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1 Bispecific monoclonal antiboldies increase the fibrin-specific fibrinolytic activity of tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA)
article 1992    
Author: Bos, R. · Nieuwenhuizen, W.
Keywords: Health · fibrin · monoclonal antibody · plasminogen activator · tissue plasminogen activator · urokinase · drug carrier · cell fusion · conference paper · drug binding · drug efficacy · drug megadose · endothelium cell · enzyme activity · fibrinolysis · fibrinolytic therapy · hybridoma · plasminogen activation · antibody specificity · drug effect · immunology · metabolism · Antibodies, Monoclonal · Antibody Specificity · Drug Carriers · Fibrin · Fibrinolysis · Human · Kinetics · Plasminogen Activator Inhibitor 1 · Tissue Plasminogen Activator · Urinary Plasminogen Activator

2 Lactotripeptides and antihypertensive effects: A critical review
article 2009    
Author: Boelsma, E. · Kloek, J.
Keywords: Health Nutrition · Biomedical Research · Antihypertensive effects · Blood pressure · Lactotripeptides · Milk peptides · antihypertensive agent · Beta adrenergic receptor blocking agent · Calcium antagonist · Dipeptidyl carboxypeptidase inhibitor · Lactotripeptide derivative · Placebo · Unclassified drug · Absence of side effects · Antihypertensive activity · Antihypertensive therapy · Blood chemistry · Blood pressure regulation · Caucasian · Clinical trial · Diastolic blood pressure · Dose response · Dose time effect relation · Drug bioavailability · Drug efficacy · Drug megadose · Drug potency · Drug safety · Food intake · Human · Hypertension · Japanese · Low drug dose · Nonhuman · Race difference · Review · Side effect · Systolic blood pressure · Treatment duration
[PDF] [Abstract]

3 Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm doxycycline selectively depletes aortic wall neutrophils and cytotoxic t cells
article 2009    
Author: Lindeman, J.H.N. · Abdul-Hussien, H. · Bockel, J.H. van · Wolterbeek, R. · Kleemann, R.
Keywords: Health · Aneurysm · Immunology · Inflammation · Molecular biology · Trials · Doxycycline · Gelatinase B · Granulocyte colony stimulating factor receptor · Interleukin 13 · Interleukin 6 · Interleukin 8 · Antiinfective agent · CCAAT enhancer binding protein · Enzyme inhibitor · IL6 protein, human · Transcription factor AP 1 · Transcription factor RelA · Abdominal aorta aneurysm · Aged · Cytotoxic T lymphocyte · Drug effect · Drug megadose · Drug tolerability · Enzyme inhibition · Aortic Aneurysm, Abdominal · CCAAT-Enhancer-Binding Proteins · Doxycycline · Enzyme Inhibitors · Matrix Metalloproteinase 9 · Middle Aged · Neutrophils · T-Lymphocytes, Cytotoxic · Vasculitis
[PDF] [Abstract]

4 Lipidomic approach to evaluate rosuvastatin and atorvastatin at various dosages: Investigating differential effects among statins
article 2008    
Author: Bergheanu, S.C. · Reijmers, T. · Zwinderman, A.H. · Bobeldijk, I. · Ramaker, R. · Liem, A.-H. · Greef, J. van der · Hankemeier, T. · Jukema, J.W.
Keywords: Biology · Atorvastatin · Cardiovascular risk · Phosphatidylcholines · Rosuvastatin · Sphingomyelins · Atorvastatin · Cholesterol · High density lipoprotein cholesterol · Hydroxymethylglutaryl coenzyme A reductase inhibitor · Low density lipoprotein cholesterol · Phosphatidylcholine · Rosuvastatin · Sphingomyelin · Triacylglycerol · Adult · Aged · Article · Cardiovascular risk · Cholesterol blood level · Clinical trial · Controlled clinical trial · Controlled study · Coronary artery disease · Drug dose increase · Drug efficacy · Drug megadose · Female · Human · Lipid blood level · Lipid metabolism · Lipidomics · Liquid chromatography · Low drug dose · Major clinical study · Male · Mass spectrometry · Multicenter study · Phase 3 clinical trial · Randomized controlled trial · Therapy effect · Treatment outcome · Chromatography, Liquid · Dose-Response Relationship, Drug · Fluorobenzenes · Heptanoic Acids · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Lipids · Mass Spectrometry · Prospective Studies · Pyrimidines · Pyrroles · Sulfonamides
[Abstract]

