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1 Exposome: connecting the dots for effective prevention of disease
report 2018    
Author: Pronk, A. · Stierum, R.
Keywords: Health · Health · Environment · Exposome · Prevention · Diseases · Healthy for Life · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

2 Nutrigenomics : the interaction between nutrients and genes
bookPart 2002    
Author: Ommen, B. van · Stierum, R.
Keywords: Nutrition

3 Nutrigenomics : exploiting systems biology in the nutrition and health arena
article 2002    
Author: Ommen, B. van · Stierum, R.
Keywords: Biology · Biological Markers · Cardiovascular Diseases · Diet · Food · Genome, Human · Genomics · Health · Humans · Nutrition Physiology · Probiotics · Arena
[Abstract]

4 Nutrigenomics : een nieuwe uitdaging in de voedingsmiddelenindustrie
article 2001    
Author: Ommen, B. van · Stierum, R.
Keywords: Nutrition

5 Niacin, poly(ADP-ribose) polymerase-1 and genomic stability
article 2001    
Author: Hageman, G.J. · Stierum, R.H.
Keywords: Nutrition · Animals · DNA · DNA Damage · Humans · Niacin · Poly(ADP-ribose) Polymerases · Animalia
[Abstract]

6 Single-nucleotide patch base excision repair of uracil in DNA by mitochondrial protein extracts
article 1999    
Author: Stierum, R.H. · Dianov, G.L. · Bohr, V.A.

7 Toxicogenomics of bromobenzene hepatotoxicity: A combined transcriptomics and proteomics approach
article 2003    
Author: Heijne, W.H.M. · Stierum, R.H. · Slijper, M. · Bladeren, P.J. van · Ommen, B. van
Keywords: Toxicology Health · Physiological Sciences · Bromobenzene · cDNA microarray · Hepatotoxicity · Proteomics · Toxicogenomics · Transcriptomics · alpha glutamylcysteine synthetase · bromobenzene · cathepsin L · enzyme · epoxide hydrolase · glutathione · glutathione transferase · heme oxygenase · messenger RNA · peroxiredoxin · proteasome · unclassified drug · animal experiment · animal model · animal tissue · article · controlled study · enzyme activity · enzyme induction · enzyme regulation · enzyme subunit · gene control · gene expression · gene identification · gene induction · genomics · glutathione metabolism · liver toxicity · lysosome · male · nonhuman · nucleotide sequence · oxidative stress · priority journal · protein content · protein degradation · protein depletion · protein expression · protein synthesis · proteomics · rat · RNA analysis · tissue level · unindexed sequence · weight reduction · Animals · Bromobenzenes · Liver · Male · Oligonucleotide Array Sequence Analysis · Pharmacogenetics · Proteomics · Rats · Rats, Wistar · Transcription, Genetic
[Abstract]

8 The oocyte in vitro maturation system : A potential tool for reproductive toxicology screening
article 2011    
Author: Beker-van Woudenberg, A.R.C.L. · Mulderij, M. · Stierum, R.H. · Wolterbeek, A.P.M.
Keywords: Toxicology · Biomedical Innovation · Healthy Living · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences

9 Unraveling toxicological mechanisms and predicting toxicity classes with gene dysregulation networks
article 2013    
Author: Pronk, T.E. · Someren, P. van · Stierum, R.H. · Ezendam, J. · Pennings, J.L.A.
Keywords: Toxicology · Biomarkers · Classification · Network · Regulation · Skin sensitization · Toxicogenomics · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[Abstract]

10 Toxicogenomics concepts and applications to study hepatic effects of food additives and chemicals
article 2005    
Author: Stierum, R. · Heijne, W. · Kienhuis, A. · Ommen, B. van · Groten, J.
Keywords: Toxicology Nutrition · Physiological Sciences · In vitro · In vivo · Liver · Toxicogenomics · bromobenzene · butylcresol · chemical compound · curcumin · food additive · gallic acid propyl ester · proteome · tiabendazole · transcriptome · biochemistry · bioinformatics · comparative toxicology · conference paper · disease marker · DNA fingerprinting · gene expression profiling · genetic procedures · genetic toxicology · genomics · in vitro study · in vivo study · laboratory · liver toxicity · metabolomics · molecular biology · nonhuman · prediction · proteomics · rat · technology · toxicological parameters · transcriptomics · Animals · Food Additives · Genomics · Humans · Liver · Toxicology
[Abstract]

