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1 Effects of flavonoid mixtures on the transport of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through Caco-2 monolayers: An in vitro and kinetic modeling approach to predict the combined effects on transporter inhibition
article 2008    
Author: Schutte, M.E. · Boersma, M.G. · Verhallen, D.A.M. · Groten, J.P. · Rietjens, I.M.C.M.
Keywords: ABC transporters · Caco-2 · Flavonoids · Kinetic modeling · Mixtures · PhIP · 2 amino 1 methyl 6 phenylimidazo[4,5 b]pyridine · Biological Transport, Active · Caco-2 Cells · Carcinogens · Drug Synergism · Flavonoids · Humans · Imidazoles · Models, Biological
[Abstract]

2 In vitro intestinal lead uptake and transport in relation to speciation
article 2003    
Author: Oomen, A.G. · Tolls, J. · Sips, A.J.A.M. · Groten, J.P.
Keywords: Biology Health · Physiological Sciences · lead · pollution exposure · article · bioavailability · cell strain CACO 2 · controlled study · first pass effect · human · human cell · intestine absorption · lead poisoning · membrane permeability · metal metabolism · priority journal · risk assessment · soil pollution · tissue level · Administration, Oral · Biological Availability · Caco-2 Cells · Digestive System · Humans · Intestinal Mucosa · Ions · Lead · Soil Pollutants
[Abstract]

3 Effect of fatty acids and the aqueous diffusion barrier on the uptake and transport of polychlorinated biphenyls in Caco-2 cells
article 1996    
Author: Dulfer, W.J. · Groten, J.P. · Govers, H.A.J.
Keywords: Nutrition · Enterocytes · Lipoproteins · Metabolism · Triglyceride · Xenobiotics · Bile salt · Fatty acid · Polychlorinated biphenyl · Aqueous solution · Cancer cell culture · Cell transport · Diffusion · Fat intake · Human · Human cell · Hydrophobicity · Intestine cell · Micelle · Permeability barrier · Priority journal · Solubility · Xenobiotic metabolism · Biological Transport · Caco-2 Cells · Cell Polarity · Diffusion · Fatty Acids · Humans · Polychlorinated Biphenyls · Solubility · Water
[PDF] [Abstract]

4 Pathway and single gene analyses of inhibited Caco-2 differentiation by ascorbate-stabilized quercetin suggest enhancement of cellular processes associated with development of colon cancer
article 2007    
Author: Dihal, A.A. · Tilburgs, C. · Erk, M.J. van · Rietjens, I.M.C.M. · Woutersen, R.A. · Stierum, R.H.
Keywords: Toxicology and Applied Pharmacology · Caco-2 · Colorectal cancer · Differentiation · Microarray · Quercetin · ascorbic acid · quercetin · article · cell differentiation · cell division · cell strain CACO 2 · colon tumor · comparative study · DNA microarray · drug effect · drug stability · gene expression · genetics · human · pathology · Ascorbic Acid · Caco-2 Cells · Cell Differentiation · Cell Division · Colonic Neoplasms · Drug Stability · Gene Expression · Humans · Oligonucleotide Array Sequence Analysis · Quercetin
[Abstract]

5 A pilot study to investigate effects of inulin on Caco-2 cells through in vitro metabolic fingerprinting
article 2003    
Author: Lamers, R.-J.A.N. · Wessels, E.C.H.H. · Sandt, J.J.M. van de · Venema, K. · Schaafsma, G. · Greef, J. van der · Nesselrooij, J.H.J. van
Keywords: Nutrition Packaging · Analytical research · 1H NMR spectroscopy · Metabolic fingerprinting · Biochemical marker · Cell culture · Cell metabolism · Cell strain CACO 2 · Chemical analysis · Controlled study · Experimental model · Glucose metabolism · Health status · Human cell · In vitro study · In vivo study · Laboratory test · Multivariate analysis · Nutrition · Pilot study · Proton nuclear magnetic resonance · Alanine · Analysis of Variance · Caco-2 Cells · Colon · Fermentation · Glucose · Glutamic Acid · Humans · Inulin · Ketoglutaric Acids · Lactic Acid · Magnetic Resonance Spectroscopy · Niacin · Niacinamide · Proline · Succinic Acid
[Abstract]

