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1 Primary hepatocyte cultures as a model system for the determination of induction of biotransformation enzymes; effects of glucosinolate hydrolysis products./Primaire hepatocyten cultures als een in vitro model ter bepaling van inductie van biotransformatie enzymen: effecten van hydrolyse produkten van glucosinolaten
dissertation 1991    
Author: Wortelboer, H.M.
Keywords: Nutrition · Biology · Biochemistry
[PDF]

2 Ex vivo systems to study host-microbiota interactions in the gastrointestinal tract
article 2013    
Author: Roeselers, G. · Ponomarenko, M. · Lukovac, S. · Wortelboer, H.M.
Keywords: Biology · Experimental model · Gut · Microbiome · Microcosms · Mucosa · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

3 Grip on health: A complex systems approach to transform health care
article 2016    
Author: Wietmarschen, H.A. · Wortelboer, H.M. · Greef, J. van der
Keywords: Health Nutrition · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences

4 Liquid chromatography-tandem mass spectrometry analysis of free and esterified fatty acid N-acyl ethanolamines in plasma and blood cells
article 2013    
Author: Balvers, M.G.J. · Wortelboer, H.M. · Witkamp, R.F. · Verhoeckx, K.C.M.
Keywords: Biology · Diet · Endocannabinoids · LC-MS/MS · NAEs · Plasma · Validation · Biomedical Innovation · Healthy Living · Life · QS - Quality & Safety PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

5 Protein transport across the small intestine in food allergy
article 2014    
Author: Reitsma, M. · Westerhout, J. · Wichers, H.J. · Wortelboer, H.M. · Verhoeckx, K.C.M.
Keywords: Biology · Food hypersensitivity · Intestinal protein transport · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

6 Effects of long- and short-chain fatty acids on the release of gastrointestinal hormones using an ex vivo porcine intestinal tissue model
article 2012    
Author: Voortman, T. · Hendriks, H.F.J. · Witkamp, R.F. · Wortelboer, H.M.
Keywords: Health · ex vivo porcine intestinal model · fatty acids · gut hormones · satiety · Healthy for Life · Healthy Living · Life · PHS - Pharmacokinetics & Human Studies MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

7 Measurement of Palmitoylethanolamide and Other N-Acylethanolamines During Physiological and Pathological Conditions
article 2013    
Author: Balvers, M.G.J. · Verhoeckx, K.C.M. · Meijerink, J. · Wortelboer, H.M. · Witkamp, R.F.
Keywords: Biology · Endocannabinoids · Inflammation · Kinetics · Liquid Chromatography-mass Spectrometry · Palmitoylethanolamide · Biomedical Innovation · Healthy Living · Life · PHS - Pharmacokinetics & Human Studies RAPID - Risk Analysis for Products in Development · EELS - Earth, Environmental and Life Sciences
[Abstract]

8 The effect of chitosan on the bioaccessibility and intestinal permeability of acyclovir
article 2019    
Author: Kubbinga, M. · Augustijns, P. · Garcia, M.A. · Heinen, C. · Wortelboer, H.M. · Verwei, M. · Langguth, P.
Keywords: Biology · Acyclovir · Caco-2 · Chitosan · Intestinal tissue segments · TNO gastro-Intestinal Model (TIM-1)
[Abstract]

9 A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices
article 2014    
Author: Westerhout, J. · Steeg, E. van de · Grossouw, D. · Zeijdner, E.E. · Krul, C.A.M. · Verwei, M. · Wortelboer, H.M.
Keywords: Biology · Caco-2 · Food-effect · Human intestine · Intestinal absorption · InTESTine™ · Porcine intestine · Acebutolol · Atenolol · Candesartan · Cetirizine · Cimetidine · Ciprofloxacin · Diazepam · Digoxin · Famotidine · Hydrocortisone · Ibuprofen · Indometacin · Mannitol · Melagatran · Metoprolol · Mucin · Oxprenolol · Phenazone · Pindolol · Propranolol · Ranitidine · Salazosulfapyridine · Salicylic acid · Testosterone · Verapamil · Active transport · Animal tissue · CACO 2 cell line · Controlled study · Domestic pig · Drug absorption · Drug bioavailability · Drug penetration · Drug transport · Electric resistance · Ex vivo study · Female · Human · Human tissue · Intestine absorption · Intestine mucosa · Male · Nonhuman · Passive transport · Prediction · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

