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1 Functions of OATP1a/1b transporters in vivo: insights from mouse models
article 2011    
Author: Steeg, E. van de · Lusuf, D. · Schinkel, A.H.
Keywords: Biology · Biomedical Innovation · Healthy Living · Life · PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

2 ERP organ-function on a chip in 2017
report 2018    
Author: Hanemaaijer, R. · Steeg, E. van de · Bobeldijk, I. · Ostendorf, R.
Keywords: Health · Predictive Health Technologies · Healthy Living · Life Healthy Living · MHR - Metabolic Health Research HL - Healthy for Life · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

3 Mechanisms and immunomodulatory properties of pre- and probiotics
article 2019    
Author: Peters, V.B.M. · Steeg, E. van de · Bilsen, J. van · Meijerink, M.
Keywords: Beneficial microbes · Gastrointestinal tract · ImmunologyMicrobial substrates · Microbiota
[Abstract]

4 Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling.
article 2014    
Author: Bosgra, S. · Steeg, E. van de · Vlaming, M.L. · Verhoeckx, K.C. · Huisman, M.T. · Verwei, M. · Wortelboer, H.M.
Keywords: Biology · Transporter · Hepatic disposition · Transfected cell-lines · Protein abundance · LC–MS · Hepatic disposition · OATP · PBPK model · Polymorphisms · Protein abundance · Transfected cell-lines · Drug carrier · Organic anion transporter B · Rosuvastatin · Solute carrier organic anion transporter 1B1 · Solute carrier organic anion transporter 1B3 · Controlled study · Drug clearance · Drug disposition · Drug transport · Enterohepatic circulation · Gene overexpression · Genetic transfection · Genetic variability · HEK293 cell line cell tissue · In vitro study · In vivo study · Intrinsic clearance · Liquid chromatography · Liver · Liver cell · Model · Outer membrane · Physiology based pharmacokinetic model · Prediction · Protein analysis · Simulation · Single drug dose · Tandem mass spectrometry · Food and Nutrition · Healthy Living · Life · RAPID - Risk Assessment Products in Development MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

5 A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices
article 2014    
Author: Westerhout, J. · Steeg, E. van de · Grossouw, D. · Zeijdner, E.E. · Krul, C.A.M. · Verwei, M. · Wortelboer, H.M.
Keywords: Biology · Caco-2 · Food-effect · Human intestine · Intestinal absorption · InTESTine™ · Porcine intestine · Acebutolol · Atenolol · Candesartan · Cetirizine · Cimetidine · Ciprofloxacin · Diazepam · Digoxin · Famotidine · Hydrocortisone · Ibuprofen · Indometacin · Mannitol · Melagatran · Metoprolol · Mucin · Oxprenolol · Phenazone · Pindolol · Propranolol · Ranitidine · Salazosulfapyridine · Salicylic acid · Testosterone · Verapamil · Active transport · Animal tissue · CACO 2 cell line · Controlled study · Domestic pig · Drug absorption · Drug bioavailability · Drug penetration · Drug transport · Electric resistance · Ex vivo study · Female · Human · Human tissue · Intestine absorption · Intestine mucosa · Male · Nonhuman · Passive transport · Prediction · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

6 Combined analysis of pharmacokinetic and efficacy data of preclinical studies with statins markedly improves translation of drug efficacy to human trialss
article 2013    
Author: Steeg, E. van de · Kleemann, R. · Jansen, H.T. · Duyvenvoorde, W. van · Offerman, E.H. · Wortelboer, H.M. · DeGroot, J.
Keywords: Biology · Biomedical Innovation · Healthy Living · Life · PHS - Pharmacokinetics & Human Studies (tot 2013 daarna KFP) MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

7 The 3 dimensions of Organ-on-a-chip
report 2016    
Author: Grootaers, G. · Ostendorf, R. · Bobeldijk, I. · Hanemaaijer, R. · Kooter, I. · Sandt, H. van de · Steeg, E. van de · Krul, C.
Keywords: Health · Predictive Health Technologies · Healthy Living · Life · MHR - Metabolic Health Research
[PDF]

