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1 The chicken enucleated eye test (CEET) : a practical (pre)screen for the assessment of eye irritation/corrosion potential of test materials
article 1996    
Author: Prinsen, M.K.
Keywords: Toxicology · Animal Testing Alternatives · Animals · Chickens · Cornea · Corneal Opacity · Drug Evaluation, Preclinical · Epithelium · Eye Enucleation · Irritants · Rabbits · Toxicity Tests · Animalia · Gallus gallus · Oryctolagus cuniculus
[Abstract]

2 Organotypic models for the assessment/prediction of ocular irritation
article 1997    
Author: Chamberlain, M. · Gad, S.C. · Gautheron, P. · Prinsen, M.K.
Keywords: Animal Testing Alternatives · Animals · Cattle · Cells, Cultured · Chickens · Cornea · Corneal Opacity · Eye · Eye Diseases · Irritants · Lens, Crystalline · Permeability · Predictive Value of Tests · Rabbits · Toxicity Tests
[Abstract]

3 Physiologically-based kinetic modelling (PBK modelling): Meeting the 3Rs agenda. The report and recommendations of ECVAM workshop 63
article 2007    
Author: Bouvier D'Yvoire, M. · Prieto, P. · Blaauboer, B.J. · Bois, F.Y. · Boobis, A. · Brochot, C. · Coecke, S. · Freidig, A. · Gundert-Remy, U. · Hartung, T. · Jacobs, M.N. · Lavé, T. · Leahy, D.E. · Lennernäs, H. · Loizou, G.D. · Meek, B. · Pease, C. · Rowland, M. · Spendiff, M. · Yang, J. · Zeilmaker, M.
Keywords: Biology · Biomedical Research · toxic substance · animal welfare · excretion · experimental animal · human · kinetics · medical research · metabolism · nonhuman · priority journal · review · risk assessment · Animal Testing Alternatives · Animals · Kinetics · Models, Biological · Physiology · Reproducibility of Results · Toxicology

4 The Draize Eye Test and in vitro alternatives; a left-handed marriage?
article 2006    
Author: Prinsen, M.K.
Keywords: Biology · Toxicology and Applied Pharmacology · Draize Eye Test · In vitro assay · Validation · article · draize eye test · exposure · in vitro study · nonhuman · solid · technique · validation process · Acute Toxicity Tests · Animal Testing Alternatives · Animals · Eye · Irritants · Rabbits · Reproducibility of Results

5 Optimisation of the post-validation process: The report and recommendations of ECVAM workshop 67
article 2008    
Author: Bottini, A.A. · Alepee, N. · Phillips, B. · Gribaldo, L. · Silva, O. de · Hartung, T. · Hendriksen, C. · Kuil, J. · Pazos, P. · Rhein, C. · Schiffelers, M.-J. · Stokes, W. · Theobald, A. · Vidal, J.-M. · Sandt, H. van de · Breier, S. · Sintes, J.R. · Blaauboer, B.
Keywords: Nutrition · Food and Chemical Risk Analysis · animal welfare · conference paper · health care policy · industry · law · medical research · priority journal · public health problem · skin test · validation process · Animal Testing Alternatives · Animals · Health Planning Guidelines · Validation Studies as Topic

6 Integrated in vitro-in silico models for predicting in vivo development toxicity: facilitating non-animal based safety asssment
dissertation 2012    
Author: Louisse, J.
Keywords: Toxicology · Embryonale ontwikkeling · Foetale ontwikkeling · In vitro kweek · Toxiciteit · Biomarkers · Computational science · Alternatieven voor dierproeven · Risicoschatting · Embryonic development · Fetal development · In vitro culture · Toxicity · Animal testing alternatives · Risk assessment · Biomedical Innovation · Healthy Living
[PDF]

7 Release of arachidonic and linoleic acid metabolites in skin organ cultures as characteristics of in vitro skin irritancy
article 1995    
Author: Sandt, J.J.M. van de · Maas, W.J.M. · Doornink, P.C. · Rutten, A.A.J.J.L.
Keywords: Biology · Animal · Animal Testing Alternatives · Arachidonic Acid · Benzalkonium Compounds · Eicosanoids · Epidermis · Female · Formaldehyde · Human · Hydroxyeicosatetraenoic Acids · In Vitro · Irritants · Linoleic Acid · Linoleic Acids · Male · Organ Culture · Rabbits · Skin · Sodium Dodecyl Sulfate · Support, Non-U.S. Gov't · Toxicity Tests
[Abstract]

