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1 Establishment of the enzymatic protein acetylation independent of acetyl CoA : recombinant glutathione S-transferase 3-3 is acetylated by a novel membrane-bound transacetylane using 7,8-diacetoxy-4-methyl coumarin as the acetyl donor
article 2002    
Author: Kohli, E. · Gaspari, M. · Raj, H.G. · Parmar, V.S. · Greef, J. van der · Gupta, G. · Kumari, R. · Prasad, A.K. · Goel, S. · Pal, G. · Tyagi, K. · Jain, S.C. · Ahmad, N. · Watterson, A.C. · Olsen, C.E.
Keywords: Acetyl Coenzyme A · Acetylation · Acetylesterase · Coumarins · Glutathione Transferase · Recombinant Proteins · Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
[PDF] [Abstract]

2 Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans
article 1988    
Author: Kempen, H.J.M. · Glatz, J.F.C. · Gevers Leuven, J.A. · Voort, H.A. van der · Katan, M.B.
Keywords: Biology · Fatty acid · Hydroxymethylglutaryl coenzyme a reductase · Lanosterol · Lathosterol · Simvastatin · Cholesterol synthesis · Clinical article · Diet · Familial hypercholesterolemia · Human cell · Normal human · Serum · Anticholesteremic Agents · Biological Markers · Cholesterol · Female · Human · Hypercholesterolemia, Familial · Isomerism · Lovastatin · Male · Simvastatin
[PDF] [Abstract]

3 Cholestrol content of the rat lens is lowered by administration of simvastatin, but not pravastatin
article 1993    
Author: Vries, A.C.J. de · Vermeer, M.A. · Bredman, J.J. · Bar, P.R. · Cohen, L.H.
Keywords: Pharmacology · 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors · hypocholesterolaemic drugs · antilipemic agent · drug derivative · hydroxymethylglutaryl coenzyme A reductase inhibitor · hypocholesterolemic agent · mevinolin · animal experiment · cholesterol metabolism · oral drug administration · biosynthesis · dose response · drug effect · enzymology · liver microsome · metabolism · organ culture · rat strain · time · Aging · Animal · Anticholesteremic Agents · Antilipemic Agents · Cholesterol · Dose-Response Relationship, Drug · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Lens, Crystalline · Lovastatin · Microsomes, Liver · Organ Culture · Pravastatin · Rats · Rats, Wistar · Simvastatin · Time Factors
[Abstract]

4 Simultaneous quantitative analysis of metabolites using ion-pair liquid chromatography-electrospray ionization mass spectrometry
article 2006    
Author: Coulier, L. · Bas, R. · Jespersen, S. · Verheij, E. · Werf, M.J. van der · Hankemeier, T.
Keywords: Biology · Biotechnology · Chemical analysis · Esters · Liquid chromatography · Mass spectrometry · Optimization · PH effects · Electrospray ionization mass spectrometry · Energy charge · Ion pair liquid chromatography · Polar metabolites · Metabolites · Acyl coenzyme A · Ammonium acetate · Bisphosphonic acid derivative · Hexylamine · Methanol · Nucleotide · Sugar bisphosphonate · Sugar nucleotide · Unclassified drug · Water · Acidity · Alkalinity · Analytic method · Bacillus subtilis · Electrospray mass spectrometry · Energy expenditure · Escherichia coli · Ion pair chromatography · Metabolite · Metabolomics · Nonhuman · Process optimization · Quantitative assay · Reproducibility · Sampling · Validation process · Amines · Bacillus subtilis · Chromatography, Liquid · Coenzyme A · Escherichia coli · Esters · Hydrogen-Ion Concentration · Nucleotides · Reproducibility of Results · Spectrometry, Mass, Electrospray Ionization · Sugar Phosphates
[Abstract]

