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1 Persistence of the anti-cholinesterase soman in rats: Antagonism with a non-toxic simulator of this organophosphate
article 1981    
Author: Wolthuis, O.L. · Benschop, H.P. · Berends, F.
Keywords: Biology · Acetylcholinesterase · Atropine · Soman · Animal experiment · Controlled study · Drug intoxication · Intoxication · Intravenous drug administration · Rat · Simulator · Sustained release preparation · Acetylcholinesterase · Animal · Male · Organophosphorus Compounds · Pyridinium Compounds · Rats · Soman · Time Factors
[Abstract]

2 Peripheral site ligand-oxime conjugates: A novel concept towards reactivation of nerve agent-inhibited human acetylcholinesterase
article 2011    
Author: Koning, M.C. de · Joosen, M.J.A. · Noort, D. · Zuylen, A. van · Tromp, M.C.
Keywords: Pharmacology · Acetylcholinesterase · Nerve agent · Oxime · Peripheral site · Reactivation · Life · CBRN - CBRN Protection · EELS - Earth, Environmental and Life Sciences
[Abstract]

3 Discovery of a potent non-oxime reactivator of nerve agent inhibited human acetylcholinesterase
article 2018    
Author: Koning, M.C. de · Horn, G. · Grol, M. van
Keywords: Chemistry · Acetylcholinesterase · Nerve agents · Chemical warfare agent · Reactivator · Non-oxime · Observation, Weapon & Protection Systems · CBRN - CBRN Protection
[Abstract]

4 Direct determination of the chemical composition of acetylcholinesterase phosphonylation products utilizing electrospray-ionization mass spectrometry
article 1997    
Author: Barak, R. · Ordentlich, A. · Barak, D. · Fischer, M. · Benschop, H.P. · Jong, L.P.A. de · Segall, Y. · Velan, B. · Shafferman, A.
Keywords: Determination · Chemical compounds · Acetylcholinesterase · Electrospray · Mass spectroscopy · Ionization · Aging (biology) · Inhibitors · Organic phosphates · Acetylcholinesterase, EC 3.1.1.7 · Cholinesterase Inhibitors · Organophosphorus Compounds · Recombinant Proteins · Acetylcholinesterase · Aging · ESI-MS · Organophosphonate inhibitor · Enzyme activity · Enzyme phosphorylation · Mass spectrometry · Alkylation · Cholinesterase inhibitors · Humans · Mass spectrometry · Molecular structure · Molecular weight · Organophosphorus compounds · Recombinant proteins
[PDF] [Abstract]

5 Neurological symptoms among Sri Lankan farmers occupationally exposed to acetylcholinesterase-inhibiting insecticides
article 2003    
Author: Smit, L.A.M. · Wendel- de Joode, B.N. van · Heederik, D. · Peiris-John, R.J. · Hoek, W. van der
Keywords: Health Chemistry · Food and Chemical Risk Analysis · Acetylcholinesterase inhibition · IPM · Neurological symptoms · Pesticide exposure · Sri Lanka · acetylcholinesterase · insecticide · adult · agricultural worker · article · cholinesterase inhibition · controlled study · enzyme activity · female · human · integrated pest management · intoxication · major clinical study · male · neurologic disease · occupational exposure · questionnaire · Sri Lanka · symptomatology · Acetylcholinesterase · Adult · Agriculture · Cholinesterase Inhibitors · Female · Humans · Insecticides · Male · Middle Aged · Nervous System Diseases · Occupational Exposure · Prevalence · Sri Lanka
[Abstract]

