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Showing 1 to 19 of 19 found. | Sort by date

1 Chromatography and mass spectrometry of chemical warfare agents, toxins and related compounds: state of the art and future prospects
article 1998    
Author: Kientz, C.E.
Keywords: Defence · Reviews · Toxins · Chemical Warfare Agents · Chromatography · Chromatography, Liquid · Mass Spectrometry
[Abstract]

2 Identification of chemicals related to the chemical weapons convention during an interlaboratory proficiency test
article 2002    
Author: Hooijschuur, E.W.J. · Hulst, A.G. · Jong, A.L. de · Reuver, L.P. de · Krimpen, S.H. van · Baar, B.L.M. van · Wils, E.R.J. · Kientz, C.E. · Brinkman, U.A.Th
Keywords: Chemical warfare agents · Interlaboratory proficiency test · Lewisite · Mustard agents · Nerve agents · Chemical analysis · Chemicals · Laboratories · Production · Testing · Chemical weapons · Chemical warfare · Chemical warfare agent · Analytic method · Article · Chemical warfare · Laboratory test · Netherlands · Priority journal · Water sampling
[Abstract]

3 Intravenous and inhalation toxicokinetics of sarin stereoisomers in atropinized guinea pigs
article 2000    
Author: Spruit, W.E.T. · Langenberg, J.P. · Trap, H.C. · Wiel, H.J. van der · Helmich, R.B. · Helden, H.P.M. van · Benschop, H.P.
Keywords: Acetylcholinesterase inhibition · Guinea pig · Intravenous bolus · Nose-only exposure · Respiratory parameters · Stereoisomers · Toxicokinetics · Animal experiment · Animal model · Binding site · Chemical warfare · Controlled study · Drug absorption · Drug elimination · Enzyme inhibition · Gas chromatography · Guinea pig · Nonhuman · Nose mucosa · Stereoisomerism · Toxicokinetics · Acetylcholinesterase · Administration, Inhalation · Animals · Area Under Curve · Atropine · Chemical Warfare Agents · Guinea Pigs · Injections, Intravenous · Male · Stereoisomerism · Acetylcholinesterase, EC 3.1.1.7 · Atropine, 51-55-8 · Chemical warfare agents · Sarin, 107-44-8
[Abstract]

4 Low levels of sarin affect the EEG in marmoset monkeys: A pilot study
article 2004    
Author: Helden, H.H.P.M. van · Vanwersch, R.A.P. · Kuijpers, W.C. · Trap, H.C. · Philippens, I.H.C. · Benschop, H.P.
Keywords: EEG · Exposure limits · Field alarm · Lowest observable adverse effect level (LOAEL) · Nerve agent · O-isopropyl methylphosphonofluoridate · Pyridostigmine · Sarin · Sleep-spindles · Whole-body exposure · Pyridostigmine · Sarin · Animal experiment · Blood · Cholinergic system · Controlled study · Electroencephalogram · Energy · Female · Male · Marmoset · Nonhuman · Oscillation · Pilot study · Priority journal · Sleep spindle · Animals · Callithrix · Chemical Warfare Agents · Cholinesterase Inhibitors · Dose-Response Relationship, Drug · Electroencephalography · Female · Humans · Inhalation Exposure · Male · Pyridostigmine Bromide · Sarin · Time Factors · Animalia · marmosets · Pyridostigmine, 101-26-8, 155-97-5 · Sarin, 107-44-8 · Chemical warfare agents · Cholinesterase inhibitors · Pyridostigmine Bromide, 101-26-8
[Abstract]