5 Transcriptome analysis provides new insights into liver changes induced in the rat upon dietary administration of the food additives butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole
article 2008    
Author: Stierum, R. · Conesa, A. · Heijne, W. · Ommen, B.v. · Junker, K. · Scott, M.P. · Price, R.J. · Meredith, C. · Lake, B.G. · Groten, J.
Keywords: Nutrition · Toxicology and Applied Pharmacology · Butylated hydroxytoluene · Curcumin · Drug metabolism · Mixtures · p53 · Peroxisome proliferation · Propyl gallate · Rat · Thiabendazole · Toxicogenomics · butylcresol · complementary DNA · curcumin · cyanide · cytochrome P450 · cytochrome P450 2B1 · cytochrome P450 2B2 · cytochrome P450 2C6 · cytochrome p450 3a9 · cytochrome p450 4a3 · enoyl coenzyme A hydratase · enzyme · gallic acid propyl ester · glutathione transferase · growth arrest and DNA damage inducible protein 45 · palmitoyl coenzyme A · phytanoyl coenzyme a dioxygenase · protein kinase C beta · protein p53 · RNA · serum albumin · tiabendazole · transcriptome · animal tissue · article · controlled study · diet · DNA microarray · food poisoning · gene expression · gene expression profiling · liver · male · metabolism · nonhuman · nucleotide sequence · rat · real time polymerase chain reaction · Western blotting · Animals · Aryl Hydrocarbon Hydroxylases · Body Weight · Butylated Hydroxytoluene · Curcumin · Cytochrome P-450 CYP1A2 · Cytochrome P-450 CYP2B1 · Data Interpretation, Statistical · Diet · DNA, Complementary · Food Additives · Gene Expression · Gene Expression Profiling · Glutathione Transferase · Liver · Male · Organ Size · Oxidation-Reduction · Palmitoyl Coenzyme A · Propyl Gallate · Rats · Rats, Sprague-Dawley · Reverse Transcriptase Polymerase Chain Reaction · Steroid Hydroxylases · Thiabendazole · Rattus
[Abstract]

6 Activity-based protein profiling reveals broad activity of the nerve agent sarin
article 2009    
Author: Tuin, A.W. · Mol, M.A.E. · Berg, R.M. van den · Fidder, A. · Marel, G.A. van der · Overkleeft, H.S. · Noort, D.
Keywords: Chemistry · 1 alkyl 2 acetylglycerophosphocholine esterase · Acylamino acid releasing enzyme · Carboxylesterase · Dipeptidyl peptidase · Dipeptidyl peptidase 9 · Fatty acid synthase · Methylphosphonofluoridic acid · Organophosphate · Palmitoyl coenzyme A hydrolase · Prolyl endopeptidase · Sarin · Unclassified drug · Animal cell · Biotinylation · Chemical structure · Controlled study · Human · Human cell · Matrix assisted laser desorption ionization time of flight mass spectrometry · Nonhuman · Protein analysis · Quantitative analysis · Sensitivity analysis · Macaca mulatta
[Abstract]

7 Different effects of the hypolipidemic drugs pravastatin and lovastatin on the cholesterol biosynthesis of the human ocular lens in organ culture and on the cholesterol content of the rat lens in vivo
article 1993    
Author: Vries, A.C.J. de · Cohen, L.H.
Keywords: Health · HMG-CoA reductase inhibitor · Ocular lens · Pravastatin · Vastatin · hydroxymethylglutaryl coenzyme a reductase · mevinolin · animal experiment · cholesterol synthesis · human tissue · lens · Adult · Aged · Animal · Cholesterol · Comparative Study · Fatty Acids · Human · Lens, Crystalline · Lovastatin · Middle Age · Organ Culture · Pravastatin · Rats · Rats, Wistar · Animalia · Rattus norvegicus
[Abstract]

8 Different effects of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors on sterol synthesis in various human cell types
article 1995    
Author: Vliet, A.K. van · Thiel, G.C.F. van · Huisman, R.H. · Moshage, H. · Yap, S.H. · Cohen, L.H.
Keywords: Biology · HMG-CoA reductase inhibitor · Human cell · Lovastatin · Pravastatin · Simvastatin · Sterol synthesis · Transport · hydroxymethylglutaryl coenzyme a reductase inhibitor · mevinolin · pravastatin · simvastatin · controlled study · human · human cell · liver cell · priority journal · sterol synthesis · Blotting, Northern · Cells, Cultured · Endothelium, Vascular · Female · Granulosa Cells · Human · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Liver · Lovastatin · Pigment Epithelium of Eye · RNA, Messenger · Simvastatin · Sterols · Umbilical Veins
[Abstract]

