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Showing 1 to 14 of 14 found. | Sort by date

1 Improved proteolytic stability of chicken cathelicidin-2 derived peptides by d-amino acid substitutions and cyclization
article 2011    
Author: Molhoek, E.M. · Dijk, A. van · Veldhuizen, E.J.A. · Haagsman, H.P. · Bikker, F.J.
Keywords: Chicken cathelicidin-2 · Cyclization · d-Amino acid substitution · Host defense peptide · Stability · Bacterial protein · Bacterium lipopolysaccharide · Cathelicidin · Cathelicidin 2 · Phenylalanine · Proteinase · Tryptophan · Unclassified drug · Amino acid substitution · Antibacterial activity · Article · Bactericidal activity · Controlled study · Cyclization · Cytotoxicity · Human · Human cell · Nonhuman · Peptide synthesis · Peripheral blood mononuclear cell · Priority journal · Protein degradation · Protein engineering · Protein modification · Protein stability · Protein variant · Bacteria (microorganisms) · Life · CBRN - CBRN Protection · EELS - Earth, Environmental and Life Sciences
[Abstract]

2 GSTP1-1 stereospecifically catalyzes glutathione conjugation of ethacrynic acid
article 1998    
Author: Iersel, M.L.P.S. van · Lipzig, M.M.H. van · Rietjens, I.M.C.M. · Vervoort, J. · Bladeren, P.J. van
Keywords: EA, ethacrynic acid · Ethacrynic acid · Glutathione S-transferase · Stereoselectivity · Etacrynic acid · Glutathione · Glutathione transferase · Multidrug resistance protein · Chemical reaction · Conjugate · Controlled study · Diastereoisomer · Drug conjugation · Enzyme mechanism · Glutathione metabolism · Human cell · Melanoma cell · Nuclear magnetic resonance spectroscopy · Stereochemistry · Amino Acid Substitution · Ethacrynic Acid · Glutathione · Glutathione Transferase · Humans · Isoenzymes · Melanoma · Point Mutation · Stereoisomerism · Substrate Specificity · Tumor Cells, Cultured
[PDF] [Abstract]

3 Mutation-based growth charts for SEDC and other COL2A1 related dysplasias
article 2012    
Author: Terhal, P.A. · Dommelen, P. van · Le Merrer, M. · Zankl, A. · Simon, M.E. · Smithson, S.F. · Marcelis, C. · Kerr, B. · Kinning, E. · Mansour, S. · Hennekam, R.C. · Hout, A.H. van der · Cormier-Daire, V. · Lund, A.M. · Goodwin, L. · Mégarbané, A. · Lees, M. · Betz, R.C. · Tobias, E.S. · Coucke, P. · Mortier, G.R.
Keywords: Health · COL2A1 · Growth · Spondylo-epiphyseal dysplasia congenita · arginine · asparagine · cysteine · glycine · valine · adult · adulthood · amino acid substitution · amino terminal sequence · anthropometric parameters · article · carboxy terminal sequence · child · codon · Col2a1 gene · female · gene · gene mutation · growth curve · human · major clinical study · male · nucleotide sequence · preschool child · priority journal · spondyloepiphyseal dysplasia · Healthy for Life · Healthy Living · Human · LS - Life Style · BSS - Behavioural and Societal Sciences
[Abstract]

4 Biological evaluation of Tyr6 and Ser7 modified drosocin analogues
article 2005    
Author: Visser, P.C. de · Hooft, P.A.V. van · Vries, A.-M. de · Jong, A. de · Marel, G.A. van der · Overkleeft, H.S. · Noort, D.
Keywords: Antibiotic agent · Amino acid substitution · Amino terminal sequence · Article · Controlled study · Drug screening · Drug stability · Drug synthesis · Nonhuman · Protein degradation · Amino Acid Sequence · Glycopeptides · Humans · Microbial Sensitivity Tests · Molecular Sequence Data · Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization · Chemicals · Drosocin, 179048-25-0 · Serine, 56-45-1, 6898-95-9 · Tyrosine, 16870-43-2, 55520-40-6, 60-18-4 · Drosocin, 149924-99-2 · Glycopeptides · Serine, 56-45-1 · Tyrosine, 55520-40-6
[Abstract]

