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1 Aging of phosphonylated cholinesterases
dissertation 1971    
Author: Keijer, J.H.
Keywords: Biology · Stereochemistry · Dealkylation · G agents · Cholinesterase inhibitors · Phosphorus organic compounds · Activation · Cholinesterase · Oximes · Therapy · Reaction kinetics · Potentiometric analysis · PH · Ionic mobility · Ions · Activation energy · Temperature · Ionization

2 Retrospective detection of exposure to organophosphorus anti-cholinesterases: Mass spectrometric analysis of phosphylated human butyrylcholinesterase
article 2002    
Author: Fidder, A. · Hulst, A.G. · Noort, D. · Ruiter, R. de · Schans, M.J. van der · Benschop, H.P. · Langenberg, J.P.
Keywords: Warfare · Cholinesterase · Cholinesterase inhibitor · Nerve gas · Organophosphorus compound · Pronase · Sarin · Article · Colorimetry · Enzyme activity · Enzyme assay · High performance liquid chromatography · Hydrolysis · Intoxication · Mass spectrometry · Protein phosphorylation · Spectrometry · Synthesis · Butyrylcholinesterase · Cholinesterase Inhibitors · Environmental Exposure · Environmental Monitoring · Humans · Insecticides · Peptide Fragments · Sarin · Spectrometry, Mass, Electrospray Ionization · Terrorism · Butyrylcholinesterase, EC 3.1.1.- · Cholinesterase Inhibitors · Insecticides · Peptide fragments · Sarin, 107-44-8
[Abstract]

3 Retrospective detection of exposure to nerve agents: Analysis of phosphofluoridates originating from fluoride-induced rectivation of phospylated BuChE
article 2004    
Author: Schans, M.J. van der · Polhuijs, M. · Dijk, C. van · Degenhardt, C.E.A.M. · Pleijsier, K. · Langenberg, J.P. · Benschop, H.P.
Keywords: Biology · Biomarker · Biomonitoring · Butyryl cholinesterase · Fluoride ions · Lexposure · Nerve agents · Organophosphates · Reactivation · Retrospective detection · Cholinesterase · Cholinesterase inhibitor · Cyclosarin · Fluoride · Nerve gas · Organophosphate · Paraoxon · Parathion · Phosphorus derivative · Sarin · Soman · Tabun · Unclassified drug · Biological monitoring · Biological warfare · Chemical structure · Concentration (parameters) · Environmental exposure · Enzyme activation · Enzyme active site · Enzyme inhibition · Gas chromatography · Half life time · Human · Nonhuman · pH · Priority journal · Retrospective study · Rhesus monkey · Animals · Butyrylcholinesterase · Chemical Warfare Agents · Cholinesterase Inhibitors · Cholinesterase Reactivators · Gas chromatography · Female · Fluorides · Half-Life · Humans · Injections, Intravenous · Macaca mulatta · Male · Organophosphorus compounds · Paraoxon · Reference standards · Time factors · Macaca mulatta · Cholinesterase, 9001-08-5 · Cyclosarin, 329-99-7 · Fluoride, 16984-48-8 · Paraoxon, 311-45-5 · Parathion, 3270-86-8, 56-38-2, 597-88-6 · Sarin, 107-44-8 · Soman, 96-64-0 · Tabun, 77-81-6 · Butyrylcholinesterase, EC 3.1.1.- · Chemical warfare agents · Cholinesterase inhibitors · Cholinesterase reactivators · Fluorides · Organophosphorus compounds
[Abstract]

