Repository hosted by TU Delft Library

Home · Contact · About · Disclaimer ·
 

Search results also available in MS Excel format.

Showing 1 to 16 of 16 found. | Sort by date

1 The use of in vitro toxicity data and physiologically based kinetic modeling to predict dose-response curves for in vivo developmental toxicity of glycol ethers in rat and man
article 2010    
Author: Louisse, J. · Jong, E. de · Sandt, J.J.M. van de · Blaauboer, B.J. · Woutersen, R.A. · Piersma, A.H. · Rietjens, I.M.C.M. · Verwei, M.
Keywords: Nutrition · Biomedical Research · Benchmark dose · Developmental toxicity · Embryonic stem cell test · Glycol ethers · Physiologically based kinetic modeling
[Abstract]

2 Relative embryotoxic potency of p-substituted phenols in the embryonic stem cell test (EST) and comparison to their toxic potency in vivo and in the whole embryo culture (WEC) assay
article 2012    
Author: Strikwold, M. · Woutersen, R.A. · Spenkelink, B. · Punt, A. · Rietjens, I.M.C.M.
Keywords: Alternative toxicity testing · Developmental toxicity · Embryonic stem cell test · Embryotoxicity · Potency ranking · Substituted phenols · Healthy Living · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

3 Relative developmental toxicity potencies of retinoids in the embryonic stem cell test compared with their relative potencies in in vivo and two other in vitro assays for developmental toxicity
article 2011    
Author: Louisse, J. · Gönen, S. · Rietjens, I.M.C.M. · Verwei, M.
Keywords: Pharmacology · Benchmark dose · Developmental toxicity · Embryonic stem cell test · Embryotoxicity · In vitro · Retinoids · Life · PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

4 Toward in vitro biomarkers for developmental toxicity and their extrapolation to the in vivo situation
article 2012    
Author: Louisse, J. · Verwei, M. · Woutersen, R.A. · Blaauboer, B.J. · Rietjens, I.M.C.M.
Keywords: Biology · 3Rs · Biomarkers · Developmental toxicity · Embryotoxicity · in vitro · Kinetic modeling · Biomedical Innovation · Healthy Living Healthy Living · Life · PHS - Pharmacokinetics & Human Studies RAPID - Risk Analysis for Products in Development · EELS - Earth, Environmental and Life Sciences
[Abstract]

5 Transmaternal bisphenol a exposure accelerates diabetes type 1 development in NOD mice
article 2014    
Author: Bodin, J. · Bølling, A.B. · Becher, R. · Kuper, F. · Løvik, M. · Nygaard, U.C.
Keywords: Biology · Bisphenol A · Developmental toxicity · Diabetes mellitus type 1 · Immunotoxicity · Insulitis · NOD mice · Food and Nutrition · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

6 Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery
article 2014    
Author: Zimmer, B. · Pallocca, G. · Dreser, N. · Foerster, S. · Waldmann, T. · Westerhout, J. · Julien, S. · Krause, K.H. · Van Thriel, C. · Hengstler, J.G. · Sachinidis, A. · Bosgra, S. · Leist, M.
Keywords: Pharmacology · Developmental toxicity testing · hESC-based test system · Neural crest migration assay · Test battery-based compound screening · abiraterone · arsenic trioxide · beta interferon · chlorpromazine · cyproconazole · environmental chemical · gefitinib · geldanamycin · polybrominated diphenyl ether · triadimefon · unclassified drug · animal cell · cell migration · concentration (parameters) · concentration response · controlled study · cytotoxicity · data mining · developmental toxicity · embryonic stem cell · HEK293 cell line · human · human cell · in vivo study · migration inhibition · mouse · neural crest cell · neurotoxicity · nonhuman · Food and Nutrition · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

