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1 Advanced glycation endproducts in the development of osteoarthritis cartilage biochemistry and biomechanics
dissertation 2001    
Author: Verzijl, N.
Keywords: Health
[PDF]

2 Chondrocytes cultured in alginate beads: a model system to measure collagen synthesis and degradation
article 1995    
Author: Koppele, J.M. te · Verzijl, N. · Beekman, B.
Keywords: Health · Healthy for Life · Healthy Living
[Abstract]

3 Molecular markers for osteoarthritis: The road ahead
article 2002    
Author: Groot, J. de · Bank, R.A. · Tchetverikov, I. · Verzijl, N. · TeKoppele, J.M.
Keywords: Biology · Biomedical Research · biological marker · cartilage oligomeric matrix protein · chondroitin sulfate · collagen · collagen type 2 · cytokine · epitope · hyaluronic acid · keratan sulfate · matrix metalloproteinase · osteocalcin · proteoglycan · sialoprotein · tissue inhibitor of metalloproteinase · transforming growth factor beta1 · tumor necrosis factor receptor 2 · cross linking reagent · arthritis · articular cartilage · collagen synthesis · cross linking · disease course · inflammation · prognosis · review · synovium · extracellular matrix · genetic marker · genetics · metabolism · pathology · Collagen Type II · Cross-Linking Reagents · Extracellular Matrix · Genetic Markers · Matrix Metalloproteinases · Osteoarthritis · Proteoglycans · Support, Non-U.S. Gov't · Humans
[Abstract]

4 Putative role of lysyl hydroxylation and pyridinoline cross-linking during adolescence in the occurrence of osteoarthritis at old age
article 2002    
Author: Bank, R.A. · Verzijl, N. · Lafeber, F.P.J.G. · Tekoppele, J.M.
Keywords: Health Biology · Biomedical Research · Collagen · Fatigue · Hydroxylysine · Osteoarthritis · Pyridinoline · collagen · hydroxylysine · pentosidine · pyridinoline · adolescence · adult · aged · article · articular cartilage · cartilage degeneration · clinical article · collagen synthesis · controlled study · cross linking · fatigue · femur condyle · human · human tissue · hydroxylation · knee osteoarthritis · onset age · pathogenesis · priority journal · senescence · stress · stress strain relationship · Aged · Aged, 80 and over · Amino Acids · Arginine · Case-Control Studies · Collagen · Cross-Linking Reagents · Humans · Hydroxylysine · Lysine · Middle Aged · Osteoarthritis, Knee
[Abstract]

5 Ageing and osteoarthritis: A different perspective
article 2003    
Author: Verzijl, N. · Bank, R.A. · TeKoppele, J.M. · Groot, J. de
Keywords: Biology Health · Biomedical Research · Advanced glycation end products · Cartilage · Chondrocyte · Collagen · Osteoarthritis · Articular cartilage · Cartilage degeneration · Cartilage matrix · Diabetes mellitus · Economic aspect · Musculoskeletal disease · Rigidity · Aging · Cartilage, Articular · Glycosylation End Products, Advanced · Humans
[Abstract]

6 Active MMPs captured by alpha2Macroglobulin as a marker of disease activity in rheumatoid arthritis
article 2003    
Author: Tchetverikov, I. · Verzijl, N. · Huizinga, T.W.J. · TeKoppele, J.M. · Hanemaaijer, R. · Groot, J. de
Keywords: Biology · Biomedical Research · α2Macroglobulin · Matrix metalloproteases · Rheumatoid arthritis · alpha 2 macroglobulin · batimastat · collagenase 3 · matrix metalloproteinase · tissue inhibitor of metalloproteinase 1 · article · circulation · clinical article · complex formation · concentration (parameters) · controlled study · correlation analysis · disease activity · disease course · disease marker · enzyme linked immunosorbent assay · erythrocyte sedimentation rate · fast protein liquid chromatography · fluorescence analysis · human · molecular weight · priority journal · protein analysis · protein blood level · quantitative analysis · rheumatoid arthritis · Adult · alpha-Macroglobulins · Arthritis, Rheumatoid · Biological Markers · Case-Control Studies · Disease Progression · Enzyme-Linked Immunosorbent Assay · Female · Humans · Male · Matrix Metalloproteinases · Middle Aged · Probability · Prognosis · Reference Values · Sensitivity and Specificity · Severity of Illness Index
[PDF] [Abstract]

