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1 Network signatures link hepatic effects of anti-diabetic interventions with systemic disease parameters
article 2014    
Author: Kelder, T. · Verschuren, L. · Ommen, B. van · Gool, A.J. van · Radonjic, M.
Keywords: Biology · Metabolic health · Network biology · Systems biology · Transcriptomics · Type II diabetes mellitus · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

2 Systems biology analysis unravels the complementary action of combined rosuvastatin and ezetimibe therapy
article 2012    
Author: Verschuren, L. · Radonjic, M. · Wielinga, P.Y. · Kelder, T. · Kooistra, T. · Ommen, B. van · Kleemann, R.
Keywords: Biology · adverse effect · coamplified · combination therapy · inflammation · mouse model · systems biology · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

3 LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: Time course and mechanisms
article 2009    
Author: Verschuren, L. · Vries de Weij, J. van der · Zadelaar, A.S.M. · Kleemann, R. · Kooistra, T.
Keywords: Health · Biomedical Research · Atherosclerosis · Inflammation · Liver-X-receptor · Macrophages · ABC transporter A1 · ABC transporter G1 · apolipoprotein E3 · cell adhesion molecule · chemokine receptor CCR7 · cholesterol · endothelial leukocyte adhesion molecule 1 · Hermes antigen · immunoglobulin enhancer binding protein · intercellular adhesion molecule 1 · lipid · liver X receptor agonist · n (2,2,2 trifluoroethyl) n [4 [2,2,2 trifluoro 1 hydroxy 1 (trifluoromethoxy)ethyl]phenyl]benzenesulfonamide · serum amyloid A · triacylglycerol · ABC transporter · ABCG1 protein, mouse · apolipoprotein E3 (Leidein) · cell receptor · DNA binding protein · fluorinated hydrocarbon · hypocholesterolemic agent · lipoprotein · liver X receptor · n (2,2,2 trifluoroethyl) n [4 (2,2,2 trifluoro 1 hydroxy 1 trifluoromethylethyl)phenyl]benzenesulfonamide · sulfonamide · TO-901317 · animal experiment · animal model · atherosclerosis · cell adhesion · cholesterol blood level · cholesterol diet · controlled study · disease course · drug mechanism · drug potency · endothelium · female · immunohistochemistry · macrophage · monocyte · mouse · nonhuman · priority journal · protein expression · remission · triacylglycerol blood level · animal · drug potentiation · genetics · metabolism · pathology · transgenic mouse · Animals · Anticholesteremic Agents · Antigens, CD44 · Apolipoprotein E3 · Atherosclerosis · ATP-Binding Cassette Transporters · DNA-Binding Proteins · E-Selectin · Female · Hydrocarbons, Fluorinated · Intercellular Adhesion Molecule-1 · Lipoproteins · Mice · Mice, Transgenic · Receptors, Cytoplasmic and Nuclear · Serum Amyloid A Protein · Sulfonamides
[PDF] [Abstract]

4 Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFκB-C/EBP-β complex formation
article 2003    
Author: Kleemann, R. · Gervois, P.P. · Verschuren, L. · Staels, B. · Princen, H.M.G. · Kooistra, T.
Keywords: Biology · Animals · Antilipemic Agents · Bezafibrate · C-Reactive Protein · CCAAT-Enhancer-Binding Protein-beta · Cell Nucleus · Clofibric Acid · Down-Regulation · Hepatocytes · Humans · Interleukin-1 · Mice · Mice, Knockout · NF-kappa B · NF-kappa B p50 Subunit · Protein Binding · Receptors, Cytoplasmic and Nuclear · Transcription Factors · Transcription, Genetic · Transfection
[Abstract]

5 Key Inflammatory Processes in Human NASH Are Reflected in Ldlr−/−.Leiden Mice: A Translational Gene Profiling Study
article 2018    
Author: Morrison, M.C. · Kleemann, R. · Koppen, A. van · Hanemaaijer, R. · Verschuren, L.
Keywords: Biology · Liver · NASH, · Inflammation · Molecular · Gene expression · Translational · Mouse · Human · Translational · Cytokine · Growth factor · Transcription factor · Animal experiment · Animal model · Controlled study · Extracellular matrix · Gene expression profiling · Human tissue · Inflammation · Lipid diet · Lipid metabolism · Liver biopsy · Mouse · Nonalcoholic fatty liver · Nonhuman · Transcriptomics · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

