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Showing 1 to 9 of 9 found. | Sort by date

1 Insulin suppresses bile acid synthesis in cultured rat hepatocytes by down-regulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase gene transcription
article 1995    
Author: Twisk, J. · Hoekman, M.F.M. · Lehmann, E.M. · Meijer, P. · Mager, W.H. · Princen, H.M.G.
Keywords: Biology · cholesterol 7alpha monooxygenase · insulin · oxygenase · sterol 27 hydroxylase · unclassified drug · animal cell · article · bile acid synthesis · controlled study · down regulation · enzyme activity · gene expression regulation · hormone action · liver cell culture · nonhuman · transcription regulation · Animal · Bile Acids and Salts · Cells, Cultured · Chloramphenicol O-Acetyltransferase · Cholesterol 7-alpha-Hydroxylase · Cytochrome P-450 Enzyme System · Down-Regulation · Gene Expression Regulation, Enzymologic · Insulin · Liver · Male · Membrane Glycoproteins · Nuclear Proteins · Rats · Rats, Wistar · RNA, Messenger · Steroid Hydroxylases · Support, Non-U.S. Gov't · Transcription, Genetic · Transfection
[Abstract]

2 Heterogeneous expression of cholesterol 7α-hydroxylase and sterol 27- hydroxylase genes in the rat liver lobulus
article 1995    
Author: Twisk, J. · Hoekman, M.F.M. · Mager, W.H. · Moorman, A.F.M. · Boer, P.A.J. de · Scheja, L. · Princen, H.M.G. · Gebhardt, R.
Keywords: Health · 3 hydroxy 3 methylglutaryl coenzyme a · alanine aminotransferase · cholesterol 7alpha monooxygenase · colestipol · glutamate ammonia ligase · glyceraldehyde 3 phosphate dehydrogenase · messenger rna · pyruvate kinase · sterol 27 hydroxylase · unclassified drug · animal cell · animal experiment · bile acid synthesis · controlled study · enterohepatic circulation · enzyme isolation · enzyme localization · gene expression · in situ hybridization · liver metabolism · sterol analysis · Animal · Biological Markers · Blotting, Northern · Cell Separation · Cholesterol 7-alpha-Hydroxylase · Colestipol · Cytochrome P-450 Enzyme System · Gene Expression Regulation, Enzymologic · In Situ Hybridization · Liver · Male · Rats · Rats, Sprague-Dawley · RNA, Messenger · Steroid Hydroxylases · Support, Non-U.S. Gov't · Tissue Distribution · Transcription, Genetic
[Abstract]

3 Suppression of sterol 27-hydroxylase mRNA and transcriptional activity by bile acids in cultured rat hepatocytes
article 1995    
Author: Twisk, J. · Wit, E.C.M. de · Princen, H.M.G.
Keywords: Biology · bile acid · chenodeoxycholic acid · cholesterol 7alpha monooxygenase · cholic acid · deoxycholic acid · lithocholic acid · messenger rna · oxygenase · sterol · taurocholic acid · animal cell · article · bile acid synthesis · cholesterol metabolism · controlled study · enzyme inhibition · gene repression · liver cell culture · nonhuman · priority journal · rat · transcription regulation · Adenosine Triphosphate · Animal · Bile Acids and Salts · Cells, Cultured · Cholesterol 7-alpha-Hydroxylase · Cytochrome P-450 Enzyme System · Dose-Response Relationship, Drug · Down-Regulation · Gene Expression Regulation, Enzymologic · Liver · Male · Mitochondria · Oxidoreductases · Rats · Rats, Wistar · RNA, Messenger · Steroid Hydroxylases · Support, Non-U.S. Gov't · Taurocholic Acid · Transcription, Genetic
[Abstract]

4 Differential feedback regulation of cholesterol 7α-hydroxylase mRNA and transcriptional activity by rat bile acids in primary monolayer cultures of rat hepatocytes
article 1993    
Author: Twisk, J. · Lehmann, E.M. · Princen, H.M.G.
Keywords: Health · bile acid · chenodeoxycholic acid · cholesterol 7alpha monooxygenase · deoxycholic acid · glycocholic acid · messenger rna · animal cell · bile acid synthesis · controlled study · culture medium · dose time effect relation · down regulation · enzyme activity · enzyme regulation · feedback system · gene expression regulation · gene repression · genetic transcription · hydrophobicity · kinetics · liver cell · liver cell culture · monolayer culture · negative feedback · nonhuman · transcription regulation · Animal · Base Sequence · Bile Acids and Salts · Cells, Cultured · Chenodeoxycholic Acid · Cholesterol 7-alpha-Hydroxylase · Cholic Acid · Cholic Acids · Feedback · Gene Expression Regulation · Glycocholic Acid · Kinetics · Liver · Male · Molecular Sequence Data · Rats · RNA, Messenger · Support, Non-U.S. Gov't · Taurocholic Acid · Transcription, Genetic
[Abstract]