5 Improvements of the fluoride reactivation method for the verification of nerve agent exposure
article 2004    
Author: Degenhardt, C.E.A.M. · Pleijsier, K. · Schans, M.J. van der · Langenberg, J.P. · Preston, K.E. · Solano, M.I. · Maggio, V.L. · Barr, J.R.
Keywords: Warfare · Biological marker · Cholinesterase · Cyclosarin · Organophosphorus compound · Potassium fluoride · Sarin · Soman · Tabun · Unclassified drug · Calibration · Chemical analysis · Chemical warfare · Enzyme activity · Gas chromatography · Human · Mass spectrometry · Methodology · Neurotoxicity · Plasma · Solid phase extraction · Biological Markers · Butyrylcholinesterase · Chemical warfare agents · Cholinesterase reactivators · Environmental exposure · Environmental monitoring · Erythrocytes · Fluorides · Gas Chromatography-Mass Spectrometry · Humans · Reproducibility of results · Sensitivity and specificity · Cholinesterase, 9001-08-5 · Cyclosarin, 329-99-7 · Potassium fluoride, 7789-23-3 · Sarin, 107-44-8 · Soman, 96-64-0 · Tabun, 77-81-6 · Biological Markers · Butyrylcholinesterase, EC 3.1.1.- · Chemical Warfare Agents · Cholinesterase reactivators · Fluorides
[Abstract]

6 Low-level exposure of guinea pigs and marmosets to sarin vapour in air: Lowest-observable-adverse-effect level (LOAEL) for miosis
article 2004    
Author: Helden, H.P.M. van · Trap, H.C. · Kuijpers, W.C. · Oostdijk, J.P. · Benschop, H.P. · Langenberg, J.P.
Keywords: Biology · Exposure limits · Field alarm · Lowest-observable-adverse-effect level (LOAEL) · Miosis · Nerve agent · o-isopropyl methylphosphonofluoridate · Pupil size · Pyridostigmine · Sarin · Whole-body exposure · Acetylcholinesterase · Erythrocyte enzyme · Pyridostigmine · Sarin · Air · Animal experiment · Article · Calculation · Concentration (parameters) · Controlled study · Data analysis · Environmental exposure · Eye photography · Guinea pig · Iris · Male · Marmoset · Miosis · Nonhuman · Pilot study · Priority journal · Pupil · Statistical analysis · Vapor · Acetylcholinesterase · Administration, Inhalation · Animals · Callithrix · Chemical Warfare Agents · Dose-Response Relationship, Drug · Guinea Pigs · Inhalation Exposure · Pyridostigmine Bromide · Sarin · Volatilization · Animalia · Cavia · Marmosets · Acetylcholinesterase, 9000-81-1 · Pyridostigmine, 101-26-8, 155-97-5 · Sarin, 107-44-8 · Chemical warfare agents
[Abstract]

7 Comprehensive gas chromatography with Time of Flight MS and large volume introduction for the detection of fluoride-induced regenerated nerve agent in biological samples
article 2010    
Author: Meer, J.A. van der · Trap, H.C. · Noort, D. · Schans, M.J. van der
Keywords: Defence · Comprehensive GC · Time of Flight MS · Nerve agents · Fluoride reactivation · Diagnosis · Chemicals/CAS: · Fluoride, 16984-48-8 · Sarin, 107-44-8 · Tabun, 77-81-6 · Chemical warfare agents · Cholinesterase inhibitors · Fluorides · Organophosphorus compounds · Phosphoric acid esters · Organophosphate · Organophosphorus compound · Blood · Chemistry · Human · Mass fragmentography · Methodology · Reproducibility · Sensitivity and specificity · Statistical model · Gas Chromatography-Mass Spectrometry · Linear models
[Abstract]

8 Assessment of nerve agent exposure: existiting and emerging methods
article 2009    
Author: Langenberg, J.P. · Schans, M.J. van der · Noort, D.
Keywords: Warfare · analytic sample preparation methods · chemical warfare agents · cholinesterase inhibitor analysis · computer systems · electronics · environmental exposure · hospital information system · human · immunoassay · instrumentation · lab on a chip · lab-on-a-chip devices · limit of detection · mass spectrometry · methodology · miniaturization · point-of-care systems · review
[Abstract]

9 Retrospective detection of exposure to sulfur mustard: Improvements on an assay for liquid chromatography-tandem mass spectrometry analysis of albumin/sulfur mustard adducts
article 2004    
Author: Noort, D. · Fidder, A. · Hulst, A.G. · Woolfitt, A.R. · Ash, D. · Barr, J.R.
Keywords: Toxicology · Tripeptide · Alkylation · Autoanalysis · Blood analysis · Chemical analysis · Chemical warfare · Controlled study · Digestion · Human · Human tissue · Liquid chromatography · Mass spectrometry · Protein isolation · Serum · Standard · Albumins · Alkylation · Chemical warfare agents · Chromatography, Affinity · Environmental exposure · Humans · Reference values · Retrospective studies · Mass spectrometry · Electrospray ionization · Mustard gas, 505-60-2 · Pronase, 9036-06-0 · Albumins
[PDF] [Abstract]

