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1 A physiologically based biokinetic (PBBK) model for estragole bioactivation and detoxification in rat
article 2008    
Author: Punt, A. · Freidig, A.P. · Delatour, T. · Scholz, G. · Boersma, M.G. · Schilter, B. · Bladeren, P.J. van · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · Bioactivation · Detoxification · Estragole · In vitro · PBPK · Rat · 1' hydroxyestragole glucuronide · 1' sulfooxyestragole · Benzene derivative · Chavicol · Estragole · Glucuronide · Phenol derivative · Unclassified drug · Animal tissue · Arterial blood · Body fat · Controlled study · Detoxification · In vitro study · Kinetics · Liver · Nonhuman · Partition coefficient · Rat · Tissue perfusion · Venous blood · Allyl Compounds · Animals · Anisoles · Carcinogens · Dose-Response Relationship, Drug · Female · Glucuronides · Kidney · Lung · Male · Metabolic Detoxication, Drug · Models, Biological · Phenols · Rats · Rats, Sprague-Dawley · Rats, Wistar · Sulfones · Tissue Distribution · Rattus · Food and Nutrition · Healthy Living
[Abstract]

2 The application of in vitro data in the derivation of the acceptable daily intake (ADI) of food additives
article 1999    
Author: Walton, K. · Walker, R. · Sandt, J.J.M. van de · Castell, J.V. · Knapp, A.G.A.C. · Kozianowski, G. · Roberfroid, M. · Schilter, B.

3 The application of in vitro data in the derivation of the acceptable daily intake of food additives
article 1999    
Author: Walton, K. · Walker, R. · Sandt, J.J.M. van de · Castell, J.V. · Knapp, A.G.A.A. · Kozianowski, G. · Roberfroid, M. · Schilter, B.
Keywords: Nutrition · Acceptable daily intake · Food additives · In vitro · Metabolism · Toxicodynamics and uncertainty factor · Toxicokinetics · 2 hydroxybiphenyl · Aluminum · Aspartame · Biphenyl · Brilliant blue · Butylcresol · Curcumin · Cyclamate sodium · Cyclohexylamine · Dodecyl gallate · Erythrosine · Ferrocyanide · Food additive · Gallic acid · Gallic acid propyl ester · Nitrate · Nitrite · Tartrazine · Tiabendazole · Dietary intake · Food safety · Human · Nonhuman · Review · Risk assessment · Species difference · Toxicity testing · Toxicokinetics · Animals · Food Additives · Humans · No-Observed-Adverse-Effect Level · Toxicity Tests · Animalia
[Abstract]

4 Human cytochrome P450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes
article 2007    
Author: Jeurissen, S.M.F. · Punt, A. · Boersma, M.G. · Bogaards, J.J.P. · Fiamegos, Y.C. · Schilter, B. · Bladeren, P.J. van · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · 1' hydroxyestragole · alkenylbenzene derivative · alpha naphthoflavone · benzene derivative · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2C19 · cytochrome P450 2D6 · cytochrome P450 2E1 · estragole · methyleugenol · safrole · article · enzyme specificity · human · human cell · hydroxylation · liver microsome · phenotype · protein expression · Anisoles · Biotransformation · Chromatography, High Pressure Liquid · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Eugenol · Flavoring Agents · Humans · Hydroxylation · Microsomes, Liver · Safrole · Substrate Specificity
[Abstract]

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