5 The evaluation of the immunomodulating properties of ERA-63 a pharmaceutical with estrogenic activity
article 2008    
Author: Janssen, G.B. · Penninks, A.H. · Knippels, L.M.J. · Zijverden, M. van · Spanhaak, S.
Keywords: Chemistry · Ethinyl estradiol · Host resistance · Immunotoxicity · Listeria monocytogenes · PFC · Plaque-forming cell assay · T cell-dependent antibody response · bilirubin · era 63 · ethinylestradiol · gamma glutamyltransferase · immunomodulating agent · unclassified drug · animal experiment · antibody response · article · bilirubin blood level · body weight · controlled study · drug dose comparison · drug megadose · drug screening · estrogen activity · female · gamma glutamyl transferase blood level · immunomodulation · Listeria monocytogenes · low drug dose · male · nonhuman · priority journal · qualitative analysis · rat · testis weight · thymus · Animals · Antibody Formation · Body Weight · Estrogens · Ethinyl Estradiol · Female · Hemolytic Plaque Technique · Immunologic Factors · Listeria Infections · Male · Organ Size · Rats · Rats, Sprague-Dawley · Risk Assessment · T-Lymphocytes · Listeria monocytogenes · Rattus
[Abstract]

6 Sirolimus and paclitaxel provoke different vascular pathological responses after local delivery in a murine model for restenosis on underlying atherosclerotic arteries
article 2007    
Author: Pires, N.M.M. · Eefting, D. · Vries, M.R.de · Quax, P.H.A. · Jukema, J.W.
Keywords: Biology · Biomedical Research · collagen · Fas antigen · gelatinase B · messenger RNA · paclitaxel · protein Bax · protein bcl 2 · rapamycin · tissue inhibitor of metalloproteinase 1 · animal experiment · animal model · animal tissue · apoptosis · article · atherosclerosis · blood vessel reactivity · cell disruption · controlled study · dose response · drug eluting stent · drug megadose · femoral artery · histopathology · hypercholesterolemia · male · mouse · nonhuman · priority journal · protein expression · real time polymerase chain reaction · restenosis · upregulation · Actins · Animals · Apoptosis · Atherosclerosis · Cell Proliferation · Collagen · Drug Implants · Femoral Artery · Image Interpretation, Computer-Assisted · In Situ Nick-End Labeling · Male · Mice · Mice, Mutant Strains · Models, Animal · Muscle, Smooth, Vascular · Paclitaxel · Recurrence · Reverse Transcriptase Polymerase Chain Reaction · RNA, Messenger · Sirolimus · Stents · Tunica Intima
[Abstract]

7 The minipig as an alternative non-rodent model for immunogenicity testing using the TNFα blockers adalimumab and infliximab
article 2014    
Author: Mierlo, G.J.D. van · Cnubben, N.H.P. · Wouters, D. · Wolbink, G.J. · Hart, M.H.L. · Rispens, T. · Ganderup, N.C. · Kuper, C.F. · Aarden, L. · Penninks, A.H.
Keywords: Biology · Adalimumab · Alternative model · Anti-drug antibodies · Immunogenicity · Infliximab · Minipig · Pharmacokinetics Ddrug antibody · Animal experiment · Animal model · Animal tissue · Antibody response · Antibody titer · Area under the curve · Body weight · Clinical chemistry · Clinical feature · Clinical observation · Controlled study · Drug blood level · Drug clearance · Drug half life · Drug megadose · Female · Hematological parameters · Histopathology · Immune function test · Immune system · Low drug dose · Maximum plasma concentration · Mean residence time · Nonhuman · Organ weight · Predictive value · Priority journal · Time to maximum plasma concentration · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

8 Activation of the innate immune system in atherosclerotic disease
article 2007    
Author: Oude Nijhuis, M.M. · Keulen, J.K. van · Pasterkamp, G. · Quax, P.H. · Kleijn, D.P.V. de
Keywords: Biomedical Research · Atherogenesis · Infection · Inflammation · Innate immunity · Toll-like receptors · antibiotic agent · azithromycin · e 5331 · e 5531 · e 5564 · eritoran · ligand · lipid A derivative · lipopolysaccharide antagonist · low density lipoprotein · malonaldehyde · oxidized low density lipoprotein · placebo · receptor blocking agent · toll like receptor · vaccine · antigen recognition · atherogenesis · atherosclerosis · clinical trial · disease course · drug megadose · drug targeting · genetic polymorphism · human · innate immunity · knockout mouse · low drug dose · nonhuman · priority journal · review · signal transduction · vaccination · Animals · Atherosclerosis · Communicable Diseases · Humans · Immunity, Natural · Immunotherapy · Inflammation · Ligands · Lipopolysaccharides · Lipoproteins · Peptidoglycan · Signal Transduction · Toll-Like Receptors · Vaccines
[Abstract]

