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1 Prediction of brain target site concentrations on the basis of CSF PK : impact of mechanisms of blood-to-brain transport and within brain distribution
dissertation 2014    
Author: Westerhout, J.
Keywords: Pharmacology · Pharmacokinetics · Blood-brain barrier · Systems-based pharmacokinetic modeling · Brain extracellular fluid · Cerebrospinal fluid · Microdialysis · Food and Nutrition · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

2 PET-CT imaging with [18F]-gefitinib to measure Abcb1a/1b (P-gp) and Abcg2 (Bcrp1) mediated drug-drug interactions at the murine blood-brain barrier
article 2015    
Author: Vlaming, M.L.H. · Läppchen, T. · Jansen, H.T. · Kivits, S. · Driel, A. van · Steeg, E. van der · Hoorn, J.W. van der · Sio, C.F. · Steinbach, O.C. · Groot, J. de
Keywords: Biology · Abcg2/Bcrp1 · Blood-brain barrier · Gefitinib · P-glycoprotein · PET-CT imaging · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

3 Multiple sclerosis: An altered immune response or an altered stress response?
article 1996    
Author: Noort, J.M. van
Keywords: Health · Adult · Autoantigens · Autoimmune Diseases · Blood-Brain Barrier · Central Nervous System · Crystallins · Disease Models, Animal · Encephalomyelitis, Autoimmune, Experimental · Gene Expression Regulation · Humans · Immunodominant Epitopes · Lymphocyte Activation · Models, Immunological · Molecular Mimicry · Multiple Sclerosis · Myelin Proteins · Myelin Sheath · Nerve Tissue Proteins · Stress · Superantigens · T-Lymphocytes, Helper-Inducer
[Abstract]

4 Therapy with antibodies against CD40L (CD154) and CD44-variant isoforms reduces experimental autoimmune encephalomyelitis induced by a proteolipid protein peptide
article 1998    
Author: Laman, J.D. · Maassen, C.B.M. · Schellekens, M.M. · Visser, L. · Kap, M. · Jong, E. de · Puijenbroek, M. van · Stipdonk, M.J.B. van · Meurs, M. van · Schwärzler, C. · Günthert, U.
Keywords: Health · Accessory molecules · Blood-brain barrier · CD44 variant isoforms · Central nervous system (CNS) costimulation · Immunohistochemistry · Immunotherapy · Multiple sclerosis · Animals · Antibodies, Monoclonal · Antigens, CD40 · Antigens, CD44 · CD40 Ligand · Encephalomyelitis, Autoimmune, Experimental · Female · Immunization · Immunohistochemistry · Isoantigens · Membrane Glycoproteins · Mice · Myelin Proteolipid Protein · Peptide Fragments
[Abstract]

5 Peripheral site ligand conjugation to a non-quaternary oxime enhances reactivation of nerve agent-inhibited human acetylcholinesterase
article 2011    
Author: Koning, M.C. de · Grol, M. van · Noort, D.
Keywords: Acetylcholinesterase · Nerve agent · Non-quaternary oxime · Peripheral site · Reactivation · 4 methoxyphenyl oxo ethanaloxime · Acetylcholinesterase · Cholinesterase reactivator · Oxime · Pyridinium derivative · Unclassified drug · Article · Binding affinity · Blood brain barrier · Drug conjugation · Drug inhibition · Drug structure · Drug synthesis · Electrospray mass spectrometry · Enzyme active site · High performance liquid chromatography · Liquid chromatography · Priority journal · Purification · Chemicals/CAS: acetylcholinesterase, 9000-81-1 · Life · CBRN - CBRN Protection · EELS - Earth, Environmental and Life Sciences
[Abstract]

6 Presentation of αB-crystallin to T cells in active multiple sclerosis lesions: An early event following inflammatory demyelination
article 2000    
Author: Bajramović, J.J. · Plomp, A.C. · Goes, A. van der · Koevoets, C. · Newcombe, J. · Cuzner, M.L. · Noort, J.M. van
Keywords: Health · Alpha crystallin · B7 antigen · Beta crystallin · CD40 antigen · Cytokine · Gamma interferon · Major histocompatibility antigen class 2 · Myelin basic protein · Adult · Blood brain barrier · Clinical article · Controlled stud · Demyelination · Human tissue · Immunohistochemistry · Inflammation · Macrophage function · Multiple sclerosis · Neurologic disease · Antigen Presentation · Antigens, CD40 · Antigens, CD80 · Autoantigens · Cathepsins · Cell Movement · Crystallins · Demyelinating Diseases · Histocompatibility Antigens Class II · Humans · Hydrolysis · Inflammation · Macrophages · Multiple Sclerosis · Myelin Proteins · Myelin Sheath · Phagocytosis · T-Lymphocytes
[Abstract]

7 Review on the toxicity of ethylmercury including its presence as a preservative in biological and pharmaceutical products
article 2001    
Author: Magos, L.
Keywords: Toxicology · Biological preparations · Clinical studies · Dietary exposure · Ethylmercury · Kinetics · Methylmercury · Occupational exposure · Thimerosal · Ethylmercury derivative · Methylmercury · Natural product · Thiomersal · Acrodynia · Adolescent · Adult · Aged · Blood brain barrier · Child · Clinical article · Contact allergy · Decomposition · Female · Human · Intoxication · Neurotoxicology · Occupational exposure · Protein losing gastroenteropathy · Review · Toxicity testing · Animals · Biological Products · Environmental Exposure · Ethylmercury Compounds · Food Additives · Food Contamination · Humans · Mercury Poisoning · Nervous System Diseases · Occupational Exposure · Pharmaceutical Preparations · Preservatives, Pharmaceutical · Thimerosal
[Abstract]

