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Showing 1 to 12 of 12 found. | Sort by date

1 Toxicology in the 21st century - Working our way towards a visionary reality
article 2011    
Author: Berg, N. · Wever, B.de · Fuchs, H.W. · Gaca, M. · Krul, C.A.M. · Roggen, E.L.
Keywords: Health · -Omics · 21st Century vision · 3Rs · Computational · In vitro · Replacement · Testing strategy · Toxicity testing · Validation · article · biological model · education · Europe · ex vivo study · financial management · in vitro study · in vivo study · interpersonal communication · leadership · medical research · practice guideline · risk assessment · standardization · systems biology · toxicity testing · toxicology · validation process · Animalia · Healthy living · Biomedical Innovations · Themalijn
[Abstract]

2 Implementation challenges for designing Integrated In Vitro Testing Strategies (ITS) aiming at reducing and replacing animal experimentation
article 2012    
Author: Wever, B.de · Fuchs, H.W. · Gaca, M. · Krul, C.A.M. · Mikulowski, S. · Poth, A. · Roggen, E.L. · Vilà, M.R.
Keywords: Eye irritation · ITS · ITS design · IVTIP · Replacement · Reproductive toxicity · Testing strategies · Validation · Healthy for Life · Healthy Living · Healthy Living Life · RAPID - Risk Analysis for Products in Development · Themalijn
[Abstract]

3 State of the art on alternative methods to animal testing from an industrial point of view: ready for regulation?
article 2014    
Author: Ashton, R. · Wever, B. de · Fuchs, H.W. · Gaca, M. · Hill, E. · Krul, C.A.M. · Poth, A. · Roggen, E.L.
Keywords: Health · Non-animal testing · Legislation · Regulation · In vitro modeling · Harmonization · Standardization · Analytic method · Animal testing alternative · Conference paper · Industry · Law · Toxicity testing · Biomedical Innovation · Healthy Living · Healthy Living · Themalijn
[Abstract]

4 Chemical respiratory allergy: Opportunities for hazard identification and characterisation
article 2007    
Author: Kimber, I. · Agius, R. · Basketter, D.A. · Corsini, E. · Cullinan, P. · Dearman, R.J. · Gimenez-Arnau, E. · Greenwell, L. · Hartung, T. · Kuper, F. · Maestrelli, P. · Roggen, E. · Rovida, C. · Casati, S.
Keywords: Toxicology and Applied Pharmacology · cell assay · clinical feature · conference paper · nonhuman · occupational asthma · occupational exposure · pathogenesis · priority journal · quantitative structure activity relation · respiratory tract allergy · risk assessment · risk factor · sensitization · skin test · Animal Testing Alternatives · Animals · Hazardous Substances · Humans · Respiratory Hypersensitivity · Skin Tests · Structure-Activity Relationship

5 Skin sensitisation and epidermal disposition: The relevance of epidermal disposition for sensitisation hazard identification and risk assessment: The report and recommendations of ECVAM workshop 59a
article 2007    
Author: Basketter, D. · Pease, C. · Kasting, G. · Kimber, I. · Casati, S. · Cronin, M. · Diembeck, W. · Gerberick, F. · Hadgraft, J. · Hartung, T. · Marty, J.P. · Nikolaidis, E. · Patlewicz, G. · Roberts, D. · Roggen, E. · Rovida, C. · Sandt, J. van de
Keywords: Food and Chemical Risk Analysis · cosmetic · analytic method · clearance · conference paper · environmental exposure · epidermis cell · gap junction · hazard assessment · immunity · mathematical computing · priority journal · protein binding · risk assessment · sensitization · skin sensitization · steady state · theoretical model · Allergens · Animal Testing Alternatives · Animals · Cells, Cultured · Guidelines · Humans · Risk Assessment · Skin · Skin Absorption · Skin Tests · Toxicity Tests