9 Nur77 modulates hepatic lipid metabolism through suppression of SREBP1c activity
article 2008    
Author: Pols, T.W.H. · Ottenhoff, R. · Vos, M. · Levels, J.H.M. · Quax, P.H.A. · Meijers, J.C.M. · Pannekoek, H. · Groen, A.K. · Vries, C.J.M. de
Keywords: Biology · Lipid metabolism · NR4A nuclear receptors · NR4A1 · Nur77 · SREBP1c · Sterol regulatory element binding protein-1 · ABC transporter · ABC transporter G5 · ABC transporter G8 · acyl coenzyme A desaturase · acyl coenzyme A desaturase 1 · adenovirus vector · fatty acid synthase · glycerol 3 phosphate acyltransferase · low density lipoprotein receptor · nuclear receptor Nur77 · sterol regulatory element binding protein 1c · triacylglycerol · animal experiment · animal tissue · article · controlled study · enzyme activity · enzyme repression · gene expression · genetic analysis · lipid blood level · lipid liver level · lipid metabolism · male · mouse · nonhuman · nucleotide sequence · priority journal · protein expression · protein function · Adenoviridae · Animals · DNA-Binding Proteins · Gene Expression Regulation · Lipid Metabolism · Liver · Male · Mice · Mice, Inbred C57BL · Receptors, Cytoplasmic and Nuclear · Receptors, Steroid · RNA, Messenger · Sterol Regulatory Element Binding Protein 1 · Transcription Factors · Triglycerides · Mus
[Abstract]

10 Activity based protein profiling leads to identification of novel protein targets for nerve agent VX
article 2017    
Author: Carmany, D. · Walz, A.J. · Hsu, F.L. · Benton, B. · Burnett, D. · Gibbons, J. · Noort, D. · Glaros, T. · Sekowski, J.W.
Keywords: Acylglycerol lipase · Fatty acid amidase · Isocitrate dehydrogenase · Isocitrate dehydrogenase 2 · Isocitrate dehydrogenase 3 · Malate dehydrogenase · Methylphosphonothioic acid s (2 diisopropylaminoethyl) o ethyl ester · Streptavidin · Succinate coenzyme A ligase · Unclassified drug · Animal tissue · Brain tissue · Cell lysate · Cholinergic system · Controlled study · Covalent bond · Eiaphragm · Energy metabolism · Enzyme inhibition · Heart tissue · Kidney tissue · Liquid chromatography-mass spectrometry · Liver tissue · Nonhuman · Protein interaction · Protein targeting · Quantitative analysis · Rat · Acylglycerol lipase, 9040-75-9 · Fatty acid amidase, 153301-19-0 · Isocitrate dehydrogenase, 9001-58-5 · Malate dehydrogenase, 9001-64-3 · Methylphosphonothioic acid s (2 diisopropylaminoethyl) o ethyl ester, 50782-69-9 · Streptavidin, 9013-20-1 · Succinate coenzyme A ligase, 37341-57-4, 9014-36-2, 9080-33-5 · Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[Abstract]

11 Optimization of the solvent-tolerant Pseudomonas putida S12 as host for the production of p-coumarate from glucose
article 2007    
Author: Nijkamp, K. · Westerhof, R.G.M. · Ballerstedt, H. · Bont, J.A.M.de · Wery, J.
Keywords: Biology · Biotechnology · Degradation · Feeding · Genes · Genetic engineering · Glucose · Mutagenesis · Optimization · Production control · Solvents · Cellular L-tyrosine · Molar ratio · p-coumarate · Solvent-tolerant Pseudomonas putida · Bacteria · cinnamic acid · glucose · para coumaric acid · phenylalanine · tyrosine · amino acid · bacterium · biodegradation · degradation · enzyme · glucose · metabolite · optimization · organic acid · article · controlled study · feeding · host · mutant · nonhuman · Pseudomonas putida · Cinnamates · Coenzyme A Ligases · Coumaric Acids · Fermentation · Gene Deletion · Glucose · Phenylalanine · Pseudomonas putida · Tyrosine · Pseudomonas putida
[Abstract]

