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Showing 1 to 16 of 16 found. | Sort by date

1 Aging of phosphonylated cholinesterases
dissertation 1971    
Author: Keijer, J.H.
Keywords: Biology · Stereochemistry · Dealkylation · G agents · Cholinesterase inhibitors · Phosphorus organic compounds · Activation · Cholinesterase · Oximes · Therapy · Reaction kinetics · Potentiometric analysis · PH · Ionic mobility · Ions · Activation energy · Temperature · Ionization

2 New generic approach to the treatment of organophosphate poisoning: Adenosine receptor mediated inhibition of ACh-release
article 1998    
Author: Helden, H.P.M. van · Groen, B. · Moor, E. · Westerink, B.H.C. · Bruijnzeel, P.L.B.
Keywords: Adenosine-5'-(N-ethylcarboxamide) · Animals · Brain Chemistry · Cholinesterase Inhibitors · Dinucleoside Phosphates · Injections, Intramuscular · Injections, Subcutaneous · Poisoning · Rats · Receptors, Purinergic P1 · Soman · Survival Rate · Time Factors
[Abstract]

3 Biomonitoring of exposure to chemical warfare agents: A review
article 2002    
Author: Noort, D. · Benschop, H.P. · Black, R.M.
Keywords: Warfare · Biomonitoring · Chemical warfare agents · Mass spectrometry · Nerve agent · Review · Sulfur mustard · Terrorism · Biological marker · DNA · Glutathione · Protein · Biological monitoring · Blood analysis · Chemical analysis · Chemical warfare · Conjugation · Dosimetry · Exposure · Health survey · Humans · Hydrolysis · Immunochemistry · Mass spectrometry · Metabolite · Review · Urinalysis · Animals · Cholinesterase inhibitors · DNA adducts · Environmental monitoring · Protein binding · Arsenicals · Cholinesterase inhibitors · Lewisite, 541-25-3 · Mustard gas, 505-60-2
[Abstract]

4 Direct determination of the chemical composition of acetylcholinesterase phosphonylation products utilizing electrospray-ionization mass spectrometry
article 1997    
Author: Barak, R. · Ordentlich, A. · Barak, D. · Fischer, M. · Benschop, H.P. · Jong, L.P.A. de · Segall, Y. · Velan, B. · Shafferman, A.
Keywords: Determination · Chemical compounds · Acetylcholinesterase · Electrospray · Mass spectroscopy · Ionization · Aging (biology) · Inhibitors · Organic phosphates · Acetylcholinesterase, EC 3.1.1.7 · Cholinesterase Inhibitors · Organophosphorus Compounds · Recombinant Proteins · Acetylcholinesterase · Aging · ESI-MS · Organophosphonate inhibitor · Enzyme activity · Enzyme phosphorylation · Mass spectrometry · Alkylation · Cholinesterase inhibitors · Humans · Mass spectrometry · Molecular structure · Molecular weight · Organophosphorus compounds · Recombinant proteins
[PDF] [Abstract]

5 Retrospective detection of exposure to organophosphorus anti-cholinesterases: Mass spectrometric analysis of phosphylated human butyrylcholinesterase
article 2002    
Author: Fidder, A. · Hulst, A.G. · Noort, D. · Ruiter, R. de · Schans, M.J. van der · Benschop, H.P. · Langenberg, J.P.
Keywords: Warfare · Cholinesterase · Cholinesterase inhibitor · Nerve gas · Organophosphorus compound · Pronase · Sarin · Article · Colorimetry · Enzyme activity · Enzyme assay · High performance liquid chromatography · Hydrolysis · Intoxication · Mass spectrometry · Protein phosphorylation · Spectrometry · Synthesis · Butyrylcholinesterase · Cholinesterase Inhibitors · Environmental Exposure · Environmental Monitoring · Humans · Insecticides · Peptide Fragments · Sarin · Spectrometry, Mass, Electrospray Ionization · Terrorism · Butyrylcholinesterase, EC 3.1.1.- · Cholinesterase Inhibitors · Insecticides · Peptide fragments · Sarin, 107-44-8
[Abstract]