7 Doxycycline inhibits collagen synthesis by bovine chondrocytes cultured in alginate
article 1997    
Author: Beekman, B. · Verzijl, N. · Roos, J.A.D.M.de · Koopman, J.L. · Tekoppele, J.M.
Keywords: Biology · Biomedical Research · alginic acid · cysteine · methionine · collagen · glucuronic acid · hexuronic acid · messenger RNA · protein synthesis inhibitor · sulfur · articular cartilage · cell culture · cell proliferation · collagen synthesis · metabolic inhibition · nonhuman · osteoarthritis · phenotype · animal · biosynthesis · culture technique · cytology · dose response · drug effect · genetic transcription · metabolism · metacarpophalangeal joint · methodology · protein synthesis · Alginates · Animals · Cartilage, Articular · Cattle · Cell Culture Techniques · Cell Division · Cell Survival · Collagen · Cysteine · DNA · Dose-Response Relationship, Drug · Doxycycline · Glucuronic Acid · Hexuronic Acids · Kinetics · Metacarpophalangeal Joint · Methionine · Protein Biosynthesis · Protein Synthesis Inhibitors · RNA, Messenger · Sulfur Radioisotopes · Transcription, Genetic
[Abstract]

8 Synthesis of collagen by bovine chondrocytes cultured in alginate; posttranslational modifications and cell-matrix interaction
article 1997    
Author: Beekman, B. · Verzijl, N. · Bank, R.A. · Von Der Mark, K. · TeKoppele, J.M.
Keywords: Biology · Biomedical Research · Alginate beads · Articular chondrocyte · Collagen · Collagen crosslinks · Posttranslational modification · Proteoglycan · 3 aminopropionitrile · alginic acid · collagen · integrin · pyridinoline · animal cell · binding affinity · cartilage cell · cell interaction · cell proliferation · collagen synthesis · nonhuman · priority journal · protein cross linking · protein processing · Alginates · Amino Acid Sequence · Amino Acids · Aminopropionitrile · Animals · Cartilage, Articular · Cattle · Cell Division · Cells, Cultured · Collagen · DNA · Extracellular Matrix · Glucuronic Acid · Glycosylation · Hexuronic Acids · Kinetics · Oligopeptides · Protein Processing, Post-Translational · Proteoglycans · Time Factors · Animalia · Bos taurus · Bovinae
[Abstract]

9 Doxycycline inhibits collagen synthesis by differentiated articular chondrocytes.
article 1998    
Author: TeKoppele, J.M. · Beekman, B. · Verzijl, N. · Koopman, J.L. · Groot, J. de · Bank, R.A.
Keywords: Biology · Biomedical Research · antiinfective agent · collagen · doxycycline · metalloproteinase · protein synthesis inhibitor · proteinase inhibitor · animal · article · articular cartilage · biosynthesis · cartilage cell · cattle · cell culture · cytology · dog · drug antagonism · metabolism · osteoarthritis · Animals · Anti-Bacterial Agents · Cartilage, Articular · Cattle · Cells, Cultured · Chondrocytes · Collagen · Dogs · Doxycycline · Metalloendopeptidases · Osteoarthritis · Protease Inhibitors · Protein Synthesis Inhibitors
[Abstract]

10 Matrix degradation by chondrocytes cultured in alginate : IL-1β induces proteoglycan degradation and proMMP synthesis but does not result in collagen degradation
article 1998    
Author: Beekman, B. · Verzijl, N. · Roos, J.A.D.M. de · TeKoppele, J.M.
Keywords: Biology · Biomedical Research · Matrix degradation · Matrix metalloproteinases · alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid · collagen · glycosaminoglycan · interleukin 1beta · metalloproteinase · proteoglycan · cartilage cell · degradation · enzyme synthesis · extracellular matrix · Alginates · Animals · Cattle · Cells, Cultured · Chondrocytes · Collagen · Extracellular Matrix · Interleukin-1 · Metalloendopeptidases · Microspheres · Proteoglycans
[Abstract]

11 Age-related decrease in proteoglycan synthesis of human articular chondrocytes: The role of nonenzymatic glycation
article 1999    
Author: Groot, J. de · Verzijl, N. · Bank, R.A. · Lafeber, F.P.J.G. · Bijlsma, J.W.J. · TeKoppele, J.M.
Keywords: Health Biology · Biomedical Research · age · article · articular cartilage · cartilage cell · glycation · human · human tissue · pathogenesis · priority journal · proteoglycan synthesis · rheumatic disease · Adult · Aged · Aged, 80 and over · Aging · Arginine · Cartilage, Articular · Cross-Linking Reagents · Extracellular Matrix · Glycosylation End Products, Advanced · Humans · Lysine · Middle Aged · Osteoarthritis · Proteoglycans · Ribose
[Abstract]

