Repository hosted by TU Delft Library

Home · Contact · About · Disclaimer ·
 

Search results also available in MS Excel format.

Showing 1 to 20 of 62 found. Next | Sort by date

1 Use of transgenic mice in lipoprotein metabolism and atherosclerosis research
article 1997    
Author: Havekes, L.M. · Vlijmen, B.J.M. van · Jong, M.C. · Dijk, K.W. van · Hofker, M.H.
Keywords: Biology · Age Factors · Animals · Apolipoprotein E3 · Apolipoproteins C · Apolipoproteins E · Arteriosclerosis · Cholesterol · Female · Humans · Lipids · Lipoproteins · Lipoproteins, VLDL · Male · Mice · Mice, Transgenic · Sex Factors · Animalia · Mus musculus
[Abstract]

2 Mice expressing only the mutant APOE3Leiden gene show impaired VLDL secretion
article 2001    
Author: Mensenkamp, A.R. · Teusink, B. · Baller, J.F.W. · Wolters, H. · Havinga, R. · Dijk, K.W. van · Havekes, L.M. · Kuipers, F.
Keywords: Animals · Apolipoprotein E3 · Apolipoproteins B · Apolipoproteins E · Fatty Liver · Lipid Metabolism · Lipoproteins, VLDL · Liver · Mice · Mice, Transgenic · Protein Isoforms · RNA, Messenger · Triglycerides
[Abstract]

3 Atherosclerosis in APOE(*)3-Leiden transgenic mice from proliferative to atheromatous stage
article 1999    
Author: Lutgens, E. · Daemen, M. · Kockx, M. · Doevendans, P. · Hofker, M. · Havekes, L. · Wellens, H. · Muinck, E.D. de
Keywords: Biology · Apoptosis · Atherosclerosis · Genetics · Animals · Apolipoprotein E3 · Apolipoproteins E · Apoptosis · Arteriosclerosis · Diet, Atherogenic · Disease Models, Animal · Disease Progression · DNA · Female · Foam Cells · Male · Mice · Mice, Transgenic · Phenotype
[Abstract]

4 Accelerated atherosclerosis and calcification in vein grafts: A study in APOE*3 Leiden transgenic mice
article 2002    
Author: Lardenoye, J.H.P. · Vries, M.R. de · Löwik, C.W.G.M. · Xu, Q. · Dhore, C.R. · Cleutjens, J.P.M. · Hinsbergh, V.W.M. van · Bockel, J.H. van · Quax, P.H.A.
Keywords: Animals · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Calcinosis · Foam Cells · Graft Rejection · Hypercholesterolemia · Kinetics · Lipids · Male · Mice · Mice, Inbred C57BL · Mice, Transgenic · Veins
[Abstract]

5 Time-resolved and tissue-specific systems analysis of the pathogenesis of insulin resistance.
article 2010    
Author: Kleemann, R. · Erk, M. van · Verschuren, L. · Hoek, A.M. van den · Koek, M. · Wielinga, P.Y. · Jie, A. · Pellis, L. · Bobeldijk-Pastorova, I. · Kelder, T. · Toet, K. · Wopereis, S. · Cnubben, N. · Evelo, C. · Ommen, B. van · Kooistra, T.
Keywords: Biology · Biomedical Research · Apolipoprotein E3 · Fatty acid · Blood · DNA microarray · Genetics · Obesity · physiology · transgenic mouse · Western blotting · Adiposity · Animals · Apolipoprotein E3 · Blotting, Western · Fatty Acids, Nonesterified · Glucose Tolerance Test · Insulin Resistance · Male · Mice · Mice, Transgenic · Oligonucleotide Array Sequence Analysis · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

6 Preferential campesterol incorporation into various tissues in apolipoprotein E*3-Leiden mice consuming plant sterols or stanols
article 2008    
Author: Plat, J. · Jong, A.de · Volger, O.L. · Princen, H.M.G. · Mensink, R.P.
Keywords: Biology · Biomedical Research · apolipoprotein E3 · campesterol · cholesterol · phytosterol · sitosterol · stanol ester · animal experiment · animal tissue · article · concentration (parameters) · controlled study · diet supplementation · female · mouse · nonhuman · priority journal · tissue distribution · Animals · Apolipoprotein E3 · Cholesterol · Diet · Female · Mice · Mice, Transgenic · Osmolar Concentration · Phytosterols · Sitosterols · Tissue Distribution
[Abstract]