6 International ring trial of the epidermal equivalent sensitizer potency assay: reproducibility and predictive-capacity
article 2014    
Author: Teunis, M.A.T. · Spiekstra, S.W. · Smits, M. · Adriaens, E. · Eltze, T. · Galbiati, V. · Krul, C.A.M. · Landsiedel, R. · Pieters, R. · Reinders, J. · Roggen, E. · Corsini, E. · Gibbs, S.
Keywords: Health · Epidermal equivalent · In vitro · NOEL · Sensitizer potency · 1 chloro 2,4 dinitrobenzene · 2 mercaptobenzothiazole · allergen · benzocaine · cinnamaldehyde · citral · cobalt chloride · formaldehyde · interleukin 1alpha · isoeugenol · oxazolone · phenylenediamine · accuracy · assay · controlled study · cytotoxicity · epidermal equivalent sensitizer potency assay · reproducibility · skin sensitization · Biomedical Innovation · Healthy Living · Healthy Living · Themalijn
[Abstract]

7 Transfer of a two-tiered keratinocyte assay: IL-18 production by NCTC2544 to determine the skin sensitizing capacity and epidermal equivalent assay to determine sensitizer potency
article 2013    
Author: Teunis, M. · Corsini, E. · Smits, M. · Madsen, C.B. · Eltze, T. · Ezendam, J. · Galbiati, V. · Gremmer, E. · Krul, C.A.M. · Landin, A. · Landsiedel, R. · Pieters, R. · Rasmussen, T.F. · Reinders, J. · Roggen, E. · Spiekstra, S. · Gibbs, S.
Keywords: Biology · Alternatives To Animal Use · Epidermal Equivalent · Keratinocytes · Prevalidation · Ring Study · Skin Sensitization · Tiered Test · Biomedical Innovation · Healthy Living · Healthy Living Life · HL - Healthy for Life RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social SciencesThemalijn
[Abstract]

8 T4 report. An expert consortium review of the EC-commissioned report "Alternative (non-animal) methods for cosmetics testing: Current status and future prospects - 2010"
article 2011    
Author: Hartung, T. · Blaauboer, B.J. · Bosgra, S. · Carney, E. · Coenen, J. · Conolly, R.B. · Corsini, E. · Green, S. · Faustman, E.M. · Gaspari, A. · Hayashi, M. · Hayes, A.W. · Hengstler, J.G. · Knudsen, L.E. · Knudsen, T.B. · McKim, J.M. · Pfaller, W. · Roggen, E.L.
Keywords: Health Pharmacology · 3Rs · Alternatives to animal testing · Novel approaches · Product safety · Toxicology · Life · PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

9 Respiratory sensitization : Advances in assessing the risk of respiratory inflammation and irritation
article 2011    
Author: Vandebriel, R. · Callant Cransveld, C. · Crommelin, D. · Diamant, Z. · Glazenburg, B. · Joos, G. · Kuper, F. · Natsch, A. · Nijkamp, F. · Noteborn, H. · Pieters, R. · Roberts, D. · Roggen, E. · Rorije, E. · Seed, M. · Sewald, K. · Heuvel, R. van den · Engelen, J. van · Verstraelen, S. · Loveren, H. van
Keywords: Toxicology · ASAT · Asthma · In vitro · In vivo · Integrated testing · QSAR · Respiratory tract · Rhinitis · Risk assessment · Sensitization · contact allergen · immunoglobulin E · airway remodeling · animal testing alternative · biosafety · bronchus hyperreactivity · cell assay · cellular immunity · dendritic cell · disease predisposition · functional genomics · human · immunopathology · immunoreactivity · in vitro study · mathematical model · mucosal immunity · nonhuman · occupational asthma · predictive value · process development · process model · quantitative analysis · quantitative structure activity relation · reaction analysis · respiratory sensitization · respiratory tract inflammation · respiratory tract injury · review · risk assessment · risk factor · sensitization · Animal Testing Alternatives · Hazardous Substances · Humans · Respiratory Hypersensitivity · Respiratory Tract Diseases · Toxicity Tests · Animalia · Healthy for Life · Healthy Living · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

