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1 Repeated topical treatment, in contrast to single oral doses, with Vitamin A-containing preparations does not affect plasma concentrations of retinol, retinyl esters or retinoic acids in female subjects of child-bearing age
article 2006    
Author: Nohynek, G.J. · Meuling, W.J.A. · Vaes, W.H.J. · Lawrence, R.S. · Shapiro, S. · Schulte, S. · Steiling, W. · Bausch, J. · Gerber, E. · Sasa, H. · Nau, H.
Keywords: Nutrition · Analytical research · Biomonitoring · CAS 68-26-8 · CAS 79-81-2 · Human subjects · Plasma concentrations · Retinoic acids · Retinol · Retinyl palmitate · Teratogenicity · Topical and oral administration · 4 oxoretinoic acid · oleic acid · retinoic acid · retinol · retinol ester · retinol palmitate · stearic acid · absence of side effects · adult · area under the curve · article · blood sampling · body surface · clinical article · controlled study · dose response · female · human · pregnancy · priority journal · retinol deficiency · skin irritation · statistical analysis · vitamin blood level · Administration, Oral · Administration, Topical · Adult · Cosmetics · Female · Humans · Risk Assessment · Vitamin A
[Abstract]

2 Human systemic exposure to [14C]-paraphenylenediamine-containing oxidative hair dyes: Absorption, kinetics, metabolism, excretion and safety assessment
article 2015    
Author: Nohynek, G.J. · Skare, J.A. · Meuling, W.J.A. · Wehmeyer, K.R. · Bie, A.T.H.J. de · Vaes, W.H.J. · Dufour, E.K. · Fautz, R. · Steiling, W. · Bramante, M. · Toutain, H.
Keywords: Biology · Consumer exposure · Hair dyes · Margin of safety · Paraphenylenediamine · TK-based safety assessment · Toxicokinetics · Carbon phenylenediamine c 14 · Hair dye · Phenylenediamine · Unclassified drug · Absorption · Adult · Blood analysis · Chemical reaction kinetics · Controlled study · Female · High performance liquid chromatography · Human · Human experiment · Male · Mass spectrometry · Metabolism · Population exposure · Radioactivity · Risk assessment · Skin test · Urinalysis · Urinary excretion · Rattus · Biomedical Innovation · Healthy Living · Life Triskelion BV · MSB - Microbiology and Systems Biology TARA - Toxicology and Risk Assessment · ELSS - Earth, Life and Social Sciences
[Abstract]

3 Toxicokinetics and metabolism
article 2005    
Author: Coecke, S. · Blaauboer, B.J. · Elaut, G. · Freeman, S. · Freidig, A. · Gensmantel, N. · Hoet, P. · Kapoulas, V.M. · Ladstetter, B. · Langley, G. · Leahy, D. · Mannens, G. · Meneguz, A. · Monshouwer, M. · Nemery, B. · Pelkonen, O. · Pfaller, W. · Prieto, P. · Proctor, N. · Rogiers, V. · Rostami-Hodjegan, A. · Sabbioni, E. · Steiling, W. · Sandt, J.J.M. van de
Keywords: Toxicology · Food and Chemical Risk Analysis · cosmetic · acute toxicity · artificial membrane · bioavailability · biotransformation · carcinogenicity · cell line · cell strain CACO 2 · computer model · concentration response · electric resistance · eye irritation · genotoxicity · human · metabolism · nonhuman · phototoxicity · plasma protein binding · practice guideline · priority journal · reproductive toxicity · review · skin absorption · skin sensitization · species difference · toxicokinetics · validation process · Animals · Biotransformation · Consumer Product Safety · Cosmetics · Drug Administration Routes · European Union · Humans

Search results also available in MS Excel format.

Showing 1 to 3 of 3 found. | Sort by date