12 A combined transcriptomics and lipidomics analysis of subcutaneous, epididymal and mesenteric adipose tissue reveals marked functional differences
article 2010    
Author: Caesar, R. · Manieri, M. · Kelder, T. · Boekschoten, M. · Evelo, C. · Müller, M. · Kooistra, T. · Cinti, S. · Kleemann, R. · Drevon, C.A.
Keywords: Biology · Biomedical Research · Acetyl coenzyme A · Adenosine triphosphate citrate lyase · Androgen receptor · Carbohydrate responsive element binding protein · Fatty acid synthase · Linoleic acid · Linolenic acid · Monounsaturated fatty acid · Omega 3 fatty acid · Omega 6 fatty acid · Transcription factor · Unclassified drug · Abdominal fat · Adipocyte · Animal cell · Animal tissue · Controlled study · Down regulation · Epididymis fat · Fat intake · Fatty acid desaturation · Fatty acid synthesis · Gene expression regulation · Lipid diet · Lipid metabolism · Lipid storage · Lipidomics · Lipogenesis · Male · Microarray analysis · Mouse · Nonhuman · Spermatogenesis · Subcutaneous fat · Transcriptomics
[PDF] [Abstract]

13 Effect of D-tagatose on liver weight and glycogen content of rats
article 1999    
Author: Bär, A. · Lina, B.A.R. · Groot, D.M.G. de · Bie, B. de · Appel, M.J.
Keywords: Nutrition · Acyl coenzyme a oxidase · Glycogen · Lauric acid derivative · Lipid · Liver protein · Tagatose · Animal cell · Animal experiment · Animal model · Animal tissue · Body weight · Controlled study · DNA content · DNA synthesis · Dose response · Glycogen liver level · Lipid liver level · Liver weight · Male · Nonhuman · Priority journal · Rat · Toxicity testing · Animals · Body Weight · Cecum · Cell Nucleus · DNA · Eating · Hexoses · Liver · Liver Glycogen · Male · Microscopy, Electron · Organ Size · Peroxisome Proliferators · Rats · Rats, Sprague-Dawley · Sweetening Agents
[Abstract]

14 Action of lovastatin, simvastatin, and pravastatin on sterol synthesis and their antiproliferative effect in cultured myoblasts from human striated muscle
article 1996    
Author: Vliet, A.K. van · Nègre-Arrariou, P. · Thiel, G.C.F. van · Bolhuis, P.A. · Cohen, L.H.
Keywords: Biology · HMG-CoA reductase inhibitors · Human myoblasts · Sterol synthesis · Adenosine triphosphate · Hydroxymethylglutaryl coenzyme a reductase inhibitor · Mevinolin · Mitochondrial enzyme · Cell culture · Cell proliferation · Cell viability · Concentration response · Controlled study · Dna synthesis · Human cell · Human tissue · Muscle biopsy · Myoblast · Myopathy · Skeletal muscle · Acetic Acid · Adenosine Triphosphate · Anticholesteremic Agents · Cell Division · Cell Survival · Cells, Cultured · DNA · Enzyme Inhibitors · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Lovastatin · Mitochondria · Muscle, Skeletal · Oxidoreductases · Pravastatin · Simvastatin · Sterols
[Abstract]