5 Site-directed mutagenesis study of the three catalytic residues of the fructosyltransferases of Lactobacillus reuteri 121
article 2004    
Author: Ozimek, L.K. · Hijum, S.A.F.T. van · Koningsveld, G.A. van · Maarel, M.J.E.C. van der · Geel-Schutten, G.H. van · Dijkhuizen, L.
Keywords: Food technology · Catalytic residue · Fructosyltransferase · Inulosucrase · Levansucrase · Mutagenesis · Acid · Base · Glycosidase · Levansucrase · Mutant protein · Stabilizing agent · Sucrase · Transferase · Bacterium mutant · Enzyme activity · Nonhuman · Site directed mutagenesis · Amino Acid Motifs · Amino Acid Sequence · Amino Acid Substitution · Catalysis · Circular Dichroism · Cloning, Molecular · Conserved Sequence · Escherichia coli · Gene Expression · Genes, Bacterial · Hexosyltransferases · Kinetics · Lactobacillus · Molecular Sequence Data · Mutagenesis, Site-Directed · Sequence Homology, Amino Acid · Substrate Specificity · Bacillus subtilis · Bacteria (microorganisms) · Lactobacillus reuteri
[PDF] [Abstract]

6 Single amino acid residue changes in subsite - 1 of inulosucrase from Lactobacillus reuteri 121 strongly influence the size of products synthesized
article 2006    
Author: Ozimek, L.K. · Kralj, S. · Kaper, T. · Maarel, M.J.E.C. van der · Dijkhuizen, L.
Keywords: Food technology · Inulosucrase · Lactobacillus reuteri · Processivity · Site-directed mutagenesis · Amino acid · Arginine · Aspartic acid · Fructan · Fructansucrase · Fructose oligosaccharide · Glutamic acid · Glycosidase · Histidine · Inulin · Inulosucrase · Levan · Lysine · Mutant protein · Oligosaccharide · Polymer · Sucrase · Sucrose · Tryptophan · Unclassified drug · Amino acid sequence · Carbohydrate synthesis · Catalysis · Concentration (parameters) · Controlled study · Enzyme active site · Enzyme activity · Enzyme specificity · Enzyme structure · Enzyme substrate · Glycosylation · Molecular recognition · Molecular size · Nonhuman · Nucleotide sequence · Protein family · Amino Acid Substitution · Binding Sites · Hexosyltransferases · Lactobacillus reuteri · Molecular Weight · Oligosaccharides · Bacillus subtilis · Bacteria (microorganisms) · Lactobacillus reuteri
[PDF] [Abstract]

7 Structure-function relationships of glucansucrase and fructansucrase enzymes from lactic acid bacteria
article 2006    
Author: Hijum, S.A.F.T. van · Kralj, S. · Ozimek, L.K. · Dijkhuizen, L. · Geel-Schutten, G.H. van
Keywords: Nutrition · Food technology · bacterial enzyme · calcium ion · fructan · fructan sucrase · glucan · glucan sucrase · oligosaccharide · polymer · signal peptide · sucrase · unclassified drug · amino acid substitution · binding site · catalysis · enzyme activity · enzyme mechanism · enzyme structure · gene mutation · lactic acid bacterium · nomenclature · nonhuman · nucleotide sequence · review · synthesis · Amino Acid Sequence · Bacterial Proteins · Fructans · Glycosyltransferases · Gram-Positive Bacteria · Lactic Acid · Molecular Sequence Data · Protein Conformation · Structure-Activity Relationship · Sucrase · Bacteria (microorganisms) · Negibacteria · Posibacteria
[Abstract]

8 Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers
article 1999    
Author: Ordentlich, A. · Barak, D. · Kronman, C. · Benschop, H.P. · Jong, L.P.A. de · Ariel, N. · Barak, R. · Segall, Y. · Velan, B. · Shafferman, A.
Keywords: Cholinesterase reactivator · Soman · Binding site · Chirality · Dealkylation · Enzyme activity · Enzyme analysis · Enzyme binding · Enzyme specificity · Enzyme structure · Enzyme substrate · Human cell · Protein expression · Stereochemistry · Stereoisomerism · Alkylation · Amino acid substitution · Binding sites · Cell line · Cholinesterase inhibitors · Humans · Hydrogen Bonding · Kidney · Macromolecular substances · Models, Molecular · Mutagenesis, Site-Directed · Stereoisomerism · Acetylcholinesterase, EC 3.1.1.7 · Alanine, 56-41-7 · Phenylalanine, 63-91-2 · Phosphorus, 7723-14-0 · Soman, 96-64-0
[Abstract]

