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1 Systems biology based studies on anti-inflmammatory compounds
dissertation 2005    
Author: Verhoeckx, K.C.M.
Keywords: Nutrition
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2 Integration of two-dimensional LC-MS with multivariate statistics for comparative analysis of proteomic samples
article 2006    
Author: Gaspari, M. · Verhoeckx, K.C.M. · Verheij, E.R. · Greef, J. van der
Keywords: Pharmacology · Analytical research · Computer aided software engineering · Data handling · Data processing · Mass spectrometry · Polysaccharides · Proteins · Data preprocessing · Lipopolysaccharide · Multivariate statistical analysis · Liquid chromatography · antiinflammatory agent · beta 2 adrenergic receptor · biological marker · lipopolysaccharide · peptide · propranolol · proteome · unclassified drug · zilpaterol · article · automation · comparative study · controlled study · human · human cell · information processing · liquid chromatography · macrophage · mass spectrometry · model · multivariate analysis · nanoparticle · nucleotide sequence · principal component analysis · proteomics · Adrenergic beta-Antagonists · Amino Acid Sequence · Anti-Inflammatory Agents · Biological Markers · Chromatography, Liquid · Humans · Lipopolysaccharides · Macrophages · Mass Spectrometry · Molecular Sequence Data · Multivariate Analysis · Principal Component Analysis · Propranolol · Proteome · Proteomics · Receptors, Adrenergic, beta-2 · Reproducibility of Results · Trimethylsilyl Compounds · U937 Cells
[Abstract]

3 Protein transport across the small intestine in food allergy
article 2014    
Author: Reitsma, M. · Westerhout, J. · Wichers, H.J. · Wortelboer, H.M. · Verhoeckx, K.C.M.
Keywords: Biology · Food hypersensitivity · Intestinal protein transport · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

4 Liquid chromatography-tandem mass spectrometry analysis of free and esterified fatty acid N-acyl ethanolamines in plasma and blood cells
article 2013    
Author: Balvers, M.G.J. · Wortelboer, H.M. · Witkamp, R.F. · Verhoeckx, K.C.M.
Keywords: Biology · Diet · Endocannabinoids · LC-MS/MS · NAEs · Plasma · Validation · Biomedical Innovation · Healthy Living · Life · QS - Quality & Safety PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

5 Measurement of Palmitoylethanolamide and Other N-Acylethanolamines During Physiological and Pathological Conditions
article 2013    
Author: Balvers, M.G.J. · Verhoeckx, K.C.M. · Meijerink, J. · Wortelboer, H.M. · Witkamp, R.F.
Keywords: Biology · Endocannabinoids · Inflammation · Kinetics · Liquid Chromatography-mass Spectrometry · Palmitoylethanolamide · Biomedical Innovation · Healthy Living · Life · PHS - Pharmacokinetics & Human Studies RAPID - Risk Analysis for Products in Development · EELS - Earth, Environmental and Life Sciences
[Abstract]

6 Development and validation of a quantitative method for the determination of 12 endocannabinoids and related compounds in human plasma using liquid chromatography-tandem mass spectrometry
article 2009    
Author: Balvers, M.G.J. · Verhoeckx, K.C.M. · Witkamp, R.F.
Keywords: Biology · Analytical research · Biomedical research · Endocannabinoids · Human plasma · LC-MS/MS · Sample pre-treatment · Endocannabinoids · Gradient elutions · Human plasma · LC-MS/MS · Liquid chromatography-tandem mass spectrometries · Quadrupole · Quantitative methods · Related compounds · Sample pre-treatment · Solid-phase extractions · Acetonitrile · Brain · Chromatographic analysis · Ethers · Glycerol · High performance liquid chromatography · Mass spectrometry · Phase separation · Plasma (human) · Plasmas · Extraction · 2 arachidonoylglycerol · 2 arachidonylglycerol ether · anandamide · dihomo gamma linolenoylethanolamide · docosatetraenoylethanolamide · dopamine derivative · endocannabinoid · ethanolamine · glycine derivative · n arachidonoylglycine · n arachidonyldopamine · n oleoyl dopamine · n oleoylethanolamine · o arachidonoylethanolamide · octadecylamine · palmidrol · stearoylethanolamide · unclassified drug · article · diagnostic accuracy · drug determination · drug isolation · human · human cell · liquid chromatography · priority journal · quantitative analysis · sensitivity and specificity · solid phase extraction · tandem mass spectrometry · validation process · Chromatography, Liquid · Endocannabinoids · Humans · Tandem Mass Spectrometry
[Abstract]