15 Cholesteryl ester transfer protein inhibition: Effect on reverse cholesterol transport?
article 2006    
Author: Rensen, P.C.N. · Havekes, L.M.
Keywords: Biology · Biomedical Research · 2 methylpropanethioic acid s [2 [1 (2 ethylbutyl)cyclohexylcarboxamido]phenyl] ester · Atorvastatin · Cholesterol ester transfer protein inhibitor · Fibric acid derivative · High density lipoprotein cholesterol · Hydroxymethylglutaryl coenzyme A reductase inhibitor · Nicotinic acid · Torcetrapib · Atherosclerosis · Cholesterol transport · Clinical trial · Drug efficacy · Drug mechanism · Dyslipidemia · Editorial · Ischemic heart disease · Nonhuman · Plasma clearance · Protein expression · Reverse cholesterol transport · Animals · Biological Transport · Cardiovascular Diseases · Carrier Proteins · Cholesterol Ester Transfer Proteins · Cholesterol Esters · Cholesterol, HDL · Glycoproteins · Humans · Lipid Metabolism · Lipoproteins, HDL · Rabbits · Risk Factors
[Abstract]

16 Differential effects of amlodipine and atorvastatin treatment and their combination on atherosclerosis in ApoE*3-Leiden transgenic mice
article 2003    
Author: Delsing, D.J.M. · Jukema, J.W. · Wiel, M.A. van de · Emeis, J.J. · Laarse, A. van der · Havekes, L.M. · Princen, H.M.G.
Keywords: Biology · Biomedical Research · Atherosclerosis · Calcification · Calcium antagonists · Inflammation · Statins · Amlodipine · Atorvastatin · Hydroxymethylglutaryl coenzyme A reductase inhibitor · Very low density lipoprotein cholesterol · Animal model · Animal tissue · Aorta root · Cholesterol blood level · Cholesterol diet · Controlled study · Drug effect · Inflammation · Mouse · Nonhuman · Amlodipine · Animals · Aorta, Thoracic · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Blood Pressure · Calcium Channel Blockers · Cholesterol · Cholesterol, Dietary · Drug Therapy, Combination · Female · Heptanoic Acids · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Mice · Mice, Transgenic · Pyrroles
[Abstract]

17 Fenofibrate increases very low density lipoprotein triglyceride production despite reducing plasma triglyceride levels in APOE*3-Leiden.CETP mice
article 2010    
Author: Bijland, S. · Pieterman, E.J. · Maas, A.C.E. · Hoorn, J.W.A. van der · Erk, M.J. van · Klinken, J.B. van · Havekes, L.M. · Dijk, K.W. van · Princen, H.M.G. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Apolipoprotein B (apoB) · Emulsion particles · Fenofibrate · Hepatic genes · Kinetic study · Lipoprotein lipase · Lipoprotein metabolism · Male mouse · Mouse models · Palmitic acid · Peroxisome proliferator-activated receptor · Plasma cholesterol · Plasma triglycerides · Production rates · Skeletal muscle · Very low density lipoproteins · White adipose tissues · Acids · Cytology · Emulsification · Fatty acids · Gene expression · Glycerol · Liver · Mammals · Nutrition · Plasmas · Acetyl coenzyme A acetyltransferase · Acyl coenzyme A desaturase 1 · Acyl coenzyme A oxidase · Apolipoprotein A4 · Apolipoprotein B · Apolipoprotein B messenger RNA editing enzyme catalytic polypeptide 1 · Apolipoprotein C1 · Apolipoprotein C2 · Apolipoprotein C3 · Apolipoprotein E3 · Blood clotting factor 5 Leiden · Carnitine palmitoyltransferase I · Cholesterol · Cholesterol ester transfer protein · Diacylglycerol acyltransferase 1 · Diacylglycerol acyltransferase 2 · Fas antigen · Fatty acid · Fatty acid binding protein 2 · Fenofibrate · Lipoprotein lipase · Palmitic acid · Sterol regulatory element binding protein 1a · Sterol regulatory element binding protein 1c · Triacylglycerol · Triolein · Tritium · Animal experiment · Controlled study · Emulsion · Enzyme activity · Esterification · Food intake · Gene expression profiling · Lipid transport · Lipogenesis · Lipoprotein synthesis · Liver parenchyma · Nnhuman · Skeletal muscle · Treatment duration · Treatment outcome · Animals · Apolipoproteins B · Lipid Metabolism · Lipoproteins, HDL · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Transgenic · Procetofen · Triglycerides · Biomedical Innovation · Healthy Living
[PDF] [Abstract]

