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Showing 1 to 18 of 18 found. | Sort by date

1 Serum apolipoprotein e level is not increased in Alzheimer's disease : The Rotterdam study
article 1998    
Author: Slooter, A.J.C. · Knijff, P. de · Hofman, A. · Cruts, M. · Breteler, M.M.B. · Broeckhoven, C. van · Havekes, L.M. · Duijn, C.M. van
Keywords: Health · Alzheimer's disease · Apolipoprotein E · Atherosclerosis · Dementia · Plasma · Serum level · Aged · Aged, 80 and over · Alzheimer Disease · Apolipoproteins E · Cohort Studies · Female · Genotype · Humans · Male · Middle Aged
[Abstract]

2 Reduced levels of cholesterol, phospholipids, and fatty acids in cerebrospinal fluid of Alzheimer disease patients are not related to apolipoprotein E4
article 1998    
Author: Mulder, M. · Ravid, R. · Kloet, J.E.R. de · Haasdijk, E.D. · Julk, J. · Boom, J. van der · Havekes, L.M.
Keywords: Biology · Cerebrospinal fluid · Lipids · Aged · Aged, 80 and over · Alzheimer Disease · Apolipoprotein E4 · Apolipoproteins E · Brain · Cholesterol · Fatty Acids · Female · Genotype · Homeostasis · Humans · Male · Phospholipids · Reference Values
[Abstract]

3 Signalering van beginnende Alzheimer-dementie in de huisartspraktijk: Ontwikkeling en validering van de observatie lijst voor vroege symptomen van dementie (OLD) [Observation of early symptoms of Alzheimer dementia in general practice: Development and validation of the observation list for early signs of dementia (OLD)]
article 2001    
Author: Hopman-Rock, M. · Tak, E.C.P.M. · Staats, P.G.M. · Jonker, C. · Wind, A.W.
Keywords: Health · Alzheimer disease · Controlled study · General practice · Major clinical study · Rating scale · Statistical analysis · Symptomatology · Validation process · Aged · Aged, 80 and over · Alzheimer Disease · Family Practice · Female · Humans · Male · Mass Screening · Netherlands · Neuropsychological Tests · Predictive Value of Tests · Psychiatric Status Rating Scales · Reproducibility of Results · Sampling Studies · Lepisosteidae
[Abstract]

4 Bace1 activity in cerebrospinal fluid and its relation to markers of ad pathology
article 2010    
Author: Mulder, S.D. · Flier, W.M. van der · Verheijen, J.H. · Mulder, C. · Scheltens, P. · Blankenstein, M.A. · Hack, C.E. · Veerhuis, R.
Keywords: Biology · Biomedical Research · Aβ<sub>-{40}Aβ</sub> · Alzheimer's disease · BACE1 activity · CSF biomarker profile · p-tau · t-tau · {42} · amyloid beta protein[1-40] · amyloid beta protein[1-42] · beta secretase · tau protein · threonine · adult · aged · Alzheimer disease · article · cerebrospinal fluid analysis · clinical article · controlled study · correlational study · enzyme activity · female · human · male · mild cognitive impairment · mini mental state examination · priority journal · protein phosphorylation · Aged · Alzheimer Disease · Amyloid beta-Protein · Amyloid Precursor Protein Secretases · Apolipoproteins E · Aspartic Acid Endopeptidases · Cognition Disorders · Enzyme-Linked Immunosorbent Assay · Female · Humans · Male · Middle Aged · Peptide Fragments · Statistics as Topic · tau Proteins
[Abstract]

5 Circadian and age-related modulation of thermoreception and temperature regulation: mechanisms and functional implications
article 2002    
Author: Someren, E.J.W. van · Raymann, R.J.E.M. · Scherder, E.J.A. · Daanen, H.A.M. · Swaab, D.F.
Keywords: Psychology · Chronobiology · Thermal physiology · Aging · Circadian physiology · Alzheimer's disease · Circadian rhythm · Immune function · Sleep · Thermoreception · Thermoregulation · Vasomotor control · Body temperature · Fitness · Heat loss · Heat sensation · Host resistance · Human · Immunology · Physical activity · Vasodilatation · Thermoreceptors
[Abstract]

6 Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease
article 1996    
Author: Bronzova, J. · Duijn, C.M. van · Havekes, L.M. · Knijff, P. de · Broeckhoven, C. van · Hofman, A.
Keywords: Biology · Apolipoprotein E gene · Apolipoprotein e · Apolipoprotein e4 · Adult · Allele · Clinical feature · Disease course · Genotype · Major clinical study · Myoclonus · Rigidity · Risk · Seizure · Tremor · Alleles · Alzheimer Disease · Apolipoproteins · Female · Humans · Male · Middle Aged · Prognosis
[Abstract]