6 Apical sodium-dependent bile acid transporter inhibition with volixibat improves metabolic aspects and components of non-alcoholic steatohepatitis in Ldlr-/-.Leiden mice
article 2019    
Author: Salic, K. · Kleemann, R. · Wilkins-Port, C. · McNulty, J. · Verschuren, L. · Palmer, M.
[PDF] [Abstract]

7 A dietary mixture containing fish oil, resveratrol, lycopene, catechins, and vitamins E and C reduces atherosclerosis in transgenic mice
article 2011    
Author: Verschuren, L. · Wielinga, P.Y. · Duyvenvoorde, W. van · Tijani, S. · Toet, K. · Ommen, B. van · Kooistra, T. · Kleemann, R.
Keywords: Nutrition · alpha tocopherol · apolipoprotein E3 · ascorbic acid · biological marker · C reactive protein · catechin · cell adhesion molecule · cholesterol · cytokine · docosahexaenoic acid · endothelial leukocyte adhesion molecule 1 · epigallocatechin gallate · fibrinogen · fish oil · green tea extract · icosapentaenoic acid · intercellular adhesion molecule 1 · interleukin 1beta · lipid · lycopene · omega 3 700 · placebo · polyunsaturated fatty acid · resveratrol · serum amyloid A · triacylglycerol · unclassified drug · animal experiment · animal model · antiinflammatory dietary mixture · article · atherogenic diet · atherosclerosis · cholesterol blood level · controlled study · diet supplementation · dietary intake · drug efficacy · drug megadose · feeding · female · inflammation · long term care · male · mouse · nonhuman · powder · protein blood level · protein expression · risk factor · risk reduction · transgenic animal · treatment duration · treatment outcome · triacylglycerol blood level · vasculitis · omega 3 700 · Solgar Vitamin and Herb · Life · MSB - Microbiology and Systems Biology MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

8 Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models
article 2011    
Author: Kleemann, R. · Verschuren, L. · Morrison, M. · Zadelaar, A.S.M. · Erk, M.J. van · Wielinga, P.Y. · Kooistra, T.
Keywords: Nutrition · Anti-inflammatory · Atherosclerosis · Cholesterol · CRP · Inflammation · Polyphenol · Proliferation · Quercetin · C reactive protein · endothelial leukocyte adhesion molecule 1 · fibrinogen · immunoglobulin enhancer binding protein · quercetin · vascular cell adhesion molecule 1 · animal experiment · animal model · antiinflammatory activity · article · atherosclerosis · cardiovascular risk · controlled study · drug activity · drug blood level · drug effect · endothelium cell · human · human cell · inflammation · liver cell · male · mouse · nonhuman · priority journal · protein expression · risk factor · transgenic mouse · Life · MHR - Metabolic Health Research MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[Abstract]

9 Novel combination of collagen dynamics analysis and transcriptional profiling reveals fibrosis-relevant genes and pathways
article 2013    
Author: Blaauboer, M.E. · Emson, C.L. · Verschuren, L. · Erk, M. van · Turner, S.M. · Everts, V. · Hanemaaijer, R. · Stoop, R.
Keywords: Biology · Bleomycin · Cell proliferation · Extracellular matrix · Gene expression · Lung fibrosis · New collagen formation · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[Abstract]

10 A systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone
article 2014    
Author: Verschuren, L. · Wielinga, P.Y. · Kelder, T. · Radonjic, M. · Salic, K. · Kleemann, R. · Ommen, B. van · Kooistra, T.
Keywords: Biology Nutrition · Systems biology · Food and Nutrition · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

11 Epicatechin attenuates atherosclerosis and exerts anti-inflammatory effects on diet-induced human-CRP and NFκB invivo
article 2014    
Author: Morrison, M. · Heijden, R. van der · Heeringa, P. · Kaijzel, E. · Verschuren, L. · Blomhoff, R. · Kooistra, T. · Kleemann, R.
Keywords: Biology · Atherosclerosis · CRP · Epicatechin · Inflammation · NFκB · Polyphenol · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

