Cai, X. · Wang, R.W. · Price, R.J. · Lake, B.G. · Evans, D.C.
Keywords: Nutrition

14 Carbamazapine : a 'blind' assessment of CYP-associated metabolism and interactions in human liver-derived in vitro systems
article 2001    
Author: Pelkonen, O. · Myllynen, P. · Taavitsainen, P. · Boobis, A.R. · Watts, P. · Lake, B.G. · Price, R.J. · Renwick, A.B. · Gómez-Lechón, M.J. · Castell, J.V. · Ingelman-Sundberg, M. · Hidestrand, M. · Guillouzo, A. · Corcos, L. · Goldfarb, P.S. · Lewis, D.F.V.
Keywords: Nutrition · ISDN · MANAGED OBJECTS · PMBS · TELECOMMUNICATIONS MANAGEMENT

15 An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant
article 2001    
Author: Andersson, T.B. · Sjöberg, H. · Hoffmann, K.J. · Boobis, A.R. · Watts, P. · Edwards, R.J. · Lake, B.G. · Price, R.J. · Renwick, A.B. · Gómez-Lechón, M.J. · Castell, J.V. · Ingelman-Sundberg, M. · Hidestrand, M. · Goldfarb, P.S. · Lewis, D.F.V. · Corcos, L. · Guillouzo, A. · Taavitsainen, P. · Pelkonen, O.
Keywords: Nutrition

Search results also available in MS Excel format.

Showing 1 to 15 of 15 found. | Sort by date