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1 Relevance of animal studies in regulatory toxicology : current approaches and future opportunities
article 1996    
Author: Sandt, J.J.M. van de · Feron, V.J.
Keywords: Toxicology · Animal testing · Regulatory toxicology · Risk assessment
[Abstract]

2 Regulatory acceptance and use of 3R models for pharmaceuticals and chemicals: Expert opinions on the state of affairs and the way forward
article 2014    
Author: Schiffelers, M.J.W.A. · Blaauboer, B.J. · Bakker, W.E. · Beken, S. · Hendriksen, C.F.M. · Koeter, H. · Krul, C.A.M.
Keywords: Pharmacology · 3R models · Chemicals · Drivers and barriers · Multilevel perspective on technology transitions · Pharmaceuticals · Regulatory acceptance and use · Risk assessment · Animal testing alternative · Animal testing reduction · Animal testing refinement · Animal testing replacement · Drug industry · International cooperation · Interpersonal communication · Process development · Process optimization · Risk management · Biomedical Innovation · Healthy Living · Healthy Living · Themalijn
[Abstract]

3 State of the art on alternative methods to animal testing from an industrial point of view: ready for regulation?
article 2014    
Author: Ashton, R. · Wever, B. de · Fuchs, H.W. · Gaca, M. · Hill, E. · Krul, C.A.M. · Poth, A. · Roggen, E.L.
Keywords: Health · Non-animal testing · Legislation · Regulation · In vitro modeling · Harmonization · Standardization · Analytic method · Animal testing alternative · Conference paper · Industry · Law · Toxicity testing · Biomedical Innovation · Healthy Living · Healthy Living · Themalijn
[Abstract]

4 T4 report. An expert consortium review of the EC-commissioned report "Alternative (non-animal) methods for cosmetics testing: Current status and future prospects - 2010"
article 2011    
Author: Hartung, T. · Blaauboer, B.J. · Bosgra, S. · Carney, E. · Coenen, J. · Conolly, R.B. · Corsini, E. · Green, S. · Faustman, E.M. · Gaspari, A. · Hayashi, M. · Hayes, A.W. · Hengstler, J.G. · Knudsen, L.E. · Knudsen, T.B. · McKim, J.M. · Pfaller, W. · Roggen, E.L.
Keywords: Health Pharmacology · 3Rs · Alternatives to animal testing · Novel approaches · Product safety · Toxicology · Life · PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

5 The chicken enucleated eye test (CEET) : a practical (pre)screen for the assessment of eye irritation/corrosion potential of test materials
article 1996    
Author: Prinsen, M.K.
Keywords: Toxicology · Animal Testing Alternatives · Animals · Chickens · Cornea · Corneal Opacity · Drug Evaluation, Preclinical · Epithelium · Eye Enucleation · Irritants · Rabbits · Toxicity Tests · Animalia · Gallus gallus · Oryctolagus cuniculus
[Abstract]

6 Organotypic models for the assessment/prediction of ocular irritation
article 1997    
Author: Chamberlain, M. · Gad, S.C. · Gautheron, P. · Prinsen, M.K.
Keywords: Animal Testing Alternatives · Animals · Cattle · Cells, Cultured · Chickens · Cornea · Corneal Opacity · Eye · Eye Diseases · Irritants · Lens, Crystalline · Permeability · Predictive Value of Tests · Rabbits · Toxicity Tests
[Abstract]

7 Inhalation toxicity studies: OECD guidelines in relation to REACH and scientific developments
article 2008    
Author: Arts, J.H.E. · Muijser, H. · Jonker, D. · Sandt, J.J.M. van de · Bos, P.M.J. · Feron, V.J.
Keywords: Health · Chemicals · Guidelines · Hazard · Inhalation · OECD · Reach · Toxicity · acute toxicity · animal testing alternative · article · health hazard · inhalation · nonhuman · practice guideline · risk assessment · safety · toxicity · Animal Testing Alternatives · Animals · European Union · Government Regulation · Guidelines as Topic · Inhalation Exposure · Risk Assessment · Tissue Culture Techniques · Toxicity Tests · Xenobiotics · Animalia
[Abstract]