12 Accumulation of advanced glycation end products decreases collagen turnover by bovine chondrocytes
article 2001    
Author: Groot, J. de · Verzijl, N. · Budde, M. · Bijlsma, J.W.J. · Lafeber, F.P.J.G. · TeKoppele, J.M.
Keywords: Biology · Biomedical Research · Advanced glycation end product · Alginate culture · Cartilage · Chondrocyte · Collagen · Matrix metalloproteinase · Turnover · advanced glycation end product · alginic acid · collagen · matrix metalloproteinase · ribose · animal cell · article · articular cartilage · cartilage cell · cattle · cell culture · collagen defect · collagen degradation · collagen synthesis · controlled study · culture medium · enzyme activity · extracellular matrix · nonhuman · osteoarthritis · priority journal · reaction time · Animals · Cattle · Cells, Cultured · Chondrocytes · Collagen · Enzyme Precursors · Extracellular Matrix · Glycosylation End Products, Advanced · Matrix Metalloproteinases · Osteoarthritis · Ribose · Bovinae
[Abstract]

13 Induction of advanced glycation end products and alterations of the tensile properties of articular cartilage
article 2002    
Author: Chen, A.C. · Temple, M.M. · Ng, D.M. · Verzijl, N. · Groot, J. de · TeKoppele, J.M. · Sah, R.L.
Keywords: Biology · Biomedical Research · advanced glycation end product · buffer · pentosidine · ribose · age · aging · animal tissue · article · articular cartilage · biomechanics · cattle · controlled study · culture medium · fluorescence · joint degeneration · joint fracture · light absorption · nonhuman · priority journal · rigidity · stress · tensile strength · Animals · Biomechanics · Cartilage, Articular · Cattle · Elasticity · Glycosylation End Products, Advanced · Ribose · Tensile Strength
[PDF] [Abstract]

14 Sensitive fluorimetric quantitation of pyridinium and pentosidine crosslinks in biological samples in a single high-performance liquid chromatographic run
article 1997    
Author: Bank, R.A. · Beekman, B. · Verzijl, N. · Roos, J.A.D.M.de · Nico Sakkee, A. · Tekoppele, J.M.
Keywords: Biology · Biomedical Research · Collagen · Pentosidine · Pyridinium · collagen · pyridinium derivative · animal tissue · articular cartilage · bone · cattle · collagen synthesis · connective tissue · cross linking · high performance liquid chromatography · human tissue · measurement · nonhuman · priority journal · reproducibility · reversed phase high performance liquid chromatography · standard · urine · Adolescent · Arginine · Bone and Bones · Cartilage, Articular · Chromatography, High Pressure Liquid · Circadian Rhythm · Connective Tissue · Cross-Linking Reagents · Humans · Hydrolysis · Ligaments · Linear Models · Lysine · Middle Aged · Pyridinium Compounds · Reproducibility of Results · Sensitivity and Specificity · Spectrometry, Fluorescence · Tendons
[Abstract]

15 MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis
article 2005    
Author: Tchetverikov, I. · Lohmander, L.S. · Verzijl, N. · Huizinga, T.W.J. · TeKoppele, J.M. · Hanemaaijer, R. · Groot, J. de
Keywords: Biomedical Research · alpha 2 macroglobulin · interstitial collagenase · matrix metalloproteinase · prointerstitial collagenase · prostromelysin · stromelysin · tissue inhibitor of metalloproteinase 3 · unclassified drug · arthritis · controlled study · enzyme activation · enzyme activity · enzyme inhibition · human · immunoassay · joint injury · knee · major clinical study · osteoarthritis · priority journal · protein determination · pseudogout · quantitative analysis · synovial fluid level · Acute Disease · Adult · alpha-Macroglobulins · Arthritis · Chondrocalcinosis · Cross-Sectional Studies · Female · Humans · Knee Injuries · Male · Matrix Metalloproteinases · Middle Aged · Osteoarthritis, Knee · Synovial Fluid · Tissue Inhibitor of Metalloproteinase-1
[Abstract]

