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1 Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole
article 2002    
Author: Smith, R.L. · Adams, T.B. · Doull, J. · Feron, V.J. · Goodman, J.I. · Marnett, L.J. · Portoghese, P.S. · Waddell, W.J. · Wagner, B.M. · Rogers, A.E. · Caldwell, J. · Sipes, I.G.
Keywords: Nutrition · Animals · Biotransformation · Eugenol · Female · Flavoring Agents · Humans · Animalia · Mammalia · RodentiaAnimals · Biotransformation · Eugenol · Female · Flavoring Agents · Humans · Animalia · Mammalia · Rodentia
[Abstract]

2 Involvement of human glutathione S-transferase isoenzymes in the conjugation of cyclophosphamide metabolites with glutathione
article 1994    
Author: Dirven, H.A.A.M. · Ommen, B. van · Bladeren, P.J. van
Keywords: Biology · Biotransformation · Cyclophosphamide · Glutathione · Glutathione Transferase · Human · Isoenzymes · Phosphoramide Mustards · Support, Non-U.S. Gov't
[Abstract]

3 Cytochrome P450 enzyme systems in fungi
article 1998    
Author: Brink, H.M. van den · Gorcom, R.F.M. van · Hondel, C.A.M.J.J. van den · Punt, P.J.
Keywords: Nutrition · Bioconversion · Biotransformation · CPR · CYP · Cytochrome P450 · Index descriptors · Cytochrome p450 · Biotransformation · Fungal genetics · Fungus · Molecular genetics · Nonhuman · Priority journal · Review · Saccharomyces cerevisiae · Cytochrome P-450 Enzyme System · Fungi · Genes, Plant · Multigene Family · Saccharomyces cerevisiae
[Abstract]

4 Geraniol biotransformation-pathway in spores of Penicillium digitatum
article 2001    
Author: Wolken, W.A.M. · Werf, M.J. van der
Keywords: Biology · Penicillium digitatum · Alcohol Oxidoreductases · Biotransformation · Carbon-Carbon Lyases · Kinetics · Monoterpenes · Penicillium · Spores, Fungal · Terpenes · Fungi · Penicillium · Penicillium digitatum
[Abstract]

5 The role of biotransformation in dietary (anti)carcinogenesis
article 1999    
Author: Iersel, M.L.P.S. van · Verhagen, H. · Bladeren, P.J. van
Keywords: Nutrition · (Anti)carcinogenic · Biotransformation · Dietary compound · Modulation · Cytochrome p450 · Glutathione transferase · Biotransformation · Cancer risk · Carcinogenesis · Drug detoxification · Enzyme activity · Genetic polymorphism · Human · Nutrition · Priority journal · Review · Biotransformation · Carcinogens · Cytochrome P-450 Enzyme System · Diet · Gene Expression Regulation, Neoplastic · Glutathione Transferase · Humans · Kinetics · Neoplasms · Variation (Genetics) · Xenobiotics
[Abstract]

6 Toxicity of terpenes to spores and mycelium of Penicillium digitatum
article 2002    
Author: Wolken, W.A.M. · Tramper, J. · Werf, M.J. van der
Keywords: Nutrition · Biotransformation · Cell Division · Colony Count, Microbial · Dose-Response Relationship, Drug · Lethal Dose 50 · Monoterpenes · Mycelium · Penicillium · Sensitivity and Specificity · Species Specificity · Spores, Fungal · Terpenes
[Abstract]

7 Lipase-mediated resolution of branched chain fatty acids
article 2002    
Author: Heinsman, N.W.J.T. · Franssen, M.C.R. · Padt, A. van der · Boom, R.M. · Riet, K. van 't · Groot, A.E. de
Keywords: Nutrition · Branched chain fatty acids · Ester hydrolysis · Esterification · Flavours · Kinetic resolution · Lipases · Transesterification · Biosynthesis · Carboxylic acids · Esterification · Fatty acids · Hydrolysis · Biotransformation · Biocatalysts
[Abstract]

