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1 Effect of butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole on cytochrome P450 forms in cultured human hepatocytes
article 2008    
Author: Price, R.J. · Scott, M.P. · Giddings, A.M. · Walters, D.G. · Stierum, R.H. · Meredith, C. · Lake, B.G.
Keywords: Biology · Physiological Sciences · Butylated hydroxytoluene · Curcumin · CYP induction · Cytochrome P450 (CYP) · Human hepatocytes · Propyl gallate · Thiabendazole · butylcresol · curcumin · cytochrome P450 · cytochrome P450 1A2 · cytochrome P450 2B6 · cytochrome P450 3A4 · ethoxyresorufin deethylase · gallic acid propyl ester · messenger RNA · tiabendazole · adult · aged · article · controlled study · enzyme activity · human · human cell · liver cell · male · Aged · Anthelmintics · Antioxidants · Butylated Hydroxytoluene · Cells, Cultured · Curcumin · Cytochrome P-450 CYP1A1 · Cytochrome P-450 CYP1A2 · Cytochrome P-450 CYP3A · Cytochrome P-450 Enzyme System · Hepatocytes · Humans · Male · Middle Aged · Propyl Gallate · RNA, Messenger · Steroid Hydroxylases · Thiabendazole
[Abstract]

2 Human cytochrome P450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1′-hydroxymethyleugenol
article 2006    
Author: Jeurissen, S.M.F. · Bogaards, J.J.P. · Boersma, M.G. · Horst, J.P.F. ter · Awad, H.M. · Fiamegos, Y.C. · Beek, T.A. van · Alink, G.M. · Sudhölter, E.J.R. · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · 1' hydroxymethyleugenol · barbituric acid derivative · carcinogen · cytochrome P450 · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2C19 · cytochrome P450 2C9 · cytochrome P450 2D6 · methyleugenol · unclassified drug · article · carcinogenicity · concentration (parameters) · enzyme activation · enzyme kinetics · enzyme specificity · enzyme substrate · human · hydroxylation · incubation time · insect cell · lifestyle · liver microsome · nonhuman · sensitivity analysis · smoking · Aryl Hydrocarbon Hydroxylases · Benzoflavones · Biotransformation · Carcinogens · Cell Line · Cytochrome P-450 CYP1A2 · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Eugenol · Flavoring Agents · Humans · Kinetics · Microsomes, Liver · Mixed Function Oxygenases · Recombinant Proteins · Risk Assessment · Sulfaphenazole · Insecta
[Abstract]

3 Development of an on-line high performance liquid chromatography detection system for human cytochrome P450 1A2 inhibitors in extracts of natural products
article 2007    
Author: Jeurissen, S.M.F. · Claassen, F.W. · Havlik, J. · Bouwmans, E.E. · Cnubben, N.H.P. · Sudhölter, E.J.R. · Rietjens, I.M.C.M. · Beek, T.A. van
Keywords: Biomedical Research · Methoxyresorufin-O-demethylase · Mixture analysis · On-line detection · P450 1A2 inhibitors · Bioassay · Cytology · Enzyme inhibition · Fluorescence · Metabolites · Screening · Methoxyresorufin-O-demethylase · Mixture analysis · On-line detection · P450 1A2 inhibitors · High performance liquid chromatography · basil extract · cytochrome P450 1A2 · cytochrome P450 1A2 inhibitor · cytochrome P450 inhibitor · fluvoxamine · furafylline · kava extract · methoxyresorufin · naringenin · natural product · plant extract · propranolol · resorufin · resorufin derivative · tacrine · article · assay · basil · demethylation · fluorescence · high performance liquid chromatography · metabolite · methoxyresorufin O demethylation assay · minimum detectable amount · online analysis · parameter · priority journal · screening · Biological Products · Chromatography, High Pressure Liquid · Cytochrome P-450 CYP1A2 · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Humans · Inhibitory Concentration 50 · Kava · Methanol · Ocimum basilicum · Online Systems · Oxidoreductases · Plant Extracts · Spectrometry, Fluorescence · Spectrophotometry, Ultraviolet · Ocimum basilicum · Piper methysticum
[Abstract]

4 Transcriptome analysis provides new insights into liver changes induced in the rat upon dietary administration of the food additives butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole
article 2008    
Author: Stierum, R. · Conesa, A. · Heijne, W. · Ommen, B.v. · Junker, K. · Scott, M.P. · Price, R.J. · Meredith, C. · Lake, B.G. · Groten, J.
Keywords: Nutrition · Toxicology and Applied Pharmacology · Butylated hydroxytoluene · Curcumin · Drug metabolism · Mixtures · p53 · Peroxisome proliferation · Propyl gallate · Rat · Thiabendazole · Toxicogenomics · butylcresol · complementary DNA · curcumin · cyanide · cytochrome P450 · cytochrome P450 2B1 · cytochrome P450 2B2 · cytochrome P450 2C6 · cytochrome p450 3a9 · cytochrome p450 4a3 · enoyl coenzyme A hydratase · enzyme · gallic acid propyl ester · glutathione transferase · growth arrest and DNA damage inducible protein 45 · palmitoyl coenzyme A · phytanoyl coenzyme a dioxygenase · protein kinase C beta · protein p53 · RNA · serum albumin · tiabendazole · transcriptome · animal tissue · article · controlled study · diet · DNA microarray · food poisoning · gene expression · gene expression profiling · liver · male · metabolism · nonhuman · nucleotide sequence · rat · real time polymerase chain reaction · Western blotting · Animals · Aryl Hydrocarbon Hydroxylases · Body Weight · Butylated Hydroxytoluene · Curcumin · Cytochrome P-450 CYP1A2 · Cytochrome P-450 CYP2B1 · Data Interpretation, Statistical · Diet · DNA, Complementary · Food Additives · Gene Expression · Gene Expression Profiling · Glutathione Transferase · Liver · Male · Organ Size · Oxidation-Reduction · Palmitoyl Coenzyme A · Propyl Gallate · Rats · Rats, Sprague-Dawley · Reverse Transcriptase Polymerase Chain Reaction · Steroid Hydroxylases · Thiabendazole · Rattus
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 4 of 4 found. | Sort by date