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1 Regulation of urokinase-type plasminogen activator expression in gastrointestinal neoplasia
dissertation 1993    
Author: Sier, C.F.M.
Keywords: Biology
[PDF]

2 Increased urokinase receptor levels in human gastrointestinal neoplasia and related liver metastases
article 1995    
Author: Sier, C.F.M.
Keywords: Biology

3 Determination of matrilysin activity in gastrointestinal neoplasia
article 2007    
Author: Hawinkels, L.J.A.C. · Verspaget, H.W. · Berg, M. van den · Hanemaaijer, R. · Sier, C.F.M.
Keywords: Biology · Biomedical Research · Controlled study · Digestive system cancer · Enzyme activity · Western blotting · Colorectal Neoplasms · Humans · Immunohistochemistry · Matrix Metalloproteinase 7 · Tumor Markers, Biological

4 Proteolysis of the urokinase-type plasminogen activator receptor by metalloproteinase-12: Implication for angiogenesis in fibrin matrices
article 2001    
Author: Koolwijk, P. · Sidenius, N. · Peters, E. · Sier, C.F.M. · Hanemaaijer, R. · Blasi, F. · Hinsbergh, V.W.M. van
Keywords: Binding Sites · Blotting, Western · Cells, Cultured · Endothelium, Vascular · Fibrin · Fibroblast Growth Factor 2 · Gene Expression · Humans · Metalloendopeptidases · Microcirculation · Neovascularization, Physiologic · Phenylalanine · Protease Inhibitors · Receptors, Cell Surface · Recombinant Proteins · Reverse Transcriptase Polymerase Chain Reaction · RNA, Messenger · Thiophenes · Transfection · Tumor Necrosis Factor-alpha · Urinary Plasminogen Activator
[Abstract]

5 Enhanced urinary gelatinase activities (matrix metalloproteinases 2 and 9) are associated with early-stage bladder carcinoma: A comparison with clinically used tumor markers
article 2000    
Author: Sier, C.F.M. · Casetta, G. · Verheijen, J.H. · Tizzani, A. · Agape, V. · Kos, J. · Blasi, F. · Hanemaaijer, R.
Keywords: Adult · Aged · Aged, 80 and over · Carcinoma · Case-Control Studies · Cathepsin B · Creatinine · Enzyme-Linked Immunosorbent Assay · Female · Humans · Male · Matrix Metalloproteinase 2 · Matrix Metalloproteinase 9 · Middle Aged · Neoplasm Invasiveness · Nuclear Proteins · Tumor Markers, Biological · Urinary Bladder Neoplasms · Urinary Plasminogen Activator
[Abstract]

6 Active TGF-β1 correlates with myofibroblasts and malignancy in the colorectal adenoma-carcinoma sequence
article 2009    
Author: Hawinkels, L.J.A.C. · Verspaget, H.W. · Reijden, J.J. van der · Zon, J.M. van der · Verheijen, J.H. · Hommes, D.W. · Lamers, C.B.H.W. · Sier, C.F.M.
Keywords: Biology · Biomedical Research · actin · desmin · keratin · plasminogen activator inhibitor 1 · Smad2 protein · SMAD2 protein, human · transforming growth factor beta1 · tumor marker · urokinase · vimentin · adenoma · article · carcinoma · cell strain HT29 · colorectal tumor · enzyme linked immunosorbent assay · female · fibroblast · human · immunohistochemistry · male · metabolism · pathology · reproducibility · sensitivity and specificity · smooth muscle · Actins · Adenoma · Carcinoma · Colorectal Neoplasms · Desmin · Enzyme-Linked Immunosorbent Assay · Female · Fibroblasts · HT29 Cells · Humans · Immunohistochemistry · Keratins · Male · Muscle, Smooth · Plasminogen Activator Inhibitor 1 · Reproducibility of Results · Sensitivity and Specificity · Smad2 Protein · Transforming Growth Factor beta1 · Tumor Markers, Biological · Urokinase-Type Plasminogen Activator · Vimentin
[Abstract]

