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1 Mutagenicity of ethidium bromide after metabolic activation in vitro
article 1976    
Author: Mattern, I.E.
Keywords: Biology · Cell culture · Drug activation · Drug metabolism · Electron microscopy · Ethidium chloride · In vitro study · Mutagenesis · Pharmacokinetics · Theoretical study

2 Anaerobic formation of alpha-hexachlorocyclohexane from gamma-hexachlorocyclohexane in soil and by Escherichia coli
article 1979    
Author: Vonk, J.W. · Quirijns, J.K.
Keywords: Lindane · Anaerobic metabolism · Animal experiment · Drug metabolism · Escherichia coli · In vitro study · Isomerism · Pharmacokinetics · Preliminary communication · Soil · Soil microflora
[Abstract]

3 Metabolic conversion of methyl benzimidazol 2 yl carbamate (MBC) in Aspergillus nidulans
article 1976    
Author: Davidse, L.C.
Keywords: benomyl · benzimidazole · benzimidazole derivative · carbon 14 · radioisotope · 2 aminobenzimidazole · aspergillus · aspergillus nidulans · drug metabolism · in vitro study · microorganism · pharmacokinetics · theoretical study
[Abstract]

4 Glutamate metabolism in ageing rat brain
article 1980    
Author: Koning-Verest, I.F. de
Keywords: Biology · Glutamic acid · Radioisotope · Acetic acid h 3 · Age · Aging · Animal experiment · Brain · Central nervous system · Drug metabolism · Glucose c 14 · In vitro study · Rat · Acetates · Aging · Animal · Aspartic Acid · Brain · Comparative Study · Female · Glucose · Glutamates · Glutamine · Rats
[Abstract]

5 Criteria to distinguish between natural situations and illegal use of boldenone, boldenone esters and boldione in cattle. 1. Metabolite profiles of boldenone, boldenone esters and boldione in cattle urine
article 2006    
Author: Le Bizec, B. · Courant, F. · Gaudin, I. · Bichon, E. · Destrez, B. · Schilt, R. · Draisci, R. · Monteau, F. · André, F.
Keywords: Biology · Analytical research · Anabolic · Boldenone · Endogenous · 17 Beta boldenone · Biological marker · Boldione · Drug metabolite · Unclassified drug · Animal experiments · Comparative study · Controlled study · Drug abuse · Drug metabolism · Drug urine level · Androstadienes · Cattle · Esters · Gas Chromatography-Mass Spectrometry · Testosterone · Animalia · Bos taurus
[Abstract]

6 Analytical possibilities for the detection of stanozolol and its metabolites
article 2002    
Author: Poelmans, S. · Wasch, K. de · Brabander, H.F. de · Wiele, M. van de · Courtheyn, D. · Ginkel, L.A. van · Sterk, S.S. · Delahaut, Ph. · Dubois, M. · Schilt, R. · Nielen, M. · Vercammen, J. · Impens, S. · Stephany, R. · Hamoir, T. · Pottie, G. · Poucke, C. van · Peteghem, C. van
Keywords: Health · Analytical research · Anabolic steroids · GC-MS · LC-MS · Metabolites · Stanozolol · anabolic agent · chemical compound · stanozolol · chemistry · conference paper · drug blood level · drug metabolism · extraction · gas chromatography · hydrolysis · immunoaffinity chromatography · kidney clearance · liquid chromatography · liquid liquid extraction · literature · mass spectrometry · metabolite · nonhuman · priority journal · solid phase extraction · urinary excretion · urine · Animalia
[Abstract]