4 Verification of exposure to organophosphates: Generic mass spectrometric method for detection of human butyrylcholinesterase adducts
article 2006    
Author: Noort, D. · Fidder, A. · Schans, M.J. van der · Hulst, A.G.
Keywords: Enzyme inhibition · Ethanol · Mass spectrometry · Phosphates · Plasmas · Proteins · Generic mass spectrometric · Human butyrylcholinesterase adducts · Organophosphates · Phosphylated peptides · Biochemistry · Cholinesterase · Cholinesterase inhibitor · Dichlorvos · Methylphosphonothioic acid s (2 diisopropylaminoethyl) o ethyl ester · Nerve gas · Nonapeptide · Organophosphate pesticide · Organophosphorus compound · Pepsin A · Phosphoserine · Procainamide · Proton · Sarin · Soman · Analytic method · Article · Biological monitoring · Chemical warfare · Cholinesterase inhibition · Human · Liquid chromatography · Plasma · Solid phase extraction · Spectrometer · Tandem mass spectrometry · Terrorism · Time of flight mass spectrometry · Butyrylcholinesterase · Chromatography, Liquid · Humans · Phosphoric Acid Esters · Solid Phase Extraction · Tandem Mass Spectrometry
[Abstract]

5 New generic approach to the treatment of organophosphate poisoning: Adenosine receptor mediated inhibition of ACh-release
article 1998    
Author: Helden, H.P.M. van · Groen, B. · Moor, E. · Westerink, B.H.C. · Bruijnzeel, P.L.B.
Keywords: Adenosine-5'-(N-ethylcarboxamide) · Animals · Brain Chemistry · Cholinesterase Inhibitors · Dinucleoside Phosphates · Injections, Intramuscular · Injections, Subcutaneous · Poisoning · Rats · Receptors, Purinergic P1 · Soman · Survival Rate · Time Factors
[Abstract]

6 Improvements of the fluoride reactivation method for the verification of nerve agent exposure
article 2004    
Author: Degenhardt, C.E.A.M. · Pleijsier, K. · Schans, M.J. van der · Langenberg, J.P. · Preston, K.E. · Solano, M.I. · Maggio, V.L. · Barr, J.R.
Keywords: Warfare · Biological marker · Cholinesterase · Cyclosarin · Organophosphorus compound · Potassium fluoride · Sarin · Soman · Tabun · Unclassified drug · Calibration · Chemical analysis · Chemical warfare · Enzyme activity · Gas chromatography · Human · Mass spectrometry · Methodology · Neurotoxicity · Plasma · Solid phase extraction · Biological Markers · Butyrylcholinesterase · Chemical warfare agents · Cholinesterase reactivators · Environmental exposure · Environmental monitoring · Erythrocytes · Fluorides · Gas Chromatography-Mass Spectrometry · Humans · Reproducibility of results · Sensitivity and specificity · Cholinesterase, 9001-08-5 · Cyclosarin, 329-99-7 · Potassium fluoride, 7789-23-3 · Sarin, 107-44-8 · Soman, 96-64-0 · Tabun, 77-81-6 · Biological Markers · Butyrylcholinesterase, EC 3.1.1.- · Chemical Warfare Agents · Cholinesterase reactivators · Fluorides
[Abstract]

7 Biomonitoring of exposure to chemical warfare agents: A review
article 2002    
Author: Noort, D. · Benschop, H.P. · Black, R.M.
Keywords: Warfare · Biomonitoring · Chemical warfare agents · Mass spectrometry · Nerve agent · Review · Sulfur mustard · Terrorism · Biological marker · DNA · Glutathione · Protein · Biological monitoring · Blood analysis · Chemical analysis · Chemical warfare · Conjugation · Dosimetry · Exposure · Health survey · Humans · Hydrolysis · Immunochemistry · Mass spectrometry · Metabolite · Review · Urinalysis · Animals · Cholinesterase inhibitors · DNA adducts · Environmental monitoring · Protein binding · Arsenicals · Cholinesterase inhibitors · Lewisite, 541-25-3 · Mustard gas, 505-60-2
[Abstract]

8 On the oscillatory decay of the myotonic action of 9 anthroic acid. Influence of cholinesterase inhibition
article 1977    
Author: Velsen, F.L. van · Nickolson, V.J.
Keywords: Biology · 9 Anthroic acid · Acetylcholinesterase · Adenosine triphosphatase (potassium sodium) · Cholinesterase inhibitor · Curare · Ouabain · Soman · In vitro study · Muscle contraction · Myotonia · Rat · Theoretical study · Animal · Anthracenes · Calcium · Carboxylic Acids · Chlorides · Cholinesterase Inhibitors · Diaphragm · Drug Interactions · Electric Stimulation · In Vitro · Magnesium · Male · Motor Endplate · Muscle Contraction · Neuromuscular Junction · Ouabain · Potassium · Rats · Sodium · Soman
[Abstract]