7 Acute inhibition of hepatic β-oxidation in APOE*3Leiden mice does not affect hepatic VLDL secretion or insulin sensitivity
article 2005    
Author: Duivenvoorden, I. · Teusink, B. · Rensen, P.C.N. · Kuipers, F. · Romijn, J.A. · Havekes, L.M. · Voshol, P.J.
Keywords: Biology · Biomedical Research · Fatty acids · Glucose metabolism · Steatosis · Triglycerides · Very low density lipoprotein · 3 hydroxybutyrate dehydrogenase · carnitine palmitoyltransferase inhibitor · cholesterol · insulin · palmoxiric acid · triacylglycerol · very low density lipoprotein · apolipoprotein E · apolipoprotein E3 · apolipoprotein E3 (Leidein) · fatty acid · messenger RNA · analytic method · animal cell · animal experiment · article · cholesterol blood level · comparative study · controlled study · fatty acid oxidation · gluconeogenesis · insulin blood level · insulin sensitivity · ketogenesis · mouse · nonhuman · transgenic mouse · animal · blood · genetics · insulin resistance · metabolism · oxidation reduction reaction · physiology · secretion · Animals · Apolipoprotein E3 · Apolipoproteins E · Fatty Acids, Nonesterified · Insulin Resistance · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Transgenic · Oxidation-Reduction · RNA, Messenger
[PDF] [Abstract]

8 Hyperlipidemia of ApoE2(Arg158-Cys) and ApoE3-Leiden transgenic mice is modulated predominantly by LDL receptor expression
article 1999    
Author: Dijk, K.W. van · Vlijmen, B.J.M. van · Winther, M.P.J. de · Hof, B. van 't · Zee, A. van der · Boom, H. van der · Havekes, L.M. · Hofker, M.H.
Keywords: Biology · Apolipoprotein E · Hypertriglyceridemia · LDL receptor · LDL receptor-related protein · VLDL triglyceride lipolysis · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Cholesterol, VLDL · Gene Expression · Hypertriglyceridemia · Lipolysis · Mice · Mice, Knockout · Point Mutation · Receptors, LDL · Triglycerides
[Abstract]

9 Inhibition of accelerated atherosclerosis in vein grafts by placement of external stent in ApoE*3-Leiden transgenic mice
article 2002    
Author: Lardenoye, J.H.P. · Vries, M.R. de · Grimbergen, J.M. · Havekes, L.M. · Knaapen, M.W.M. · Kockx, M.M. · Hinsbergh, V.W.M. van · Bockel, J.H. van · Quax, P.H.A.
Keywords: Animals · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Carotid Arteries · Disease Progression · Endothelium, Vascular · Foam Cells · Graft Occlusion, Vascular · Hypercholesterolemia · Male · Mice · Mice, Inbred C57BL · Mice, Transgenic · Stents · Tunica Intima · Veins
[Abstract]

10 Cafestol increases serum cholesterol levels in apolipoprotein E*3- leiden transgenic mice by suppression of bile acid synthesis
article 2000    
Author: Post, S.M. · Roos, B.de · Vermeulen, M. · Afman, L. · Jong, M.C. · Dahlmans, V.E.H. · Havekes, L.M. · Stellaard, F. · Katan, M.B. · Princen, H.M.G.
Keywords: Biology · Animals · Apolipoprotein E3 · Apolipoproteins E · Bile Acids and Salts · Cholesterol · Diet · Diterpenes · Feces · Female · Lipid Metabolism · Lipoproteins · Lipoproteins, IDL · Lipoproteins, VLDL · Liver · Mice · Mice, Inbred C57BL · Mice, Knockout · Mice, Transgenic · Receptors, LDL
[Abstract]

11 Apolipoprotein E2 (Lys146→Gln) causes hypertriglyceridemia due to an apolipoprotein E variant-specific inhibition of lipolysis of very low density lipoproteins-triglycerides
article 2000    
Author: Beer, F. de · Dijk, K.W. van · Jong, M.C. · Vark, L.C. van · Zee, A. van der · Hofker, M.H. · Fallaux, F.J. · Hoeben, R.C. · Smelt, A.H.M. · Havekes, L.M.
Keywords: Adenoviridae · Alleles · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Gene Expression · Gene Transfer Techniques · Humans · Hydrolysis · Hyperlipoproteinemia Type III · Hypertriglyceridemia · Lipolysis · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Knockout · Point Mutation · RNA, Messenger · Triglycerides
[Abstract]

12 Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice
article 1999    
Author: Winther, M.P.J. de · Gijbels, M.J.J. · Dijk, K.W. van · Gorp, P.J.J. van · Suzuki, H. · Kodama, T. · Frants, R.R. · Havekes, L.M. · Hofker, M.H.
Keywords: Biology · Apolipoprotein E · Atherosclerosis · Mouse models · Animals · Aorta, Thoracic · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Diet, Atherogenic · Female · Humans · Male · Membrane Proteins · Mice · Mice, Knockout · Mice, Transgenic · Receptors, Immunologic · Receptors, Lipoprotein · Receptors, Scavenger · Risk Factors · Scavenger Receptors, Class B
[Abstract]