10 Low level nose-only exposure to the nerve agent soman: Toxicokinetics of soman stereoisomers and cholinesterase inhibition in atropinized guinea pigs
article 1998    
Author: Benschop, H.P. · Trap, H.C. · Spruit, H.E.T. · Wiel, H.J. van der · Langenberg, J.P. · Jong, L.P.A. de
Keywords: Perception · Atropine · Carboxylesterase · Cholinesterase · Animal cell · Blood level · Enzyme inhibition · Exposure · Guinea pig · Inhalation · Male · Neurotoxicity · Nonhuman · Stereoisomerism · Toxicokinetics · Administration, Inhalation · Animals · Carboxylic ester hydrolases · Chemical warfare agents · Dose-response relationship · Drugs · Erythrocytes · Soman · Stereoisomerism · Time factors · Atropine, 51-55-8 · Carboxylesterase, EC 3.1.1.1 · Carboxylic ester hydrolases, EC 3.1.1.- · Soman, 96-64-0
[Abstract]

11 Alkylation of human serum albumin by sulfur mustard in vitro and in vivo : Mass spectrometric analysis of a cysteine adduct as a sensitive biomarker of exposure
article 1999    
Author: Noort, D. · Hulst, A.G. · Jong, L.P.A. de · Benschop, H.P.
Keywords: Carbon 14 · Cysteine 52-90-4 · Mustard gas 505-60-2 · Pronase · Serum albumin · Alkylation · Binding kinetics · Human · Human tissue · In vitro study · Iran · Mass spectrometry · Quantitative assay · Alkylating Agents · Alkylation · Amino acid sequence · Biological markers · Chemical warfare · Chemical warfare agents · High Pressure Liquid Chromatography · Hydrolysis · Molecular sequence data · Protein binding · Serum albumin · Trypsin · Trypsin, EC 3.4.21.4
[Abstract]

12 Biomonitoring of exposure to chemical warfare agents: A review
article 2002    
Author: Noort, D. · Benschop, H.P. · Black, R.M.
Keywords: Warfare · Biomonitoring · Chemical warfare agents · Mass spectrometry · Nerve agent · Review · Sulfur mustard · Terrorism · Biological marker · DNA · Glutathione · Protein · Biological monitoring · Blood analysis · Chemical analysis · Chemical warfare · Conjugation · Dosimetry · Exposure · Health survey · Humans · Hydrolysis · Immunochemistry · Mass spectrometry · Metabolite · Review · Urinalysis · Animals · Cholinesterase inhibitors · DNA adducts · Environmental monitoring · Protein binding · Arsenicals · Cholinesterase inhibitors · Lewisite, 541-25-3 · Mustard gas, 505-60-2
[Abstract]

13 Characterization of sulfur mustard induced structural modifications in human hemoglobin by liquid chromatography-tandem mass spectrometry
article 1996    
Author: Noort, D. · Verheij, E.R. · Hulst, A.G. · Jong, L.P.A. de · Benschop, H.P.
Keywords: Toxicology · globin · hemoglobin · mustard gas · trypsin · alkylation · article · blood · chemical warfare · human · liquid chromatography · protein modification · tandem mass spectrometry · Alkylation · Amino Acid Sequence · Carcinogens · Chemical Warfare Agents · Chromatography, High Pressure Liquid · Erythrocytes · Gas Chromatography-Mass Spectrometry · Hemoglobins · Humans · Molecular Sequence Data · Mustard Gas · Peptide Fragments · Spectrophotometry, Ultraviolet · Sulfur Radioisotopes · Trypsin
[Abstract]