7 Differences in metabolism and isomerization of all-trans-retinoic acid and 9-cis-retinoic acid between human endothelial cells and hepatocytes
article 1997    
Author: Lansink, M. · Bennekum, A.M. van · Blaner, W.S. · Kooistra, T.
Keywords: Health · Human endothelial cell · Human hepatocyte · Isomerization · Metabolism · Liarozole · Plasminogen activator · Retinoic acid · Cell culture · Controlled study · Drug metabolism · Endothelium cell · High performance liquid chromatography · Human cell · In vitro study · Isomerism · Isotope labeling · Liver cell culture · Lliver metabolism · Biotransformation · Cells, Cultured · Chromatography, High Pressure Liquid · Endothelium, Vascular · Humans · Isomerism · Kinetics · Liver · Tretinoin · Umbilical Veins
[Abstract]

8 The influence of aging on the metabolism of simultaneously administered hexobarbital enantiomers and antipyrine before and after phenobarbital induction in male rats: A longitudinal study
article 1994    
Author: Groen, K. · Breimer, D.D. · Jansen, E.J. · Bezooijen, C.F.A. van
Keywords: Health · 3 hydroxymethylphenazone · 4 hydroxyphenazone · Norphenazone · Phenazone · Adolescent · Aged · Body weight · Controlled study · Drug blood level · Drug clearance · Drug metabolism · Drug urine level · Enantiomer · Enzyme activity · Enzyme specificity · High performance liquid chromatography · Nonhuman · Survival rate · Aging · Animal · Antipyrine · Cytochrome P-450 Enzyme System · Enzyme Induction · Hexobarbital · Longitudinal Studies · Male · Metabolic Clearance Rate · Phenobarbital · Rats · Rats, Inbred BN · Stereoisomerism
[Abstract]

9 Effect of low-dose oral contraceptives on lipoproteins and lipolytic enzymes : Differences between two commonly used preparations
article 1984    
Author: Gevers Leuven, J.A. · Havekes, L. · Kooij-Pontier, H.A. van der · Starmans, R.J.H. · Jansen, H. · Bouwhuis-Hoogerwerf, M.L. · Pagter, H.A.T. de · Hessel, L.W.
Keywords: apoprotein · ethinylestradiol · ethinylestradiol plus lynestrenol · ethinylestradiol plus norgestrel · liver triacylglycerol lipase · lynestrenol · norgestrel · oral contraceptive agent · drug comparison · drug metabolism · endocrine system · female genital system · human experiment · oral drug administration · Adult · Apolipoproteins · Cholesterol · Comparative Study · Contraceptives, Oral · Contraceptives, Oral, Combined · Contraceptives, Oral, Sequential · Ethinyl Estradiol · Ethinyl Estradiol-Norgestrel Combination · Female · Human · Lipase · Lipoprotein Lipase · Lipoproteins · Liver · Lynestrenol · Norgestrel · Triglycerides
[Abstract]

10 Report of a workshop on bacterial in vitro mutagenicity test systems
article 1978    
Author: Mattern, I.E. · Greim, H.
Keywords: Biology · 2 Aminoanthracene · 2 Nitrofluorene · Aflatoxin · Aroclor 1254 · Benzo[a]pyrene · Clophen a50 · Cyclophosphamide · Diethylnitrosamine · Dimethylnitrosamine · Mesylic acid ethyl ester · Methylnitronitrosoguanidine · Mitomycin c · N (2 fluorenyl)acetamide · Nitrosomorpholine · Polychlorinated biphenyl · Unclassified drug · Vinylidene chloride · 4 Nitroquinoline · Abstract report · Animal experiment · Bacterium · Benzoflavone · Drug activation · Drug metabolism · Drug screening · Hamster · In vitro study · Liver microsome · Methodology · Mouse · Mutagen testing · Mutagenesis · Rat
[Abstract]