12 Transgenic flavonoid tomato intake reduces C-reactive protein in human C-reactive protein transgenic mice more than wild-type tomato
article 2006    
Author: Rein, D. · Schijlen, E. · Kooistra, T. · Herbers, K. · Verschuren, L. · Hall, R. · Sonnewald, U. · Bovy, A. · Kleemann, R.
Keywords: Biology · Biomedical Research · Alanine aminotransferase · C reactive protein · Cholesterol · Endothelial leukocyte adhesion molecule 1 · Fenofibrate · Fibrinogen · Flavonoid · Alanine aminotransferase blood level · Animal experiment · Animal tissue · Body weight · Cardiovascular risk · Cholesterol blood level · Controlled study · Dietary intake · Drug effect · Enzyme activity · Food intake · Male · Mouse · Nonhuman · Protein expression · Tomato · Transgenic mouse · Wild type · Alanine Transaminase · Animals · C-Reactive Protein · Cardiovascular Diseases · Cholesterol · Cholesterol, HDL · Diet · E-Selectin · Fibrinogen · Flavonoids · Fruit · Humans · Lycopersicon esculentum · Mice · Mice, Transgenic · Plants, Genetically Modified · Procetofen · Risk Factors · Lycopersicon esculentum · Mus musculus
[Abstract]

13 Resolvin E1 attenuates atherosclerosis in absence of cholesterol-lowering effects and on top of atorvastatin
article 2016    
Author: Salic, K. · Morrison, M.C. · Verschuren, L. · Wielinga, P.Y. · Wu, L. · Kleemann, R. · Gjorstrup, P. · Kooistra, T.
Keywords: Biology · Atherosclerosis · Inflammation · Resolution · Resolvin E1 · Statin · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

14 Reduction of obesity-associated white adipose tissue inflammation by rosiglitazone is associated with reduced non-alcoholic fatty liver disease in LDLr-deficient mice
article 2016    
Author: Mulder, P. · Morrison, M.C. · Verschuren, L. · Liang, W. · Bockel, J.H. van · Kooistra, T. · Wielinga, P.Y. · Kleemann, R.
Keywords: Biology · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

15 Effect of low dose atorvastatin versus diet-induced cholesterol lowering on atherosclerotic lesion progression and inflammation in apolipoprotein E*3-Leiden transgenic mice
article 2005    
Author: Verschuren, L. · Kleemann, R. · Offerman, E.H. · Szalai, A.J. · Emeis, S.J. · Princen, H.M.G. · Kooistra, T.
Keywords: Biology · Biomedical Research · Growth factors · Lipids · Lipoprotein metabolism · Pathophysiology · C reactive protein · Cholesterol · Gelatinase B · Macrophage migration inhibition factor · Plasminogen activator inhibitor 1 · Vascular cell adhesion molecule 1 · Animal cell · Animal experiment · animal model · Antiinflammatory activity · Aorta arch · Cholesterol blood level · Cholesterol diet · Controlled study · Dietary intake · Disease activity · Disease course · Disease severity · Inflammation · Lipoprotein metabolism · Low drug dose · Macrophage · Monocyte · Mouse · Nonhuman · Pathophysiology · Protein expression · Smooth muscle fiber · Transgenic mouse · Treatment outcome · Amyloid A protein · Apolipoprotein E3 · Atorvastatin · Animals · Anticholesteremic Agents · Aorta · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Biological Markers · C-Reactive Protein · Cholesterol · Diet · Diet, Atherogenic · Drug Administration Schedule · Female · Heptanoic Acids · Inflammation · Male · Mice · Mice, Transgenic · Pyrroles · Serum Amyloid A Protein
[Abstract]