8 Metabolism of sinigrin (2-propenyl glucosinolate) by the human colonic microflora in a dynamic in vitro large-intestinal model
article 2002    
Author: Krul, C.A.M. · Humblot, C. · Philippe, C. · Vermeulen, M. · Nuenen, M. van · Havenaar, R. · Rabot, S.
Keywords: Biology · Adult · Anticarcinogenic Agents · Biotransformation · Brassica · Colon · Cookery · Digestion · Feces · Female · Glucosinolates · Humans · Intestinal Mucosa · Kinetics · Male · Models, Biological · Time Factors
[Abstract]

9 Toxicokinetics and metabolism
article 2005    
Author: Coecke, S. · Blaauboer, B.J. · Elaut, G. · Freeman, S. · Freidig, A. · Gensmantel, N. · Hoet, P. · Kapoulas, V.M. · Ladstetter, B. · Langley, G. · Leahy, D. · Mannens, G. · Meneguz, A. · Monshouwer, M. · Nemery, B. · Pelkonen, O. · Pfaller, W. · Prieto, P. · Proctor, N. · Rogiers, V. · Rostami-Hodjegan, A. · Sabbioni, E. · Steiling, W. · Sandt, J.J.M. van de
Keywords: Toxicology · Food and Chemical Risk Analysis · cosmetic · acute toxicity · artificial membrane · bioavailability · biotransformation · carcinogenicity · cell line · cell strain CACO 2 · computer model · concentration response · electric resistance · eye irritation · genotoxicity · human · metabolism · nonhuman · phototoxicity · plasma protein binding · practice guideline · priority journal · reproductive toxicity · review · skin absorption · skin sensitization · species difference · toxicokinetics · validation process · Animals · Biotransformation · Consumer Product Safety · Cosmetics · Drug Administration Routes · European Union · Humans

10 Effect of short-term dietary administration of eugenol in humans
article 1996    
Author: Rompelberg, C.J.M. · Vogels, J.T.W.E. · Vogel, N. de · Bruijntjes-Rozier, G.C.D.M. · Stenhuis, W.H. · Bogaards, J.J.P. · Verhagen, H.
Keywords: Nutrition · Antigenotoxicity · Eugenol · GST · antitoxin · eugenol · glutathione transferase · mitomycin c · vinblastine · article · biotransformation · blood sampling · chromosome aberration · controlled study · enzyme activity · erythrocyte · genotoxicity · human · human experiment · leukocyte · male · micronucleus · priority journal · xenobiotic metabolism · Acetaminophen · Adult · Antibiotics, Antineoplastic · Antineoplastic Agents, Phytogenic · Biotransformation · Cells, Cultured · Chromosome Aberrations · Cross-Over Studies · Erythrocytes · Eugenol · Glutathione Transferase · Humans · Intervention Studies · Leukocytes · Liver · Magnetic Resonance Spectroscopy · Male · Mitomycin · Vinblastine
[Abstract]

11 Mobilization of PCBs and lindane from soil during in vitro digestion and their distribution among bile salt micelles and proteins of human digestive fluid and the soil
article 2000    
Author: Oomen, A.G. · Sips, A.J.A.M. · Groten, J.P. · Sijm, D.T.H.M. · Tolls, J.
Keywords: Nutrition · Bile salt · Lindane · Polychlorinated biphenyl · Biotransformation · Child · Distribution volume · Human · In vitro study · Ingestion · Mathematical analysis · Micelle · Soil pollution · Stomach juice · Body fluids · Micelles · Polychlorinated biphenyls · Proteins · Bile · Lindane · Soil pollution
[Abstract]

12 Urine profile analysis by field desorption mass spectrometry, a technique for detecting metabolites of xenobiotics. Application to 3,5-dinitro-2-hydroxytoluene
article 1983    
Author: Greef, J. van der · Leegwater, D.C.
Keywords: Nutrition · Dinitro ortho cresol · Drug metabolite · Radioisotope · Xenobiotic agent · Dinitro ortho cresol c 14 · Drug analysis · Drug determination · Mass spectrometry · Methodology · Nonhuman · Thin layer chromatography · Urine · Animal · Biotransformation · Cresols · Dinitrocresols · Male · Rats · Rats, Inbred Strains · Spectrum Analysis, Mass
[Abstract]