7 Decreased sensitivity to dexamethasone in lymphocytes from patients with Alzheimer's disease
article 1994    
Author: Nijhuis, E. · Hinloopen, B. · Duijn, C. van · Hofman, A. · Rozing, J. · Nagelkerken, L.
Keywords: Health · cd4 antigen · dexamethasone · glucocorticoid · hydrocortisone · interleukin 2 · interleukin 4 · clinical article · clinical trial · controlled clinical trial · controlled study · Male · t lymphocyte subpopulation · Aged · Alzheimer Disease · Dexamethasone · Female · Humans · Lymphocyte Activation · Phenotype · Sensitivity and Specificity · T-Lymphocytes
[Abstract]

8 Analytical strategies in lipidomics and applications in disease biomarker discovery
article 2009    
Author: Hu, C. · Heijden, R. van der · Wang, M. · Greef, J. van der · Hankemeier, T. · Xu, G.
Keywords: Biology Health · Analytical research · Lipid profiling · Lipid-associated disorders · Alzheimer's disease · Analytical strategy · Chromatographic techniques · Comprehensive analysis · Disease biomarker · Human disease · Human health · Lipidomics · Metabolomics · Molecular species · Rapid expansion · Research fields · Technological advancement · Biological systems · Biomarkers · Lipids · Mass spectrometry · Information management · Biological marker · Ceramide · Cholesterol ester · Glycerophosphoethanolamine · Glycerophosphorylcholine · Inositol phosphate · Long chain triacylglycerol · Lysophosphatidylcholine · Phosphatidylcholine · Phosphoserine · Sulfatide · Alzheimer disease · Atherosclerosis · Chemical structure · Diabetes mellitus · Disease marker · Electrospray mass spectrometry · High performance liquid chromatography · Human · Lipid analysis · Lipid metabolism · Lipidomics · Liquid chromatography · Mass spectrometry · Matrix assisted laser desorption ionization time of flight mass spectrometry · Nonhuman · Nuclear magnetic resonance spectroscopy · Obesity · Priority journal · Review · Sensitivity and specificity · Thin layer chromatography
[Abstract]

9 Differences in dexamethasone-sensitivity between lymphocytes from patients with Alzheimer's disease and patients with multi-infarct dementia
article 1996    
Author: Nijhuis, E.W.P. · Oostervink, F. · Hinloopen, B. · Rozing, J. · Nagelkerken, L.
Keywords: Health · Glucocorticoid receptor · Clinical article · Cognitive defect · Drug sensitivity · Human cell · Lymphocyte · Mononuclear cell · Multiinfarct dementia · Screening · Aged · Aged, 80 and over · Alzheimer Disease · Apoptosis · Cells, Cultured · Dementia, Multi-Infarct · Dexamethasone · Drug Resistance · Female · Gene Expression Regulation · Humans · Immunosuppressive Agents · Interleukin-2 · Interleukin-4 · Lymphocyte Activation · Male · Phytohemagglutinins · Proto-Oncogene Proteins c-bcl-2 · Receptors, Glucocorticoid · T-Lymphocytes
[Abstract]

10 Translational research in genomics of Alzheimer's disease: A review of current practice and future perspectives
article 2010    
Author: Mihaescu, R. · Detmar, S.B. · Cornel, M.C. · Flier, W.M. van der · Heutink, P. · Hol, E.M. · Rikkert, M.G.M.O. · Duijn, C.M. van · Janssens, A.C.J.W.
Keywords: Health · Leefomgeving en gezondheid · Alzheimer's disease · genomics · review · translational research · amyloid precursor protein · antidepressant agent · antiinflammatory agent · apolipoprotein C1 · apolipoprotein C2 · apolipoprotein E · bapineuzumab · cholinergic receptor stimulating agent · clathrin assembly protein · clozapine · complement component C3b receptor · cystatin C · disrupted in schizophrenia 1 protein · endothelial nitric oxide synthase · galantamine · growth factor receptor bound protein 2 · growth hormone · mitochondrial transcription factor A · phosphatidylinositol · phosphoenolpyruvate carboxykinase (GTP) · presenilin 1 · presenilin 2 · progranulin · risperidone · rosiglitazone · sortilin · tau protein · transient receptor potential channel 4 · unindexed drug · zinc finger protein · Alzheimer disease · autosomal dominant inheritance · clinical trial · diagnostic accuracy · differential diagnosis · drug efficacy · early diagnosis · evidence based medicine · evidence based practice · gene expression profiling · gene locus · genetic analysis · genetic association · genetic counseling · genetic polymorphism · genetic risk · genetic screening · genetic variability · genomics · genotype · health care management · high risk patient · high risk population · human · incidence · medical research · pharmacogenomics · practice guideline · prediction · priority journal · review · treatment response
[Abstract]