6 Human glutathione S-transferase-mediated glutathione conjugation of curcumin and efflux of these conjugates in caco-2 cells
article 2007    
Author: Usta, M. · Wortelboer, H.M. · Vervoort, J. · Boersma, M.G. · Rietjens, I.M.C.M. · Bladeren, P.J. van · Cnubben, N.H.P.
Keywords: Biology · Toxicology and Applied Pharmacology · curcumin · glutathione transferase · adult · aged · article · atom · catalysis · cell strain CACO 2 · conjugate · drug degradation · drug excretion · drug structure · female · glutathione metabolism · human · human cell · human tissue · intestine · intestine epithelium cell · liquid chromatography · liver cytosol · male · mass spectrometry · monolayer culture · proton nuclear magnetic resonance · Adult · Aged · Caco-2 Cells · Curcumin · Cytosol · Female · Glutathione · Glutathione Transferase · Humans · Intestines · Liver · Magnetic Resonance Spectroscopy · Male · Metabolic Detoxication, Phase II · Middle Aged · Molecular Structure
[Abstract]

7 Effect of folate-binding protein on intestinal transport of folic acid and 5-methyltetrahydrofolate across Caco-2 cells
article 2005    
Author: Verwei, M. · Berg, H. van den · Havenaar, R. · Groten, J.P.
Keywords: Biology · Biomedical Research · Bioavailability · Caco-2 · Folate · Folate-binding protein · Intestinal transport · 5 methyltetrahydrofolic acid · caffeine · folate binding protein · folic acid · mannitol · article · cell growth · cell membrane permeability · controlled study · human · human cell · intestine absorption · intestine cell · monolayer culture · protein binding · Biological Transport · Caco-2 Cells · Carrier Proteins · Cell Culture Techniques · Chromatography, Gel · Folic Acid · Humans · Intestinal Absorption · Intestine, Small · Receptors, Cell Surface · Tetrahydrofolates · Time Factors · Bovinae
[Abstract]

8 The influence of microbial metabolites on human intestinal epithelial cells and macrophages in vitro
article 2005    
Author: Nuenen, M.H.M.C. van · Ligt, R.A.F. de · Doornbos, R.P. · Woude, J.C.J. van der · Kuipers, E.J. · Venema, K.
Keywords: Nutrition · Physiological Sciences · Interleukin-10 · Intestinal epithelial cells · Macrophages · Microbial metabolites · Tumour necrosis factor-α · ammonia · butyric acid · cytokine · interleukin 10 · tumor necrosis factor alpha · valeric acid · article · cell strain CACO 2 · concentration (parameters) · cytokine release · electric resistance · enteritis · epithelium cell · human · human cell · immunity · macrophage · metabolism · metabolite · physiology · priority journal · Ammonium Chloride · Butyrates · Caco-2 Cells · Epithelial Cells · Humans · Immunity, Mucosal · Inflammatory Bowel Diseases · Interleukin-10 · Intestines · Macrophages · Pentanoic Acids · Tumor Necrosis Factor-alpha · U937 Cells
[Abstract]

9 Modulatory effects of quercetin on proliferation and differentiation of the human colorectal cell line Caco-2
article 2006    
Author: Dihal, A.A. · Woutersen, R.A. · Ommen, B.v. · Rietjens, I.M.C.M. · Stierum, R.H.
Keywords: Biology · Toxicology and Applied Pharmacology · Caco-2 · Colorectal cancer · Differentiation · Metabolism · Proliferation · Quercetin · 3' o methylquercetin 4' o glucuronide · 3' o methylquercetin 7 o sulfate · 4' o methylquercetin 3' o glucuronide · 4' o methylquercetin 7 o glucuronide · isorhamnetin · quercetin · quercetin derivative · unclassified drug · article · cell differentiation · cell proliferation · cell strain CACO 2 · controlled study · human · human cell · priority journal · statistical significance · Anticarcinogenic Agents · Caco-2 Cells · Cell Differentiation · Cell Proliferation · Colorectal Neoplasms · Drug Stability · Humans · Quercetin
[Abstract]