9 Genetic inflammatory factors predict restenosis after percutaneous coronary interventions
article 2005    
Author: Monraats, P.S. · Pires, N.M.M. · Agema, W.R.P. · Zwinderman, A.H. · Schepers, A. · Maat, M.P.M. de · Doevendans, P.A. · Winter, R.J. de · Tio, R.A. · Waltenberger, J. · Frants, R.R. · Quax, P.H.A. · Vlijmen, B.J.M. van · Atsma, D.E. · Laarse, A. van der · Wall, E.E. van der · Jukema, J.W.
Keywords: Biology · Biomedical Research · Angioplasty · Genetics · Restenosis · Risk factors · alanine · beta 2 adrenergic receptor · glycine · threonine · adult · aged · allele · Cd14 gene · colony stimulating factor 2 gene · controlled study · coronary artery disease · disease predisposition · eotaxin gene · female · gene identification · genetic polymorphism · genetic risk · haplotype · heart muscle revascularization · human · major clinical study · male · percutaneous coronary intervention · probability · prospective study · restenosis · risk assessment · risk factor · Amino Acid Substitution · Angioplasty, Transluminal, Percutaneous Coronary · Coronary Restenosis · Humans · Inflammation · Polymorphism, Single Nucleotide · Prospective Studies · Treatment Outcome
[Abstract]

10 Examining the role of glutamic acid 183 in chloroperoxidase catalysis
article 2003    
Author: Yi, X. · Conesa, A. · Punt, P.J. · Hager, L.P.
Keywords: Biology · Biotechnology · Catalysis · Genetic engineering · Organic acids · X ray crystallography · Active sites · Enzymes · Chloride peroxidase · Clutamic acid · Histidine · Hydrogen peroxide · Natural product · Epoxidase · Oxidoreductase · Amino acid substitution · Animal cell · Asymmetric catalysis · Chlorination · Enzyme active site · Enzyme activity · Epoxidation · Genetic analysis · Hydrophobicity · Nonhuman · Plasmid · Site directed mutagenesis · X ray crystallography · Chemistry · Circular dichroism · Enzymology · Immunoblotting · Ion exchange chromatography · Isoelectric focusing · Metabolism · PH · polyacrylamide gel electrophoresis · Animalia · Aspergillus · Aspergillus niger · Catalase · Catalysis · Chloride Peroxidase · Chlorine · Chromatography, Ion Exchange · Circular Dichroism · Crystallography, X-Ray · Electrophoresis, Polyacrylamide Gel · Fungi · Glutamic Acid · Histidine · Hydrogen-Ion Concentration · Immunoblotting · Isoelectric Focusing · Mutation · Oxidoreductases · Plasmids
[PDF] [Abstract]

11 A study of the clinical and radiological features in a cohort of 93 patients with a COL2A1 mutation causing spondyloepiphyseal dysplasia congenita or a related phenotype
article 2015    
Author: Terhal, P.A. · Nievelstein, R.J.A.J. · Verver, E.J.J. · Topsakal, V. · Dommelen, P. van · Hoornaert, K. · Merrer, M. le · Zankl, A. · Simon, M.E. · Smithson, S.F. · Marcelis, C. · Kerr, B. · Clayton-Smith, J. · Kinning, E. · Mansour, S. · Elmslie, F. · Goodwin, L. · Hout, A.H. van der · Veenstra-Knol, H.E. · Herkert, J.C. · Lund, A.M. · Hennekam, R.C. · Mégarbané, A. · Lees, M.M. · Wilson, L.C. · Male, A. · Hurst, J. · Alanay, Y. · Annerén, G. · Betz, R.C. · Bongers, E.M. · Cormier-Daire, V. · Dieux, A. · David, A. · Elting, M.W. · Ende, J. van den · Green, A. · Hagen, J.M. van · Hertel, N.T. · Holder-Espinasse, M. · Hollander, N. den · Homfray, T. · Hove, H.D. · Price S · Raas-Rothschild, A. · Rohrbach, M. · Schroeter, B. · Suri, M. · Thompson, E.M. · Tobias, E.S. · Toutain, A. · Vreeburg, M. · Wakeling, E. · Knoers, N.V. · Coucke, P. · Mortier, G.R.
Keywords: Health · SEDC · Genotype-phenotype · Spondyloepiphyseal dysplasia · Review · SEDC · Aspartic acid · Glycine · Procollagen · Serine · Adolescent · Amino acid substitution · Atlantoaxial dislocation · Bronchomalacia · Child · Cleft palate · Clinical feature · Clubfoot · COL2A1 gene · Coxa vara · Disease severity · Female · Gene · Gene mutation · Genotype phenotype correlation · Gestational age · Hearing impairment · Heterozygosity · Hip arthroplasty · Hypermetropia · Major clinical study · Male · Missense mutation · Mutational analysis · Myopia · Osteotomy · Pierre Robin syndrome · Population research · Respiratory distress · Retina detachment · School child · Scoliosis · Spondyloepiphyseal dysplasia · Tracheomalacia · Tracheostomy · Healthy for Life · Healthy Living · Behavioural Changes · LS - Life Style · ELSS - Earth, Life and Social Sciences
[Abstract]