11 Toxicogenomic analysis of gene expression changes in rat liver after a 28-day oral benzene exposure
article 2005    
Author: Heijne, W.H.M. · Jonker, D. · Stierum, R.H. · Ommen, B. van · Groten, J.P.
Keywords: Toxicology Biology · Toxicology and Applied Pharmacology · Benzene · cDNA microarrays · Gene expression · Hepatotoxicity · Metabolomics · Toxicogenomics · Transcriptomics · benzene · bromobenzene · paracetamol · animal experiment · animal tissue · biotransformation · blood toxicity · cholesterol metabolism · conference paper · DNA microarray · gene expression · genetic analysis · genetic toxicology · glutathione metabolism · liver necrosis · liver weight · male · nonhuman · nuclear magnetic resonance spectroscopy · nucleotide sequence · priority journal · rat · rat strain · unindexed sequence · Animals · Benzene · Blood Cell Count · Cholesterol · Fatty Acids · Gene Expression Profiling · Gene Expression Regulation · Hemoglobins · Liver · Male · Mutagens · Oligonucleotide Array Sequence Analysis · Organ Size · Rats · Rats, Inbred F344 · Spleen · Thymus Gland · Time Factors · Urinalysis · Martes pennanti
[Abstract]

12 Hazard assessment of nitrosamine and nitramine by-products of amine-based CCS: Alternative approaches
article 2015    
Author: Buist, H.E. · Devito, S. · Goldbohm, R.A. · Stierum, R.H. · Venhorst, J. · Kroese, E.D.
Keywords: Nutrition · Carbon capture and storage · Carcinogenicity · Cell transformation assay · Mutagenicity · Nitramines · Nitrosamines · Predictive in vitro models · Predictive in vivo models · QSARs · Transgenic animal test · Aniline derivative · Nitrobenzene derivative · Animal · Biological model · Carbon sequestration · Carcinogen testing · Cell transformation · Chemical structure · Chemically induced · Chemistry · LD50 · Mutagen testing · Neoplasm · Procedures · Quantitative structure activity relation · Risk assessment · Transgenic mouse · Aniline Compounds · Animals · Carbon Sequestration · Carcinogenicity Tests · Cell Transformation, Neoplastic · Lethal Dose 50 · Mice, Transgenic · Models, Biological · Molecular Structure · Mutagenicity Tests · Neoplasms · Nitrobenzenes · Quantitative Structure-Activity Relationship · Food and Nutrition · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

13 Toxicology of chemical mixtures : a challenging quest along empirical sciences
article 2004    
Author: Groten, J.P. · Heijne, W.H.M. · Stierum, R.H. · Freidig, A.P. · Feron, V.J.
Keywords: Toxicology · Physiological Sciences

14 The introduction of toxicogenomics; potential new markers of hepatotoxicity.
article 2005    
Author: Heijne, W.H. · Stierum, R.H. · Leeman, W.R. · Ommen, B. van
Keywords: Toxicology · Physiological Sciences · biological marker · drug · animal · biological model · chemically induced disorder · drug toxicity · gene expression profiling · genetics · human · liver disease · methodology · review · toxicogenetics · toxicology · Animals · Biological Markers · Drug Toxicity · Gene Expression Profiling · Humans · Liver Diseases · Models, Biological · Pharmaceutical Preparations · Toxicogenetics · Toxicology

15 Bioinformatics Methods for Interpreting Toxicogenomics Data: The Role of Text-Mining
bookPart 2014    
Author: Hettne, K.M. · Kleinjans, J. · Stierum, R.H. · Boorsma, A. · Kors, J.A.
Keywords: Biology · Bioinformatics · Gene-expression profiling · Gene-set analysis · Text-mining · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