10 Presence, formation and putative biological activities of N-acyl serotonins, a novel class of fatty-acid derived mediators, in the intestinal tract
article 2011    
Author: Verhoeckx, K.C.M. · Voortman, T. · Balvers, M.G.J. · Hendriks, H.F.J. · Wortelboer, H.M. · Witkamp, R.F.
Keywords: Biology · Food and Nutrition · Healthy Living · Life · QS - Quality & Safety PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences

11 Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory properties
article 2010    
Author: Balvers, M.G.J. · Verhoeckx, K.C.M. · Plastina, P. · Wortelboer, H.M. · Meijerink, J. · Witkamp, R.F.
Keywords: Biology · Biomedical Research · Adipocytes · DHA · EPA · Inflammation · N-acyl ethanolamines · docosahexaenoic acid · docosahexaenoyl ethanolamine · eicosapentanaenoyl ethanolamine · icosapentaenoic acid · interleukin 6 · lipopolysaccharide · monocyte chemotactic protein 1 · n acyl ethanolamine · unclassified drug · antiinflammatory activity · article · cell strain 3T3 · enzyme structure · enzyme synthesis · nonhuman · priority journal
[Abstract]

12 Effect of body fat distribution on the transcription response to dietary fat interventions
article 2009    
Author: Radonjic, M. · Erk, M.J. van · Pasman, W.J. · Wortelboer, H.M. · Hendriks, H.F.J. · Ommen, B. van
Keywords: Biomedical Research · Dietary interventions · DNA microarrays · Long-chain fatty acids (PUFA) · Lower body obesity (LBO) · Medium-chain fatty acids (MCT) · Upper body obesity (UBO)
[PDF] [Abstract]

13 Metabolism of ATP-binding cassette drug transporter inhibitors: complicating factor for multidrug resistance.
article 2005    
Author: Cnubben, N.H. · Wortelboer, H.M. · Zanden, J.J. van · Rietjens, I.M. · Bladeren, P.J. van
Keywords: Health Pharmacology · Physiological Sciences · ABC transporter · cyclosporin derivative · dibenzo[a,d]cycloheptene derivative · glycoprotein P · quinoline derivative · valspodar · zosuquidar · drug antagonism · drug design · drug effect · genetics · human · metabolism · multidrug resistance · review · RNA interference · transport at the cellular level · ATP-Binding Cassette Transporters · Biological Transport · Cyclosporins · Dibenzocycloheptenes · Drug Design · Drug Resistance, Multiple · Humans · P-Glycoproteins · Quinolines · RNA Interference
[Abstract]

14 Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling.
article 2014    
Author: Bosgra, S. · Steeg, E. van de · Vlaming, M.L. · Verhoeckx, K.C. · Huisman, M.T. · Verwei, M. · Wortelboer, H.M.
Keywords: Biology · Transporter · Hepatic disposition · Transfected cell-lines · Protein abundance · LC–MS · Hepatic disposition · OATP · PBPK model · Polymorphisms · Protein abundance · Transfected cell-lines · Drug carrier · Organic anion transporter B · Rosuvastatin · Solute carrier organic anion transporter 1B1 · Solute carrier organic anion transporter 1B3 · Controlled study · Drug clearance · Drug disposition · Drug transport · Enterohepatic circulation · Gene overexpression · Genetic transfection · Genetic variability · HEK293 cell line cell tissue · In vitro study · In vivo study · Intrinsic clearance · Liquid chromatography · Liver · Liver cell · Model · Outer membrane · Physiology based pharmacokinetic model · Prediction · Protein analysis · Simulation · Single drug dose · Tandem mass spectrometry · Food and Nutrition · Healthy Living · Life · RAPID - Risk Assessment Products in Development MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

