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1 Unheated Cannabis sativa extracts and its major compound THC-acid have potential immuno-modulating properties not mediated by CB1 and CB2 receptor coupled pathways
article 2006    
Author: Verhoeckx, K.C.M. · Korthout, H.A.A.J. · Meeteren-Kreikamp, A.P. van · Ehlert, K.A. · Wang, M. · Greef, J. van der · Rodenburg, R.J.T. · Witkamp, R.F.
Keywords: Health · Analytical research · Biomedical research · Δ9-tetrahydrocanabinoid · Δ9-tetrahydrocanabinoid acid · cAMP · Cannabis sativa · Inflammation · PC-PLC · TNF-alpha · 1 (2,4 dichlorophenyl) 5 (4 iodophenyl) 4 methyl n morpholino 1h pyrazole 3 carboxamide · 6 iodo 3 (4 methoxybenzoyl) 2 methyl 1 (2 morpholinoethyl)indole · Beta 2 adrenergic receptor stimulating agent · Cannabidiol · Cannabidiolic acid · Cannabinoid 1 receptor · Cannabinoid 2 receptor · Cannabinoid derivative · Cannabis · Delta 9 tetrahydrocannabinoid acid · Dronabinol · Immunomodulating agent · Lipopolysaccharide · Phosphatidylcholine · Phospholipase C · Tumor necrosis factor alpha · Unclassified drug · Zilpaterol · Cell strain U937 · Concentration response · Controlled study · Cytokine production · Down regulation · Drug effect · Drug mechanism · Enzyme activity · Heating · Human cell · Immunomodulation · Immunopharmacology · Immunostimulation · Long term exposure · Macrophage · Metabolism · Protein induction · Protein synthesis regulation · Supernatant · Upregulation · Cannabis · Cell Line · Cells, Cultured · Cyclic AMP · Dose-Response Relationship, Drug · Heat · Humans · Immunologic Factors · Macrophage Activation · Macrophages · Phospholipase C · Plant Extracts · Receptor, Cannabinoid, CB1 · Receptor, Cannabinoid, CB2 · Signal Transduction · Tetrahydrocannabinol · Tumor Necrosis Factor-alpha
[Abstract]

2 Metabolomics in the context of systems biology: Bridging Traditional Chinese Medicine and molecular pharmacology
article 2005    
Author: Wang, M. · Lamers, R.J.A.N. · Korthout, H.A.A.J. · Nesselrooij, J.H.J. van · Witkamp, R.F. · Heijden, R. van der · Voshol, P.J. · Havekes, L.M. · Verpoorte, R. · Greef, J. van der
Keywords: Health Pharmacology · Analytical research · Metabolomics · Systems biology · Traditional Chinese Medicine (TCM) · 5' methoxyhdnocarpin · Alanine aminotransferase · Alkaloid · Apolipoprotein E · Berberine · Biflavonoid · Bilobalide · Cannabidiol · Cannabis · Chaconine · Cholesterol · Flavonoid · Ginkgo biloba extract · Ginkgolide · Glucoside · Herbaceous agent · Insulin · Low density lipoprotein · Plant extract · Prodrug · Salicylic acid · Saligenin · Saponin · Solanine · Tetrahydrocannabinol · Triacylglycerol · Unclassified drug · Very low density lipoprotein · Alanine aminotransferase blood level · Animal experiment · Animal model · Atherosclerosis · Bark · Blood flow · Chinese medicine · Clinical pharmacology · Controlled study · Data analysis · DNA microarray · Drug effect · Drug efficacy · Drug potentiation · Drug research · Drug safety · Drug targeting · Female · Ginkgo biloba · Headache · Herbal medicine · High performance liquid chromatography · Human · Human experiment · Insulin resistance · Insulin sensitivity · Ion cyclotron resonance mass spectrometry · Lipid metabolism · Liver function · Male · Mass spectrometry · Medicinal plant · Metabolic syndrome X · Metabolite · Molecular pharmacology · Nonhuman · Nuclear magnetic resonance spectroscopy · Pain · Phytotherapy · Plant leaf · Proton nuclear magnetic resonance · Rat · Thin layer chromatography · Traditional medicine · Willow · Drugs, Chinese Herbal · Humans · Pharmacology · Phytotherapy
[Abstract]

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