10 Myricetin stimulates the absorption of the pro-carcinogen PhIP
article 2006    
Author: Schutte, M.E. · Sandt, J.J.M. van de · Alink, G.M. · Groten, J.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · ABC transporter · Apparent permeability · Caco-2 · Myricetin · PhIP · 2 amino 1 methyl 6 phenylimidazo[4,5 b]pyridine · carcinogen · cyclosporin A · glycoprotein P inhibitor · multidrug resistance protein 2 · myricetin · valspodar · absorption · article · cell differentiation · cell strain CACO 2 · cell transport · concentration (parameters) · excretion · human · human cell · intestine epithelium cell · priority journal · stimulation · Absorption · ATP-Binding Cassette Transporters · Caco-2 Cells · Carcinogens · Flavonoids · Humans · Imidazoles · Membrane Transport Proteins · Multidrug Resistance-Associated Proteins · Permeability
[Abstract]

11 Effects of cadmium chloride on the paracellular barrier function of intestinal epithelial cell lines
article 1999    
Author: Duizer, E. · Gilde, A.J. · Versantvoort, C.H.M. · Groten, J.P.
Keywords: Nutrition · Caco-2 · Cadmium · IEC-18 · Tight junction · Cadmium chloride · Macrogol 4000 · Annitol · Occludin · Uvomorulin · Animal tissue · Apical membrane · Cell junction · Cell viability · Cellular distribution · Cytotoxicity · Electric resistance · Human · Human tissue · Intestine mucosa permeability · Long term exposure · Molecular size · Nonhuman · Tight junction · Transcytosis · Animals · Caco-2 Cells · Cadherins · Cadmium Chloride · Cadmium Radioisotopes · Cell Membrane Permeability · Cell Survival · Cells, Cultured · Epithelial Cells · Humans · Ileum · Intestinal Absorption · Mannitol · Membrane Proteins · Phosphoproteins · Polyethylene Glycols · Rats · Tight Junctions · Animalia
[Abstract]

12 Absorption enhancement, structural changes in tight junctions and cytotoxicity caused by palmitoyl carnitine in Caco-2 and IEC-18 cells
article 1998    
Author: Duizer, E. · Wulp, C. van der · Versantvoort, C.H.M. · Groten, J.P.
Keywords: Nutrition · Lactate dehydrogenase · Palmitoylcarnitine · Propidium iodide · Apical membrane · Cell membrane · Cell strain caco 2 · Cell viability · Controlled study · Drug absorption · Drug cytotoxicity · Drug transport · Electric resistance · Human · Human cell · Image processing · Intestine absorption · Macromolecule · Oral drug administration · Priority journal · Protein localization · Tight junction · Animals · Biological Transport · Caco-2 Cells · Cell Survival · Dose-Response Relationship, Drug · Egtazic Acid · Electric Impedance · Humans · Immunohistochemistry · Intestinal Absorption · Membrane Proteins · Octoxynol · Palmitoylcarnitine · Phosphoproteins · Rats · Tight Junctions
[Abstract]

13 Quercetin increases the bioavailability of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats
article 2008    
Author: Schutte, M.E. · Alink, G.M. · Freidig, A.P. · Spenkelink, B. · Vaessen, J.C.H. · Sandt, J.J.M. van de · Groten, J.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · ABC transporters · Caco-2 monolayers · In silico modelling · PhIP · Quercetin · Rat · 2 amino 1 methyl 6 phenylimidazo[4,5 b]pyridine · quercetin · animal experiment · animal tissue · article · bioavailability · cell strain CACO 2 · computer model · controlled study · dietary intake · human · human cell · in vitro study · in vivo study · male · nonhuman · rat · Animals · Antioxidants · Area Under Curve · Biological Availability · Biological Transport, Active · Caco-2 Cells · Carcinogens · Humans · Imidazoles · Male · Models, Biological · Quercetin · Random Allocation · Rats · Rats, Wistar · Rattus
[Abstract]