8 Therapy of organophosphate poisoning in the rat by direct effects of oximes unrelated to ChE reactivation
article 1991    
Author: Helden, H.P.M. van · Lange, J. de · Busker, R.W. · Melchers, B.P.C.
Keywords: Biology · Acetylcholinesterase · Direct effect · HGG-12 · HI-6 · Obidoxime · Organophosphate poisoning · P2S · 1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · [(3 benzoyl 1 pyridiniomethyl) (2 hydroxyiminomethyl 1 pyridiniomethyl)] ether · Obidoxime · Organophosphate · Oxime · Soman · Animal experiment · Animal tissue · Diaphragm · Enzyme inhibition · Enzyme reactivation · Intravenous drug administration · Male · Nonhuman · Priority journal · Rat · Animal · Antidotes · Blood-Brain Barrier · Cholinesterase Reactivators · Diaphragm · In Vitro · Male · Neuromuscular Junction · Obidoxime Chloride · Organophosphorus Compounds · Oximes · Pralidoxime Compounds · Pyridinium Compounds · Rats · Respiratory Insufficiency · Synaptic Transmission · Animalia
[Abstract]

9 Increasing oxime efficacy by blood-brain barrier modulation
article 2011    
Author: Joosen, M.J.A. · Schans, M.J. van der · Dijk, C.G.M. van · Kuijpers, W.C. · Wortelboer, H.M. · Helden, H.P.M. van
Keywords: HI6 · Nerve agent · P-glycoprotein · Seizures · Tariquidar · 1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · Acetylcholinesterase · Atropine · Tariquidar · Animal experiment · Animal model · Article · Blood brain barrier · Blood level · Brain blood volume · Controlled study · Convulsion · Drug effect · Drug efficacy · Drug intoxication · Drug penetration · Male · Microdialysis · Modulation · Nerve agent poisoning · Nonhuman · Priority journal · Quantitative analysis · Rat · Seizure · Rattus · 1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether, 34433-31-3 · Acetylcholinesterase, 9000-81-1 · Atropine, 51-55-8, 55-48-1 · Tariquidar, 206873-63-4 · Tradenames: hi 6, TNO; xr 9576, avaant · Manufacturers: TNO; avaant · Life · CBRN - CBRN Protection PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

10 Comparison of in vitro assays in selecting radiotracers for in vivo P-glycoprotein PET imaging
article 2017    
Author: Raaphorst, R.M. · Savolainen, H. · Cantore, M. · Steeg, E. van de · Waarde, A. van · Colabufo, N.A. · Elsinga, P.H. · Lammertsma, A.A. · Windhorst, A.D. · Luurtsema, G.
Keywords: Biology · Apical and basolateral membrane · Bidirectional transport · Blood-brain barrier · Calcein-AM · Tritium labeling · Calcein · Mc 224 f 18 · Mc 225 f 18 · Multidrug resistance protein · N fluoroethylverapamil f 18 · O fluoroethyl norverapamil f 18 · Radiopharmaceutical agent · Unclassified drug · Verapamil c 11 · Animal experiment · Animal tissue · Chemical analysis · Controlled study · Drug accumulation · Drug blood level · Drug brain level · Drug half life · Enzyme inhibition · Fluoroethylation · In vitro study · In vivo study · Isotope labeling · Male · Mouse · Nonhuman · Positron emission tomography · Predictive value · Protein function · Radioactivity · Rat · Synthesis · Transport assay · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

11 Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE
article 2008    
Author: Dijkstra, S. · Kooij, G. · Verbeek, R. · Pol, S.M.A. van der · Amor, S. · Geisert Jr., E.E. · Dijkstra, C.D. · Noort, J.M. van · Vries, H.E.d.
Keywords: Biology · Biomedical Research · CD81 · EAE · Multiple sclerosis · Tetraspanins · Therapeutic antibodies · Transendothelial migration · CD81 antigen · monoclonal antibody · monoclonal antibody 1 3 3 22 · monoclonal antibody 1D6 · monoclonal antibody 2F7 · monoclonal antibody AMP1 · monoclonal antibody CD81 · monoclonal antibody Eat2 · monoclonal antibody JS81 · monoclonal antibody TA2 · tetraspanin · unclassified drug · very late activation antigen 4 antibody · allergic encephalomyelitis · animal cell · animal experiment · animal model · animal tissue · antiinflammatory activity · article · controlled study · drug effect · endothelium cell · female · human · human cell · in vitro study · in vivo study · monocyte · monolayer culture · mouse · myelitis · neurologic disease · neutrophil chemotaxis · nonhuman · priority journal · protein targeting · rat · treatment outcome · Animals · Antibodies, Monoclonal · Antigens, CD · Blood-Brain Barrier · Cell Line, Transformed · Cerebral Arteries · Chemotaxis, Leukocyte · Disease Models, Animal · Encephalomyelitis, Autoimmune, Experimental · Endothelial Cells · Female · Humans · Immunosuppression · Immunosuppressive Agents · Mice · Monocytes · Multiple Sclerosis · Rats · Treatment Outcome
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 11 of 11 found. | Sort by date