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1 Human cytochrome P450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes
article 2007    
Author: Jeurissen, S.M.F. · Punt, A. · Boersma, M.G. · Bogaards, J.J.P. · Fiamegos, Y.C. · Schilter, B. · Bladeren, P.J. van · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · 1' hydroxyestragole · alkenylbenzene derivative · alpha naphthoflavone · benzene derivative · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2C19 · cytochrome P450 2D6 · cytochrome P450 2E1 · estragole · methyleugenol · safrole · article · enzyme specificity · human · human cell · hydroxylation · liver microsome · phenotype · protein expression · Anisoles · Biotransformation · Chromatography, High Pressure Liquid · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Eugenol · Flavoring Agents · Humans · Hydroxylation · Microsomes, Liver · Safrole · Substrate Specificity
[Abstract]

2 Human cytochrome P450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1′-hydroxymethyleugenol
article 2006    
Author: Jeurissen, S.M.F. · Bogaards, J.J.P. · Boersma, M.G. · Horst, J.P.F. ter · Awad, H.M. · Fiamegos, Y.C. · Beek, T.A. van · Alink, G.M. · Sudhölter, E.J.R. · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · 1' hydroxymethyleugenol · barbituric acid derivative · carcinogen · cytochrome P450 · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2C19 · cytochrome P450 2C9 · cytochrome P450 2D6 · methyleugenol · unclassified drug · article · carcinogenicity · concentration (parameters) · enzyme activation · enzyme kinetics · enzyme specificity · enzyme substrate · human · hydroxylation · incubation time · insect cell · lifestyle · liver microsome · nonhuman · sensitivity analysis · smoking · Aryl Hydrocarbon Hydroxylases · Benzoflavones · Biotransformation · Carcinogens · Cell Line · Cytochrome P-450 CYP1A2 · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Eugenol · Flavoring Agents · Humans · Kinetics · Microsomes, Liver · Mixed Function Oxygenases · Recombinant Proteins · Risk Assessment · Sulfaphenazole · Insecta
[Abstract]

3 Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices
article 2000    
Author: Renwick, A.B. · Watts, P.S. · Edwards, R.J. · Barton, P.T. · Guyonnet, I. · Price, R.J. · Tredger, J.M. · Pelkonen, O. · Boobis, A.R. · Lake, B.G.
Keywords: Nutrition · Apoprotein · Cytochrome P450 · Cytochrome p450 2a6 · Cytochrome P450 2B6 · Cytochrome P450 2C19 · Cytochrome p450 2c8 · Cytochrome P450 2C9 · Cytochrome P450 3A4 · Cytochrome P450 3A5 · Debrisoquine 4 hydroxylase · Dimethylnitrosamine demethylase · Ethoxyresorufin · O Deethylase · Peptide antibody · Phenacetin o deethylase · Tolbutamide methylhydroxylase · Unclassified drug · Enzyme activity · Enzyme metabolism · Human tissue · Liver cell culture · Liver slice · Protein stability · School child · Xenobiotic metabolism · Adolescent · Adult · Aged · Child · Child, Preschool · Culture Media · Culture Techniques · Cytochrome P-450 Enzyme System · Enzyme Stability · Female · Humans · Immunoblotting · Isoenzymes · Liver · Male · Microsomes, Liver · Middle Aged
[Abstract]

4 The novel antifungal agent PLD-118 is neither metabolized by liver microsomes nor inhibits cytochrome P450 in vitro
article 2005    
Author: Parnham, M.J. · Bogaards, J.J.P. · Schrander, F. · Schut, M.W. · Orešković, K. · Mildner, B.
Keywords: Health Pharmacology · Physiological Sciences · Cytochrome P450 · Metabolism · PLD-118 · 2 amino 4 methylenecyclopentanecarboxylic acid · alpha naphthoflavone · amino acid · antifungal agent · bufuralol · chlorzoxazone · coumarin · cytochrome P450 · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2B6 · cytochrome P450 2C19 · cytochrome P450 2C9 · cytochrome P450 2D6 · cytochrome P450 2E1 · cytochrome P450 3A · diclofenac · diethyldithiocarbamic acid · ethoxyresorufin · ketoconazole · mephenytoin · monoclonal antibody · monoclonal antibody 2B6 · quinidine · reduced nicotinamide adenine dinucleotide phosphate · resorufin · sulfaphenazole · testosterone · umbelliferone · unclassified drug · unindexed drug · analytic method · animal tissue · article · candidiasis · concentration response · controlled study · derivatization · dog · drug structure · enzyme assay · enzyme inhibition · enzyme stability · enzyme substrate · fluorescence analysis · high performance liquid chromatography · human · human tissue · in vitro study · liver homogenate · liver microsome metabolism · nonhuman · rat · structure analysis · Administration, Oral · Animals · Antifungal Agents · Chemistry, Pharmaceutical · Cycloleucine · Cytochrome P-450 Enzyme System · Dogs · Drug Evaluation, Preclinical · Humans · Microsomes, Liver · Rats · Ribosomal Proteins
[Abstract]

Search results also available in MS Excel format.

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