14 Physicochemical properties and transport of steroids across Caco-2 cells
article 2003    
Author: Faassen, F. · Kelder, J. · Lenders, J. · Onderwater, R. · Vromans, H.
Keywords: Drugs · Physiological Sciences · Absorption · Caco-2 permeability · Physicochemical properties · Steroids · 17alpha hydroxy 11 methylene 19 norpregna 4,15 dien 20 yn 3 one · aldosterone · cefalexin · cortisone · dexamethasone · estradiol · ethinylestradiol · etonogestrel · gestodene · glucose · hydrocortisone · macrogol 4000 · mannitol · nandrolone · norethisterone · norgestrel · org 32540 · org 34694 · org 36410 · org 4060 · org 4325 · org om 08 · phenazone · prednisolone · progesterone · spironolactone · steroid · testosterone · verapamil · article · calculation · cell membrane permeability · cell strain CACO 2 · controlled study · drug absorption · drug surveillance program · drug transport · human · human cell · molecular weight · physical chemistry · priority journal · Biological Transport · Caco-2 Cells · Chemistry, Physical · Humans · Solubility · Steroids
[Abstract]

15 Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro
article 2005    
Author: Erk, M.J. van · Roepman, P. · Lende, T.R. van der · Stierum, R.H. · Aarts, J.M.M.J.G. · Bladeren, P.J. van · Ommen, B. van
Keywords: Health Biology · Biomedical Research · (anti-)carcinogenic mechanisms · Caco-2 · Cell proliferation · Gene expression · Quercetin · beta catenin · mitogen activated protein kinase · quercetin · T cell factor protein · antineoplastic activity · apoptosis · article · cancer cell · cell adhesion · cell cycle · cell cycle G1 phase · cell differentiation · cell interaction · cell proliferation · cell strain CACO 2 · cellular distribution · colon carcinoma · controlled study · DNA microarray · down regulation · drug activity · energy metabolism · gene expression · genetic analysis · human · human cell · in vitro study · nucleotide sequence · oncogene · signal transduction · tumor suppressor gene · unindexed sequence · upregulation · Antineoplastic Agents · Apoptosis · Caco-2 Cells · Cell Cycle · Cell Division · Colonic Neoplasms · Dose-Response Relationship, Drug · Gene Expression · Gene Expression Profiling · Gene Expression Regulation · Humans · Quercetin
[Abstract]

16 An in vitro and in silico study on the flavonoid-mediated modulation of the transport of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through Caco-2 monolayers
article 2006    
Author: Schutte, M.E. · Freidig, A.P. · Sandt, J.J.M. van de · Alink, G.M. · Rietjens, I.M.C.M. · Groten, J.P.
Keywords: Biology · Biomedical Research · ABC transporter · Caco-2 · Flavonoid · Heterocyclic amine · In silico · 2 amino 1 methyl 6 phenylimidazo[4,5 b]pyridine · breast cancer resistance protein · chrysoeriol · elacridar · flavone · flavonoid · kaempferol · luteolin · morin · multidrug resistance protein · myricetin · naringenin · quercetin · robinetin · taxifolin · unclassified drug · verlukast · absorption · apical membrane · article · cell strain CACO 2 · computer model · controlled study · drug effect · human · human cell · Acridines · ATP-Binding Cassette Transporters · Biological Transport, Active · Caco-2 Cells · Carcinogens · Cell Membrane Permeability · Diffusion · Dose-Response Relationship, Drug · Flavanones · Flavonoids · Humans · Imidazoles · Intestinal Absorption · Intestinal Mucosa · Kinetics · Membrane Transport Proteins · Models, Biological · Multidrug Resistance-Associated Proteins · Neoplasm Proteins · P-Glycoprotein · Propionates · Quinolines · Reproducibility of Results · Tetrahydroisoquinolines
[Abstract]

