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1 Systems approach for classifying the response to biological therapies in patients with rheumatoid arthritis in clinical practice
article 2018    
Author: Fu, J. · Wietmarschen, H.A. van · Kooij, A. van der · Cuppen, B.V.J. · Schroën, Y. · Marijnissen, A.K. · Meulman, J.J. · Lafeber, F.P.J.G. · Greef, J. van der
Keywords: Biology · Biological agent · Categorical principal components analysis · Classification · Rheumatoid arthritis · Abatacept · Adalimumab · C reactive protein · Certolizumab pegol · Creatinine · Cyclic citrullinated peptide antibody · Etanercept · Golimumab · Rheumatoid factor · Rituximab · Tocilizumab · Adult · Biological therapy · Chinese medicine · Clinical assessment · Clinical practice · Disease severity · Female · Human · Major clinical study · Male · Middle aged · Predictive value · Principal component analysis · Priority journal · Questionnaire · Symptom assessment · System analysis · Treatment response · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

2 Soluble biomarkers of cartilage and bone metabolism in early proof of concept trials in psoriatic arthritis: Effects of adalimumab versus placebo
article 2010    
Author: Tak, P.P. · Kuijk, A.W.R. van · Groot, J. de · Koeman, R.C. · Sakkee, N. · Baeten, D.L. · Gerlag, D.M.
Keywords: Health · Biomedical Research · adalimumab · amino terminal cross linked telopeptide of type 1 collagen · C propeptide of type 2 collagen · carboxy terminal cross linked telopeptide of type 1 collagen · cartilage oligomeric matrix protein · collagen type 1 · collagen type 2 · osteocalcin · placebo · procollagen · procollagen serum type 1 amino terminal propeptide · stromelysin · unclassified drug · article · bone metabolism · cartilage cell · cartilage metabolism · clinical article · clinical trial · controlled clinical trial · controlled study · correlation analysis · disease marker · drug efficacy · human · ossification · protein analysis · protein blood level · protein degradation · protein function · protein synthesis · psoriatic arthritis · randomized controlled trial · tissue metabolism
[PDF] [Abstract]

3 The minipig as an alternative non-rodent model for immunogenicity testing using the TNFα blockers adalimumab and infliximab
article 2014    
Author: Mierlo, G.J.D. van · Cnubben, N.H.P. · Wouters, D. · Wolbink, G.J. · Hart, M.H.L. · Rispens, T. · Ganderup, N.C. · Kuper, C.F. · Aarden, L. · Penninks, A.H.
Keywords: Biology · Adalimumab · Alternative model · Anti-drug antibodies · Immunogenicity · Infliximab · Minipig · Pharmacokinetics Ddrug antibody · Animal experiment · Animal model · Animal tissue · Antibody response · Antibody titer · Area under the curve · Body weight · Clinical chemistry · Clinical feature · Clinical observation · Controlled study · Drug blood level · Drug clearance · Drug half life · Drug megadose · Female · Hematological parameters · Histopathology · Immune function test · Immune system · Low drug dose · Maximum plasma concentration · Mean residence time · Nonhuman · Organ weight · Predictive value · Priority journal · Time to maximum plasma concentration · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

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