5 Cholesterol 7α-hydroxylase deficiency in mice on an APOE*3-Leiden background increases hepatic ABCA1 mRNA expression and HDL-cholesterol
article 2006    
Author: Post, S.M. · Groenendijk, M. · Hoogt, C.C. van der · Fievet, C. · Luc, G. · Hoekstra, M. · Princen, H.M.G. · Staels, B. · Rensen, P.C.N.
Keywords: Health · Biomedical Research · High-density lipoprotein · ABC transporter A1 · High density lipoprotein cholesterol · Intermediate density lipoprotein · Low density lipoprotein · Messenger RNA · Phosphatidylcholine sterol acyltransferase · Very low density lipoprotein · Bile acid · Phospholipid transfer protein · Phospholipid transfer protein, mouse · Animal experiment · Animal tissue · Bile acid synthesis · Biosynthesis · Catabolism · Cholesterol blood level · Cholesterol metabolism · cholesterol transport · Conhuman · Protein expression · Transgenic mouse · Genetics · Metabolism · Mouse · Mouse mutant · Physiology · Animals · Apolipoprotein E3 · ATP-Binding Cassette Transporters · Bile Acids and Salts · Cholesterol 7-alpha-Hydroxylase · Cholesterol, HDL · Female · Gene Expression Regulation · Gene Expression Regulation, Enzymologic · Humans · Liver · Mice · Mice, Knockout · Mice, Transgenic · Phosphatidylcholine-Sterol O-Acyltransferase · Phospholipid Transfer Proteins · RNA, Messenger
[Abstract]

6 Quantitative profiling of bile acids in biofluids and tissues based on accurate mass high resolution LC-FT-MS: Compound class targeting in a metabolomics workflow
article 2008    
Author: Bobeldijk, I. · Hekman, M. · Vries de- Weij, J.van der · Coulier, L. · Ramaker, R. · Kleemann, R. · Kooistra, T. · Rubingh, C. · Freidig, A. · Verheij, E.
Keywords: Analytical research · Accurate mass · Bile acids · Body fluids · High performance liquid chromatography · Metabolomics · Targeted metabolite profiling · Tissues · Acids · Arsenic compounds · Chlorine compounds · Cholesterol · Chromatographic analysis · Complexation · Electrospray ionization · Fourier transforms · High performance liquid chromatography · Histology · Ionization · Ionization of liquids · Liquid chromatography · Liquid phase epitaxy · Liver · Mass spectrometers · Mass spectrometry · Metabolites · Phase separation · Plasmas · Separation · Spectrometers · Spectrometry · Sulfate minerals · Accurate mass · Bile acid synthesis · Bile acids · Bio-fluids · Biological fluids · Cholesterol homeostasis · Chromatography-mass spectrometry · Electro spraying · Fourier Transform Mass Spectrometer · Generic methods · High resolutions · HPLC-MS · Human plasmas · Human urine · Linear ion trap · Metabolomics · Mouse liver · Pooled samples · Reversed-phase high performance · Sample preparations · Targeted metabolite profiling · Tissues · Body fluids · Bile acid · Glycine · Sulfate · Accuracy · Animal experiment · Animal tissue · Article · Bile acid synthesis · Body fluid · Cholesterol intake · Cholesterol liver level · Controlled study · Electrospray · Fourier transform mass spectrometry · Homeostasis · Human · Liver · Metabolite · Metabolomics · Nonhuman · Priority journal · Quantitative analysis · Reversed phase high performance liquid chromatography · Statistical significance · Tissue · Animals · Bile Acids and Salts · Cholesterol, Dietary · Chromatography, Liquid · Computational Biology · Fourier Analysis · Humans · Liver · Mass Spectrometry · Metabolism · Mice · Reproducibility of Results
[Abstract]