8 The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo
article 2017    
Author: Li, M. · Graaf, I.A.M. de · Steeg, E. van de · Jager, M.H. de · Groothuis, G.M.M.
Keywords: Biology · CYP3A4 · Ex vivo · Interplay · P-glycoprotein · Precision-cut intestinal slice · Selective P-gp inhibitor · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

9 Generation of Bayesian prediction models for OATP-mediated drug-drug interactions based on inhibition screen of OATP1B1, OATP1B1∗15 and OATP1B3
article 2015    
Author: Steeg, E. van de · Venhorst, J. · Jansen, H.T. · Nooijen, I.H.G. · Degroot, J. · Wortelboer, H.M. · Vlaming, M.L.H.
Keywords: Biology · Bayesian prediction model · Computational modeling · Drugdrug interaction · OATP · Polymorphisms · Transporter · Abamectin · Acemetacin · Atazanavir · Bromocriptine mesilate · Clarithromycin · Clobetasol propionate · Dihydroergocristine methanesulfonate · Dipyridamole · Docetaxel · Estradiol · Fluindostatin · Fosinopril · Losartan · Mifepristone · Nicardipine · Olmesartan · Pranlukast · Pyrantel embonate · Rapamycin · Rifampicin · Rifamycin · Salazosulfapyridine · Solute carrier organic anion transporter 1B1 · Solute carrier organic anion transporter 1B1 15 · Solute carrier organic anion transporter 1B3 · Suramin · Telmisartan · Tibolone · Troglitazone · Unclassified drug · Unindexed drug · Bayesian learning · Controlled study · Drug protein binding · HEK293 cell line · Human cell · Nucleotide sequence · Prediction · Priority journal · Protein expression · Tandem mass spectrometry · Ultra performance liquid chromatography · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

10 Down-regulation of OATP1B proteins correlates with hyperbilirubinemia in advanced cholestasis
article 2015    
Author: Sticova, E. · Lodererova, A. · Steeg, E. van de · Frankova, S. · Kollar, M. · Lanska, V. · Kotalova, R. · Dedic, T. · Schinkel, A.H. · Jirsa, M.
Keywords: Biology · Bilirubin · Cholestasis · Immunohistochemistry · Liver disease · Organic anion transporter · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

11 Impact of Abcc2 [multidrug resistance-associated protein (Mrp) 2], Abcc3 (Mrp3), and Abcg2 (breast cancer resistance protein) on the oral pharmacokinetics of methotrexate and its main metabolite 7-hydroxymethotrexate
article 2011    
Author: Vlaming, M.L.H. · Esch, A. van · Steeg, E. van de · Pala, Z. · Wagenaar, E. · Tellingen, O. van · Schinkel, A.H.
Keywords: Nutrition · Life · PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

12 Wide Band Reflectance Spectrometry and Hyperspectral Imaging for Intraoperative Tissue Recognition (abstract only)
article 2013    
Author: Tchebotareva, A. · Schols, R.M. · Wieringa, F.P. · Alić, L. · Bouvy, N. · Stassen, L.P.S. · Steeg, E. van de · Klomp, D. · Baumer, S. · Statham, A. · Dunias. P.
Keywords: Materials · Medical Imaging · Image Enhancement · Image Processing · Tissue Recognition · Hyper Spectral Imaging · High Tech Systems & Materials · Industrial Innovation · Physics & Electronics ; Mechatronics, Mechanics & Materials ; Life · OPT - Optics ; EAM - Equipment for Additive Manufacturing ; II - Intelligent Imaging ; PHS - Pharmacokinetics & Human Studies (tot 2013 daarna KFP) · TS - Technical Sciences ; EELS - Earth, Environmental and Life Sciences
[Abstract]

13 Quantifying phenotypic flexibility as the response to a high-fat challenge test in different states of metabolic health
article 2015    
Author: Kardinaal, A.F.M. · Erk, M.J. van · Dutman, A.E. · Stroeve, J.H.M. · Steeg, E. van de · Bijlsma, S. · Kooistra, T. · Ommen, B. van · Wopereis, S.
Keywords: Biology · Clinical study · Eicosanoids · Human physiology · Nutrition · Systems biology · Fat · Glucose · Adipose tissue · Adult · Aged · Controlled study · Glucose metabolism · Health · Homeostasis · Human · Male · Metabolic syndrome X · Metabolism · Open study · Pilot study · Provocation test · Quantitative analysis · Stress · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