13 Dose-dependent kinetics and metabolism of 1,2-dichlorobenzene in rat : effect of pretreatment with phenobarbital
article 1996    
Author: Hissink, A.M. · Ommen, B. van · Bladeren, P.J. van
Keywords: Toxicology · Animals · Bile · Biotransformation · Chlorobenzenes · Chromatography, Gas · Chromatography, High Pressure Liquid · Dose-Response Relationship, Drug · Feces · Hydrolysis · Insecticides · Male · Mass Spectrometry · Phenobarbital · Rats · Rats, Wistar · Tissue Distribution · Animalia · Arene · Rattus norvegicus
[Abstract]

14 Differences in cytochrome P450-mediated biotransformation of 1,2- dichlorobenzene by rat and man: Implications for human risk assessment
article 1996    
Author: Hissink, A.M. · Oudshoorn, M.J. · Ommen, B. van · Haenen, G.R.M.M. · Bladeren, P.J. van
Keywords: 1,2 dichlorobenzene · ascorbic acid · cytochrome p450 · epoxide hydrolase · glutathione · glutathione transferase · isoniazid · phenobarbital · animal cell · animal experiment · article · biotransformation · conjugation · controlled study · covalent bond · human · human cell · hydrolysis · liver microsome metabolism · liver toxicity · male · nonhuman · rat · Animals · Biotransformation · Chlorobenzenes · Chromatography, High Pressure Liquid · Cytochrome P-450 Enzyme System · Humans · Insecticides · Isoenzymes · Male · Microsomes, Liver · Protein Binding · Rats · Rats, Inbred F344 · Rats, Sprague-Dawley · Rats, Wistar · Risk Assessment · Species Specificity · Spectrophotometry, Ultraviolet · Animalia · Rattus norvegicus
[Abstract]

15 A physiologically-based pharmacokinetic (PB-PK) model for ethylene dibromide : relevance of extrahepatic metabolism
article 2000    
Author: Hissink, A.M. · Wormhoudt, L.W. · Sherratt, P.J. · Hayes, J.D. · Commandeur, J.N.M. · Vermeulen, N.P.E. · Bladeren, P.J. van
Keywords: Ethylene dibromide · Extrapolation · Glutathione S-transferase · Interindividual variation · PBPK · Risk assessment · 1,2 dibromoethane · cytochrome P450 · glutathione · glutathione transferase · animal experiment · animal model · article · biotransformation · controlled study · male · nonhuman · pharmacokinetics · prediction · rat · risk assessment · toxicity testing · xenobiotic metabolism · Administration, Oral · Animals · Area Under Curve · Biotransformation · Chromatography, Gas · Cytochrome P-450 Enzyme System · Ethylene Dibromide · Glutathione Transferase · Humans · Injections, Intravenous · Liver · Male · Models, Biological · Rats · Rats, Wistar · Risk Assessment
[Abstract]

16 What can spores do for us?
article 2003    
Author: Wolken, W.A.M. · Tramper, J. · Werf, M.J. van der
Keywords: Biology · Biotechnology · Cells · Radiation · Thermal effects · Toxic materials · Vegetative cells · Biotechnology · Antibiotic agent · Antiinflammatory agent · Antineoplastic agent · Carbohydrate · Ester · Estrogen · Probiotic agent · Progesterone · Steroid · Spore · Biocatalyst · Biological pest control · Biological warfare · Biosensor · Biotransformation · Cancer control · Cell function · Desiccation · Drug transformation · Genetic procedures · Life cycle · Longevity · Microbial pest control · Microspore · Nonhuman · Priority journal · Radiosensitivity · Review · Spore germination · Sporogenesis · Temperature · Weed control · Animals · Biological Warfare · Biosensing Techniques · Biotransformation · Humans · Insects · Neoplasms · Probiotics · Spores
[Abstract]