9 Direct determination of the chemical composition of acetylcholinesterase phosphonylation products utilizing electrospray-ionization mass spectrometry
article 1997    
Author: Barak, R. · Ordentlich, A. · Barak, D. · Fischer, M. · Benschop, H.P. · Jong, L.P.A. de · Segall, Y. · Velan, B. · Shafferman, A.
Keywords: Determination · Chemical compounds · Acetylcholinesterase · Electrospray · Mass spectroscopy · Ionization · Aging (biology) · Inhibitors · Organic phosphates · Acetylcholinesterase, EC 3.1.1.7 · Cholinesterase Inhibitors · Organophosphorus Compounds · Recombinant Proteins · Acetylcholinesterase · Aging · ESI-MS · Organophosphonate inhibitor · Enzyme activity · Enzyme phosphorylation · Mass spectrometry · Alkylation · Cholinesterase inhibitors · Humans · Mass spectrometry · Molecular structure · Molecular weight · Organophosphorus compounds · Recombinant proteins
[PDF] [Abstract]

10 Long-term, low-level exposure of guinea pigs and marmosets to sarin vapor in air: Lowest observable effect level
article 2003    
Author: Helden, H.P.M. van · Trap, H.C. · Oostdijk, J.P. · Kuijpers, W.C. · Langenberg, J.P. · Benschop, H.P.
Keywords: Fluoride-induced reactivation · Guinea pigs · Internal dose · Lowest observable effect level (LOEL) · Marmosets · Nerve agent · O-Isopropyl methylphosphonofluoridate · Occupational exposure limits · Respiratory exposure · Sarin · Worker population limit (WPL) · Cholinesterase · Sarin · Animal experiment · Animal trapping · Article · Binding site · Chemical warfare · Cholinesterase inhibition · Controlled study · Enzyme activity · Gas chromatography · Gas mask · Guinea pig · Long term exposure · Male · Marmoset · Measurement · Nonhuman · Occupational exposure · Species comparison · Vaporization · Worker · Animals · Atmosphere Exposure Chambers · Callithrix · Dose-Response Relationship, Drug · Female · Gases · Guinea Pigs · Male · No-Observed-Adverse-Effect Level · Sarin · Threshold Limit Values · Volatilization · Animalia · Cavia · Cholinesterase, 9001-08-5 · Sarin, 107-44-8 · Gases
[Abstract]

11 Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase
article 2017    
Author: Koning, M.C. de · Joosen, M.J.A. · Worek, F. · Nachon, F. · Grol, M. van · Klaassen, S.D. · Alkema, D.P.W. · Wille, T. · Bruijn, H.M. de
Keywords: Safety · Acetylcholinesterase · Cholinesterase inhibitor · Imidazole · Imidazole derivative · Nerve gas · Oxime derivative · Pralidoxime · Unclassified drug · Safety and Security · Defence, Safety and Security · 2015 Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[Abstract]

12 Neurological symptoms among Sri Lankan farmers occupationally exposed to acetylcholinesterase-inhibiting insecticides
article 2003    
Author: Smit, L.A.M. · Wendel- de Joode, B.N. van · Heederik, D. · Peiris-John, R.J. · Hoek, W. van der
Keywords: Health Chemistry · Food and Chemical Risk Analysis · Acetylcholinesterase inhibition · IPM · Neurological symptoms · Pesticide exposure · Sri Lanka · acetylcholinesterase · insecticide · adult · agricultural worker · article · cholinesterase inhibition · controlled study · enzyme activity · female · human · integrated pest management · intoxication · major clinical study · male · neurologic disease · occupational exposure · questionnaire · Sri Lanka · symptomatology · Acetylcholinesterase · Adult · Agriculture · Cholinesterase Inhibitors · Female · Humans · Insecticides · Male · Middle Aged · Nervous System Diseases · Occupational Exposure · Prevalence · Sri Lanka
[Abstract]