7 Evaluation of an alternative in vitro test battery for detecting reproductive toxicants in a grouping context
article 2015    
Author: Kroese, E.D. · Bosgra, S. · Buist, H.E. · Lewin, G. · Linden, S.C. van der · Man, H.Y. · Piersma, A.H. · Rorije, E. · Schulpen, S.H.W. · Schwarz, M. · Uibel, F. · Vugt-Lussenburg, B.M.A. van · Wolterbeek, A.P.M. · Burg, B. van der
Keywords: Biology · Alternative model · CALUX · Developmental toxicity · Embryonic stem cell test · Grouping · Read across · ReProGlo · Zebrafish embryotoxicity assay · 2 ethylhexanoic acid · 2 methylhexanoic acid · Dibutyltin dichloride · monobutyltin trichloride · Monoethylhexyl phthalate · Monomethyl phthalate · Toxic substance · Tributyltin chloride · Unclassified drug · Valproic acid · Analytic method · Animal cell · Assay · CALUX battery · Chemical analysis · Chemical procedures · Chemical structure · Controlled study · Developmental toxicity · Dosimetry · Embryonic stem cell test · Embryotoxicity · Fertilization · In vitro study · Morphology · Mouse · Nonhuman · ReProGlo assay · Toxicokinetics · Zebrafish embryotoxicity test · Animalia · Danio rerio · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

8 Prediction of in vivo developmental toxicity of all‑trans‑retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling
article 2014    
Author: Louisse, J. · Bosgra, S. · Blaauboer, B.J. · Rietjens, Y.M.C.M. · Verwei, M.
Keywords: Toxicology · All-trans-retinoic acid · Developmental toxicity · In vitro-in vivo extrapolation · Physiologically based kinetic modeling · Reverse dosimetry · Solid phase microextraction · Food and Nutrition · Healthy Living · Life Triskelion BV · RAPID - Risk Assessment Products in Developmentv ARF - Analytical Research (Food) · ELSS - Earth, Life and Social Sciences TNO Bedrijven

9 Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling
article 2015    
Author: Louisse, J. · Bosgra, S. · Blaauboer, B.J. · Rietjens, I.M.C.M. · Verwei, M.
Keywords: Toxicology · All-trans-retinoic acid · Developmental toxicity · In vitro–in vivo extrapolation · Physiologically based kinetic modeling · Reverse dosimetry · Solid phase microextraction · Animalia · Rattus · Biomedical Innovation · Healthy Living · Life Triskelion BV · RAPID - Risk Analysis for Products in Development ARF - Analytical Research (Food) · ELSS - Earth, Life and Social Sciences
[Abstract]

10 Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling
article 2006    
Author: Verwei, M. · Burgsteden, J.A. van · Krul, C.A.M. · Sandt, J.J.M. van de · Freidig, A.P.
Keywords: Biology · Biomedical Research · Alternative test method · Developmental toxicity · Embryonic stem cells · PBPK model · 2 ethoxyethanol · 2 methoxyethanol · acetic acid derivative · ethoxyacetic acid · fluorouracil · methotrexate · methoxyacetic acid · retinoic acid · unclassified drug · animal cell · article · computer model · controlled study · embryo · embryo development · embryonic stem cell · embryotoxicity · exposure · metabolism · mouse · nonhuman · prediction · priority journal · risk assessment · rodent · Animal Testing Alternatives · Animals · Cell Line · Cell Survival · Dose-Response Relationship, Drug · Embryo · Mice · Models, Biological · Predictive Value of Tests · Rats · Risk Assessment · Stem Cells · Teratogens · Toxicity Tests · Rodentia
[Abstract]

