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Showing 1 to 9 of 9 found. | Sort by date

1 Binding of β-VLDL to heparan sulfate proteoglycans requires lipoprotein lipase, whereas apoE only modulates binding affinity
article 1999    
Author: Beer, F. de · Hendriks, W.L. · Vark, L.C. van · Kamerling, S.W.A. · Dijk, K.W. van · Hofker, M.H. · Smelt, A.H.M. · Havekes, L.M.
Keywords: Biology · β-VLDL · apoE · Heparan sulfate proteoglycans · Lipoprotein lipase · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Binding, Competitive · Cell Line · Cholesterol, VLDL · Heparan Sulfate Proteoglycans · Iodine Radioisotopes · Lipoprotein Lipase · Macrophages · Mice · Mice, Knockout
[Abstract]

2 Hyperlipidemia of ApoE2(Arg158-Cys) and ApoE3-Leiden transgenic mice is modulated predominantly by LDL receptor expression
article 1999    
Author: Dijk, K.W. van · Vlijmen, B.J.M. van · Winther, M.P.J. de · Hof, B. van 't · Zee, A. van der · Boom, H. van der · Havekes, L.M. · Hofker, M.H.
Keywords: Biology · Apolipoprotein E · Hypertriglyceridemia · LDL receptor · LDL receptor-related protein · VLDL triglyceride lipolysis · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Cholesterol, VLDL · Gene Expression · Hypertriglyceridemia · Lipolysis · Mice · Mice, Knockout · Point Mutation · Receptors, LDL · Triglycerides
[Abstract]

3 Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on cholesterol levels and atherosclerosis in apoE-deficient mice
article 2000    
Author: Eck, M. van · Winther, M.P.J. de · Herijgers, N. · Havekes, L.M. · Hofker, M.H. · Groot, P.H.E. · Berkel, T.J.C. van
Keywords: Biology · Animals · Aorta · Apolipoproteins E · Arteriosclerosis · Bone Marrow Cells · Bone Marrow Transplantation · Cells, Cultured · Cholesterol, VLDL · Female · Humans · Kupffer Cells · Lipid Metabolism · Lipoproteins, LDL · Macrophages, Peritoneal · Membrane Proteins · Mice · Mice, Knockout · Mice, Transgenic · Myocardium · Receptors, Immunologic · Receptors, Lipoprotein · Receptors, Scavenger · Scavenger Receptors, Class A · Scavenger Receptors, Class B · Triglycerides · Whole-Body Irradiation
[Abstract]

4 Severe hyperlipidemia in apolipoprotein E2 homozygotes due to a combined effect of hyperinsulinemia and an SstI polymorphism
article 1999    
Author: Sijbrands, E.J.G. · Hoffer, M.J.V. · Meinders, A.E. · Havekes, L.M. · Frants, R.R. · Smelt, A.H.M. · Knijff, P. de
Keywords: Apolipoprotein E · Hyperinsulinemia · Hyperlipoproteinemia type III · Xanthomas · Adult · Aged · Aged, 80 and over · Apolipoprotein A-I · Apolipoprotein C-III · Apolipoprotein E2 · Apolipoproteins A · Apolipoproteins C · Apolipoproteins E · Cholesterol, HDL · Cholesterol, LDL · Cholesterol, VLDL · Family Health · Female · Gene Expression · Haplotypes · Homozygote · Humans · Hyperinsulinism · Hyperlipidemias · Male · Middle Aged · Pedigree · Polymorphism, Single Nucleotide · Promoter Regions (Genetics) · Xanthomatosis
[Abstract]

5 Effect of apolipoprotein E and insulin resistance on VLDL particles in combined hyperlipidemic patients
article 1996    
Author: Sijbrands, E.J.G. · Westendorp, R.G.J. · Hoffer, M.J.V. · Frants, R.R. · Meinders, A.E. · Souverijn, J.H.M. · Leuven, J.A.G. · Laarse, A. van der · Havekes, L.M. · Smelt, A.H.M.
Keywords: Biology · ApoE · Combined hyperlipidemia · Hyperinsulinemia · Particle size · VLDL · apolipoprotein e · insulin · very low density lipoprotein · adult · aged · article · clinical trial · controlled clinical trial · controlled study · diet · female · genetic analysis · heterozygosity · human · human tissue · hyperlipidemia · hypertriglyceridemia · insulin resistance · lipid analysis · major clinical study · male · priority journal · Adult · Aged · Apolipoproteins E · Cholesterol, VLDL · Fasting · Female · Humans · Hyperlipidemia, Familial Combined · Insulin · Insulin Resistance · Lipoproteins, VLDL · Male · Middle Aged · Particle Size · Triglycerides
[Abstract]

6 The dual PPARα/γ agonist tesaglitazar blocks progression of pre-existing atherosclerosis in APOE*3Leiden.CETP transgenic mice
article 2009    
Author: Hoorn, J.W.A. van der · Jukema, J.W. · Havekes, L.M. · Lundholm, E. · Camejo, G. · Rensen, P.C.N. · Princen, H.M.G.
Keywords: Biology · Biomedical Research · 3Leiden.CETP mice · APOE · Atherogenic triad · Atherosclerosis · PPARα/γ · Tesaglitazar · 2 ethoxy 3 (4 ((4 (methylsulfonyloxy)phenethyl)oxy)phenyl)propanoic acid · Alkanesulfonic acid · High density lipoprotein cholesterol · Peroxisome proliferator activated receptor alpha · Peroxisome proliferator activated receptor gamma · Phenylpropionic acid derivative · Very low density lipoprotein cholesterol · Biosynthesis · Blood · Drug potentiation · Genetics · Inflammation · Metabolism · Mouse · Mutation · Pathology · Transgenic mouse · Alkanesulfonates · Animals · Aortic Valve · Apolipoprotein E3 · Atherosclerosis · Cholesterol Ester Transfer Proteins · Cholesterol, HDL · Cholesterol, VLDL · Female · Humans · Inflammation · Mice · Mice, Transgenic · Mutation · Phenylpropionates · PPAR alpha · PPAR gamma
[Abstract]