13 Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers
article 1999    
Author: Ordentlich, A. · Barak, D. · Kronman, C. · Benschop, H.P. · Jong, L.P.A. de · Ariel, N. · Barak, R. · Segall, Y. · Velan, B. · Shafferman, A.
Keywords: Cholinesterase reactivator · Soman · Binding site · Chirality · Dealkylation · Enzyme activity · Enzyme analysis · Enzyme binding · Enzyme specificity · Enzyme structure · Enzyme substrate · Human cell · Protein expression · Stereochemistry · Stereoisomerism · Alkylation · Amino acid substitution · Binding sites · Cell line · Cholinesterase inhibitors · Humans · Hydrogen Bonding · Kidney · Macromolecular substances · Models, Molecular · Mutagenesis, Site-Directed · Stereoisomerism · Acetylcholinesterase, EC 3.1.1.7 · Alanine, 56-41-7 · Phenylalanine, 63-91-2 · Phosphorus, 7723-14-0 · Soman, 96-64-0
[Abstract]

14 Quantitation of ortho-cresyl phosphate adducts to butyrylcholinesterase in human serum by immunomagnetic-UHPLC-MS/MS
article 2015    
Author: Johnson, D. · Carter, M.D. · Crow, B.S. · Isenberg, S.L. · Graham, L.A. · Erol, H.A. · Watson, C.M. · Pantazides, B.G. · Schans, M.J. van der · Langenberg, J.P. · Noort, D. · Blake, T.A. · Thomas, J.D. · Johnson, R.C.
Keywords: Butyrylcholinesterase · Dresyl saligenin phosphate · Jamaica ginger paralysis · Organophosphate-induced delayed neuropathy · Tri-ortho-cresyl-phosphate · Body fluids · Cabins (aircraft) · Calibration · Enzymes · Lubricants · Tribology · Butyrylcholinesterase · Esterase enzymes · Flame-retardant additives · Human exposures · Industrial lubricants · Jamaica · Neurotoxic effects · Organophosphate-induced delayed neuropathy · Cockpits (aircraft) · Cholinesterase · Tri ortho cresyl phosphate · Accuracy · Cholinesterase blood level · Controlled study · In vitro study · Limit of detection · Tandem mass spectrometry · Ultra performance liquid chromatography · Zingiber officinale · Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[Abstract]

15 Capillary gas chromatographic analysis of nerve agents using large volume injections
article 1996    
Author: Degenhardt, C.E.A.M. · Kientz, C.E.
Keywords: Biology · GC - Gas chromatography · Nerve agents · Capillarity · Phosphorus organic compounds · GB agent · Military chemical agents · Cholinesterase Inhibitors · Isoflurophate, 55-91-4 · Organophosphorus compounds · Organothiophosphorus compounds · Sarin, 107-44-8 · Soman, 96-64-0 · VX, 50782-69-9 · Water, 7732-18-5 · Chemical warfare agents · DFP · Large volume injection · Organophosphorus compounds · Tabun · Dflos · Methylphosphonothioic acid s (2 diisopropylaminoethyl) o ethyl ester · Capillary gas chromatography · Drug determination · Nonhuman · Sample · Technique · Water analysis · Water pollution · Cholinesterase Inhibitors · Chromatography, Gas · Hydrogen-Ion Concentration
[Abstract]

16 Low levels of sarin affect the EEG in marmoset monkeys: A pilot study
article 2004    
Author: Helden, H.H.P.M. van · Vanwersch, R.A.P. · Kuijpers, W.C. · Trap, H.C. · Philippens, I.H.C. · Benschop, H.P.
Keywords: EEG · Exposure limits · Field alarm · Lowest observable adverse effect level (LOAEL) · Nerve agent · O-isopropyl methylphosphonofluoridate · Pyridostigmine · Sarin · Sleep-spindles · Whole-body exposure · Pyridostigmine · Sarin · Animal experiment · Blood · Cholinergic system · Controlled study · Electroencephalogram · Energy · Female · Male · Marmoset · Nonhuman · Oscillation · Pilot study · Priority journal · Sleep spindle · Animals · Callithrix · Chemical Warfare Agents · Cholinesterase Inhibitors · Dose-Response Relationship, Drug · Electroencephalography · Female · Humans · Inhalation Exposure · Male · Pyridostigmine Bromide · Sarin · Time Factors · Animalia · marmosets · Pyridostigmine, 101-26-8, 155-97-5 · Sarin, 107-44-8 · Chemical warfare agents · Cholinesterase inhibitors · Pyridostigmine Bromide, 101-26-8
[Abstract]