16 Fenofibrate reduces atherogenesis in ApoE*3Leiden mice: Evidence for multiple antiatherogenic effects besides lowering plasma cholesterol
article 2006    
Author: Kooistra, T. · Verschuren, L. · Vries de-Weij, J.van der · Koenig, W. · Toet, K. · Princen, H.M.G. · Kleemann, R.
Keywords: Biology · Biomedical Research · Atherosclerosis · Fibrates · Inflammation · Pleiotrop · Reverse cholesterol transport · ABC transporter A1 · Cholesterol · Fenofibrate · Granulocyte macrophage colony stimulating factor · Immunoglobulin enhancer binding protein · Intercellular adhesion molecule 1 · Monocyte chemotactic protein 1 · Serum amyloid A · Vascular cell adhesion molecule 1 · Animal cell · Animal experiment · Animal model · Animal tissue · Aorta atherosclerosis · Atherogenesis · Cholesterol blood level · Cholesterol diet · Cholesterol transport · Controlled study · Disease severity · Drug effect · Macrophage · Mouse · Nonhuman · Protein blood level · Protein expression · Transgenic mouse · Upregulation · Animals · Antilipemic Agents · Aorta · Aortic Valve · Apolipoprotein E3 · Apolipoproteins E · Atherosclerosis · Cholesterol · Female · Inflammation · Lipids · Lipoproteins · Mice · Mice, Transgenic · Procetofen
[Abstract]

17 Dentistry and OMICS: Transcriptome Dynamics of an Oral Ecosystem as Measured by Changes in Oral Polymorphonuclear Neutrophils in Experimental Gingivitis
article 2020    
Author: Rijkschroeff, P. · Schoenmaker, T. · Caspers, M. · Verschuren, L. · Keijser, B.J.F. · Nicu, E.A. · Loos, B.G.
Keywords: Dentistry · Gingivitis · Neutrophils · Ooral health · Transcriptomics
[PDF] [Abstract]

18 Arachidonic acid/docosahexaenoic acid-supplemented diet in early life reduces body weight gain, plasma lipids, and adiposity in later life in ApoE*3 Leiden mice
article 2012    
Author: Wielinga, P.Y. · Harthoorn, L.F. · Verschuren, L. · Schoemaker, M.H. · Jouni, Z.E. · Tol, E.A.F. van · Kleemann, R. · Kooistra, T.
Keywords: Biology Health · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

19 A Systems Biology Strategy for Predicting Similarities and Differences of Drug Effects: Evidence for Drug-specific Modulation of Inflammation in Atherosclerosis
article 2011    
Author: Kleemann, R. · Bureeva, S. · Perlina, A. · Kaput, J. · Verschuren, L. · Wielinga, P.Y. · Hurt-Camejo, E. · Nikolsky, Y. · Ommen, B. van · Kooistra, T.
Keywords: Health Pharmacology · Trifluoro · Life · MHR - Metabolic Health Research PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

20 Mouse models for atherosclerosis and pharmaceutical modifiers
article 2007    
Author: Zadelaar, A.S.M. · Kleemann, R. · Verschuren, L. · Vries-van der Weij, J. de · Hoorn, J. van der · Princen, H.M. · Kooistra, T.
Keywords: Biology · Biomedical Research · ACE inhibitors · AT1 receptor antagonists · Atherosclerosis · LXR · Mouse models · Pharmaceutical drugs · PPAR · Statins · atorvastatin · avasimibe · candesartan · captopril · cholesterol acyltransferase inhibitor · dipeptidyl carboxypeptidase inhibitor · hydralazine · hydroxymethylglutaryl coenzyme A reductase inhibitor · irbesartan · losartan · ly 465608 · n (2,2,2 trifluoroethyl) n [4 [2,2,2 trifluoro 1 hydroxy 1 (trifluoromethoxy)ethyl]phenyl]benzenesulfonamide · olmesartan · perindopril · peroxisome proliferator activated receptor alpha agonist · pirinixic acid · pitavastatin · pravastatin · quinapril · ramipril · rosuvastatin · simvastatin · telmisartan · temocapril · unindexed drug · valsartan · zofenopril · antihypertensive agent · antilipemic agent · apolipoprotein E · atherosclerosis · pathophysiology · sensitivity and specificity · Animals · Antihypertensive Agents · Antilipemic Agents · Apolipoproteins E · Atherosclerosis · Disease Models, Animal · Dose-Response Relationship, Drug · Drug Administration Schedule · Dyslipidemias · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Hypertension · Male · Mice · Mice, Knockout · Mice, Transgenic · Sensitivity and Specificity
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 49 found. Next | Sort by date