7 Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice
article 2008    
Author: Haan, W. de · Hoogt, C.C. van der · Westerterp, M. · Hoekstra, M. · Dallinga-Thie, G.M. · Princen, H.M.G. · Romijn, J.A. · Jukema, J.W. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Health · CETP · High-density lipoprotein · HMGCoA reductase · Statin · Transgenic mice · ABC transporter A1 · apolipoprotein A1 · apolipoprotein E3 · atorvastatin · cholesterol ester transfer protein · high density lipoprotein · high density lipoprotein cholesterol · messenger RNA · phospholipid transfer protein · scavenger receptor BI · very low density lipoprotein · very low density lipoprotein cholesterol · animal experiment · animal model · article · cholesterol blood level · cholesterol diet · controlled study · drug effect · gene expression · hypercholesterolemia · lipoprotein blood level · lipoprotein metabolism · male · mouse · nonhuman · priority journal · protein expression · transgenic mouse · Animals · Apolipoprotein E3 · Cholesterol Ester Transfer Proteins · Cholesterol, Dietary · Cholesterol, HDL · Cholesterol, VLDL · Dose-Response Relationship, Drug · Female · Gene Expression · Heptanoic Acids · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Hypercholesterolemia · Liver · Male · Mice · Mice, Inbred C57BL · Mice, Transgenic · Pyrroles · RNA, Messenger
[Abstract]

8 The hepatic uptake of VLDL in lrp-ldlr-/-vldlr-/- mice is regulated by LPL activity and involves proteoglycans and SR-BI
article 2008    
Author: Hu, L. · Hoogt, C.C. van der · Espirito Santo, S.M.S. · Out, R. · Kypreos, K.E. · Vlijmen, B.J.M. van · Berkel, T.J.C. van · Romijn, J.A. · Havekes, L.M. · Dijk, K.W. van · Rensen, P.C.N.
Keywords: Biology · Apolipoprotein · Denovirus-mediated gene transfer · Lipoprotein lipase · Low density lipoprotein receptor · Low density lipoprotein receptor-related protein · Transgenic mice · Triglyceride-rich emulsion particles · Very low density lipoprotein receptor · apolipoprotein E · cell surface protein · cholesterol · lipoprotein lipase · low density lipoprotein receptor · low density lipoprotein receptor related protein · proteoglycan · proteoheparan sulfate · scavenger receptor BI · triacylglycerol · very low density lipoprotein · very low density lipoprotein receptor · CD36 antigen · ligand · very low density lipoprotein cholesterol · Adenovirus · animal cell · animal experiment · animal tissue · article · cell isolation · cell surface · controlled study · enzyme activity · in vitro study · in vivo study · internalization · lipid analysis · liver cell · male · mouse · nonhuman · priority journal · protein expression · regulatory mechanism · animal · blood · emulsion · genetics · liver · metabolism · mouse mutant · Animals · Antigens, CD36 · Cholesterol, VLDL · Emulsions · LDL-Receptor Related Proteins · Ligands · Lipoprotein Lipase · Liver · Male · Mice · Mice, Knockout · Proteoglycans · Receptors, LDL · Healthy for Life · Healthy Living
[Abstract]

9 Ritonavir impairs lipoprotein lipase-mediated lipolysis and decreases uptake of fatty acids in adipose tissue
article 2006    
Author: Boer, M.A.M. den · Berbée, J.F.P. · Reiss, P. · Valk, M. van der · Voshol, P.J. · Kuipers, F. · Havekes, L.M. · Rensen, P.C.N. · Romijn, J.A.
Keywords: Dyslipidemia · FA metabolism · Protease inhibitor · TG metabolism · Transgenic mice · Albumin · Lipoprotein lipase · Proteinase inhibitor · Ritonavir · Triacylglycerol · Triolein · Very low density lipoprotein · Anticoagulant agent · Apolipoprotein E · Apolipoprotein E3 (Leidein) · Diagnostic agent · Fatty acid · Heparin · Tritium · Very low density lipoprotein cholesterol · Adipose tissue · Animal tissue · Clearance · Controlled study · Drug mechanism · Emulsion · Enzyme activity · Fat intake · Fatty acid metabolism · Fatty acid transport · Half life time · Hypertriglyceridemia · Lipid diet · Lipodystrophy · Lipolysis · Mouse · Nonhuman · Postprandial state · Transgenic mouse · Triacylglycerol blood level · Biosynthesis · Blood · Chemically induced disorder · Drug effect · Enzyme activation · Genetics · Human immunodeficiency virus infection · Metabolism · Adipose Tissue · Animals · Anticoagulants · Apolipoprotein E3 · Apolipoproteins E · Cholesterol, VLDL · Emulsions · Enzyme Activation · Fatty Acids · Female · Heparin · HIV Infections · HIV Protease Inhibitors · Hypertriglyceridemia · Lipolysis · Lipoprotein Lipase · Mice · Mice, Transgenic · Postprandial Period · Ritonavir · Triglycerides · Triolein · Tritium
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 9 of 9 found. | Sort by date