6 Intravenous and inhalation toxicokinetics of sarin stereoisomers in atropinized guinea pigs
article 2000    
Author: Spruit, W.E.T. · Langenberg, J.P. · Trap, H.C. · Wiel, H.J. van der · Helmich, R.B. · Helden, H.P.M. van · Benschop, H.P.
Keywords: Acetylcholinesterase inhibition · Guinea pig · Intravenous bolus · Nose-only exposure · Respiratory parameters · Stereoisomers · Toxicokinetics · Animal experiment · Animal model · Binding site · Chemical warfare · Controlled study · Drug absorption · Drug elimination · Enzyme inhibition · Gas chromatography · Guinea pig · Nonhuman · Nose mucosa · Stereoisomerism · Toxicokinetics · Acetylcholinesterase · Administration, Inhalation · Animals · Area Under Curve · Atropine · Chemical Warfare Agents · Guinea Pigs · Injections, Intravenous · Male · Stereoisomerism · Acetylcholinesterase, EC 3.1.1.7 · Atropine, 51-55-8 · Chemical warfare agents · Sarin, 107-44-8
[Abstract]

7 Peripheral site ligand conjugation to a non-quaternary oxime enhances reactivation of nerve agent-inhibited human acetylcholinesterase
article 2011    
Author: Koning, M.C. de · Grol, M. van · Noort, D.
Keywords: Acetylcholinesterase · Nerve agent · Non-quaternary oxime · Peripheral site · Reactivation · 4 methoxyphenyl oxo ethanaloxime · Acetylcholinesterase · Cholinesterase reactivator · Oxime · Pyridinium derivative · Unclassified drug · Article · Binding affinity · Blood brain barrier · Drug conjugation · Drug inhibition · Drug structure · Drug synthesis · Electrospray mass spectrometry · Enzyme active site · High performance liquid chromatography · Liquid chromatography · Priority journal · Purification · Chemicals/CAS: acetylcholinesterase, 9000-81-1 · Life · CBRN - CBRN Protection · EELS - Earth, Environmental and Life Sciences
[Abstract]

8 A step toward the reactivation of aged cholinesterases-crystal structure of ligands binding to aged human butyrylcholinesterase
article 2013    
Author: Wandhammer, M. · Koning, M. de · Grol, M. van · Loiodice, M. · Saurel, L. · Noort, D. · Goeldner, M. · Nachon, F.
Keywords: Biology · Acetylcholinesterase · Aging · Butyrylcholinesterase · Nerve agents · Reactivators · X-ray structure · Food and Nutrition · Healthy Living · Life · CBRN - CBRN Protection FI - Functional Ingredients · EELS - Earth, Environmental and Life Sciences
[Abstract]

9 Theoretical NMR and conformational analysis of solvated oximes for organophosphates-inhibited acetylcholinesterase reactivation
article 2018    
Author: Valle da Silva, J.A. · Modesto-Costa, L. · Koning, M.C. de · Borges, I. · Costa França, T.C.
Keywords: Chemistry · Acetylcholinesterase · Oximes · Conformational analysis · DFT/B3LYP calculations · Solvent effect · NMR · Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[Abstract]

10 Docking and molecular dynamics studies of peripheral site ligand–oximes as reactivators of sarin-inhibited human acetylcholinesterase
article 2016    
Author: Almeida, J.S.F.D. de · Cuya Guizado, T.R. · Guimarães, A.P. · Ramalho, T.C. · Gonçalves, A.S. · Koning, M.C. de · França, T.C.C.
Keywords: Acetylcholinesterase 9000-81-1 · Sarin, 107-44-8 · Ligands · Nerve agents · Oximes · Peripheral site · Reactivation · Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[Abstract]

11 Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro
article 2018    
Author: Horn, G. · Koning, M.C. de · Grol, M. van · Thiermann, H. · Worek, F.
Keywords: Organophosphorus compounds · Acetylcholinesterase · Non-oxime reactivator · Reactivation · In vitro · Defence, Safety and Security · Observation, Weapon & Protection Systems 2015 Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[Abstract]