6 Capillary gas chromatographic analysis of nerve agents using large volume injections
article 1996    
Author: Degenhardt, C.E.A.M. · Kientz, C.E.
Keywords: Biology · GC - Gas chromatography · Nerve agents · Capillarity · Phosphorus organic compounds · GB agent · Military chemical agents · Cholinesterase Inhibitors · Isoflurophate, 55-91-4 · Organophosphorus compounds · Organothiophosphorus compounds · Sarin, 107-44-8 · Soman, 96-64-0 · VX, 50782-69-9 · Water, 7732-18-5 · Chemical warfare agents · DFP · Large volume injection · Organophosphorus compounds · Tabun · Dflos · Methylphosphonothioic acid s (2 diisopropylaminoethyl) o ethyl ester · Capillary gas chromatography · Drug determination · Nonhuman · Sample · Technique · Water analysis · Water pollution · Cholinesterase Inhibitors · Chromatography, Gas · Hydrogen-Ion Concentration
[Abstract]

7 Low levels of sarin affect the EEG in marmoset monkeys: A pilot study
article 2004    
Author: Helden, H.H.P.M. van · Vanwersch, R.A.P. · Kuijpers, W.C. · Trap, H.C. · Philippens, I.H.C. · Benschop, H.P.
Keywords: EEG · Exposure limits · Field alarm · Lowest observable adverse effect level (LOAEL) · Nerve agent · O-isopropyl methylphosphonofluoridate · Pyridostigmine · Sarin · Sleep-spindles · Whole-body exposure · Pyridostigmine · Sarin · Animal experiment · Blood · Cholinergic system · Controlled study · Electroencephalogram · Energy · Female · Male · Marmoset · Nonhuman · Oscillation · Pilot study · Priority journal · Sleep spindle · Animals · Callithrix · Chemical Warfare Agents · Cholinesterase Inhibitors · Dose-Response Relationship, Drug · Electroencephalography · Female · Humans · Inhalation Exposure · Male · Pyridostigmine Bromide · Sarin · Time Factors · Animalia · marmosets · Pyridostigmine, 101-26-8, 155-97-5 · Sarin, 107-44-8 · Chemical warfare agents · Cholinesterase inhibitors · Pyridostigmine Bromide, 101-26-8
[Abstract]

8 Protection against toxic compounds : chemical and technological aspects
book 1973    
Keywords: Biology · Medicine · Geneeskunde · Pharmacology · Toxicology · Protection · Cholinesterase inhibitors · Military chemical agents · G agents · Stereochemistry · Activation · Reaction kinetics · Dextrins · Carbohydrates · Chemical agent detection · Monitors · Hydrogen fluoride · Fluorides · Identification systems · Sampling · Light scattering · Aerosols · Particle size distribution · Phthalates · Activated carbon · Adsorption · Leakage · Penetration · Benzene · Water treatment · Potable water · Hydrolysis · Aluminum oxide · Phthalocyanines
[PDF]

9 On the oscillatory decay of the myotonic action of 9 anthroic acid. Influence of cholinesterase inhibition
article 1977    
Author: Velsen, F.L. van · Nickolson, V.J.
Keywords: Biology · 9 Anthroic acid · Acetylcholinesterase · Adenosine triphosphatase (potassium sodium) · Cholinesterase inhibitor · Curare · Ouabain · Soman · In vitro study · Muscle contraction · Myotonia · Rat · Theoretical study · Animal · Anthracenes · Calcium · Carboxylic Acids · Chlorides · Cholinesterase Inhibitors · Diaphragm · Drug Interactions · Electric Stimulation · In Vitro · Magnesium · Male · Motor Endplate · Muscle Contraction · Neuromuscular Junction · Ouabain · Potassium · Rats · Sodium · Soman
[Abstract]

10 Comprehensive gas chromatography with Time of Flight MS and large volume introduction for the detection of fluoride-induced regenerated nerve agent in biological samples
article 2010    
Author: Meer, J.A. van der · Trap, H.C. · Noort, D. · Schans, M.J. van der
Keywords: Defence · Comprehensive GC · Time of Flight MS · Nerve agents · Fluoride reactivation · Diagnosis · Chemicals/CAS: · Fluoride, 16984-48-8 · Sarin, 107-44-8 · Tabun, 77-81-6 · Chemical warfare agents · Cholinesterase inhibitors · Fluorides · Organophosphorus compounds · Phosphoric acid esters · Organophosphate · Organophosphorus compound · Blood · Chemistry · Human · Mass fragmentography · Methodology · Reproducibility · Sensitivity and specificity · Statistical model · Gas Chromatography-Mass Spectrometry · Linear models
[Abstract]