8 Chemical respiratory allergy: Opportunities for hazard identification and characterisation
article 2007    
Author: Kimber, I. · Agius, R. · Basketter, D.A. · Corsini, E. · Cullinan, P. · Dearman, R.J. · Gimenez-Arnau, E. · Greenwell, L. · Hartung, T. · Kuper, F. · Maestrelli, P. · Roggen, E. · Rovida, C. · Casati, S.
Keywords: Toxicology and Applied Pharmacology · cell assay · clinical feature · conference paper · nonhuman · occupational asthma · occupational exposure · pathogenesis · priority journal · quantitative structure activity relation · respiratory tract allergy · risk assessment · risk factor · sensitization · skin test · Animal Testing Alternatives · Animals · Hazardous Substances · Humans · Respiratory Hypersensitivity · Skin Tests · Structure-Activity Relationship

9 Skin sensitisation and epidermal disposition: The relevance of epidermal disposition for sensitisation hazard identification and risk assessment: The report and recommendations of ECVAM workshop 59a
article 2007    
Author: Basketter, D. · Pease, C. · Kasting, G. · Kimber, I. · Casati, S. · Cronin, M. · Diembeck, W. · Gerberick, F. · Hadgraft, J. · Hartung, T. · Marty, J.P. · Nikolaidis, E. · Patlewicz, G. · Roberts, D. · Roggen, E. · Rovida, C. · Sandt, J. van de
Keywords: Food and Chemical Risk Analysis · cosmetic · analytic method · clearance · conference paper · environmental exposure · epidermis cell · gap junction · hazard assessment · immunity · mathematical computing · priority journal · protein binding · risk assessment · sensitization · skin sensitization · steady state · theoretical model · Allergens · Animal Testing Alternatives · Animals · Cells, Cultured · Guidelines · Humans · Risk Assessment · Skin · Skin Absorption · Skin Tests · Toxicity Tests

10 Inhalation toxicity studies: OECD guidelines in relation to REACH and scientific developments
article 2008    
Author: Arts, J.H.E. · Muijser, H. · Jonker, D. · Sandt, J.J.M. van de · Bos, P.M.J. · Feron, V.J.
Keywords: Health · Chemicals · Guidelines · Hazard · Inhalation · OECD · Reach · Toxicity · acute toxicity · animal testing alternative · article · health hazard · inhalation · nonhuman · practice guideline · risk assessment · safety · toxicity · Animal Testing Alternatives · Animals · European Union · Government Regulation · Guidelines as Topic · Inhalation Exposure · Risk Assessment · Tissue Culture Techniques · Toxicity Tests · Xenobiotics · Animalia
[Abstract]

11 Carcinogenicity
article 2005    
Author: Maurici, D. · Aardema, M. · Corvi, R. · Kleber, M. · Krul, C.A.M. · Laurent, C. · Loprieno, N. · Pasanen, M. · Pfuhler, S. · Phillips, B. · Prentice, D. · Sabbioni, E. · Sanner, T. · Vanparys, P.
Keywords: Health · Biomedical Research · animal testing alternative · carcinogenesis · carcinogenicity · cell communication · cell culture · cell transformation · gap junction · genotoxicity · heterozygosity · nonhuman · priority journal · review · risk assessment · standardization · transgenic mouse · validation process · Animal Testing Alternatives · Animals · Carcinogenicity Tests · Carcinogens · Cell Transformation, Neoplastic · Cells, Cultured · Consumer Product Safety · Cosmetics · European Union · Gap Junctions · Mice · Mice, Transgenic · Quantitative Structure-Activity Relationship · Rats · Animalia · Mus musculus

12 Genotoxicity and mutagenicity
article 2005    
Author: Maurici, D. · Aardema, M. · Corvi, R. · Kleber, M. · Krul, C.A.M. · Laurent, C. · Loprieno, N. · Pasanen, M. · Pfuhler, S. · Phillips, B. · Sabbioni, E. · Sanner, T. · Vanparys, P.
Keywords: Toxicology · Physiological sciences · Animal testing replacement · Animal testing alternatives · Chromosome aberration · Comet assay · DNA damage · DNA synthesis · Gene mutation · Genotoxicity · In vitro study · In vivo study · Micronucleus test · Mitotic recombination · Mutagenicity · Sister chromatid exchange · Toxicity testing · Toxicogenetics · Toxicokinetics · Toxicological parameters · Carcinogen testing · Cell culture · Chemistry · Legal aspects · Structure activity relation · Animalia · Consumer product safety · Cosmetics · European Union · Structure-Activity Relationship

