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1 Allosteric modulation and constitutive activity of fusion proteins between the adenosine A1 receptor and different 351Cys-mutated Gi α-subunits
article 2004    
Author: Klaasse, E. · Ligt, R.A.F.de · Roerink, S.F. · Lorenzen, A. · Milligan, G. · Leurs, R. · IJzerman, A.P.
Keywords: Health · Physiological Sciences · Adenosine A1 receptor · Allosteric modulation · Constitutive activity · Fusion protein · G protein · Inverse agonism · 2 amino 4,5 dimethyl 3 (3 trifluoromethylbenzoyl)thiophene · 6 n cyclopentyladenosine · 8 cyclopentyl 1,3 dipropylxanthine · 8 cyclopentyltheophylline · Adenosine A1 receptor · Amino acid · Arginine · Cysteine · Glycine · Guanine nucleotide binding protein · Guanosine 5' o (3 thiotriphosphate) · Histidine · Hybrid protein · Isoleucine · Phenylalanine · Proline · Radioligand · Serine · Sodium ion · Sulfur 35 · Valine · Allosterism · Alpha chain · Animal cell · Cercopithecidae · Ligand binding · Nonhuman · Priority journal · Protein analysis · Adenosine · Allosteric Site · Animals · Binding, Competitive · Cell Membrane · COS Cells · Cysteine · Dose-Response Relationship, Drug · GTP-Binding Protein alpha Subunits, Gi-Go · Guanosine 5'-O-(3-Thiotriphosphate) · Humans · Mutation · Radioligand Assay · Receptor, Adenosine A1 · Recombinant Fusion Proteins · Sodium Chloride · Sulfur Radioisotopes · Thiophenes · Transfection · Tritium · Xanthines
[Abstract]

2 Low efficacy adenosine A1 agonists inhibit striatal acetylcholine release in rats improving central selectivity of action
article 2003    
Author: Bueters, T.J.H. · Helden, H.P.M. van · IJzerman, A.P. · Danhof, M.
Keywords: Acetylcholine · Adenosine · Adenosine A1 receptor · Low efficacy agonist · Microdialysis · Tissue selectivity · 2' deoxy 6 n cyclopentyladenosine · 3' deoxy 6 n cyclopentyladenosine · 6 n cyclopentyladenosine · 8 butylamino 6 n cyclopentyladenosine · 8 cyclopentyltheophylline · 8 ethylamino 6 n cyclopentyladenosine · Acetylcholine · Adenosine A1 receptor agonist · Unclassified drug · Acetylcholine release · Animal experiment · Animal tissue · Cardiovascular system · Controlled study · Corpus striatum · Dose response · Drug effect · Drug efficacy · Male · Microdialysis · Nonhuman · Rat · Animals · Dose-Response Relationship, Drug · Microdialysis · Neostriatum · Rats, Wistar · Receptor, Adenosine A2B · Receptors, Purinergic P1 · Reproducibility of Results · Sensitivity and Specificity · 6 n cyclopentyladenosine, 41552-82-3 · 8 cyclopentyltheophylline, 35873-49-5 · Acetylcholine, 51-84-3, 60-31-1, 66-23-9 · Adenosine, 58-61-7; · N(6)-cyclopentyladenosine, 41552-82-3 · Receptor, Adenosine A2B · Receptors, Purinergic P1
[Abstract]

3 Synthesis and biological evaluation of disubstituted N6- cyclopentyladenine analogues: The search for a neutral antagonist with high affinity for the adenosine A1 receptor
article 2004    
Author: Ligt, R.A.F. de · Klein, P.A.M. van der · Frijtag Drabbe Künzel, J.K. von · Lorenzen, A. · El Maate, F.A. · Fujikawa, S. · Westhoven, R. van · Hoven, T. van den · Brussee, J. · Ijzerman, A.P.
Keywords: Biology Toxicology · Physiological Sciences · [35S]GTPγS binding · Adenosine A1 receptor · Inverse agonism · N-0840 derivatives · Neutral antagonist · 8 bromo 9 methyladenine · 8 bromo n 6 cyclopentyl 9 methyladenine · 8 bromo n 6 cyclopentyl 9 propyladenine · 9 allyl 8 bromo n 6 cyclopentyladenine · 9 allyl n 6 cyclopentyl 8 methoxyadenine · adenine derivative · adenosine A1 receptor antagonist · luf 5666 · luf 5668 · luf 5669 · luf 5674 · n 0840 · n 6 cyclopentyl 8 (ethylthio) 9 methyladenine · n 6 cyclopentyl 8 (n ethyl n butylamino) 9 methyladenine · n 6 cyclopentyl 8 (n methyl n ethylamino) 9 methyladenine · n 6 cyclopentyl 8 (n methyl n propylamino) 9 methyladenine · n 6 cyclopentyl 8 (n methylamino) 9 methyladenine · n 6 cyclopentyl 8 (n methylisopropylamino) 9 methyladenine · n 6 cyclopentyl 8 (n piperidino) 9 methyladenine · n 6 cyclopentyl 8 (n pyrrolidino) 9 methyladenine · n 6 cyclopentyl 8 (n,n diethylamino) 9 methyladenine · n 6 cyclopentyl 8 ethoxy 9 methyladenine · n 6 cyclopentyl 8 isopropoxy 9 methyladenine · n 6 cyclopentyl 8 methoxy 9 methyladenine · n 6 cyclopentyl 8 methoxy 9 propyladenine · n 6 cyclopentyl 9 methyl 8 oxoadenine · n 6 cyclopentyl 9 methyl 8 propoxyadenine · n 6 cyclopentyl 9 methyladenine · unclassified drug · article · binding affinity · drug determination · drug synthesis · drug tolerability · receptor affinity · substitution reaction · Adenine · Adenosine · Animals · Cell Line · CHO Cells · Cricetinae · Drug Evaluation, Preclinical · Humans · Receptor, Adenosine A1
[Abstract]