14 Comparison of in vitro assays in selecting radiotracers for in vivo P-glycoprotein PET imaging
article 2017    
Author: Raaphorst, R.M. · Savolainen, H. · Cantore, M. · Steeg, E. van de · Waarde, A. van · Colabufo, N.A. · Elsinga, P.H. · Lammertsma, A.A. · Windhorst, A.D. · Luurtsema, G.
Keywords: Biology · Apical and basolateral membrane · Bidirectional transport · Blood-brain barrier · Calcein-AM · Tritium labeling · Calcein · Mc 224 f 18 · Mc 225 f 18 · Multidrug resistance protein · N fluoroethylverapamil f 18 · O fluoroethyl norverapamil f 18 · Radiopharmaceutical agent · Unclassified drug · Verapamil c 11 · Animal experiment · Animal tissue · Chemical analysis · Controlled study · Drug accumulation · Drug blood level · Drug brain level · Drug half life · Enzyme inhibition · Fluoroethylation · In vitro study · In vivo study · Isotope labeling · Male · Mouse · Nonhuman · Positron emission tomography · Predictive value · Protein function · Radioactivity · Rat · Synthesis · Transport assay · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

15 An ex Vivo fermentation screening platform to study drug metabolism by human gut microbiota
article 2018    
Author: Steeg, E. van de · Schuren, F.H.J. · Obach, R.S. · Woudenbergh, C. van · Walker, G.S. · Heerikhuisen, M. · Nooijen, I.H.G. · Vaes, W.H.J.
Keywords: Biology
[Abstract]

16 Regional expression levels of drug transporters and metabolizing enzymes along the pig and human intestinal tract and comparison with Caco-2 cells
article 2017    
Author: Vaessen, S.F.C. · Lipzig, M.M.H. van · Pieters, R.H.H. · Krul, C.A.M. · Wortelboer, H.M. · Steeg, E. van de
Keywords: Biology · Food and Nutrition · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

17 A higher throughput and physiologically relevant two-compartmental human ex vivo intestinal tissue system for studying gastrointestinal processes
article 2019    
Author: Stevens, L.J. · Lipzig M.M.H. van · Erpelinck, S.L.A. · Pronk, A. · Gorp J. van · Wortelboer, H.M. · Steeg, E. van de
Keywords: InTESTine · Transwell · Predictive gut model · Permeability · Human ex vivo tissue
[Abstract]

18 Drug-drug interactions between rosuvastatin and oral antidiabetic drugs occurring at the level of oatp1b1s
article 2013    
Author: Steeg, E. van de · Greupink, R. · Schreurs, M. · Nooijen, I.H.G. · Verhoeck, K.C.M. · Hanemaaijer, R. · Ripken, D. · Monshouwer, M. · Vlaming, M.L.H. · DeGroot, J. · Verwei, M. · Russel, F.G.M. · Huisman, M.T. · Wortelboer, H.M.
Keywords: Biology · Biomedical Innovation · Healthy Living · Life · PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

19 Bcrp1;Mdr1a/b;Mrp2 Combination Knockout Mice: Altered Disposition of the Dietary Carcinogen PhIP (2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine) and Its Genotoxic Metabolites
article 2014    
Author: Vlaming, M.L.H. · Teunissen, S.F. · Steeg, E. van de · Esch, A. van · Wagenaar, E. · Brunsveld, L. · Greef, T.F.A. de · Rosing, H. · Schellens, J.H.M. · Beijnen, J.H. · Schinkel, A.H.
Keywords: Health · Food and Nutrition · Healthy Living · Life · MSB - Microbiology and Systems Biology CH - Child Health · ELSS - Earth, Life and Social Sciences
[Abstract]

20 Proteomic analysis of the developmental trajectory of human hepatic membrane transporter proteins in the first three months of life
article 2016    
Author: Mooij, M.G. · Steeg, E. van de · Rosmalen, J. van · Windster, J.D. · Koning, B.A.E. de · Vaes, W.H.J. · Groen, B.D. van · Tibboel, D. · Wortelboer, H.M. · Wildt, S.N. de
Keywords: Biology · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 26 found. Next | Sort by date