12 Low-level exposure of guinea pigs and marmosets to sarin vapour in air: Lowest-observable-adverse-effect level (LOAEL) for miosis
article 2004    
Author: Helden, H.P.M. van · Trap, H.C. · Kuijpers, W.C. · Oostdijk, J.P. · Benschop, H.P. · Langenberg, J.P.
Keywords: Biology · Exposure limits · Field alarm · Lowest-observable-adverse-effect level (LOAEL) · Miosis · Nerve agent · o-isopropyl methylphosphonofluoridate · Pupil size · Pyridostigmine · Sarin · Whole-body exposure · Acetylcholinesterase · Erythrocyte enzyme · Pyridostigmine · Sarin · Air · Animal experiment · Article · Calculation · Concentration (parameters) · Controlled study · Data analysis · Environmental exposure · Eye photography · Guinea pig · Iris · Male · Marmoset · Miosis · Nonhuman · Pilot study · Priority journal · Pupil · Statistical analysis · Vapor · Acetylcholinesterase · Administration, Inhalation · Animals · Callithrix · Chemical Warfare Agents · Dose-Response Relationship, Drug · Guinea Pigs · Inhalation Exposure · Pyridostigmine Bromide · Sarin · Volatilization · Animalia · Cavia · Marmosets · Acetylcholinesterase, 9000-81-1 · Pyridostigmine, 101-26-8, 155-97-5 · Sarin, 107-44-8 · Chemical warfare agents
[Abstract]

13 Development of detection techniques for monitoring and optimizing biocide dosing in seawater flooding systems
article 2013    
Author: Al-Moniee, M.A. · Al-Abeedi, F.N. · Koopal, C.G.J. · Akmal, N. · Sanders, P.F. · Veen, S. van
Keywords: Biology · Acetylcholinesterase · Benzyl-dimethyldecylammonium · Biocide residuals · Colorimetric. · Real-time detection · Seawater · Thiocholine · Biomedical Innovation · Healthy Living · Life · PHS - Pharmacokinetics & Human Studies RAPID - Risk Analysis for Products in Development · EELS - Earth, Environmental and Life Sciences
[Abstract]

14 Effects of innervation by ciliary ganglia on developing muscle in vitro
article 1979    
Author: Slaaf, D.W. · Hooisma, J. · Meeter, E. · Stevens, W.F.
Keywords: Biology · Acetylcholine · Acetylcholinesterase · Tetrodotoxin · Animal experiment · Chicken · Ciliary ganglion · Endplate potential · In vitro study · Muscle · Neuromuscular synapse · Tissue culture · Animal · Atropine · Cells, Cultured · Chick Embryo · Electric Stimulation · Ganglia, Parasympathetic · Membrane Potentials · Motor Endplate · Muscles · Physostigmine · Tetrodotoxin · Tubocurarine
[Abstract]

15 Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase
article 2017    
Author: Koning, M.C. de · Joosen, M.J.A. · Worek, F. · Nachon, F. · Grol, M. van · Klaassen, S.D. · Alkema, D.P.W. · Wille, T. · Bruijn, H.M. de
Keywords: Safety · Acetylcholinesterase · Cholinesterase inhibitor · Imidazole · Imidazole derivative · Nerve gas · Oxime derivative · Pralidoxime · Unclassified drug · Safety and Security · Defence, Safety and Security · 2015 Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[Abstract]

16 Theoretical NMR and conformational analysis of solvated oximes for organophosphates-inhibited acetylcholinesterase reactivation
article 2018    
Author: Silva, J.A.V. da · Modesto-Costa, L. · Koning, M.C. de · Borges, I.Jr. · França, T.C.C.
Keywords: Safety · Acetylcholinesterase · Conformational analysis · DFT/B3LYP calculations · NMR · Oximes · Solvent effect · Safety and Security · Defence, Safety and Security · 2015 Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[Abstract]