13 Binding of β-VLDL to heparan sulfate proteoglycans requires lipoprotein lipase, whereas apoE only modulates binding affinity
article 1999    
Author: Beer, F. de · Hendriks, W.L. · Vark, L.C. van · Kamerling, S.W.A. · Dijk, K.W. van · Hofker, M.H. · Smelt, A.H.M. · Havekes, L.M.
Keywords: Biology · β-VLDL · apoE · Heparan sulfate proteoglycans · Lipoprotein lipase · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Binding, Competitive · Cell Line · Cholesterol, VLDL · Heparan Sulfate Proteoglycans · Iodine Radioisotopes · Lipoprotein Lipase · Macrophages · Mice · Mice, Knockout
[Abstract]

14 Reversal of hypercholesterolemia in apolipoprotein E2 and apolipoprotein E3-Leiden transgenic mice by adenovirus-mediated gene transfer of the VLDL receptor
article 1998    
Author: Dijk, K.W. van · Vlijmen, B.J.M. van · Zee, A. van der · Hof, B. van 't · Boom, H. van der · Kobayashi, K. · Chan, L. · Havekes, L.M. · Hofker, M.H.
Keywords: Health · ApoE variants · Atherosclerosis · Gene therapy · VLDL receptor · Adenoviridae · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Cholesterol · Female · Gene Transfer Techniques · Humans · Hypercholesterolemia · Mice · Mice, Knockout · Mice, Transgenic · Receptors, LDL · Triglycerides
[Abstract]

15 Effect of apolipoprotein E variants on lipolysis of very low density lipoproteins by heparan sulphate proteoglycan-bound lipoprotein lipase
article 1998    
Author: Man, F.H.A.F. de · Beer, F. de · Laarse, A. van der · Smelt, A.H.M. · Leuven, J.A.G. · Havekes, L.M.
Keywords: Health · Atherosclerosis · Familial dysbetalipoproteinemia · Metabolism · Triglyceride · VLDL · Adult · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Female · Heparan Sulfate Proteoglycans · Heterozygote · Homozygote · Humans · Hyperlipoproteinemia Type III · Lipolysis · Lipoprotein Lipase · Lipoproteins, VLDL · Male · Middle Aged
[Abstract]

16 Acyl-CoA:Cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE*3-leiden mice
article 2001    
Author: Delsing, D.J.M. · Offerman, E.H. · Duyvenvoorde, W. van · Boom, H. van der · Wit, E.C.M. de · Gijbels, M.J.J. · Laarse, A. van der · Jukema, J.W. · Havekes, L.M. · Princen, H.M.G.
Keywords: Biology · Acetates · Animals · Anticholesteremic Agents · Aortic Valve · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Body Weight · Cell Adhesion · Cell Line · Cholesterol · Diet, Atherogenic · Disease Models, Animal · Eating · Endothelium, Vascular · Female · Heterozygote · Lipoproteins · Macrophages · Mice · Mice, Transgenic · Sterol O-Acyltransferase · Sulfonic Acids
[Abstract]

17 Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis in APOE*3Leiden mice
article 2006    
Author: Duivenvoorden, I. · Voshol, P.J. · Rensen, P.C.N. · Duyvenvoorde, W. van · Romijn, J.A. · Emeis, J.J. · Havekes, L.M. · Nieuwenhuizen, W.F.
Keywords: Health Biology · Food technology · APOE*3Leiden mice · Cholesterol · Free fatty acids · Sphingolipids · Steatosis · Triacylglycerol · alanine aminotransferase · amyloid · apolipoprotein E3 · cholesterol · cholesterol ester · fatty acid · messenger RNA · phytosphingosine · RNA · sphingolipid · triacylglycerol · apolipoprotein E · apolipoprotein E3 (Leidein) · very low density lipoprotein · animal experiment · animal model · animal tissue · article · cholesterol blood level · cholesterol metabolism · controlled study · diet supplementation · dose response · drug effect · drug structure · fatty liver · female · gene expression · hepatitis · lipogenesis · lipolysis · mouse · nonhuman · nutritional assessment · plasma clearance · prophylaxis · animal · blood · chemistry · cholesterol intake · enzymology · feces · genetics · intestine absorption · lipid metabolism · liver · metabolism · physiology · randomization · transgenic mouse · Animals · Apolipoprotein E3 · Apolipoproteins E · Cholesterol · Cholesterol, Dietary · Dose-Response Relationship, Drug · Fatty Acids, Nonesterified · Fatty Liver · Feces · Female · Gene Expression · Intestinal Absorption · Lipid Metabolism · Lipolysis · Lipoproteins, VLDL · Liver · Mice · Mice, Transgenic · Random Allocation · RNA · Sphingolipids · Triglycerides
[Abstract]