11 Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus
article 2004    
Author: Mulder, M. · Jansen, P.J. · Janssen, B.J.A. · Berg, W.D.J. van de · Boom, H. van der · Havekes, L.M. · Kloet, R.E. de · Ramaekers, F.C.S. · Blokland, A.
Keywords: Environment · Alzheimer's disease · Apolipoprotein E · Lipid metabolism · Low-density lipoprotein receptor family · Memory · Low density lipoprotein receptor · Synaptophysin · Animal experiment · Animal model · Animal tissue · Atherosclerosis · Controlled study · Hippocampus · Homozygosity · Knockout mouse · Maze test · Memory disorder · Mouse · Nerve ending · Nonhuman · Spatial memory · Task performance · Wild type · Working memory · Animals · Cell Count · Hippocampus · Male · Maze Learning · Memory Disorders · Mice · Mice, Inbred C57BL · Mice, Knockout · Presynaptic Terminals · Receptors, LDL · Synapses
[Abstract]

12 Low-grade inflammation, diet composition and health: Current research evidence and its translation
article 2015    
Author: Minihane, A.M. · Vinoy, S. · Russell, W.R. · Baka, A. · Roche, H.M. · Tuohy, K.M. · Teeling, J.L. · Blaak, E.E. · Fenech, M. · Vauzour, D. · McArdle, H.J. · Kremer, B.H.A. · Sterkman, L. · Vafeiadou, K. · Benedetti, M.M. · Williams, C.M. · Calder, P.C.
Keywords: Biology · Biomarkers · Chronic diseases · Health claims · Low-grade inflammation · Bacterium lipopolysaccharide · Biological marker · C reactive protein · Chemokine · Flavonoid · Interleukin 6 · Tumor necrosis factor alpha · Alzheimer disease · Atherosclerosis · Carbohydrate intake · Cardiovascular disease · Chronic disease · Chronic inflammation · Cytokine production · Degenerative disease · Diet · Endotoxemia · Fat intake · Human · Inflammation · Intestine flora · Maternal obesity · Mucosal immunity · Nervous system inflammation · Non insulin dependent diabetes mellitus · Nonalcoholic fatty liver · Nonhuman · Review · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

13 Genetic heterogeneity of apolipoprotein E and its influence on plasma lipid and lipoprotein levels
article 1994    
Author: Knijff, P. de · Maagdenberg, A.M.J.M. van den · Frants, R.R. · Havekes, L.M.
Keywords: Biology · Apolipoprotein (apo) E · Atherosclerosis · Familial Dysbetalipoproteinemia (FD) · Mutations · Polymorphisms · Type III Hyperlipoproteinemia · Cholesterol · Chylomicron · Low density lipoprotein receptor · Triacylglycerol · Very low density lipoprotein · Alzheimer disease · Atherosclerosis · Cholesterol blood level · Coronary artery disease · Creutzfeldt jakob disease · Gene mutation · Genetic heterogeneity · Genetic linkage · Genetic polymorphism · Ligand binding · Lipoprotein metabolism · Alleles · Amino Acid Sequence · Base Sequence · DNA · Female · Gene Frequency · Human · Hyperlipidemia · Hyperlipoproteinemia Type III · Lipids · Lipoproteins · Male · Molecular Sequence Data · Mutation · Variation (Genetics)
[Abstract]

14 Development and validation of the observation list for early signs of dementia (OLD)
article 2001    
Author: Hopman-Rock, M. · Tak, E.C.P.M. · Staats, P.G.M.
Keywords: Health · Activities of daily living · Behaviour · Cognition · Family physician · Observation · Signs and symptoms · Clinical observation · Cognition · Controlled study · Daily life activity · Early diagnosis · Elderly care · General practice · General practitioner · Interview · Learning test · Major clinical study · Neuropsychological test · Questionnaire · Reliability · Screening test · Statistical analysis · Symptom · Validation process · Aged · Aged, 80 and over · Alzheimer Disease · Cluster Analysis · Dementia · Depression · Family Practice · Female · Humans · Male · Mass Screening · Netherlands · Population Surveillance · Psychiatric Status Rating Scales · Reproducibility of Results · Sampling Studies
[Abstract]