8 Carcinogenicity
article 2005    
Author: Maurici, D. · Aardema, M. · Corvi, R. · Kleber, M. · Krul, C.A.M. · Laurent, C. · Loprieno, N. · Pasanen, M. · Pfuhler, S. · Phillips, B. · Prentice, D. · Sabbioni, E. · Sanner, T. · Vanparys, P.
Keywords: Health · Biomedical Research · animal testing alternative · carcinogenesis · carcinogenicity · cell communication · cell culture · cell transformation · gap junction · genotoxicity · heterozygosity · nonhuman · priority journal · review · risk assessment · standardization · transgenic mouse · validation process · Animal Testing Alternatives · Animals · Carcinogenicity Tests · Carcinogens · Cell Transformation, Neoplastic · Cells, Cultured · Consumer Product Safety · Cosmetics · European Union · Gap Junctions · Mice · Mice, Transgenic · Quantitative Structure-Activity Relationship · Rats · Animalia · Mus musculus

9 Genotoxicity and mutagenicity
article 2005    
Author: Maurici, D. · Aardema, M. · Corvi, R. · Kleber, M. · Krul, C.A.M. · Laurent, C. · Loprieno, N. · Pasanen, M. · Pfuhler, S. · Phillips, B. · Sabbioni, E. · Sanner, T. · Vanparys, P.
Keywords: Toxicology · Physiological sciences · Animal testing replacement · Animal testing alternatives · Chromosome aberration · Comet assay · DNA damage · DNA synthesis · Gene mutation · Genotoxicity · In vitro study · In vivo study · Micronucleus test · Mitotic recombination · Mutagenicity · Sister chromatid exchange · Toxicity testing · Toxicogenetics · Toxicokinetics · Toxicological parameters · Carcinogen testing · Cell culture · Chemistry · Legal aspects · Structure activity relation · Animalia · Consumer product safety · Cosmetics · European Union · Structure-Activity Relationship

10 A First Exploration of Health Impact Assessment of Chemical Exposure: Assigning Weights to Subclinical Effects Based on Animal Studies
article 2015    
Author: Burg, W. ter · Bokkers, B.G.H. · Kroese, E.D. · Schuur, A.G.
Keywords: Biology · Animal testing · Benchmark dose · Disability adjusted life year (DALY) · Dose–response relationship · Health impact assessment (HIA) · Subclinical effects · Animalia · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

11 Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose-response curves for developmental toxicity of phenol in rat and human
article 2013    
Author: Strikwold, M. · Spenkelink, B. · Woutersen, R.A. · Rietjens, I.M.C.M. · Punt, A.
Keywords: Biology · Alternative for animal testing · Embryonic stem cell test (EST) · In vitro-in vivo (IVIV) extrapolation · Phenol · Physiologically based kinetic (PBK) modelling · Risk assessment · Biomedical Innovation · Healthy Living · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

12 Optimisation of the post-validation process: The report and recommendations of ECVAM workshop 67
article 2008    
Author: Bottini, A.A. · Alepee, N. · Phillips, B. · Gribaldo, L. · Silva, O. de · Hartung, T. · Hendriksen, C. · Kuil, J. · Pazos, P. · Rhein, C. · Schiffelers, M.-J. · Stokes, W. · Theobald, A. · Vidal, J.-M. · Sandt, H. van de · Breier, S. · Sintes, J.R. · Blaauboer, B.
Keywords: Nutrition · Food and Chemical Risk Analysis · animal welfare · conference paper · health care policy · industry · law · medical research · priority journal · public health problem · skin test · validation process · Animal Testing Alternatives · Animals · Health Planning Guidelines · Validation Studies as Topic

13 Physiologically-based kinetic modelling (PBK modelling): Meeting the 3Rs agenda. The report and recommendations of ECVAM workshop 63
article 2007    
Author: Bouvier D'Yvoire, M. · Prieto, P. · Blaauboer, B.J. · Bois, F.Y. · Boobis, A. · Brochot, C. · Coecke, S. · Freidig, A. · Gundert-Remy, U. · Hartung, T. · Jacobs, M.N. · Lavé, T. · Leahy, D.E. · Lennernäs, H. · Loizou, G.D. · Meek, B. · Pease, C. · Rowland, M. · Spendiff, M. · Yang, J. · Zeilmaker, M.
Keywords: Biology · Biomedical Research · toxic substance · animal welfare · excretion · experimental animal · human · kinetics · medical research · metabolism · nonhuman · priority journal · review · risk assessment · Animal Testing Alternatives · Animals · Kinetics · Models, Biological · Physiology · Reproducibility of Results · Toxicology