10 The carcinoGENOMICS project: Critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays
article 2008    
Author: Vinken, M. · Doktorova, T. · Ellinger-Ziegelbauer, H. · Ahr, H.-J. · Lock, E. · Carmichael, P. · Roggen, E. · Delft, J. van · Kleinjans, J. · Castell, J. · Bort, R. · Donato, T. · Ryan, M. · Corvi, R. · Keun, H. · Ebbels, T. · Athersuch, T. · Sansone, S.-A. · Rocca-Serra, P. · Stierum, R. · Jennings, P. · Pfaller, W. · Gmuender, H. · Vanhaecke, T. · Rogiers, V.
Keywords: Biology · Physiological Sciences · carcinoGENOMICS · Chemical carcinogenesis · FP6 project · Genomics · Genotoxic carcinogen · Metabolomics · Metabonomics · Model compounds · Non-genotoxic carcinogen · REACH · Selection criteria · 1,3 butadiene · 2 nitrofluorene · 2,3,7,8 tetrachlorodibenzo para dioxin · aflatoxin B1 · alkanone · arsenate sodium · asbestos · benzo[a]pyrene · bromodichloromethane · cadmium derivative · chemical compound · chloroprene · chlorothalonil · dichromate sodium · dimethylnitrosamine · isobutyl nitrite · methapyrilene · monuron · nifedipine · ochratoxin · phenobarbital · phorbol 13 acetate 12 myristate · piperonyl butoxide · pirinixic acid · potassium bromate · s (1,2 dichlorovinyl)cysteine · streptozocin · tolbutamide · unindexed drug · vinyl chloride · carcinogenicity · genomics · human · in vitro study · medical information · medical research · model · nonhuman · priority journal · review · screening · Animal Testing Alternatives · Carcinogenicity Tests · European Union · Gene Expression Profiling · Genomics · Hazardous Substances · International Cooperation · Toxicogenetics · Animalia
[Abstract]

11 Applying the adverse outcome pathway (AOP) for food sensitization to support in vitro testing strategies
article 2019    
Author: Lozano-Ojalvo, D. · Benede, S. · Antunes, C.M. · Bavaro, S.L. · Bouchaud, G. · Costa, A. · Denery-Papini, S. · Diaz-Perales, A. · Garrido-Arandia, M. · Gavrovic-Jankulovic, M. · Hayen, S. · Martinez-Blanco, M. · Molina, E. · Monaci, L. · Pieters, R.H.H. · Villemin, C. · Wichers, H.J. · Wroblewska, B. · Willemsen, L.E.M. · Roggen, E.L. · Bilsen, J.H.M. van
Keywords: Nutrition · Adverse outcome pathway · Dendritic cells · Epithelial cells · IgE-mediated food allergy · In vitro models · T and B cells · Allergies · Cytology · Immune system · Proteins · Risk assessment · Adverse outcomes · B cells · Dendritic cells · Epithelial cells · Food allergies · In-vitro models · Cells · Life · RAPID - Risk Analysis for Products in Development
[Abstract]

12 Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins
article 2017    
Author: Bilsen, J.H.M. van · Sienkiewicz-Szłapka, E. · Lozano-Ojalvo, D. · Willemsen, L.E.M. · Antunes, C.M. · Molina, E. · Smit, J.J. · Wróblewska, B. · Wichers, H.J. · Knol, E.F. · Ladics, G.S. · Pieters, R.H.H. · Denery-Papini, S. · Vissers, Y.M. · Bavaro, S.L. · Larré, C. · Verhoeckx, K.C.M. · Roggen, E.L.
Keywords: Biology · Adverse outcome pathway · Food allergy · Food proteins · Key event relations · Key events · Mechanistic understanding · Molecular initiating event · Sensitization · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 12 of 12 found. | Sort by date