18 Local lentiviral short hairpin RNA silencing of CCR2 inhibits vein graft thickening in hypercholesterolemic apolipoprotein E3-Leiden mice
article 2009    
Author: Eefting, D. · Bot, I. · Vries, M.R. de · Schepers, A. · Bockel, J.H. van · Berkel, T.J.C. van · Biessen, E.A.L. · Quax, P.H.A.
Keywords: Biology · Biomedical Research · apolipoprotein E3 · chemokine receptor CCR2 · lentiviral short hairpin RNA · lentivirus vector · messenger RNA · monocyte chemotactic protein 1 · unclassified drug · animal cell · animal model · article · atherosclerosis · carotid artery · cell migration · cell proliferation · clinical feature · controlled study · disease course · drug delivery system · drug efficacy · drug targeting · gene silencing · gene therapy · hypercholesterolemia · in vitro study · in vivo study · infection · Lentivirinae · male · morphometrics · mouse · nonhuman · priority journal · protein expression · receptor upregulation · smooth muscle fiber · treatment outcome · vein graft · vein graft disease · vein surgery · viral gene delivery system · Animals · Apolipoprotein E3 · Atherosclerosis · Chemokine CCL2 · Disease Models, Animal · Graft Occlusion, Vascular · Hypercholesterolemia · Lentivirus · Male · Mice · Receptors, CCR2 · RNA Interference · Veins
[Abstract]

19 Methods for the differential integrative omic analysis of plasma from a transgenic disease animal model
article 2004    
Author: Davidov, E. · Clish, C.B. · Oresic, M. · Meys, M. · Stochaj, W. · Snell, P. · Lavine, G. · Londo, T.R. · Adourian, A. · Zhang, X. · Johnston, M. · Morel, N. · Marple, E.W. · Plasterer, T.N. · Neumann, E. · Verheij, E. · Vogels, J.T.W.E. · Havekes, L.M. · Greef, J. van der · Naylor, S.
Keywords: Biology · Analytical research · Biomedical research · Apolipoprotein E3 · Lipid · Protein · Analytic method · Animal experiment · Animal model · Computer program · Controlled study · Correlation analysis · DNA modification · Gene mutation · Information processing · Lipoprotein metabolism · Metabolic regulation · Metabolite · Mouse · Multivariate analysis · Nonhuman · Plasma · Quantitative analysis · Transgenic mouse · Animals · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Chromatography, Liquid · Crosses, Genetic · Female · Genes, Dominant · Genetic Techniques · Humans · Hyperlipoproteinemias · Lipid Metabolism · Lipoproteins · Magnetic Resonance Spectroscopy · Male · Mass Spectrometry · Mice · Mice, Inbred C57BL · Mice, Transgenic · Multivariate Analysis · Mutation · Peptides · Principal Component Analysis · Proteins · Software · Time Factors · Trypsin
[Abstract]

20 No effect of C-reactive protein on early atherosclerosis development in apolipoprotein E*3-Leiden/human C-reactive protein transgenic mice
article 2005    
Author: Trion, A. · Maat, M.P.M. de · Jukema, J.W. · Laarse, A. van der · Maas, M.C. · Offerman, E.H. · Havekes, L.M. · Szalai, A.J. · Princen, H.M.G. · Emeis, J.J.
Keywords: Biology · Biomedical Research · Atherosclerosis · C-reactive protein · Inflammation · Mouse · Transgene · Acute phase protein · Apolipoprotein E3 Leiden · Biological marker · C reactive protein · Cholesterol · Unclassified drug · Animal experiment · Animal model · Animal tissue · Atherogenesis · Blood sampling · Cardiovascular risk · Cholesterol blood level · Cholesterol diet · Controlled study · Enzyme linked immunosorbent assay · Experimental model · Histopathology · Hypercholesterolemia · Immunohistochemistry · Inflammation · Mouse strain · Nonhuman · Pathophysiology · Protein blood level · Protein expression · Protein function · Transgenic mouse · Animals · Apolipoprotein E3 · Apolipoproteins E · Atherosclerosis · Biological Markers · Body Weight · C-Reactive Protein · Cholesterol · Early Diagnosis · Eating · Endothelium, Vascular · Female · Humans · Hypercholesterolemia · Male · Mice · Mice, Transgenic · Monocytes · Risk Factors · Severity of Illness Index
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 62 found. Next | Sort by date