13 Current status of methods for defining the applicability domain of (quantitative) structure-activity relationships
article 2005    
Author: Netzeva, T.I. · Worth, A.P. · Aldenberg, T. · Benigni, R. · Cronin, M.T.D. · Gramatica, P. · Jaworska, J.S. · Kahn, S. · Klopman, G. · Marchant, C.A. · Myatt, G. · Nikolova-Jeliazkova, N. · Patlewicz, G.Y. · Perkins, R. · Roberts, D.W. · Schultz, T.W. · Stanton, D.T. · Sandt, J.J.M. van de · Tong, W. · Veith, G. · Yang, C.
Keywords: Biology · Food and Chemical Risk Analysis · chemical environment · chemical industry · conference paper · decision theory · geometry · mathematical analysis · priority journal · probability · quantitative structure activity relation · skin sensitization · statistical analysis · water contamination · Animal Testing Alternatives · Animals · Education · European Union · Health Planning Guidelines · Quantitative Structure-Activity Relationship · Reproducibility of Results · Toxicity Tests

14 Strategies to replace in vivo acute systemic toxicity testing: The report and recommendations of ECVAM workshop 50
article 2004    
Author: Gennari, A. · Berghe, C. van den · Casati, S. · Castell, J. · Clemedson, C. · Coecke, S. · Colombo, A. · Curren, R. · Dal Negro, G. · Goldberg, A. · Gosmore, C. · Hartung, T. · Langezaal, I. · Lessigiarska, I. · Maas, W. · Mangelsdorf, I. · Parchment, R. · Prieto, P. · Sintes, J.R. · Ryan, M. · Schmuck, G. · Stitzel, K. · Stokes, W. · Vericat, J.A. · Gribaldo, L.
Keywords: Toxicology Health · Physiological Sciences · acute toxicity · conference paper · cytotoxicity · environmental protection · European Union · in vivo study · LD 50 · priority journal · toxicity testing · Acute Toxicity Tests · Animal Testing Alternatives · Animals · Cell Death · Cosmetics · Europe · Guidelines · Lethal Dose 50 · Mouth Diseases · Registries · Reproducibility of Results · Toxicity Tests · United States

15 REACH, non-testing approaches and the urgent need for a change in mind set
article 2009    
Author: Schaafsma, G. · Kroese, E.D. · Tielemans, E.L.J.P. · Sandt, J.J.M. van de · Leeuwen, C.J. van
Keywords: Chemistry · Food and Chemical Risk Analysis · Intelligent testing strategies · Mind set change · Non-testing · REACH · Uncertainty paradox · chemical agent · acute toxicity · animal testing alternative · article · chronic toxicity · cost · drug screening · environmental exposure · hazard assessment · health care policy · human · human tissue · in vivo study · priority journal · process optimization · public opinion · REACH program · reproductive toxicity · risk assessment · skin toxicity · toxicity testing · uncertainty · Animal Testing Alternatives · Animals · Databases, Factual · Environmental Exposure · Europe · Hazardous Substances · Humans · Registries · Risk Assessment · Toxicity Tests · Animalia
[Abstract]

16 Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling
article 2006    
Author: Verwei, M. · Burgsteden, J.A. van · Krul, C.A.M. · Sandt, J.J.M. van de · Freidig, A.P.
Keywords: Biology · Biomedical Research · Alternative test method · Developmental toxicity · Embryonic stem cells · PBPK model · 2 ethoxyethanol · 2 methoxyethanol · acetic acid derivative · ethoxyacetic acid · fluorouracil · methotrexate · methoxyacetic acid · retinoic acid · unclassified drug · animal cell · article · computer model · controlled study · embryo · embryo development · embryonic stem cell · embryotoxicity · exposure · metabolism · mouse · nonhuman · prediction · priority journal · risk assessment · rodent · Animal Testing Alternatives · Animals · Cell Line · Cell Survival · Dose-Response Relationship, Drug · Embryo · Mice · Models, Biological · Predictive Value of Tests · Rats · Risk Assessment · Stem Cells · Teratogens · Toxicity Tests · Rodentia
[Abstract]