17 Characterization of human cytochrome P450s involved in the bioactivation of tri-Ortho-Cresyl phosphate (ToCP)
article 2015    
Author: Reinen, J. · Nematollahi, L. · Fidder, A. · Vermeulen, N.P.E. · Noort, D. · Commandeur, J.N.M.
Keywords: Toxicology · Cytochrome P450 1A2 · Cytochrome P450 2C18 · Cytochrome P450 2D6 · Cytochrome P450 3A4 · Cytochrome P450 3A5 · Organophosphorus compound · Unclassified drug · Animal cell · Biotransformation · Cholinesterase inhibition · Controlled study · Enzyme inactivation · Humans · human cell · Hydrolysis · IC50 · In vitro study · Liver microsome · Liver microsome metabolism · Neurotoxicity · Nonhuman · Rats · Acetylcholinesterase, 9000-81-1 · Cholinesterase, 9001-08-5 · cytochrome P450, 9035-51-2 · Cytochrome P450 3A4, 329736-03-0 · Cytochrome P450 3A5, 336874-97-6 · Tri ortho cresyl phosphate, 78-30-8 · Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[Abstract]

18 Assessment of nerve agent exposure: existiting and emerging methods
article 2009    
Author: Langenberg, J.P. · Schans, M.J. van der · Noort, D.
Keywords: Warfare · analytic sample preparation methods · chemical warfare agents · cholinesterase inhibitor analysis · computer systems · electronics · environmental exposure · hospital information system · human · immunoassay · instrumentation · lab on a chip · lab-on-a-chip devices · limit of detection · mass spectrometry · methodology · miniaturization · point-of-care systems · review
[Abstract]

19 Comprehensive gas chromatography with Time of Flight MS and large volume introduction for the detection of fluoride-induced regenerated nerve agent in biological samples
article 2010    
Author: Meer, J.A. van der · Trap, H.C. · Noort, D. · Schans, M.J. van der
Keywords: Defence · Comprehensive GC · Time of Flight MS · Nerve agents · Fluoride reactivation · Diagnosis · Chemicals/CAS: · Fluoride, 16984-48-8 · Sarin, 107-44-8 · Tabun, 77-81-6 · Chemical warfare agents · Cholinesterase inhibitors · Fluorides · Organophosphorus compounds · Phosphoric acid esters · Organophosphate · Organophosphorus compound · Blood · Chemistry · Human · Mass fragmentography · Methodology · Reproducibility · Sensitivity and specificity · Statistical model · Gas Chromatography-Mass Spectrometry · Linear models
[Abstract]

20 Low level nose-only exposure to the nerve agent soman: Toxicokinetics of soman stereoisomers and cholinesterase inhibition in atropinized guinea pigs
article 1998    
Author: Benschop, H.P. · Trap, H.C. · Spruit, H.E.T. · Wiel, H.J. van der · Langenberg, J.P. · Jong, L.P.A. de
Keywords: Perception · Atropine · Carboxylesterase · Cholinesterase · Animal cell · Blood level · Enzyme inhibition · Exposure · Guinea pig · Inhalation · Male · Neurotoxicity · Nonhuman · Stereoisomerism · Toxicokinetics · Administration, Inhalation · Animals · Carboxylic ester hydrolases · Chemical warfare agents · Dose-response relationship · Drugs · Erythrocytes · Soman · Stereoisomerism · Time factors · Atropine, 51-55-8 · Carboxylesterase, EC 3.1.1.1 · Carboxylic ester hydrolases, EC 3.1.1.- · Soman, 96-64-0
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 33 found. Next | Sort by date