7 Inhibitory effects of the β2-adrenergic receptor agonist zilpaterol on the LPS-induced production of TNF-α in vitro and in vivo
article 2005    
Author: Verhoeckx, K.C.M. · Doornbos, R.P. · Greef, J. van der · Witkamp, R.F. · Rodenburg, R.J.T.
Keywords: Biology Pharmacology · Analytical research · 3 isopropylamino 1 (7 methyl 4 indanyloxy) 2 butanol · alprenolol · atenolol · bacterium lipopolysaccharide · beta 1 adrenergic receptor blocking agent · beta 2 adrenergic receptor blocking agent · beta 2 adrenergic receptor stimulating agent · clenbuterol · cyclic AMP · formoterol · isoprenaline · propranolol · salbutamol · tumor necrosis factor alpha · unclassified drug · zilpaterol · animal experiment · antiinflammatory activity · article · cattle · cell strain U937 · controlled study · cytokine production · dose response · drug effect · drug receptor binding · drug structure · human · human cell · inflammation · macrophage · male · nonhuman · priority journal · rat · rat strain · Adrenergic beta-Agonists · Animals · Cattle · Cyclic AMP · Dose-Response Relationship, Drug · Escherichia coli · Humans · Immunologic Factors · Lipopolysaccharides · Macrophage Activation · Male · Rats · Rats, Wistar · Trimethylsilyl Compounds · Tumor Necrosis Factor-alpha · U937 Cells · Animalia · Bacteria (microorganisms) · Bos taurus · Rattus norvegicus
[Abstract]

8 Beta-adrenergic receptor agonists induce the release of granulocyte chemotactic protein-2, oncostatin M, and vascular endothelial growth factor from macrophages
article 2006    
Author: Verhoeckx, K.C.M. · Doornbos, R.P. · Witkamp, R.F. · Greef, J. van der · Rodenburg, R.J.T.
Keywords: Biology · Analytical research · β2-adrenergic receptor · β2-adrenergic receptor agonist · cAMP · Clenbuterol · CXCL6 · GCP-2 · Oncostatin M · VEGF · Zilpaterol · 3 isopropylamino 1 (7 methyl 4 indanyloxy) 2 butanol · beta 2 adrenergic receptor · beta 2 adrenergic receptor blocking agent · beta 2 adrenergic receptor stimulating agent · bronchodilating agent · butyryl cyclic AMP · chemokine · chemokine cxcl 6 · clenbuterol · Escherichia coli lipopolysaccharide · forskolin · oncostatin M · prostaglandin E2 · unclassified drug · vasculotropin · zilpaterol · angiogenesis · article · asthma · controlled study · drug potency · histiocytic lymphoma · human · human cell · lymphoma cell · macrophage · neutrophil · priority journal · upregulation · Adrenergic beta-Agonists · Bucladesine · Chemokines, CXC · Clenbuterol · Cyclic AMP · Cytokines · Dinoprostone · Forskolin · Humans · Lipopolysaccharides · Macrophage Activation · Macrophages · Oncostatin M · Trimethylsilyl Compounds · U937 Cells · Up-Regulation · Vascular Endothelial Growth Factor A
[Abstract]