4 Therapeutic efficacy of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) against organophosphate intoxication
article 2002    
Author: Bueters, T.J.H. · Groen, B. · Danhof, M. · IJzerman, A.P. · Helden, H.P.M. van
Keywords: Biology · Acetylcholine release · Adenosine A1 receptor · N6-Cyclopentyladenosine · Organophosphate · Adenosine A1 receptor agonist · Adenosine receptor stimulating agent · Cyclohexyladenosine · Methylphosphonothioic acid s (2 diisopropylaminoethyl) o ethyl ester · Adenosine receptor · Cholinesterase · Drug derivative · N(6) cyclopentyladenosine · Organophosphate · Phosphorothioic acid derivative · Bioaccumulation · Cholinergic system · Concentration response · Controlled study · Corpus striatum · Crug efficacy · Enzyme activity · Hippocampus · Intoxication · Male · Microdialysis · Nonhuman · Rat · Reduction · Animal · Drug potentiation · Enzymology · Metabolism · Secretion · Wistar rat · Animals · Cholinesterase Inhibitors · Cholinesterases · Corpus Striatum · Male · Microdialysis · Organothiophosphorus Compounds · Parathion · Phosphoric Acid Esters · Rats · Rats, Wistar · Receptors, Purinergic P1 · Sarin · Acetylcholinesterase, 9000-81-1 · Cyclohexyladenosine, 36396-99-3 · Methylphosphonothioic acid s (2 diisopropylaminoethyl) o ethyl ester, 50782-69-9 · Parathion, 3270-86-8, 56-38-2, 597-88-6 · Sarin, 107-44-8; tabun, 77-81-6 · Acetylcholine, 51-84-3 · Adenosine, 58-61-7; · Cholinesterase Inhibitors · Cholinesterases, EC 3.1.1.8 · N(6)-cyclopentyladenosine, 41552-82-3 · Organothiophosphorus Compounds · Parathion, 56-38- · Phosphoric Acid Esters · Receptors, Purinergic P1 · Sarin, 107-44-8 · Tabun, 77-81-6 · VX, 50782-69-9
[Abstract]

5 Cyclopentyladenosine and some of its low-efficacy derivatives inhibit striatal synaptosomal release of acetylcholine to a similar degree
article 2003    
Author: Bueters, T.J.H. · Duivenvoorde, L.M. van · Danhof, M. · IJzerman, A.P. · Helden, H.P.M. van
Keywords: Biology · 3D-CPA (3′-deoxy-CPA) · 8-BCPA (8-butylamino-CPA) · 8-PCPA (8-propylamino-CPA) · Acetylcholine release · Adenosine A1 receptor · CPA (cyclopentyladenosine) · Low-efficacy agonist · Neuronal synaptosome · Partial agonist · 3' deoxy 6 n cyclopentyladenosine · 8 butylamino 6 n cyclopentyladenosine · 8 propylamino 6 n cyclopentyladenosine · Adenosine A2 receptor antagonist · Adenosine derivative · Adenosine receptor blocking agent · Partial agonist · Tritium · Unclassified drug · Animal tissue · Brain synaptosome · Cardiotoxicity · Concentration response · Controlled study · Corpus striatum · Drug effect · Evoked response · Inhibition kinetics · Male · Nonhuman · Rat · Adenosine · Animals · Dose-Response Relationship, Drug · Rats, Wistar · Synaptosomes · 4 aminopyridine, 1003-40-3, 504-24-5 · 5 amino 2 (2 furyl) 7 (2 phenylethyl)pyrazolo[4,3 e][1,2,4]triazolo[1,5 c]pyrimidine, 160098-96-4 · 6 n cyclopentyladenosine, 41552-82-3 · Acetylcholine, 51-84-3, 60-31-1, 66-23-9 · Theophylline, 58-55-9, 5967-84-0, 8055-07-0, 8061-56-1, 99007-19-9 · Tritium, 10028-17-8 · Adenosine, 58-61-7 · N(6)-cyclopentyladenosine, 41552-82-3
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 5 of 5 found. | Sort by date