11 A physiologically based pharmacokinetic (PB/PK) model for multiple exposure routes for soman in multiple species
article 2006    
Author: Sweeney, R.E. · Langenberg, J.P. · Maxwell, D.M.
Keywords: Toxicology · Acetylcholinesterase · Carboxylesterase · Enzyme · Soman · Adipose tissue · Allometry · Animal experiment · Animal tissue · Arterial blood · Blood flow velocity · BLood level · Body weight · Breathing rate · Computer language · Computer simulation · Controlled study · Exposure · Guinea pig · In vitro study · Kidney perfusion · LD 50 · Liver perfusion · Lung perfusion · Male · Marmoset · Metabolism · Nonhuman · Partition coefficient · Priority journal · Provocation test · Rat · Regression analysis · Sensitivity analysis · Stereoisomerism · Tidal volume · Tissue level · Toxicokinetics · Venous blood · Administration, Inhalation · Animals · Callithrix · Chemical Warfare Agents · Cholinesterase Inhibitors · Computer Simulation · Guinea Pigs · Injections, Intravenous · Injections, Subcutaneous · Male · Models, Biological · Rats · Rats, Wistar · Animalia · Cavia porcellus · Marmosets · Acetylcholinesterase, 9000-81-1 · Carboxylesterase, 59536-71-9, 83380-83-0, 9016-18-6, 9028-01-7 · Soman, 96-64-0 · Chemical warfare agents · Cholinesterase inhibitors
[Abstract]

12 Retrospective detection of exposure to nerve agents: Analysis of phosphofluoridates originating from fluoride-induced rectivation of phospylated BuChE
article 2004    
Author: Schans, M.J. van der · Polhuijs, M. · Dijk, C. van · Degenhardt, C.E.A.M. · Pleijsier, K. · Langenberg, J.P. · Benschop, H.P.
Keywords: Biology · Biomarker · Biomonitoring · Butyryl cholinesterase · Fluoride ions · Lexposure · Nerve agents · Organophosphates · Reactivation · Retrospective detection · Cholinesterase · Cholinesterase inhibitor · Cyclosarin · Fluoride · Nerve gas · Organophosphate · Paraoxon · Parathion · Phosphorus derivative · Sarin · Soman · Tabun · Unclassified drug · Biological monitoring · Biological warfare · Chemical structure · Concentration (parameters) · Environmental exposure · Enzyme activation · Enzyme active site · Enzyme inhibition · Gas chromatography · Half life time · Human · Nonhuman · pH · Priority journal · Retrospective study · Rhesus monkey · Animals · Butyrylcholinesterase · Chemical Warfare Agents · Cholinesterase Inhibitors · Cholinesterase Reactivators · Gas chromatography · Female · Fluorides · Half-Life · Humans · Injections, Intravenous · Macaca mulatta · Male · Organophosphorus compounds · Paraoxon · Reference standards · Time factors · Macaca mulatta · Cholinesterase, 9001-08-5 · Cyclosarin, 329-99-7 · Fluoride, 16984-48-8 · Paraoxon, 311-45-5 · Parathion, 3270-86-8, 56-38-2, 597-88-6 · Sarin, 107-44-8 · Soman, 96-64-0 · Tabun, 77-81-6 · Butyrylcholinesterase, EC 3.1.1.- · Chemical warfare agents · Cholinesterase inhibitors · Cholinesterase reactivators · Fluorides · Organophosphorus compounds
[Abstract]

13 Neurological symptoms among Sri Lankan farmers occupationally exposed to acetylcholinesterase-inhibiting insecticides
article 2003    
Author: Smit, L.A.M. · Wendel- de Joode, B.N. van · Heederik, D. · Peiris-John, R.J. · Hoek, W. van der
Keywords: Health Chemistry · Food and Chemical Risk Analysis · Acetylcholinesterase inhibition · IPM · Neurological symptoms · Pesticide exposure · Sri Lanka · acetylcholinesterase · insecticide · adult · agricultural worker · article · cholinesterase inhibition · controlled study · enzyme activity · female · human · integrated pest management · intoxication · major clinical study · male · neurologic disease · occupational exposure · questionnaire · Sri Lanka · symptomatology · Acetylcholinesterase · Adult · Agriculture · Cholinesterase Inhibitors · Female · Humans · Insecticides · Male · Middle Aged · Nervous System Diseases · Occupational Exposure · Prevalence · Sri Lanka
[Abstract]