9 Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling.
article 2014    
Author: Bosgra, S. · Steeg, E. van de · Vlaming, M.L. · Verhoeckx, K.C. · Huisman, M.T. · Verwei, M. · Wortelboer, H.M.
Keywords: Biology · Transporter · Hepatic disposition · Transfected cell-lines · Protein abundance · LC–MS · Hepatic disposition · OATP · PBPK model · Polymorphisms · Protein abundance · Transfected cell-lines · Drug carrier · Organic anion transporter B · Rosuvastatin · Solute carrier organic anion transporter 1B1 · Solute carrier organic anion transporter 1B3 · Controlled study · Drug clearance · Drug disposition · Drug transport · Enterohepatic circulation · Gene overexpression · Genetic transfection · Genetic variability · HEK293 cell line cell tissue · In vitro study · In vivo study · Intrinsic clearance · Liquid chromatography · Liver · Liver cell · Model · Outer membrane · Physiology based pharmacokinetic model · Prediction · Protein analysis · Simulation · Single drug dose · Tandem mass spectrometry · Food and Nutrition · Healthy Living · Life · RAPID - Risk Assessment Products in Development MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

10 Presence, formation and putative biological activities of N-acyl serotonins, a novel class of fatty-acid derived mediators, in the intestinal tract
article 2011    
Author: Verhoeckx, K.C.M. · Voortman, T. · Balvers, M.G.J. · Hendriks, H.F.J. · Wortelboer, H.M. · Witkamp, R.F.
Keywords: Biology · Food and Nutrition · Healthy Living · Life · QS - Quality & Safety PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences

11 Plasma anandamide and other N-acylethanolamines are correlated with their corresponding free fatty acid levels under both fasting and non-fasting conditions in women
article 2010    
Author: Joosten, M.M. · Balvers, M.G.J. · Verhoeckx, K.C.M. · Hendriks, H.F.J. · Witkamp, R.F.
Keywords: Biology Health · Food and Nutrition · Healthy Living · Life · PHS - Pharmacokinetics & Human Studies QS - Quality & Safety MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

12 Analysis of reaction products of food contaminants and ingredients: Bisphenol A diglycidyl ether (BADGE) in canned foods
article 2010    
Author: Coulier, L. · Bradley, E.L. · Bas, R.C. · Verhoeckx, K.C.M. · Driffield, M. · Harmer, N. · Castle, L.
Keywords: Biology · Biomedical Research · Bisphenol A diglycidyl ether (BADGE) · Canned foods · Food ingredients · Food packaging · Reaction products · Stable isotopes · 2,2 bis(4 glycidyloxyphenyl)propane · 2,2-bis(4-glycidyloxyphenyl)propane · epoxide · article · food contamination · mass spectrometry · spectrofluorometry · Epoxy Compounds · Food Contamination · Mass Spectrometry · Spectrometry, Fluorescence · Malus x domestica · Scombridae
[Abstract]

13 Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory properties
article 2010    
Author: Balvers, M.G.J. · Verhoeckx, K.C.M. · Plastina, P. · Wortelboer, H.M. · Meijerink, J. · Witkamp, R.F.
Keywords: Biology · Biomedical Research · Adipocytes · DHA · EPA · Inflammation · N-acyl ethanolamines · docosahexaenoic acid · docosahexaenoyl ethanolamine · eicosapentanaenoyl ethanolamine · icosapentaenoic acid · interleukin 6 · lipopolysaccharide · monocyte chemotactic protein 1 · n acyl ethanolamine · unclassified drug · antiinflammatory activity · article · cell strain 3T3 · enzyme structure · enzyme synthesis · nonhuman · priority journal
[Abstract]

14 Allergenicity prediction of novel and modified proteins: Not a mission impossible! Development of a Random Forest allergenicity prediction model
article 2019    
Author: Westerhout, J. · Krone, T. · Snippe, A. · Babé, L. · McClain, S.U. · Ladics, G.S. · Houben, G.G. · Verhoeckx, K.C.
Keywords: Allergenicity assessment · Allergenicity prediction · Food allergy · Novel and modified proteins · Random forest · Insect protein · Protein · Allergenicity · Amino acid sequence · Biochemistry · Computer model · Data accuracy · Nonhuman · Physical chemistry · Prediction · Protein database · Risk assessment · Sensitivity and specificity · Sequence analysis
[Abstract]