7 Clinical evidence for a protective role of lipocalin-2 against MMP-9 autodegradation and the impact for gastric cancer
article 2007    
Author: Kubben, F.J.G.M. · Sier, C.F.M. · Hawinkels, L.J.A.C. · Tschesche, H. · Duijn, W. van · Zuidwijk, K. · Reijden, J.J. van der · Hanemaaijer, R. · Griffioen, G. · Lamers, C.B.H.W. · Verspaget, H.W.
Keywords: Biology · Biomedical Research · Activity assay · Cancer · Metalloproteinase · Prognosis · gelatinase B · lipocalin · matrix metalloproteinase inhibitor · tissue inhibitor of metalloproteinase 1 · adult · aged · article · autolysis · cancer survival · disease classification · enzyme activity · enzyme degradation · epithelium cell · female · human · human tissue · immunohistochemistry · major clinical study · male · multivariate analysis · priority journal · protein function · stomach cancer · tumor · univariate analysis · world health organization
[Abstract]

8 Eradication of Helicobacter pylori infection favourably affects altered gastric mucosal MMP-9 levels
article 2007    
Author: Kubben, F.J.G.M. · Sier, C.F.M. · Schram, M. · Witte, T.A.M.C. · Veenendaal, R.A. · Duijn, W. van · Verheijen, J.H. · Hanemaaijer, R. · Lamers, C.B.H.W. · Verspaget, H.W.
Keywords: Biomedical Research · Bioactivity assay (BIA) · ELISA · Gastritis · Helicobacter pylori · Matrix metalloproteinases · MMP-2 (gelatinase A) · MMP-9 (gelatinase B) · Zymography · antibiotic agent · clarithromycin · gelatin · gelatinase A · gelatinase B · metronidazole · omeprazole · proton pump inhibitor · ranitidine · adult · aged · article · controlled study · drug activity · enzyme analysis · enzyme linked immunosorbent assay · eradication therapy · female · Helicobacter infection · Helicobacter pylori · human · major clinical study · male · priority journal · quantitative analysis · statistical significance · stomach mucosa · zymography · Adult · Aged · Anti-Infective Agents · Anti-Ulcer Agents · Biopsy · Clarithromycin · Drug Therapy, Combination · Endoscopy, Gastrointestinal · Enzyme-Linked Immunosorbent Assay · Female · Gastric Mucosa · Helicobacter Infections · Helicobacter pylori · Humans · Male · Matrix Metalloproteinase 2 · Matrix Metalloproteinase 9 · Metronidazole · Middle Aged · Omeprazole · Ranitidine · Treatment Outcome · Helicobacter pylori
[Abstract]

9 Endothelium specific matrilysin (MMP-7) expression in human cancers
article 2008    
Author: Sier, C.F.M. · Hawinkels, L.J.A.C. · Zijlmans, H.J.M.A.A. · Zuidwijk, K. · Jonge de · Muller, E.S.M. · Ferreira, V. · Hanemaaijer, R. · Mulder-Stapel, A.A. · Kenter, G.G. · Verspaget, H.W. · Gorter, A.
Keywords: Health · Physiological Sciences · Angiogenesis · Breast · Carcinoma · Cervix · Colon · Matrix metalloproteinase · Prostate · Stomach · CD34 antigen · endoglin · matrilysin · vasculotropin · adult · aged · angiogenesis · antigen expression · article · cancer cell · cancer growth · cancer patient · cancer survival · endothelium cell · female · human · human cell · human tissue · immunohistochemistry · in vitro study · major clinical study · malignant neoplastic disease · priority journal · protein expression · reverse transcription polymerase chain reaction · tumor vascularization · uterine cervix cancer · Carcinoma · Cell Line, Tumor · Endothelium · Female · Gene Expression Regulation, Enzymologic · Gene Expression Regulation, Neoplastic · Humans · Matrix Metalloproteinase 7 · Neoplasm Invasiveness · Neovascularization, Pathologic · Spheroids, Cellular · Time Factors · Tissue Distribution · Umbilical Veins · Uterine Cervical Neoplasms
[Abstract]

10 Tissue level, activation and cellular localisation of TGF-β1 and association with survival in gastric cancer patients
article 2007    
Author: Hawinkels, L.J.A.C. · Verspaget, H.W. · Duijn, W. van · Zon, J.M. van der · Zuidwijk, K. · Kubben, F.J.G.M. · Verheijen, J.H. · Hommes, D.W. · Lamers, C.B.H.W. · Sier, C.F.M.
Keywords: Biology · Biomedical Research · ELISA · Fibroblast · Immunohistochemistry · Matrix metalloproteinase · Transforming growth factor-β · Tumour microenvironment · proteinase · smooth muscle actin · transforming growth factor beta1 · urokinase · adult · aged · article · cancer survival · comparative study · correlation analysis · enzyme activity · enzyme linked immunosorbent assay · epithelium cell · female · fibroblast · human · human tissue · immunohistochemistry · major clinical study · male · microenvironment · myofibroblast · priority journal · protein expression · protein function · protein localization · smooth muscle · stomach cancer · stomach mucosa · tissue homogenate · Aged · Female · Humans · Immunohistochemistry · Male · Middle Aged · Stomach Neoplasms · Survival Analysis · Transforming Growth Factor beta1
[PDF] [Abstract]