16 Anchoring molecular mechanisms to the adverse outcome pathway for skin sensitization: Analysis of existing data
article 2014    
Author: Veen, J.W. van der · Soeteman-Hernández, L.G. · Ezendam, J. · Stierum, R. · Kuper, F.C. · Loveren, H. van
Keywords: Biology · Adverse outcome pathway · Allergic contact dermatitis · Human in vitro systems · Mechanisms of toxicity · Molecular map · Skin sensitization · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

17 Effect of butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole on cytochrome P450 forms in cultured human hepatocytes
article 2008    
Author: Price, R.J. · Scott, M.P. · Giddings, A.M. · Walters, D.G. · Stierum, R.H. · Meredith, C. · Lake, B.G.
Keywords: Biology · Physiological Sciences · Butylated hydroxytoluene · Curcumin · CYP induction · Cytochrome P450 (CYP) · Human hepatocytes · Propyl gallate · Thiabendazole · butylcresol · curcumin · cytochrome P450 · cytochrome P450 1A2 · cytochrome P450 2B6 · cytochrome P450 3A4 · ethoxyresorufin deethylase · gallic acid propyl ester · messenger RNA · tiabendazole · adult · aged · article · controlled study · enzyme activity · human · human cell · liver cell · male · Aged · Anthelmintics · Antioxidants · Butylated Hydroxytoluene · Cells, Cultured · Curcumin · Cytochrome P-450 CYP1A1 · Cytochrome P-450 CYP1A2 · Cytochrome P-450 CYP3A · Cytochrome P-450 Enzyme System · Hepatocytes · Humans · Male · Middle Aged · Propyl Gallate · RNA, Messenger · Steroid Hydroxylases · Thiabendazole
[Abstract]

18 Pathway and single gene analyses of inhibited Caco-2 differentiation by ascorbate-stabilized quercetin suggest enhancement of cellular processes associated with development of colon cancer
article 2007    
Author: Dihal, A.A. · Tilburgs, C. · Erk, M.J. van · Rietjens, I.M.C.M. · Woutersen, R.A. · Stierum, R.H.
Keywords: Toxicology and Applied Pharmacology · Caco-2 · Colorectal cancer · Differentiation · Microarray · Quercetin · ascorbic acid · quercetin · article · cell differentiation · cell division · cell strain CACO 2 · colon tumor · comparative study · DNA microarray · drug effect · drug stability · gene expression · genetics · human · pathology · Ascorbic Acid · Caco-2 Cells · Cell Differentiation · Cell Division · Colonic Neoplasms · Drug Stability · Gene Expression · Humans · Oligonucleotide Array Sequence Analysis · Quercetin
[Abstract]

19 The bovine oocyte in vitro maturation model: A potential tool for reproductive toxicology screening
article 2012    
Author: Beker-van Woudenberg, A.C.R.L. · Gröllers-Mulderij, M. · Snel, C. · Jeurissen, N. · Stierum, R. · Wolterbeek, A.
Keywords: Health · Alternative test · Bovine · Female fertility · In vitro maturation · Oocyte · Reproductive toxicology · Biomedical Innovation · Healthy Living · Life Life Triskelion BV · MSB - Microbiology and Systems Biology QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

20 Oxazolone (OXA) is a respiratory allergen in Brown Norway rats
article 2011    
Author: Kuper, C.F. · Radonjic, M. · Triel, J. van · Stierum, R. · Groot, R.J. de · Arts, J.H.E.
Keywords: Toxicology · 4-Ethoxymethylene-2-phenyl-2-oxazoline-5-one · Allergic laryngitis · Gene expression · GZMB · Neutrophils · SELP · Life Triskelion BV · QS - Quality & Safety TAP - Toxicology and Applied Pharmacology · EELS - Earth, Environmental and Life Sciences TNO Bedrijven
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 50 found. Next | Sort by date