14 A physiologically based pharmacokinetic (PB/PK) model for multiple exposure routes for soman in multiple species
article 2006    
Author: Sweeney, R.E. · Langenberg, J.P. · Maxwell, D.M.
Keywords: Toxicology · Acetylcholinesterase · Carboxylesterase · Enzyme · Soman · Adipose tissue · Allometry · Animal experiment · Animal tissue · Arterial blood · Blood flow velocity · BLood level · Body weight · Breathing rate · Computer language · Computer simulation · Controlled study · Exposure · Guinea pig · In vitro study · Kidney perfusion · LD 50 · Liver perfusion · Lung perfusion · Male · Marmoset · Metabolism · Nonhuman · Partition coefficient · Priority journal · Provocation test · Rat · Regression analysis · Sensitivity analysis · Stereoisomerism · Tidal volume · Tissue level · Toxicokinetics · Venous blood · Administration, Inhalation · Animals · Callithrix · Chemical Warfare Agents · Cholinesterase Inhibitors · Computer Simulation · Guinea Pigs · Injections, Intravenous · Injections, Subcutaneous · Male · Models, Biological · Rats · Rats, Wistar · Animalia · Cavia porcellus · Marmosets · Acetylcholinesterase, 9000-81-1 · Carboxylesterase, 59536-71-9, 83380-83-0, 9016-18-6, 9028-01-7 · Soman, 96-64-0 · Chemical warfare agents · Cholinesterase inhibitors
[Abstract]

15 Retrospective detection of exposure to nerve agents: Analysis of phosphofluoridates originating from fluoride-induced rectivation of phospylated BuChE
article 2004    
Author: Schans, M.J. van der · Polhuijs, M. · Dijk, C. van · Degenhardt, C.E.A.M. · Pleijsier, K. · Langenberg, J.P. · Benschop, H.P.
Keywords: Biology · Biomarker · Biomonitoring · Butyryl cholinesterase · Fluoride ions · Lexposure · Nerve agents · Organophosphates · Reactivation · Retrospective detection · Cholinesterase · Cholinesterase inhibitor · Cyclosarin · Fluoride · Nerve gas · Organophosphate · Paraoxon · Parathion · Phosphorus derivative · Sarin · Soman · Tabun · Unclassified drug · Biological monitoring · Biological warfare · Chemical structure · Concentration (parameters) · Environmental exposure · Enzyme activation · Enzyme active site · Enzyme inhibition · Gas chromatography · Half life time · Human · Nonhuman · pH · Priority journal · Retrospective study · Rhesus monkey · Animals · Butyrylcholinesterase · Chemical Warfare Agents · Cholinesterase Inhibitors · Cholinesterase Reactivators · Gas chromatography · Female · Fluorides · Half-Life · Humans · Injections, Intravenous · Macaca mulatta · Male · Organophosphorus compounds · Paraoxon · Reference standards · Time factors · Macaca mulatta · Cholinesterase, 9001-08-5 · Cyclosarin, 329-99-7 · Fluoride, 16984-48-8 · Paraoxon, 311-45-5 · Parathion, 3270-86-8, 56-38-2, 597-88-6 · Sarin, 107-44-8 · Soman, 96-64-0 · Tabun, 77-81-6 · Butyrylcholinesterase, EC 3.1.1.- · Chemical warfare agents · Cholinesterase inhibitors · Cholinesterase reactivators · Fluorides · Organophosphorus compounds
[Abstract]

16 Toxicokinetics of the nerve agent (±)-VX in anesthetized and atropinized hairless guinea pigs and marmosets after intravenous and percutaneous administration
article 2003    
Author: Schans, M.J. van der · Lander, B.J. · Wiel, H. van der · Langenberg, J.P. · Benschop, H.P.
Keywords: Biology · Chiral HPLC · Hairless guinea pigs · Intravenous · Marmosets · Percutaneous · Persistence · Stereospecificity · Toxicokinetics · Treatment · Carbamic acid · Oxime · Volatile agent · Anesthesia · Animal experiment · Animal model · Bioavailability · Blood level · Dose response · Enantiomer · Guinea pig · Intoxication · Marmoset · Nonhuman · Primate · Toxicokinetics · Administration, Topical · Anesthesia · Animals · Atropine · Callithrix · Chemical Warfare Agents · Chromatography, Gas · Chromatography, High Pressure Liquid · Electrochemistry · Injections, Intravenous · Kinetics · Lethal Dose 50 · Male · Muscarinic Antagonists · Organothiophosphorus Compounds · Stereoisomerism · Animalia · Cavia · Cavia porcellus · Primates · Sus scrofa · Acetylcholinesterase, 9000-81-1 · Carbamic acid, 463-77-4 · Methylphosphonothioic acid s (2 diisopropylaminoethyl) o ethyl ester, 50782-69-9 · Sarin, 107-44-8 · Soman, 96-64-0 · Acetylcholinesterase, EC 3.1.1.7 · Atropine, 51-55-8 · Chemical warfare agents · Muscarinic antagonists · Organothiophosphorus compounds · VX, 50782-69-9
[Abstract]