15 Steviol Glycoside Rebaudioside A Induces Glucagon-like Peptide-1 and Peptide YY Release in a Porcine ex Vivo Intestinal Model
article 2014    
Author: Ripken, D. · Wielen, N. van der · Wortelboer, H.M. · Meijerink, J. · Witkamp, R.F. · Hendriks, H.F.J.
Keywords: Nutrition · Rebaudioside A · GLP-1 · PYY · Ex vivo intestinal porcine model · Casein · Peptides · Sugar (sucrose) · Glucagon-like peptide-1 · Porcine models · PYY · Small intestine · Steviol glycosides · Weight management · Tissue · Food and Nutrition · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

16 Interaction of digitalis-like compounds with liver uptake transporters NTCP, OATP1B1, and OATP1B3
article 2014    
Author: Gozalpour, E. · Greupink, R. · Wortelboer, H.M. · Bilos, A. · Schreurs, M. · Russel, F.G.M. · Koenderink, J.B.
Keywords: Biology Pharmacology · Bufadienolides · Cardenolides · Cell transport · Convallatoxin · Digitalis-like compounds · Dihydroouabain · Drug-induced toxicity · NTCP · OATP1B1 · OATP1B3 · Ouabagenin · Ouabain · Cardiac glycoside · Convallatoxin · Cymarin · Dehydroouabain · Digitoxigenin · Digitoxin · Digoxigenin · Digoxin · Dihydroouabain · Estradiol 17 glucuronide · Gitoxigenin · Hydroxyl group · Ouabagenin · Ouabain · Peruvoside · Plant glycoside · Proscillaridin · Sodium bile acid cotransporter · Solute carrier organic anion transporter 1B1 · Solute carrier organic anion transporter 1B3 · Strophanthidin · Strophanthidol · Sugar · Taurocholic acid · Unclassified drug · Animal cell · Chemical structure · CHO cell line · Controlled study · Drug interaction · Drug uptake · Embryo · Human · Human cell · IC 50 · Kidney cell · Liquid chromatography · Mass spectrometry · Nonhuman · Food and Nutrition · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

17 Glutathione-dependent interaction of heavy metal compounds with multidrug resistance proteins MRP1 and MRP2
article 2008    
Author: Wortelboer, H.M. · Balvers, M.G.J. · Usta, M. · Bladeren, P.J. van · Cnubben, N.H.P.
Keywords: Health · Physiological Sciences · Arsenic trioxide · Cisplatin · Glutathione · Mercury chloride · MRP1 · MRP2 · Adenosine triphosphatase · Calcein · Cisplatin · Glutathione · Multidrug resistance protein 1 · Multidrug resistance protein 2 · Animal cell · Cell viability · Complex formation · Controlled study · Enzyme activity · Kidney cell · Membrane vesicle · Molecular interaction · Nonhuman · Protein expression · Transport kinetics
[Abstract]

18 Short-term fatty acid intervention elicits differential gene expression responses in adipose tissue from lean and overweight men
article 2008    
Author: Erk, M.J. van · Pasman, W.J. · Wortelboer, H.M. · Ommen, B. van · Hendriks, H.F.J.
Keywords: Biomedical Research · Conjugated linoleic acid (CLA) · Medium chain triglycerides · Microarray · Polyunsaturated fatty acids (PUFA) · Subcutaneous adipose tissue
[PDF] [Abstract]

19 Combined analysis of pharmacokinetic and efficacy data of preclinical studies with statins markedly improves translation of drug efficacy to human trialss
article 2013    
Author: Steeg, E. van de · Kleemann, R. · Jansen, H.T. · Duyvenvoorde, W. van · Offerman, E.H. · Wortelboer, H.M. · DeGroot, J.
Keywords: Biology · Biomedical Innovation · Healthy Living · Life · PHS - Pharmacokinetics & Human Studies (tot 2013 daarna KFP) MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

20 Nutrient-induced glucagon like peptide-1 release is modulated by serotonin
article 2016    
Author: Ripken, D. · Wielen, N. van der · Wortelboer, H.M. · Meijerink, J. · Witkamp, R.F. · Hendriks, H.F.J.
Keywords: Biology · GLP-1 · Nutrients · Rebaudioside A · Serotonin · Small intestine · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 43 found. Next | Sort by date