12 Transglutaminase-Mediated Modification of Glutamine and Lysine Residues in Native Bovine β-Lactoglobulin
article 2004    
Author: Nieuwenhuizen, W.F. · Dekker, H.L. · Gröneveld, T. · Koster, C.G. de · Jong, G.A.H. de
Keywords: Nutrition · Food technology · β-lactoglobulin · Circular dichroism · Mass spectrometry · Native structure · Protein modification · Transglutaminase · Chemical modification · Crosslinking · Proteins · Reaction kinetics · Surface tension · Nondenaturing conditions · Biotechnology · beta lactoglobulin · glutamine · lysine · protein glutamine gamma glutamyltransferase · article · circular dichroism · cross linking · deamination · matrix assisted laser desorption ionization time of flight mass spectrometry · nonhuman · protein modification · protein secondary structure · Streptoverticillium · surface tension · Amino Acid Sequence · Amino Acid Substitution · Animals · Binding Sites · Cattle · Glutamine · Lactoglobulins · Lysine · Milk · Molecular Sequence Data · Protein Binding · Protein Conformation · Protein Structure, Secondary · Streptomyces · Surface Tension · Transglutaminases · Bovinae · Streptomyces · Streptomyces mobaraensis
[Abstract]

13 Molecular basis for fibrinogen Dusart (Aα 554 Arg → Cys) and its association with abnormal fibrin polymerization and thrombophilia
article 1993    
Author: Koopman, J. · Haverkate, F. · Grimbergen, J. · Lord, S.T. · Mosesson, M.W. · DiOrio, J.P. · Siebenlist, K.S. · Legrand, C. · Soria, J. · Soria, C. · Caen, J.P.
Keywords: Health · Aα chain · albumin, disulfide-linked · dysfibrogenemia · gene analysis · albumin · antithrombin iii · fibrinogen · plasminogen · protein c · protein s · thrombin · amino acid substitution · blood clotting · complex formation · controlled study · disulfide bond · dna sequence · dysfibrinogenemia · female · fibrin polymerization · gene amplification · genetic analysis · heterozygote · nucleic acid base substitution · polymerase chain reaction · priority journal · thrombosis · Adult · Base Sequence · Blood Coagulation Disorders · Case Report · Fibrin · Fibrinogen · Fibrinogens, Abnormal · Gene Amplification · Human · Immunoblotting · Male · Microscopy, Electron · Molecular Sequence Data · Mutation · Platelet Membrane Glycoproteins · Protein Binding · Sequence Analysis, DNA · Structure-Activity Relationship · Sulfhydryl Compounds · Support, Non-U.S. Gov't · Support, U.S. Gov't, P.H.S. · Thrombosis · Thrombospondins
[Abstract]

14 Generation of a recombinant apolipoprotein E variant with improved biological functions: Hydrophobic residues (LEU-261, TRP-264, PHE-265, LEU-268, VAL-269) of apoE can account for the apoE-induced hypertriglyceridemia
article 2005    
Author: Kypreos, K.E. · Dijk, K.W. van · Havekes, L.M. · Zannis, V.I.
Keywords: Biology · Biomedical Research · Amino acids · Biochemistry · Cholesterol · Genes · Molecular biology · Mutagenesis · Alanines · Apolipoprotein E (apoE) · High density lipoprotein (HDL) · Ultracentrifugation analysis · Proteins · High density lipoprotein · Leucine · Lipoprotein lipase · Phenylalanine · Recombinant apolipoprotein E · Recombinant protein · Triacylglycerol · Tryptophan · Unclassified drug · Valine · Very low density lipoprotein · Adenovirus · Amino acid substitution · Animal experiment · Carboxy terminal sequence · Controlled study · Density gradient centrifugation · Electron microscopy · Gene transfer · Human cell · Hydrophobicity · Hyperlipidemia · Hypertriglyceridemia · Mouse · Mutation · Nonhuman · Protein expression · Protein function · Animals · Apolipoproteins E · Cholesterol · Female · Humans · Hypertriglyceridemia · Lipoproteins, HDL · Lipoproteins, VLDL · Liver · Mice · Mice, Knockout · Mutagenesis, Site-Directed · Mutation, Missense · Peptide Fragments · Recombinant Proteins · Transgenes · Triglycerides
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 14 of 14 found. | Sort by date