17 Lack of clastogenic effects in cultured human lymphocytes treated with hydroquinone
article 2003    
Author: Roza, L. · Vogel, N. de · Delft, J.H.M. van
Keywords: Biology Health · Physiological Sciences · Antimutagen · Clastogenicity · Human lymphocytes · Hydroquinone · Mutagenicity · hydrogen peroxide · hydroquinone · hydroquinone derivative · mutagenic agent · oxidizing agent · article · concentration response · controlled study · cytotoxicity · genotoxicity · human · human cell · lymphocyte culture · male · metabolic activation · mutagenicity · normal human · structural chromosome aberration · animal · biotransformation · cell culture · chromatid · chromosome aberration · drug effect · in vitro study · liver · lymphocyte · metabolism · mutagen testing · rat · Wistar rat · Animalia · Animals · Biotransformation · Cells, Cultured · Chromatids · Chromosome Aberrations · Humans · Hydrogen Peroxide · Hydroquinones · Liver · Lymphocytes · Male · Mutagenicity Tests · Mutagens · Oxidants · Rats · Rats, Wistar
[Abstract]

18 Hepatic epoxide concentrations during biotransformation of 1,2- and 1,4- dichlorobenzene: The use of in vitro and in vivo metabolism, kinetics and PB- PK modeling
article 1996    
Author: Hissink, E. · Ommen, B. van · Bogaards, J.J. · Bladeren, P.J. van
Keywords: Toxicology · 1,2 dichlorobenzene · 1,4 dichlorobenzene · alanine aminotransferase · ascorbic acid · cytochrome p450 isoenzyme · epoxide · glutathione · isoniazid · animal cell · animal experiment · animal model · biotransformation · conference paper · controlled study · detoxification · enzyme substrate · liver microsome · liver toxicity · male · mathematical model · nonhuman · priority journal · rat · toxicokinetics · Animals · Biotransformation · Carcinogens · Chlorobenzenes · Cytochrome P-450 Enzyme System · Epoxy Compounds · Humans · Liver · Male · Microsomes, Liver · Models, Biological · Rats · Rats, Wistar

19 Interactions of prostaglandin A2 with the glutathione-mediated biotransformation system
article 1999    
Author: Iersel, M.L.P.S. van · Cnubben, N.H.P. · Smink, N. · Koeman, J.H. · Bladeren, P.J. van
Keywords: Nutrition · Cells · Glutathione S-transferases · Inhibition · Metabolism · Prostaglandin A2 · 1 chloro 2,4 dinitrobenzene · Glutathione · Glutathione transferase · Prostaglandin a2 · Glutathione transferase P1 · GSTP1 protein, human · Isoenzyme · Prostaglandin A · Prostaglandin A2 · Biotransformation · Cell function · Cell metabolism · Cell proliferation · Controlled study · Cytotoxicity · Enzyme activity · Enzyme modification · Human · Human cell · Melanoma cell · Priority journal · Cell culture · Drug antagonism · Melanoma · Metabolism · Biotransformation · Glutathione · Glutathione S-Transferase pi · Glutathione Transferase · Humans · Isoenzymes · Melanoma · Prostaglandins A · Tumor Cells, Cultured
[Abstract]

20 A review of mechanisms underlying anticarcinogenicity by brassica vegetables
article 1997    
Author: Verhoeven, D.T.H. · Verhagen, H. · Goldbohm, R.A. · Brandt, P.A. van den · Poppel, G. van
Keywords: Anticarcinogenesis · Brassica vegetables · Glucosinolates · Indoles · Isothiocyanates · glucosinolate · indole derivative · isothiocyanic acid derivative · biotransformation · Brassica · cancer prevention · carcinogenesis · human · mouse · mutagenic activity · nonhuman · rat · review · vegetable · Animals · Anticarcinogenic Agents · Brassica · Glucosinolates · Humans · Neoplasms · Plant Extracts · Animalia · Brassica · Brassica oleracea var. botrytis · Brassica oleracea var. gemmifera
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 52 found. Next | Sort by date