11 Contribution of plasminogen activators and their inhibitors to the survival prognosis of patients with Dukes' stage B and C colorectal cancer
article 1997    
Author: Ganesh, S. · Sier, C.F.M. · Heerding, M.M. · Krieken, J.H.J.M. van · Griffioen, G. · Welvaart, K. · Velde, C.J.H. van de · Verheijen, J.H. · Lamers, C.B.H.W. · Verspaget, H.W.
Keywords: Aged · Colorectal Neoplasms · Data Interpretation, Statistical · Enzyme-Linked Immunosorbent Assay · Female · Histological Techniques · Humans · Male · Middle Aged · Plasminogen Activator Inhibitor 1 · Plasminogen Activator Inhibitor 2 · Plasminogen Activators · Plasminogen Inactivators · Prognosis · Spectrophotometry · Survival Rate · Time Factors · Tissue Plasminogen Activator · Urinary Plasminogen Activator
[PDF] [Abstract]

12 Matrix metalloproteinase-2 is a consistent prognostic factor in gastric cancer
article 2006    
Author: Kubben, F.J.G.M. · Sier, C.F.M. · Duijn, W. van · Griffioen, G. · Hanemaaijer, R. · Velde, C.J.H. van de · Krieken, J.H.J.M. van · Lamers, C.B.H.W. · Verspaget, H.W.
Keywords: Health · Biomedical Research · Gelatinases · MMP-7 · MMP-8 · MMP-9 · TIMP · Tissue inhibitor of metalloproteinases · gelatinase A · gelatinase B · matrilysin · neutrophil collagenase · tissue inhibitor of metalloproteinase 1 · tissue inhibitor of metalloproteinase 2 · bioassay · cancer classification · cancer patient · cancer staging · cancer survival · cancer tissue · comparative study · controlled study · correlation analysis · enzyme analysis · enzyme assay · enzyme linked immunosorbent assay · histopathology · human tissue · major clinical study · prognosis · protein variant · stomach cancer · stomach mucosa · tissue section · world health organization · Adult · Aged · Aged, 80 and over · Enzyme-Linked Immunosorbent Assay · Female · Humans · Male · Matrix Metalloproteinase 2 · Middle Aged · Predictive Value of Tests · Prognosis · Stomach Neoplasms · Survival Analysis
[PDF] [Abstract]

13 Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma
article 1996    
Author: Sier, C.F.M. · Kubben, F.J.G.M. · Ganesh, S. · Heerding, M.M. · Griffioen, G. · Hanemaaijer, R. · Krieken, J.H.J.M. van · Lamers, C.B.H.W. · Verspaget, H.W.
Keywords: Biology · Gastric carcinoma · Gelatinases · Matrix metalloproteinase · Quantitative zymography · gelatinase b · proteinase · adult · cancer classification · cancer invasion · cancer survival · clinical article · controlled study · histopathology · human tissue · metastasis · priority journal · prognosis · stomach carcinoma · stomach mucosa · Aged · Collagenases · Female · Gelatinases · Humans · Male · Matrix Metalloproteinase 2 · Matrix Metalloproteinase 9 · Metalloendopeptidases · Middle Aged · Stomach Neoplasms · Survival Rate
[PDF] [Abstract]

14 Prognostic relevance of plasminogen activators and their inhibitors in colorectal cancer
article 1994    
Author: Ganesh, S. · Sier, C.F.M. · Griffioen, G. · Vloedgraven, H.J.M. · Boer, A. de · Welvaart, K. · Velde, C.J.H. van de · Krieken, J.H.J.M. van · Verheijen, J.H. · Lamers, C.B.H.W. · Verspaget, H.W.
Keywords: Aged · Aged, 80 and over · Colorectal Neoplasms · Female · Follow-Up Studies · Human · Intestinal Mucosa · Male · Middle Age · Multivariate Analysis · Neoplasm Staging · Prognosis · Tissue Plasminogen Activator · Urinary Plasminogen Activator
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 14 of 14 found. | Sort by date