11 One-generation reproductive toxicity study of DHA-rich oil in rats
article 2007    
Author: Blum, R. · Kiy, T. · Waalkens-Berendsen, I. · Wong, A.W. · Roberts, A.
Keywords: Toxicology · Toxicology and Applied Pharmacology · ω-3 Polyunsaturated fatty acid · DHA · DHA-rich oil · Docosahexaenoic acid · Food ingredient · Reproductive and developmental toxicity · Safety · algal oil · docosahexaenoic acid · lipid · adipose tissue · animal experiment · animal model · animal tissue · article · body weight · controlled study · diet · fat intake · female · fertility · food intake · liver weight · male · mortality · nonhuman · priority journal · rat · reproductive toxicity · spleen weight · toxicity testing · Algae · Animals · Animals, Newborn · Birth Weight · Docosahexaenoic Acids · Dose-Response Relationship, Drug · Eating · Embryonic Development · Female · Fetal Development · Hematopoiesis, Extramedullary · Liver · Male · Oils · Organ Size · Pituitary Gland · Pregnancy · Rats · Rats, Wistar · Reproduction · Spleen · Subcutaneous Fat, Abdominal · Toxicity Tests · Weight Gain · algae · Animalia · Protista · Rattus · Ulkenia sp. · Zea mays
[Abstract]

12 Interpreting in vitro developmental toxicity test battery results: The consideration of toxicokinetics
article 2015    
Author: Bosgra, S. · Westerhout, J.
Keywords: Toxicology · In vitro test battery · In vitro-in vivo extrapolation · Protein binding · TK modeling · Toxicokinetics · 2 ethylhexanoic acid · Ammonium derivative · Cyclosporin A · Diethylstilbestrol · Endosulfan · Gluphosinate ammonium · Hexanoic acid derivative · Methoxyacetic acid · Methylhexanoic acid · Methylmercuric chloride · Phthalic acid 2 ethylhexyl monoester · Retinoic acid · Unclassified drug · Valproic acid · Animal experiment · Clinical observation · Controlled study · Developmental toxicity · In vitro study · In vivo study · Mouse · Mouse defense test battery · Nonhuman · Predictive value · Protein binding · Quantitative analysis · Rat · Reproductive toxicity · Risk assessment · Simulation · Toxicokinetics · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

13 Relative developmental toxicity of glycol ether alkoxy acid metabolites in the embryonic stem cell test as compared with the in vivo potency of their parent compounds
article 2009    
Author: Jong, E. de · Louisse, J. · Verwei, M. · Blaauboer, B.J. · Sandt, J.J.M. van de · Woutersen, R.A. · Rietjens, I.M.C.M. · Piersma, A.H.
Keywords: Chemistry · Toxicology and Applied Pharmacology · Alternatives to animal testing · Developmental toxicology · Embryonic stem cells · Glycol ethers · butoxyacetic acid · ethoxyacetic acid · glycol ether alkoxy acid metabolite · methoxyacetic acid · phenoxyacetic acid · toxin · unclassified drug · animal cell · article · cell differentiation · chemical analysis · chemical structure · concentration response · controlled study · cytotoxicity test · developmental disorder · developmental toxicity · embryonic stem cell · embryonic stem cell test · embryotoxicity · heart muscle cell · in vivo study · mouse · nonhuman · sensitivity analysis · toxicokinetics · Animal Testing Alternatives · Animals · Biotransformation · Cell Differentiation · Cell Survival · Dose-Response Relationship, Drug · Embryonic Development · Embryonic Stem Cells · Glycols · Kinetics · Mice · Models, Statistical · Myocytes, Cardiac · Predictive Value of Tests · Reference Standards · Structure-Activity Relationship · Teratogens · Animalia
[Abstract]