9 Thalidomide inhibits UVB-induced mouse keratinocyte apoptosis by both TNF-α-dependent and TNF-α-independent pathways
article 2003    
Author: Lu, K.Q. · Brenneman, S. · Burns Jr., R. · Vink, A. · Gaines, E. · Haake, A. · Gaspari, A.
Keywords: Toxicology Biology · Toxicology and Applied Pharmacology · α-N-phthalimido-glutarimide · Mouse model · Photoprotection · Sunburn cell · Ultraviolet light · antiinflammatory agent · apoptosis inhibitor · cell DNA · cyclobutane derivative · cytokine · dimer · drug vehicle · messenger RNA · pyrimidine derivative · recombinant tumor necrosis factor alpha · thalidomide · tumor necrosis factor alpha · animal cell · animal experiment · animal model · animal tissue · antiinflammatory activity · apoptosis · article · biosynthesis · bolus injection · cell assay · cell death · controlled study · cytokine production · DNA damage · dose response · drug blood level · drug mechanism · drug megadose · female · histopathology · hypothesis · immunostimulation · in vitro study · keratinocyte · low drug dose · monocyte · mouse · newborn · nick end labeling · nonhuman · photosensitivity disorder · priority journal · radiation dose · radiation exposure · radiation injury · ribonuclease protection assay · skin · skin biopsy · skin lupus erythematosus · steady state · sunburn · ultraviolet B radiation · Animals · Anti-Inflammatory Agents, Non-Steroidal · Apoptosis · Disease Models, Animal · Dose-Response Relationship, Drug · Erythema · Female · Injections, Intravenous · Keratinocytes · Mice · Mice, Inbred BALB C · RNA, Messenger · Thalidomide · Tumor Necrosis Factor-alpha · Ultraviolet Rays
[Abstract]

10 A dietary mixture containing fish oil, resveratrol, lycopene, catechins, and vitamins E and C reduces atherosclerosis in transgenic mice
article 2011    
Author: Verschuren, L. · Wielinga, P.Y. · Duyvenvoorde, W. van · Tijani, S. · Toet, K. · Ommen, B. van · Kooistra, T. · Kleemann, R.
Keywords: Nutrition · alpha tocopherol · apolipoprotein E3 · ascorbic acid · biological marker · C reactive protein · catechin · cell adhesion molecule · cholesterol · cytokine · docosahexaenoic acid · endothelial leukocyte adhesion molecule 1 · epigallocatechin gallate · fibrinogen · fish oil · green tea extract · icosapentaenoic acid · intercellular adhesion molecule 1 · interleukin 1beta · lipid · lycopene · omega 3 700 · placebo · polyunsaturated fatty acid · resveratrol · serum amyloid A · triacylglycerol · unclassified drug · animal experiment · animal model · antiinflammatory dietary mixture · article · atherogenic diet · atherosclerosis · cholesterol blood level · controlled study · diet supplementation · dietary intake · drug efficacy · drug megadose · feeding · female · inflammation · long term care · male · mouse · nonhuman · powder · protein blood level · protein expression · risk factor · risk reduction · transgenic animal · treatment duration · treatment outcome · triacylglycerol blood level · vasculitis · omega 3 700 · Solgar Vitamin and Herb · Life · MSB - Microbiology and Systems Biology MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