17 Beneficial effects of TCP on soman intoxication in guinea pigs : seizures, brain damage and learning behaviour
article 2001    
Author: Groot, D.M.G. de · Bierman, E.P.B. · Bruijnzeel, P.L.B. · Carpentier, P. · Kulig, B.M. · Lallement, G. · Melchers, B.P.C. · Philippens, I.H.C.H.M. · Huygevoort, A.H.B.M. van
Keywords: Toxicology · 1 (1 (2 thienyl)cyclohexyl)piperidine · 1-(1-(2-thienyl)cyclohexyl)piperidine · Atropine · Chemical warfare agent · Drug derivative · Muscarinic receptor blocking agent · N methyl dextro aspartic acid receptor · Neuroprotective agent · Chemically induced disorder · Discrimination learning · Drug effect · Pathology · Physiology · Animals · Atropine · Behavior, Animal · Brain · Chemical Warfare Agents · Cholinesterase Inhibitors · Discrimination Learning · Electroencephalography · Guinea Pigs · Male · Muscarinic Antagonists · Neuroprotective Agents · Phencyclidine · Pyridostigmine Bromide · Receptors, N-Methyl-D-Aspartate · Seizures · Soman
[Abstract]

18 Capillary gas chromatographic analysis of nerve agents using large volume injections
article 1996    
Author: Degenhardt, C.E.A.M. · Kientz, C.E.
Keywords: Biology · GC - Gas chromatography · Nerve agents · Capillarity · Phosphorus organic compounds · GB agent · Military chemical agents · Cholinesterase Inhibitors · Isoflurophate, 55-91-4 · Organophosphorus compounds · Organothiophosphorus compounds · Sarin, 107-44-8 · Soman, 96-64-0 · VX, 50782-69-9 · Water, 7732-18-5 · Chemical warfare agents · DFP · Large volume injection · Organophosphorus compounds · Tabun · Dflos · Methylphosphonothioic acid s (2 diisopropylaminoethyl) o ethyl ester · Capillary gas chromatography · Drug determination · Nonhuman · Sample · Technique · Water analysis · Water pollution · Cholinesterase Inhibitors · Chromatography, Gas · Hydrogen-Ion Concentration
[Abstract]

19 Quantitative analysis of O-isopropyl methylphosphonic acid in serum samples of Japanese citizens allegedly exposed to sarin: Estimation of internal dosage
article 1998    
Author: Noort, D. · Hulst, A.G. · Platenburg, D.H.J.M. · Polhuijs, M. · Benschop, H.P.
Keywords: Defence · Chemical warfare agents · LC tandem MS · Multiple reaction monitoring · O-isopropyl methylphosphonic acid · Sarin · Cholinesterase · Fluoride ion · Methylphosphonic acid · O isopropyl metylphosphonic acid · Sarin · Unclassified drug · Anion exchange chromatography · Article · Blood level · Chemical structure · Chemical warfare · Diagnostic value · Enzyme activity · Enzyme binding · Enzyme inhibition · Human · Hydrolysis · Japan · Lethal dose · Methodology · Population exposure · Priority journal · Tandem mass spectrometry · Toxicity testing · Butyrylcholinesterase · Chemistry, Analytical · Chromatography, Liquid · Environmental Exposure · Female · Humans · Male · Mass Spectrometry · Molecular Structure · Organophosphorus Compounds · Butyrylcholinesterase, EC 3.1.1.- · Isopropyl methylphosphonic acid, 1832-54-8 · Organophosphorus Compounds · Sarin, 107-44-8
[Abstract]

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Showing 1 to 19 of 19 found. | Sort by date