15 In search of secreted protein biomarkers for the anti-inflammatory effect of β2-adrenergic receptor agonists: Application of DIGE technology in combination with multivariate and univariate data analysis tools
article 2005    
Author: Verhoeckx, K.C.M. · Gaspari, M. · Bijlsma, S. · Greef, J. van der · Witkamp, R.F. · Doornbos, R.P. · Rodenburg, R.J.T.
Keywords: Pharmacology · Analytical research · β2-adrenergic receptor · Difference gel electrophoresis · Macrophage inflammatory protein-1β · Multivariate data analysis · Partial least squares discriminant analysis · Principal component analysis · Zilpaterol · adenylate kinase · beta 2 adrenergic receptor · beta 2 adrenergic receptor blocking agent · beta 2 adrenergic receptor stimulating agent · biological marker · butyryl cyclic AMP · clenbuterol · endotoxin · Escherichia coli lipopolysaccharide · formoterol · forskolin · heat shock protein · macrophage inflammatory protein 1alpha · macrophage inflammatory protein 1beta · phosphoglycerate mutase · propranolol · prostaglandin E2 · proteome · salbutamol · unclassified drug · zilpaterol · adrenergic system · analytic method · antiinflammatory activity · article · controlled study · data analysis · discriminant analysis · human · human cell · inflammation · liquid chromatography · macrophage · mass spectrometry · multivariate analysis · nucleotide sequence · principal component analysis · priority journal · protein expression · protein secretion · proteomics · statistical analysis · two dimensional difference gel electrophoresis · two dimensional gel electrophoresis · Adrenergic Agonists · Adrenergic beta-Antagonists · Anti-Inflammatory Agents · Biological Markers · Cluster Analysis · Down-Regulation · Electrophoresis, Gel, Two-Dimensional · Enzyme-Linked Immunosorbent Assay · Humans · Immunoassay · Inflammation · Lipopolysaccharides · Macrophage Inflammatory Protein-1 · Macrophages · Mass Spectrometry · Monocytes · Multivariate Analysis · Principal Component Analysis · Propranolol · Proteome · Proteomics · Receptors, Adrenergic, beta-2 · Statistics · Trimethylsilyl Compounds · U937 Cells · Up-Regulation · Escherichia coli
[Abstract]

16 A combination of proteomics, principal component analysis and transcriptomics is a powerful tool for the identification of biomarkers for macrophage maturation in the U937 cell line
article 2004    
Author: Verhoeckx, K.C.M. · Bijlsma, S. · Groene, E.M. de · Witkamp, R.F. · Greef, J. van der · Rodenburg, R.J.T.
Keywords: Pharmacology · Analytical research · Differentiation markers · Macrophage maturation · Oligonucleotide microarray · Principal component analysis · Two-dimensional gel electrophoresis · complementary DNA · oligonucleotide · peptide · protein · RNA · analytic method · article · cell differentiation · cell strain U937 · genetic transcription · human · human cell · immunoblotting · lymphoma cell · macrophage · mass spectrometry · matrix assisted laser desorption ionization time of flight mass spectrometry · monocyte · nucleotide sequence · peptide analysis · polyacrylamide gel electrophoresis · polymerase chain reaction · principal component analysis · priority journal · proteomics · two dimensional gel electrophoresis · Cell Differentiation · Electrophoresis, Gel, Two-Dimensional · Gene Expression Profiling · Gene Expression Regulation · Humans · Macrophages · Monocytes · Principal Component Analysis · Proteome · Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization · Statistics · Tetradecanoylphorbol Acetate · U937 Cells
[Abstract]