16 Increase in the advanced glycation end product pentosidine in Bruch's membrane with age
article 1999    
Author: Handa, J.T. · Verzijl, N. · Matsunaga, H. · Aotaki-Keen, A. · Lutty, G.A. · Koppele, J.M. te · Miyata, T. · Hjelmeland, L.M.
Keywords: Adult · Aged · Aged, 80 and over · Aging · Arginine · Bruch Membrane · Choroid · Chromatography, High Pressure Liquid · Diabetic Retinopathy · Glycosylation End Products, Advanced · Humans · Immunoenzyme Techniques · Infant · Lysine · Middle Aged · Pigment Epithelium of Eye · Retinal Drusen
[Abstract]

17 Age-related accumulation of the advanced glycation endproduct pentosidine in human articular cartilage aggrecan: The use of pentosidine levels as a quantitative measure of protein turnover
article 2001    
Author: Verzijl, N. · Groot, J. de · Bank, R.A. · Bayliss, M.T. · Bijlsma, J.W.J. · Lafeber, F.P.J.G. · Maroudas, A. · TeKoppele, J.M.
Keywords: Health Biology · Biomedical Research · Articular cartilage · Osteoarthritis · Pentosidine · Turnover · Aspartic acid · Collagen · Hyaluronic acid · Protein · Binding site · Controlled study · Glycation · Half life time · Human tissue · Protein domain · Protein metabolism · School child · Adolescent · Adult · Aged · Aged, 80 and over · Aggrecans · Aging · Arginine · Cartilage, Articular · Chemical Fractionation · Child · Extracellular Matrix Proteins · Glycosylation End Products, Advanced · Humans · Lectins, C-Type · Lysine · Middle Aged · Osteoarthritis · Proteochondroitin Sulfates · Proteoglycans
[Abstract]

18 Age-related decrease in susceptibility of human articular cartilage to matrix metalloproteinase-mediated degradation: The role of advanced glycation end products
article 2001    
Author: Groot, J. de · Verzijl, N. · Wenting-Van Wijk, M.J.G. · Bank, R.A. · Lafeber, F.P.J.G. · Bijlsma, J.W.J. · Tekoppele, J.M.
Keywords: Health Biology · Biomedical Research · glycosaminoglycan · matrix metalloproteinase · pentosidine · adult · aged · article · articular cartilage · cartilage degeneration · clinical article · colorimetry · controlled study · disease course · female · high performance liquid chromatography · human · male · osteoarthritis · priority journal · protein degradation · rheumatoid arthritis · synovial fluid · Adult · Aged · Aged, 80 and over · Aging · Animals · Arginine · Arthritis, Rheumatoid · Cartilage, Articular · Cattle · Chromatography, High Pressure Liquid · Glycosaminoglycans · Humans · Knee Joint · Lysine · Matrix Metalloproteinases · Middle Aged · Osteoarthritis, Knee · Phenylmercuric Acetate · Ribose · Synovial Fluid
[Abstract]

19 Steady progression of osteoarthritic features in the canine groove model
article 2002    
Author: Marijnissen, A.C.A. · Roermund, P.M. van · Verzijl, N. · Tekoppele, J.M. · Bijlsma, J.W.J. · Lafeber, F.P.J.G.
Keywords: Biology · Biomedical Research · Canine model · Cartilage · Osteoarthritis · Proteoglycans · proteoglycan · Animal experiment · Animal model · Bone injury · Cartilage degeneration · Controlled study · Disease course · Femur condyle · Histopathology · In vivo study · Joint degeneration · Joint injury · Joint stability · Knee osteoarthritis · Laboratory test · Loading test · Nonhuman · Proteoglycan synthesis · Surgical technique · Synovitis · Treatment outcome · Animals · Cartilage, Articular · Disease Models, Animal · Dogs · Female · Joints · Osteoarthritis · Proteoglycans · Synovial Membrane · Time Factors
[Abstract]

20 Accumulation of advances glycation end products reduces chondrocyte-mediated extracellular matrix turnover in human articular cartilage
article 2001    
Author: Groot, J. de · Verzijl, N. · Jacobs, K.M.G. · Budde, M. · Bank, R.A. · Bijlsma, J.W.J. · TeKoppele, J.M. · Lafeber, F.P.J.G.
Keywords: Health · Biomedical Research

Search results also available in MS Excel format.

Showing 1 to 20 of 28 found. Next | Sort by date