17 Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning
article 2009    
Author: Joosen, M.J.A. · Jousma, E. · Boom, T.M. van den · Kuijpers, W.C. · Smit, A.B. · Lucassen, P.J. · Helden, H.P.M. van
Keywords: Toxicology · Learning · Memory · Neurogenesis · Olanzapine · Organophosphate · Soman · acetylcholine · acetylcholinesterase · atropine · doublecortin · olanzapine · soman · animal experiment · animal model · animal tissue · article · body weight · cell survival · cognitive defect · controlled study · corpus striatum · developmental disorder · drug efficacy · drug treatment failure · histopathology · learning disorder · male · maze test · memory disorder · nervous system development · neurotoxicity · nonhuman · osmotic minipump · priority journal · rat · recurrent disease · seizure · Acetylcholine · Acetylcholinesterase · Animals · Atropine · Benzodiazepines · Cholinesterase Reactivators · Corpus Striatum · Hippocampus · Male · Maze Learning · Neurogenesis · Pyridinium Compounds · Rats · Rats, Sprague-Dawley · Seizures · Soman · Animalia · Rattus
[Abstract]

18 Increasing oxime efficacy by blood-brain barrier modulation
article 2011    
Author: Joosen, M.J.A. · Schans, M.J. van der · Dijk, C.G.M. van · Kuijpers, W.C. · Wortelboer, H.M. · Helden, H.P.M. van
Keywords: HI6 · Nerve agent · P-glycoprotein · Seizures · Tariquidar · 1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · Acetylcholinesterase · Atropine · Tariquidar · Animal experiment · Animal model · Article · Blood brain barrier · Blood level · Brain blood volume · Controlled study · Convulsion · Drug effect · Drug efficacy · Drug intoxication · Drug penetration · Male · Microdialysis · Modulation · Nerve agent poisoning · Nonhuman · Priority journal · Quantitative analysis · Rat · Seizure · Rattus · 1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether, 34433-31-3 · Acetylcholinesterase, 9000-81-1 · Atropine, 51-55-8, 55-48-1 · Tariquidar, 206873-63-4 · Tradenames: hi 6, TNO; xr 9576, avaant · Manufacturers: TNO; avaant · Life · CBRN - CBRN Protection PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

19 The bispyridinium-dioxime HLö-7. A potent reactivator for acetylcholinesterase inhibited by the stereoisomers of tabun and soman
article 1989    
Author: Jong, L.P.A.de · Verhagen, M.A.A. · Langenberg, J.P. · Hagedorn, I. · Löffler, M.
Keywords: Biology · Bis(pyridinium oxime) derivative · Enzyme inhibitor · Organophosphorus compound · Radioisotope · Enzyme reactivation · Fish · Human · Nonbiological model · Nonhuman · Normal human · Rat · Stereoisomerism · Acetylcholinesterase 9000-81-1 · Animal · Cholinesterase Reactivators · Eels · Human · In Vitro · Organophosphorus Compounds · Oximes · Phosphoric Acid Esters · Pyridines · Pyridinium Compounds · Stereoisomerism · Structure-Activity Relationship · Organophosphorus compounds · Oximes · Phosphoric acid esters · Pyridines · Pyridinium compounds · Soman, 96-64-0 · Tabun, 77-81-6
[Abstract]

20 On the oscillatory decay of the myotonic action of 9 anthroic acid. Influence of cholinesterase inhibition
article 1977    
Author: Velsen, F.L. van · Nickolson, V.J.
Keywords: Biology · 9 Anthroic acid · Acetylcholinesterase · Adenosine triphosphatase (potassium sodium) · Cholinesterase inhibitor · Curare · Ouabain · Soman · In vitro study · Muscle contraction · Myotonia · Rat · Theoretical study · Animal · Anthracenes · Calcium · Carboxylic Acids · Chlorides · Cholinesterase Inhibitors · Diaphragm · Drug Interactions · Electric Stimulation · In Vitro · Magnesium · Male · Motor Endplate · Muscle Contraction · Neuromuscular Junction · Ouabain · Potassium · Rats · Sodium · Soman
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 28 found. Next | Sort by date