11 Inhibition of zaleplon metabolism by cimetidine in the human liver : in vitro studies with subcellular fractions and precision-cut liver slices
article 2002    
Author: Renwick, A.B. · Ball, S.E. · Tredger, J.M. · Price, R.J. · Walters, D.G. · Kao, J. · Scatina, J.A. · Lake, B.G.
Keywords: Nutrition · Aldehyde oxidase · Cimetidine · Cytochrome P450 3A · Reduced nicotinamide adenine dinucleotide phosphate · Zaleplon · Cell fractionation · Drug inhibition · Drug metabolism · Human · Human cell · Human tissue · In vitro study · Liver metabolism · Liver microsome · Liver slice · Acetamides · Cimetidine · Cytosol · Dose-Response Relationship, Drug · Drug Interactions · Enzyme Inhibitors · Humans · Hypnotics and Sedatives · Inhibitory Concentration 50 · Kinetics · Liver · Models, Chemical · Pyrimidines · Subcellular Fractions · Staphylococcus phage 3A
[Abstract]

12 Identification of some important metabolites of boldenone in urine and feces of cattle by gas chromatography-mass spectrometry
article 1998    
Author: Puymbroeck, M. van · Kuilman, M.E.M. · Maas, R.F.M. · Witkamp, R.F. · Leyssens, L. · Zande, D.J.M. van der · Gelan, J. · Raus, J.
Keywords: Nutrition · Anabolic agent · Androstenedione · Boldenone · Drug metabolite · Animal tissue · Cattle · Conference paper · Drug feces level · Drug metabolism · Drug urine level · Gas chromatography · Liver cell · Liver microsome · Mass spectrometry · Nonhuman · Animals · Cells, Cultured · Feces · Gas Chromatography-Mass Spectrometry · Liver · Male · Microsomes, Liver · Testosterone
[PDF] [Abstract]

13 In vitro liver models are important tools to monitor the abuse of anabolic steroids in cattle
article 1998    
Author: Puymbroeck, M. van · Kuilman, M.E.M. · Maas, R.F.M. · Witkamp, R.F. · Leyssens, T. · Zande, D.J.M. van der · Gelan, J. · Raus, J.
Keywords: Nutrition · Anabolic agent · Biological marker · Boldenone · Clostebol · Estrane derivative · Ethylestrenol · Norethandrolone · Steroid · Animal tissue · Cattle · Conference paper · Controlled study · Drug abuse · Drug determination · Drug metabolism · Drug monitoring · Female · Liver · Liver cell culture · Liver metabolism · Liver microsome · Male · Model · Nonhuman · Steroid metabolism · Anabolic Agents · Animals · Biological Markers · Cattle · Cells, Cultured · Drug Residues · Estradiol · Ethylestrenol · Liver · Microsomes, Liver · Models, Biological · Norethandrolone · Predictive Value of Tests · Testosterone
[PDF] [Abstract]

14 Retinoid metabolism and all-trans retinoic acid-induced growth inhibition in head and neck squamous cell carcinoma cell lines
article 1997    
Author: Braakhuis, B.J.M. · Klaassen, I. · Leede, B.M. van der · Cloos, J. · Brakenhoff, R.H. · Copper, M.P. · Teerlink, T. · Hendriks, H.F.J. · Saag, P.T. van der · Snow, G.B.
Keywords: CRABP-II · Head and neck cancer · Metabolism · Squamous · alitretinoin · isotretinoin · messenger RNA · retinoic acid · retinoic acid binding protein · cancer cell culture · cancer inhibition · cell metabolism · controlled study · drug blood level · drug metabolism · head cancer · homeostasis · human cell · neck cancer · squamous cell carcinoma · Antineoplastic Agents · Carcinoma, Squamous Cell · Cell Division · Chromatography, High Pressure Liquid · Culture Media · Head and Neck Neoplasms · Humans · Receptors, Retinoic Acid · Retinoids · Tretinoin · Tumor Cells, Cultured
[PDF] [Abstract]