18 Lipidomic approach to evaluate rosuvastatin and atorvastatin at various dosages: Investigating differential effects among statins
article 2008    
Author: Bergheanu, S.C. · Reijmers, T. · Zwinderman, A.H. · Bobeldijk, I. · Ramaker, R. · Liem, A.-H. · Greef, J. van der · Hankemeier, T. · Jukema, J.W.
Keywords: Biology · Atorvastatin · Cardiovascular risk · Phosphatidylcholines · Rosuvastatin · Sphingomyelins · Atorvastatin · Cholesterol · High density lipoprotein cholesterol · Hydroxymethylglutaryl coenzyme A reductase inhibitor · Low density lipoprotein cholesterol · Phosphatidylcholine · Rosuvastatin · Sphingomyelin · Triacylglycerol · Adult · Aged · Article · Cardiovascular risk · Cholesterol blood level · Clinical trial · Controlled clinical trial · Controlled study · Coronary artery disease · Drug dose increase · Drug efficacy · Drug megadose · Female · Human · Lipid blood level · Lipid metabolism · Lipidomics · Liquid chromatography · Low drug dose · Major clinical study · Male · Mass spectrometry · Multicenter study · Phase 3 clinical trial · Randomized controlled trial · Therapy effect · Treatment outcome · Chromatography, Liquid · Dose-Response Relationship, Drug · Fluorobenzenes · Heptanoic Acids · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Lipids · Mass Spectrometry · Prospective Studies · Pyrimidines · Pyrroles · Sulfonamides
[Abstract]

19 The effect of moderate alcohol consumption on adiponectin oligomers and muscle oxidative capacity: A human intervention study
article 2007    
Author: Beulens, J.W.J. · Loon, L.J.C. van · Kok, F.J. · Pelsers, M. · Bobbert, T. · Spranger, J. · Helander, A. · Hendriks, H.F.J.
Keywords: Health · Biomedical Research · High molecular weight adiponectin · Insulin sensitivity · Intramyocellular triacylglycerols · Moderate alcohol consumption · Muscle oxidative capacity · Citrate synthase · Cytochrome c oxidase · Enoyl coenzyme A hydratase · Oligomer · Aerobic metabolism · Alcohol consumption · Blood sampling · Body mass · Clinical article · Clinical trial · Controlled clinical trial · Crossover procedure · Diabetes mellitus · Enzyme activity · Female · Fluid intake · Human tissue · Lean body weight · Molecular weight · Muscle biopsy · Muscle metabolism · Obesity · Protein blood level · Randomized controlled trial · Whiskey · Adiponectin · Adolescent · Adult · Alcohol Drinking · Body Weight · Cross-Over Studies · Humans · Insulin · Male · Molecular Weight · Muscles · Overweight · Oxygen · Quality of Life · Time Factors
[PDF] [Abstract]

20 Anti-inflammatory salicylate beneficially modulates pre-existing atherosclerosis through quenching of NF-κB activity and lowering of cholesterol
article 2010    
Author: Vries-van der Weij, J. de · Toet, K. · Zadelaar, A.S.M. · Wielinga, P.Y. · Kleemann, R. · Rensen, P.C.N. · Kooistra, T.
Keywords: Health · Biomedical Research · Anti-inflammatory treatment · Established lesions · Inflammation · Mouse model of atherosclerosis · NF-κB · On-top of statin treatment · Reduce further progression of atherosclerosis · Serum amyloid A (SAA) · Statin · hydroxymethylglutaryl coenzyme A reductase inhibitor · immunoglobulin enhancer binding protein · salicylic acid · serum amyloid A · STAT3 protein · animal experiment · animal model · antiinflammatory activity · aorta · article · atherosclerosis · atherosclerotic plaque · cholesterol blood level · cholesterol diet · controlled study · disease course · drug effect · female · histology · hypercholesterolemia · inflammation · liver · low fat diet · macrophage · mouse · nonhuman · priority journal · risk factor · treatment outcome
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 29 found. Next | Sort by date