7 Determinants of postprandial plasma bile acid kinetics in human volunteers
article 2017    
Author: Fiamoncini, J. · Yiorkas, A.M. · Gedrich, K. · Rundle, M. · Alsters, S.I. · Roeselers, G. · Broek, T.J. van den · Clavel, T. · Lagkouvardos, I. · Wopereis, S. · Frost, G. · Ommen, B. van · Blakemore, A.I. · Daniel, H.
Keywords: Biology · Bile acids · Mixed-meal tolerance test · Oral glucose tolerance test · Postprandial · SLCO1A2 · Chenodeoxycholic acid · Cholic acid · Deoxycholic acid · Genomic DNA · Glycine · Glycochenodeoxycholic acid · Glycocholic acid · Glycodeoxycholic acid · Glycoursodeoxycholic acid · Solute carrier organic anion transporter 1A2 · Taurine · Taurochenodeoxycholic acid · Taurocholic acid · Taurodeoxycholic acid · Taurolitocholic acid · Tauroursodeoxycholic acid · Unclassified drug · Ursodeoxycholic acid · Bile acid blood level · Bile acid synthesis · Clinical trial · Diet restriction · Dietary intake · Enterohepatic circulation · Feces microflora · Gene expression · Genome analysis · Kinetics · Liquid chromatography-mass spectrometry · Oral glucose tolerance test · Phenotype · Postprandial state · Quantitative analysis · Sex difference · Weight reduction · Whole exome sequencing · Blood · Controlled study · Physiology · Randomized controlled trial · Bile Acids and Salts · Fasting · Female · Humans · Male · Metabolic Clearance Rate · Middle Aged · Postprandial Period · Weight Loss · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

8 Cholesterol 7α-Hydroxylase Deficiency in Mice on an APOE*3-Leiden Background Impairs Very-Low-Density Lipoprotein Production
article 2004    
Author: Post, S.M. · Groenendijk, M. · Solaas, K. · Rensen, P.C.N. · Princen, H.M.G.
Keywords: Biology · Biomedical Research · Bile acid biosynthesis · Cholesterol 7α-hydroxylase · SREBP-1 · Bile acid · Cholesterol · Cholesterol 7alpha monooxygenase · Cholesterol ester · Cytochrome P450 isoenzyme · Messenger RNA · Sterol · Sterol regulatory element binding protein 1 · Unclassified drug · Very low density lipoprotein · Vitamin · Acyltransferase · Alpha tocopherol · Apolipoprotein E3 (Leidein) · Dgat1 protein, mouse · Diacylglycerol acyltransferase · Retinol · Animal experiment · Animal model · Animal tissue · Antioxidant activity · Bile acid synthesis · Catalysis · Cholesterol blood level · Cholesterol metabolism · Controlled study · Enzyme deficiency · Feces level · Gene · Gene expression · Hyperlipidemia · Knockout mouse · Lipid diet · Lipid metabolism · Lipogenesis · Lipoprotein synthesis · Nonhuman · Srebf1 gene · Triacylglycerol blood level · Atherogenic diet · Biosynthesis · Blood · Cross breeding · Feces · Genetics · Metabolism · Mouse mutant · Physiology · Acyltransferases · Animals · Apolipoprotein E3 · Apolipoproteins B · Apolipoproteins E · Bile Acids and Salts · Cholesterol 7-alpha-Hydroxylase · Cholesterol Esters · Crosses, Genetic · Diacylglycerol O-Acyltransferase · Diet, Atherogenic · Feces · Female · Hyperlipoproteinemia Type III · Ketone Bodies · Lipid Metabolism · Lipolysis · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Knockout · RNA, Messenger · Sterols · Triglycerides · Vitamin A · Vitamin E
[Abstract]

9 Bile duct proliferation associated with bile salt-induced hypercholeresis in Mdr2 P-glycoprotein-deficient mice
article 2005    
Author: Hulzebos, C.V. · Voshol, P.J. · Wolters, H. · Kruit, J.K. · Ottenhof, R. · Groen, A.K. · Stellaard, F. · Verkade, H.J. · Kuipers, F.
Keywords: Bile flow · Bile formation · Bile salt synthesis · Cholangiocyte · Cholate kinetics · Cholehepatic shunt · beta actin · bile salt · binding protein · carrier protein · chenodeoxycholic acid · cholic acid · deoxycholic acid · glycoprotein P · ileal bile salt binding protein · lithocholic acid · messenger RNA · multidrug resistance protein 2 · multidrug resistance protein 3 · muricholic acid · tauroursodeoxycholic acid · unclassified drug · animal experiment · animal model · animal tissue · bile acid synthesis · cell proliferation · controlled study · dilution · immunohistochemistry · in vivo study · intestine mucosa · intrahepatic bile duct · kinetics · liver parenchyma · male · mouse · nonhuman · nucleotide sequence · protein analysis · protein deficiency · protein expression · upregulation · Western blotting · wild type · Animals · Bile Acids and Salts · Bile Duct Diseases · Bile Ducts · Carrier Proteins · Cell Division · Cholates · Deuterium · Gallbladder · Intestines · Membrane Glycoproteins · Mice · Mice, Mutant Strains · Organic Anion Transporters, Sodium-Dependent · P-Glycoproteins · Phospholipids · RNA, Messenger · Symporters
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 9 of 9 found. | Sort by date