11 Doxycycline therapy for abdominal aneurysm: Improved proteolytic balance through reduced neutrophil content
article 2009    
Author: Abdul-Hussien, H. · Hanemaaijer, R. · Verheijen, J.H. · Bockel, J.H. van · Geelkerken, R.H. · Lindeman, J.H.N.
Keywords: Biology · Biomedical Research · antihypertensive agent · antithrombocytic agent · cystatin C · cysteine proteinase · doxycycline · gelatinase B · hydroxymethylglutaryl coenzyme A reductase inhibitor · messenger RNA · neutrophil collagenase · stromelysin · tissue inhibitor of metalloproteinase 1 · abdominal aorta aneurysm · adult · aged · aorta wall · article · clinical article · clinical trial · controlled clinical trial · controlled study · dose response · drug effect · drug megadose · drug tolerability · enzyme activity · enzyme assay · female · gene expression · human · human tissue · immunohistochemistry · low drug dose · male · neutrophil · polymerase chain reaction · priority journal · protein degradation · quantitative analysis · randomized controlled trial · treatment duration · Western blotting · Aged · Aged, 80 and over · Aorta, Abdominal · Aortic Aneurysm, Abdominal · Cardiovascular Agents · Cystatin C · Cysteine Endopeptidases · Dose-Response Relationship, Drug · Doxycycline · Female · Gene Expression Regulation, Enzymologic · Humans · Male · Matrix Metalloproteinases · Middle Aged · Neutrophil Infiltration · Neutrophils · Prospective Studies · Protease Inhibitors · RNA, Messenger · Time Factors · Tissue Inhibitor of Metalloproteinase-1 · Treatment Outcome · Vascular Surgical Procedures
[Abstract]

12 Effect of thiabendazole on some rat hepatic xenobiotic metabolising enzymes
article 2004    
Author: Price, R.J. · Scott, M.P. · Walters, D.G. · Stierum, R.H. · Groten, J.P. · Meredith, C. · Lake, B.G.
Keywords: Nutrition · Physiological Sciences · 1-chloro-2,4-dinitrobenzene · BHT · Butylated hydroxytoluene · CDNB · CH · Cumene hydroperoxide · CYP · Cytochrome P450 · DCNB · Enzyme induction · GSH S-transferase · Rat liver · Thiabendazole · Xenobiotic metabolism · apoprotein · butylcresol · cytochrome P450 1A · cytochrome P450 1A1 · cytochrome P450 1A2 · cytochrome P450 2B · cytochrome P450 2B1 · cytochrome P450 2B2 · glutathione transferase · messenger RNA · tiabendazole · animal cell · animal experiment · article · controlled study · dose response · drug megadose · enzyme activation · enzyme activity · enzyme induction · enzyme metabolism · enzyme substrate · liver microsome metabolism · liver mitochondrion · liver weight · male · nonhuman · nucleotide sequence · protein blood level · rat · xenobiotic metabolism · Acyltransferases · Administration, Oral · Animals · Antinematodal Agents · Antioxidants · Butylated Hydroxytoluene · Cytochrome P-450 Enzyme System · Dose-Response Relationship, Drug · Glutathione Transferase · Liver · Male · Rats · Rats, Sprague-Dawley · RNA, Messenger · Thiabendazole
[Abstract]

13 Reversal of visceral hypersensitivity in rat by Menthacarin®, a proprietary combination of essential oils from peppermint and caraway, coincides with mycobiome modulation
article 2018    
Author: Botschuijver, S. · Welting, O. · Levin, E. · Maria-Ferreira, D. · Koch, E. · Montijn, R.C. · Seppen, J. · Hakvoort, T.B.M. · Schuren, F.H.J. · Jonge, W.J. de · Wijngaard, R.M. van den
Keywords: Biology · Abdominal pain · Bacteria · Fungi · IBS · Microbiome · Antibiotic agent · Antifungal agent · Bacterial DNA · Caraway oil · Decanoic acid · Digestive tract agent · DNA 16S · DNA 18S · Essential oil · Fluconazole · Fungal DNA · Internal transcribed spacer 1 · Menthacarin · Octanoic acid · Penicillin derivative · Peppermint oil · Streptomycin · Unclassified drug · Animal experiment · Animal model · Antibacterial activity · Antifungal activity · Assay · Bacillus subtilis · Candida albicans · Caraway · Colorectal disease · Colorectal distension · Controlled study · Digestive function · Digestive system disease · Dose response · Drug dose comparison · Drug efficacy · Drug mechanism · Drug megadose · Dysbiosis · Female · Growth inhibition · High throughput sequencing · Hypersensitivity · In vitro study · Intestine flora · Low drug dose · Male · Maternal deprivation · Mentha piperita · Motor activity · Mycobiome · Nonhuman · Physical sensitivity · Priority journal · Radial diffusion assay · Rat · Species composition · Treatment response · Viscera · Visceral hypersensitivity · Visceral hypersensitivity · Visceral sensitivity
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 13 of 13 found. | Sort by date