17 Characterization of anti-inflammatory compounds using transcriptions, proteomics, and metabolics in combination with multivariate data analysis
article 2004    
Author: Verhoeckx, K.C.M. · Bijlsma, S. · Jespersen, S. · Ramaker, R. · Verheij, E.R. · Witkamp, R.F. · Greef, J. van der · Rodenburg, R.J.T.
Keywords: Pharmacology Health · 2-D gel electrophoresis · Anti-inflammatory drugs · Metabolomics · Micro-array · Multivariate data analysis · Principal component discriminant analysis · 4 (4 fluorophenyl) 2 (4 methylsulfinylphenyl) 5 (4 pyridyl)imidazole · Antiinflammatory agent · Beta 2 adrenergic receptor stimulating agent · Clenbuterol · Dexamethasone · Formoterol · Lipopolysaccharide · Salbutamol · Unclassified drug · Zilpaterol · Antiinflammatory activity · controlled study · Data analysis · DNA microarray · Drug determination · Gel electrophoresis · Genetic transcription · Human · Human cell · Lipogenesis · Liquid chromatography · Mass spectrometry · Metabolism · Methodology · Molecule · Monocyte · Multivariate analysis · Priority journal · Protein expression · Proteomics · Adrenergic beta-Agonists · Anti-Inflammatory Agents · Cell Line, Tumor · Electrophoresis, Gel, Two-Dimensional · Gas Chromatography-Mass Spectrometry · Humans · Lipids · Lipopolysaccharides · Macrophage Activation · Macrophages · Multivariate Analysis · Oligonucleotide Array Sequence Analysis · Proteome · Receptors, Adrenergic, beta-2 · RNA, Messenger
[Abstract]

18 Studying metabolism with CYP450 cell llines using LC-MS/MS and fluorometric analysis
article 1999    
Author: Groene, E. de · Vreeken, R.J. · Schoutsen, F.W.P. · Hendriks, L. · Kreikamp, A.P. · Verhoeckx, K.C.M. · Witkamp, R.F.

19 Molecular characterization of trimellitic anhydride-induced respiratory allergy in Brown Norway rats
article 2008    
Author: Kuper, C.F. · Heijne, W.H. · Dansen, M. · Verhoeckx, K.C. · Boorsma, A. · Radonjic, M. · Bruijntjes, J. · Stierum, R. · Muijser, H. · Arts, J.H.
Keywords: Biology · Toxicology and Applied Pharmacology · Allergen · Immunoglobulin E · Phthalic anhydride · Toll like receptor · Trimellitic anhydride · Analysis of variance · Animal · Article · Blood · Brown Norway rat · Cluster analysis · DNA microarray · Drug effect · Female · Gene expression profiling · Genetics · Immunohistochemistry · Lung · Lung lavage · Metabolism · Nonparametric test · Pathology · Principal component analysis · Proteomics · Rat · Respiratory tract allergy · Signal transduction · Allergens · Analysis of Variance · Animals · Bronchoalveolar Lavage · Cluster Analysis · Female · Gene Expression Profiling · Immunoglobulin E · Immunohistochemistry · Lung · Oligonucleotide Array Sequence Analysis · Phthalic Anhydrides · Principal Component Analysis · Proteomics · Rats · Rats, Inbred BN · Respiratory Hypersensitivity · Signal Transduction · Statistics, Nonparametric · Toll-Like Receptors
[Abstract]

20 Fish oil and inflammatory status alter the n-3 to n-6 balance of the endocannabinoid and oxylipin metabolomes in mouse plasma and tissues
article 2012    
Author: Balvers, M.G.J. · Verhoeckx, K.C.M. · Wortelboer, H.M. · Bijlsma, S. · Rubingh, C.M. · Meijerink, J. · Witkamp, R.F.
Keywords: Nutrition · Endocannabinoids · Fish oil · Inflammation · Lipidomics · Multivariate data analysis · Oxylipins · Biomedical Innovation · Healthy Living · Life · QS - Quality & Safety MSB - Microbiology and Systems Biology PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 29 found. Next | Sort by date