17 Skin irritation and corrosion
article 2005    
Author: Zuang, V. · Alonso, M.A. · Botham, P.A. · Eskes, C. · Fentem, J. · Liebsch, M. · Sandt, J.J.M. van de
Keywords: Chemistry Safety · Food and Chemical Risk Analysis · cosmetic · acute toxicity · animal testing alternative · cell growth · cell viability · chemical structure · corrosion · electric resistance · explant · human · in vitro study · model · pH measurement · priority journal · reproducibility · review · safety · skin culture · skin irritation · skin water loss · standardization · toxicity testing · validation process · Animal Testing Alternatives · Animals · Cell Survival · Consumer Product Safety · Cosmetics · Endpoint Determination · European Union · Humans · Irritants · Organ Culture Techniques · Quantitative Structure-Activity Relationship · Skin · Skin Irritancy Tests · Swine · Animalia

18 Comparative in vitro-in vivo percutaneous absorption of the pesticide propoxur
article 2000    
Author: Sandt, J.J.M. van de · Meuling, W.J.A. · Elliott, G.R. · Cnubben, N.H.P. · Hakkert, B.C.
Keywords: Nutrition · Human · In vitro/in vivo comparisons · Perfused-pig-ear model · Propoxur · Rat · Viable skin and epidermal membranes · Carbon 14 · Pesticide · Propoxur · Animal model · Animal tissue · Blood sampling · Ear · Environmental exposure · Epidermis · Human · Human experiment · Human tissue · Isotope labeling · Nonhuman · Normal human · Pest control · Rat · Skin absorption · Swine · Urinalysis · Animal Testing Alternatives · Animals · Ear, External · Epidermis · Humans · Insecticides · Male · Models, Animal · Perfusion · Propoxur · Rats · Rats, Wistar · Skin Absorption · Species Specificity · Swine · Animalia · Sus scrofa
[Abstract]

19 Respiratory sensitization : Advances in assessing the risk of respiratory inflammation and irritation
article 2011    
Author: Vandebriel, R. · Callant Cransveld, C. · Crommelin, D. · Diamant, Z. · Glazenburg, B. · Joos, G. · Kuper, F. · Natsch, A. · Nijkamp, F. · Noteborn, H. · Pieters, R. · Roberts, D. · Roggen, E. · Rorije, E. · Seed, M. · Sewald, K. · Heuvel, R. van den · Engelen, J. van · Verstraelen, S. · Loveren, H. van
Keywords: Toxicology · ASAT · Asthma · In vitro · In vivo · Integrated testing · QSAR · Respiratory tract · Rhinitis · Risk assessment · Sensitization · contact allergen · immunoglobulin E · airway remodeling · animal testing alternative · biosafety · bronchus hyperreactivity · cell assay · cellular immunity · dendritic cell · disease predisposition · functional genomics · human · immunopathology · immunoreactivity · in vitro study · mathematical model · mucosal immunity · nonhuman · occupational asthma · predictive value · process development · process model · quantitative analysis · quantitative structure activity relation · reaction analysis · respiratory sensitization · respiratory tract inflammation · respiratory tract injury · review · risk assessment · risk factor · sensitization · Animal Testing Alternatives · Hazardous Substances · Humans · Respiratory Hypersensitivity · Respiratory Tract Diseases · Toxicity Tests · Animalia · Healthy for Life · Healthy Living · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

20 Relative developmental toxicity of glycol ether alkoxy acid metabolites in the embryonic stem cell test as compared with the in vivo potency of their parent compounds
article 2009    
Author: Jong, E. de · Louisse, J. · Verwei, M. · Blaauboer, B.J. · Sandt, J.J.M. van de · Woutersen, R.A. · Rietjens, I.M.C.M. · Piersma, A.H.
Keywords: Chemistry · Toxicology and Applied Pharmacology · Alternatives to animal testing · Developmental toxicology · Embryonic stem cells · Glycol ethers · butoxyacetic acid · ethoxyacetic acid · glycol ether alkoxy acid metabolite · methoxyacetic acid · phenoxyacetic acid · toxin · unclassified drug · animal cell · article · cell differentiation · chemical analysis · chemical structure · concentration response · controlled study · cytotoxicity test · developmental disorder · developmental toxicity · embryonic stem cell · embryonic stem cell test · embryotoxicity · heart muscle cell · in vivo study · mouse · nonhuman · sensitivity analysis · toxicokinetics · Animal Testing Alternatives · Animals · Biotransformation · Cell Differentiation · Cell Survival · Dose-Response Relationship, Drug · Embryonic Development · Embryonic Stem Cells · Glycols · Kinetics · Mice · Models, Statistical · Myocytes, Cardiac · Predictive Value of Tests · Reference Standards · Structure-Activity Relationship · Teratogens · Animalia
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 23 found. Next | Sort by date