17 Effects of iron salts and haemosiderin from a thalassaemia patient on oxygen radical damage as measured in the comet assay
article 2000    
Author: Anderson, D. · Yardley-Jones, A. · Hambly, R.J. · Vives-Bauza, C. · Smykatz-Kloss, V. · Chua-anusorn, W. · Webb, J.
Keywords: Chelating agents · Free radical damage · Haemoglobin synthesis · Haemosiderin · Iron overload · Thalassaemia · chelating agent · deferoxamine · ferric chloride · ferrous chloride · ferrous sulfate · free radical · hemosiderin · hydrogen peroxide · iron chelate · iron salt · oxygen radical · article · case report · cell strain CACO 2 · comet assay · controlled study · DNA damage · DNA strand breakage · female · human · human cell · human experiment · human tissue · iron overload · lymphocyte · male · normal human · oxidative stress · priority journal · thalassemia · Caco-2 Cells · Comet Assay · DNA Damage · Dose-Response Relationship, Drug · Female · Ferric Compounds · Ferrous Compounds · Hemosiderin · Humans · Hydrogen Peroxide · Iron Compounds · Lymphocytes · Male · Reactive Oxygen Species · Thalassemia · Production · Technology · Food · Salt
[Abstract]

18 Proteome analysis reveals novel proteins associated with proliferation and differentiation of the colorectal cancer cell line Caco-2
article 2003    
Author: Stierum, R. · Gaspari, M. · Dommels, Y. · Ouatas, T. · Pluk, H. · Jespersen, S. · Vogels, J. · Verhoeckx, K. · Groten, J. · Ommen, B. van
Keywords: Health Nutrition · Analytical research · Caco-2 · Differentiation · Mass spectrometry · Proteome analysis · Two-dimensional gel electrophoresis · cofilin · creatine kinase · disulfide · enolase · fatty acid binding protein · glutathione transferase · heat shock protein · isomerase · liver protein · mitochondrial protein · nucleoside diphosphate kinase · nucleotide · proteome · tumor protein · alkaline phosphatase · article · brush border · carcinogenesis · cell culture · cell differentiation · cell growth · cell maturation · cell proliferation · cell strain CACO 2 · colon carcinogenesis · colorectal cancer · controlled study · cytoskeleton · genetic transcription · glycolysis · human · human cell · intestine cell · matrix assisted laser desorption ionization time of flight mass spectrometry · microvillus · nucleotide metabolism · pH · phenotype · priority journal · protein analysis · protein expression · protein folding · protein function · proteomics · signal transduction · two dimensional gel electrophoresis · cell division · cytology · metabolism · physiology · principal component analysis · Western blotting · Alkaline Phosphatase · Blotting, Western · Caco-2 Cells · Cell Differentiation · Cell Division · Humans · Principal Component Analysis · Proteome
[Abstract]

19 The role of cyclooxygenase in n-6 and n-3 polyunsaturated fatty acid mediated effects on cell proliferation, PGE2 synthesis and cytotoxicity in human colorectal carcinoma cell lines
article 2003    
Author: Dommels, Y.E.M. · Haring, M.M.G. · Keestra, N.G.M. · Alink, G.M. · Bladeren, P.J. van · Ommen, B. van
Keywords: Biology · Analytical research · 5 (4 fluorophenyl) 1 [(4 methylsulfonyl)phenyl] 3 trifluoromethylpyrazole · 5,8,11,14,17 icosapentaenoic acid · acetylsalicylic acid · alpha tocopherol · antioxidant · arachidonic acid · ascorbic acid · carbene · celecoxib · cyclooxygenase 2 inhibitor · docosahexaenoic acid · indometacin · interleukin 1beta · linoleic acid · malonaldehyde · nonsteroid antiinflammatory agent · omega 3 fatty acid · omega 6 fatty acid · prostaglandin E2 · prostaglandin synthase · antineoplastic activity · cancer cell · cell growth · cell proliferation · colon cancer · colorectal carcinoma · controlled study · cytotoxicity · drug effect · drug mechanism · enzyme activation · enzyme activity · fatty acid synthesis · growth inhibition · human · human cell · hypothesis · incubation time · lipid peroxidation · priority journal · review · signal transduction · Antioxidants · Caco-2 Cells · Cell Division · Colorectal Neoplasms · Cyclooxygenase Inhibitors · Dinoprostone · Fatty Acids, Omega-3 · Fatty Acids, Omega-6 · Fatty Acids, Unsaturated · HT29 Cells · Humans · Lipid Peroxidation · Prostaglandin-Endoperoxide Synthases
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 19 of 19 found. | Sort by date