15 LDL receptor deficiency results in decreased cell proliferation and presynaptic bouton density in the murine hippocampus
article 2007    
Author: Mulder, M. · Koopmans, G. · Wassink, G. · Mansouri, G.A. · Simard, M.-L. · Havekes, L.M. · Prickaerts, J. · Blokland, A.
Keywords: Health · Biomedical Research · Apolipoprotein E · Cholesterol · Low density lipoprotein receptor · Memory · Neurogenesis · Synaptic density · apolipoprotein E · broxuridine · cholesterol · iodine 125 · low density lipoprotein · low density lipoprotein receptor · synaptophysin · Alzheimer disease · animal cell · animal experiment · animal tissue · article · astrocytoma cell · cell proliferation · cholesterol metabolism · concentration response · controlled study · dentate gyrus · hippocampus · knockout mouse · male · memory · mouse · nerve cell plasticity · nerve fiber growth · nervous system development · neuroblastoma cell · nonhuman · pathogenesis · priority journal · spatial memory · synaptogenesis · wild type · Animals · Biological Markers · Bromodeoxyuridine · Cell Count · Cell Line, Tumor · Cell Proliferation · Cholesterol · Dentate Gyrus · Down-Regulation · Hippocampus · Humans · Male · Mice · Mice, Knockout · Neural Pathways · Neuronal Plasticity · Presynaptic Terminals · Receptors, LDL · Synaptophysin
[Abstract]

16 Stress proteins in CNS inflammation
article 2008    
Author: Noort, J.M. van
Keywords: Biology · Biomedical Research · Brain · Heat shock proteins · Inflammation · Neurodegeneration · caspase 3 · chaperone · crystallin · heat shock protein · heat shock protein 70 · heat shock protein 90 · I kappa B · immunoglobulin enhancer binding protein · protein bcl 2 · RANTES · tau protein · toll like receptor · Alexander disease · Alzheimer disease · antigen presentation · antigen presenting cell · apoptosis · central nervous system disease · cytokine production · cytotoxic T lymphocyte · degenerative disease · human · inflammation · nonhuman · Parkinson disease · priority journal · protein aggregation · protein degradation · protein expression · protein folding · protein phosphorylation · protein structure · review · Antigen Presentation · Apoptosis · Encephalomyelitis · Heat-Shock Proteins · Humans · Inflammation Mediators · Molecular Chaperones · Neurodegenerative Diseases
[Abstract]

17 Broad expression of Toll-like receptors in the human central nervous system
article 2002    
Author: Bsibsi, M. · Ravid, R. · Gveric, D. · Noort, J.M. van
Keywords: Health · Central nervous system · Oligodendrocytes · Toll-like receptors · Toll like receptor · Unclassified drug · Alzheimer disease · Cell vacuole · Controlled study · Human tissue · Immunocytochemistry · Parkinson disease · Pick presenile dementia · Protein expression · Aged · Aged, 80 and over · Astrocytes · Cells, Cultured · Central Nervous System · Central Nervous System Infections · Drosophila Proteins · Encephalitis · Female · Gene Expression Regulation · Humans · Immune System · Immunohistochemistry · Male · Membrane Glycoproteins · Microglia · Middle Aged · Multiple Sclerosis · Neuroglia · Oligodendroglia · Receptors, Cell Surface · RNA, Messenger · Toll-Like Receptor 2 · Toll-Like Receptor 3 · Toll-Like Receptor 4 · Toll-Like Receptors
[Abstract]

18 Human apolipoprotein C-I expression in mice impairs learning and memory functions
article 2008    
Author: Abildayeva, K. · Berbée, J.F.P. · Blokland, A. · Jansen, P.J. · Hoek, F.J. · Meijer, O. · Lütjohann, D. · Gautier, T. · Pillot, T. · Vente, J.de · Havekes, L.M. · Ramaekers, F.C.S. · Kuipers, F. · Rensen, P.C.N. · Mulder, M.
Keywords: Health · Physiological Sciences · β-amyloid · Alzheimer's disease · Apolipoprotein E · Morris water maze task · Object recognition task · amyloid beta protein · apolipoprotein E · campesterol · cholestanol · cholesterol · cholesterol derivative · desmosterol · lanosterol · lathosterol · lysophosphatidylcholine · lysophosphatidylethanolamine · messenger RNA · phosphatidylcholine · phosphatidylethanolamine · phosphatidylinositol · phosphatidylserine · sitosterol · sphingomyelin · unclassified drug · animal cell · animal experiment · animal model · animal tissue · apoptosis · astrocyte · brain level · cell viability · controlled study · disease exacerbation · endothelium cell · female · hippocampus · human tissue · learning disorder · lipid metabolism · maze test · memory disorder · mouse · nerve cell necrosis · nonhuman · protein aggregation · protein expression · recognition · task performance · transgenic mouse · wild type · animal · C57BL mouse · gene expression regulation · genetics · metabolism · Animals · Apolipoprotein C-I · Gene Expression Regulation · Humans · Immunohistochemistry · Learning · Memory · Mice · Mice, Inbred C57BL · Mice, Transgenic · RNA, Messenger · Tissue Culture Techniques
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 18 of 18 found. | Sort by date