14 Zebrafish embryotoxicity test for developmental (neuro)toxicity: Demo case of an integrated screening approach system using anti-epileptic drugs
article 2014    
Author: Beker van Woudenberg, A. · Snel, C. · Rijkmans, E. · Groot, D. de · Bouma, M. · Hermsen, S. · Piersma, A. · Menke, A. · Wolterbeek, A.
Keywords: Biology · Antiepileptic drugs · Behavior · Developmental (neuro)toxicity · Gene expression · Histopathology · Integrated test strategy · Kinetics · Zebrafish embryotoxicity test (ZET) · Anticonvulsive agent · Carbamazepine · Cytochrome P450 26A1 · Ethosuximide · Etiracetam · Valproic acid · ALDH1A2 gene · Animal cell · Animal experiment · Animal model · Animal tissue · Case study · Cell vacuole · Concentration (parameters) · Controlled study · CYP26A1 gene · Demo case study · Developmental toxicity · Edema · Embryo · Embryotoxicity · Experimental design · Female · Gene · Gene expression · Histopathology · In situ hybridization · Larva · Liver cell · Male · Morphology · Motor activity · Nerve degeneration · Neurotoxicity · Nonhuman · Nucleotide sequence · Pericardial disease · Pericardial edema · Phenotype · Predictive value · Sensitivity analysis · Swimming · Toxicity testing · Toxicokinetics · Whole mount in situ hybridization · Zebra fish · Zebrafish embryotoxicity test · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

15 Developmental immunotoxicity of ethanol in an extended one-generation reproductive toxicity study
article 2013    
Author: Tonk, E.C.M. · Groot, D.M.G. de · Wolterbeek, A.P.M. · Penninks, A.H. · Waalkens-Berendsen, I.D.H. · Piersma, A.H. · Loveren, H. van
Keywords: Biology · Benchmark dose approach · Developmental immunotoxicity · Ethanol · Extended one-generation reproductive toxicity study · Alcohol · Concanavalin A · Drinking water · Keyhole limpet hemocyanin · Lipopolysaccharide · Nitric oxide · Tumor necrosis factor alpha · Adaptive immunity · Adult animal · Animal experiment · Animal model · blood cell · Cell adhesion · Cell proliferation · Cell stimulation · Cell subpopulation · Chemical parameters · Controlled study · Cytokine production · Developmental parameters · Developmental toxicity · Female · Immune response · Immunization · Immunological parameters · Immunomodulation · Immunotoxicity · Innate immunity · Lactation · Male · Mating · Medical parameters · Perinatal period · Priority journal · Rat · Reproductive toxicity · Spleen cell · Toxicity testing · Wistar rat · Rattus norvegicus · Biomedical Innovation · Healthy Living · Life Triskelion BV · QS - Quality & Safety TARA - Toxicology and Risk Assessment RAPID - Risk Analysis for Products in Development · EELS - Earth, Environmental and Life Sciences TNO Bedrijven
[Abstract]

16 Developmental immunotoxicity of methylmercury: The relative sensitivity of developmental and immune parameters
article 2010    
Author: Tonk, E.C.M. · Groot, D.M.G. de · Penninks, A.H. · Waalkens - Berendsen, I.D.H. · Wolterbeek, A.P.M. · Slob, W. · Piersma, A.H. · Loveren, H. van
Keywords: Toxicology · Biomedical Research · Benchmark dose · Developmental immunotoxicity · Developmental toxicity · Dose-response modeling · Methylmercury · Perinatal exposure · Rat · gamma interferon · interleukin 10 · interleukin 13 · interleukin 2 · interleukin 4 · interleukin 6 · keyhole limpet hemocyanin · methylmercury · T lymphocyte antibody · adherent cell · animal tissue · antibody response · article · basophil · body weight · CD3+ T lymphocyte · CD4 CD8 ratio · CD8+ T lymphocyte · clinical evaluation · controlled study · cytokine production · delayed hypersensitivity · developmental screening · diagnostic value · environmental exposure · epididymis · erythrocyte · female · gestational age · immunological parameters · immunotoxicity · kidney mass · leukocyte count · litter size · liver weight · lymphocyte proliferation · natural killer cell · newborn mortality · nonhuman · rat · reticulocyte count · sensitivity and specificity · spleen cell · spleen weight · stillbirth · testis weight · thrombocyte count · thymus · weight reduction
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 16 of 16 found. | Sort by date