14 Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers
article 1999    
Author: Ordentlich, A. · Barak, D. · Kronman, C. · Benschop, H.P. · Jong, L.P.A. de · Ariel, N. · Barak, R. · Segall, Y. · Velan, B. · Shafferman, A.
Keywords: Cholinesterase reactivator · Soman · Binding site · Chirality · Dealkylation · Enzyme activity · Enzyme analysis · Enzyme binding · Enzyme specificity · Enzyme structure · Enzyme substrate · Human cell · Protein expression · Stereochemistry · Stereoisomerism · Alkylation · Amino acid substitution · Binding sites · Cell line · Cholinesterase inhibitors · Humans · Hydrogen Bonding · Kidney · Macromolecular substances · Models, Molecular · Mutagenesis, Site-Directed · Stereoisomerism · Acetylcholinesterase, EC 3.1.1.7 · Alanine, 56-41-7 · Phenylalanine, 63-91-2 · Phosphorus, 7723-14-0 · Soman, 96-64-0
[Abstract]

15 Beneficial effects of TCP on soman intoxication in guinea pigs : seizures, brain damage and learning behaviour
article 2001    
Author: Groot, D.M.G. de · Bierman, E.P.B. · Bruijnzeel, P.L.B. · Carpentier, P. · Kulig, B.M. · Lallement, G. · Melchers, B.P.C. · Philippens, I.H.C.H.M. · Huygevoort, A.H.B.M. van
Keywords: Toxicology · 1 (1 (2 thienyl)cyclohexyl)piperidine · 1-(1-(2-thienyl)cyclohexyl)piperidine · Atropine · Chemical warfare agent · Drug derivative · Muscarinic receptor blocking agent · N methyl dextro aspartic acid receptor · Neuroprotective agent · Chemically induced disorder · Discrimination learning · Drug effect · Pathology · Physiology · Animals · Atropine · Behavior, Animal · Brain · Chemical Warfare Agents · Cholinesterase Inhibitors · Discrimination Learning · Electroencephalography · Guinea Pigs · Male · Muscarinic Antagonists · Neuroprotective Agents · Phencyclidine · Pyridostigmine Bromide · Receptors, N-Methyl-D-Aspartate · Seizures · Soman
[Abstract]

16 Therapeutic efficacy of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) against organophosphate intoxication
article 2002    
Author: Bueters, T.J.H. · Groen, B. · Danhof, M. · IJzerman, A.P. · Helden, H.P.M. van
Keywords: Biology · Acetylcholine release · Adenosine A1 receptor · N6-Cyclopentyladenosine · Organophosphate · Adenosine A1 receptor agonist · Adenosine receptor stimulating agent · Cyclohexyladenosine · Methylphosphonothioic acid s (2 diisopropylaminoethyl) o ethyl ester · Adenosine receptor · Cholinesterase · Drug derivative · N(6) cyclopentyladenosine · Organophosphate · Phosphorothioic acid derivative · Bioaccumulation · Cholinergic system · Concentration response · Controlled study · Corpus striatum · Crug efficacy · Enzyme activity · Hippocampus · Intoxication · Male · Microdialysis · Nonhuman · Rat · Reduction · Animal · Drug potentiation · Enzymology · Metabolism · Secretion · Wistar rat · Animals · Cholinesterase Inhibitors · Cholinesterases · Corpus Striatum · Male · Microdialysis · Organothiophosphorus Compounds · Parathion · Phosphoric Acid Esters · Rats · Rats, Wistar · Receptors, Purinergic P1 · Sarin · Acetylcholinesterase, 9000-81-1 · Cyclohexyladenosine, 36396-99-3 · Methylphosphonothioic acid s (2 diisopropylaminoethyl) o ethyl ester, 50782-69-9 · Parathion, 3270-86-8, 56-38-2, 597-88-6 · Sarin, 107-44-8; tabun, 77-81-6 · Acetylcholine, 51-84-3 · Adenosine, 58-61-7; · Cholinesterase Inhibitors · Cholinesterases, EC 3.1.1.8 · N(6)-cyclopentyladenosine, 41552-82-3 · Organothiophosphorus Compounds · Parathion, 56-38- · Phosphoric Acid Esters · Receptors, Purinergic P1 · Sarin, 107-44-8 · Tabun, 77-81-6 · VX, 50782-69-9
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 16 of 16 found. | Sort by date