14 Evaluation of research activities and research needs to increase the impact and applicability of alternative testing strategies in risk assessment practice
article 2011    
Author: Punt, A. · Schiffelers, M.J.W.A. · Jean Horbach, G. · Sandt, J.J.M. van de · Groothuis, G.M.M. · Rietjens, I.M.C.M. · Blaauboer, B.J.
Keywords: Nutrition · Alternatives to animal testing · Genomics · In vitro testing · PBK modeling · QSAR · Reduction replacement refinement · Risk assessment · Stem cells · Three R's · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

15 The Draize Eye Test and in vitro alternatives; a left-handed marriage?
article 2006    
Author: Prinsen, M.K.
Keywords: Biology · Toxicology and Applied Pharmacology · Draize Eye Test · In vitro assay · Validation · article · draize eye test · exposure · in vitro study · nonhuman · solid · technique · validation process · Acute Toxicity Tests · Animal Testing Alternatives · Animals · Eye · Irritants · Rabbits · Reproducibility of Results

16 Release of arachidonic and linoleic acid metabolites in skin organ cultures as characteristics of in vitro skin irritancy
article 1995    
Author: Sandt, J.J.M. van de · Maas, W.J.M. · Doornink, P.C. · Rutten, A.A.J.J.L.
Keywords: Biology · Animal · Animal Testing Alternatives · Arachidonic Acid · Benzalkonium Compounds · Eicosanoids · Epidermis · Female · Formaldehyde · Human · Hydroxyeicosatetraenoic Acids · In Vitro · Irritants · Linoleic Acid · Linoleic Acids · Male · Organ Culture · Rabbits · Skin · Sodium Dodecyl Sulfate · Support, Non-U.S. Gov't · Toxicity Tests
[Abstract]

17 Integrated in vitro-in silico models for predicting in vivo development toxicity: facilitating non-animal based safety asssment
dissertation 2012    
Author: Louisse, J.
Keywords: Toxicology · Embryonale ontwikkeling · Foetale ontwikkeling · In vitro kweek · Toxiciteit · Biomarkers · Computational science · Alternatieven voor dierproeven · Risicoschatting · Embryonic development · Fetal development · In vitro culture · Toxicity · Animal testing alternatives · Risk assessment · Biomedical Innovation · Healthy Living
[PDF]

18 Development of a combined in Vitro Physiologically Based Kinetic (PBK) and Monte Carlo modelling approach to predict interindividual human variation in phenol-induced developmental toxicity
article 2017    
Author: Strikwold, M. · Spenkelink, B. · Woutersen, R.A. · Rietjens, I.M.C.M. · Punt, A.
Keywords: Nutrition · Alternatives for animal testing · In vitro-in vivo extrapolation (IVIVE) · Interindividual differences · Monte Carlo simulation · PBK or PBPK modelling · UGT · Food and Nutrition · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

19 Estimation of the acute inhalation hazards of chemicals based on route-to-route and local endpoint extrapolation: Experience from Bulk Maritime Transport
article 2011    
Author: Höfer, T. · James, D. · Syversen, T. · Bowmer, T.
Keywords: Acute inhalation toxicity · ATE · Chemical safety · GESAMP · GHS · Globally harmonized system · Hazard assessment · LC50 · Maritime transport · Route-to-route extrapolation · acute toxicity · animal experiment · animal testing alternative · animal testing reduction · article · dangerous goods · dangerous goods transport · dermis · environmental protection · eye toxicity · health hazard · human · inhalation · liquid · nonhuman · organization · priority journal · ship · skin toxicity · Sustainable Chemical Industry · Industrial Innovation · Triskelion BV · AR - Analytical Research · TNO Bedrijven
[Abstract]

20 REACH, non-testing approaches and the urgent need for a change in mind set
article 2009    
Author: Schaafsma, G. · Kroese, E.D. · Tielemans, E.L.J.P. · Sandt, J.J.M. van de · Leeuwen, C.J. van
Keywords: Chemistry · Food and Chemical Risk Analysis · Intelligent testing strategies · Mind set change · Non-testing · REACH · Uncertainty paradox · chemical agent · acute toxicity · animal testing alternative · article · chronic toxicity · cost · drug screening · environmental exposure · hazard assessment · health care policy · human · human tissue · in vivo study · priority journal · process optimization · public opinion · REACH program · reproductive toxicity · risk assessment · skin toxicity · toxicity testing · uncertainty · Animal Testing Alternatives · Animals · Databases, Factual · Environmental Exposure · Europe · Hazardous Substances · Humans · Registries · Risk Assessment · Toxicity Tests · Animalia
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 32 found. Next | Sort by date