15 Pediatric Microdose Study of [14C]Paracetamol to Study Drug Metabolism Using Accelerated Mass Spectrometry: Proof of Concept
article 2014    
Author: Mooij, M.G. · Duijn, E. van · Knibbe, C.A.J. · Windhorst, A.D. · Hendrikse, N.H. · Vaes, W.H.J. · Spaans, E. · Fabriek, B.O. · Sandman, H. · Grossouw, D. · Hanff, L.M. · Janssen, P.J.J.M. · Koch, B.C.P. · Tibboel, D. · Wildt, S.N. de
Keywords: Nutrition · Carbon 14 · Drug metabolite · Paracetamol · Accelerator mass spectrometry · Blood sampling · Child · Clinical article · Drug blood level · Drug metabolism · Female · Human · Indwelling catheter · Infant · Limit of quantitation · Liquid chromatography · Male · Mass spectrometry · Maximum plasma concentration · Newborn · Open study · Pharmacokinetics · Pilot study · Preschool child · Priority journal · Single drug dose · Time to maximum plasma concentration · Food and Nutrition · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

16 In vitro inhibition of rat and human glutathione S-transferase isoenzymes by disulfiram and diethyldithiocarbamate
article 1996    
Author: Ploemen, J.-P.H.T.M. · Iersel, M.L.P.S. van · Wormhoudt, L.W. · Commandeur, J.N.M. · Vermeulen, N.P.E. · Bladeren, P.J. van
Keywords: diethyldithiocarbamate · disulfiram · gl utathion e · glutathione S-transferases · in vitro · inhibition · 1 chloro 2,4 dinitrobenzene · 1,2 epoxy 3 (4 nitrophenoxy)propane · aldehyde dehydrogenase inhibitor · diethyldithiocarbamic acid · disulfiram · dithiothreitol · glutathione transferase · isoenzyme · thiol · unclassified drug · article · controlled study · drug metabolism · enzyme inactivation · enzyme inhibition · enzyme purification · enzyme substrate · human · nonhuman · priority journal · rat · reduction · Animals · Disulfiram · Dithiothreitol · Ditiocarb · Glutathione · Glutathione Transferase · Humans · Isoenzymes · Rats · Spectrophotometry, Ultraviolet · Time Factors
[Abstract]

17 Disposition of 14C-erythritol in germfree and conventional rats
article 1996    
Author: Ommen, B. van · Bie, B. de · Bar, A.
Keywords: Toxicology · erythritol · carbon · carbon dioxide · diagnostic agent · sweetening agent · animal experiment · article · controlled study · drug disposition · drug elimination · drug metabolism · female · germfree animal · male · nonhuman · priority journal · rat · absorption · animal · body weight · intestine · kidney · metabolism · microbiology · physiology · tissue distribution · urine · Wistar rat · Absorption · Animals · Body Weight · Carbon Dioxide · Carbon Radioisotopes · Erythritol · Female · Germ-Free Life · Intestines · Kidney · Male · Rats · Rats, Wistar · Sweetening Agents · Tissue Distribution
[Abstract]

18 Clearance and clearance inhibition of the HIV-1 protease inhibitors ritonavir and saquinavir in sandwich-cultured rat hepatocytes and rat microsomes
article 2009    
Author: Treijtel, N. · Eijkeren, J.C.H.v. · Nijmeijer, S. · Greef de - Sandt, I.C.J. van der · Freidig, A.P.
Keywords: Health · Biomedical Research · HIV-protease inhibitors · Metabolism · P-Glycoprotein · Rat hepatocytes · rat liver microsomes · Sandwich-culture · cyclosporin A · drug metabolite · glycoprotein P · ketoconazole · proteinase inhibitor · ritonavir · saquinavir · testosterone derivative · valspodar · verapamil · animal cell · article · cell culture · controlled study · drug clearance · drug excretion · drug metabolism · drug transport · Human immunodeficiency virus 1 · hydroxylation · intrahepatic bile duct · liver cell · liver metabolism · male · microsome · nonhuman · rat · sandwich culture · Animals · Biological Transport, Active · Cell Culture Techniques · Cell Survival · Cells, Cultured · Cyclosporine · Cyclosporins · Dose-Response Relationship, Drug · Hepatocytes · HIV Protease Inhibitors · Ketoconazole · Male · Metabolic Clearance Rate · Microsomes, Liver · Rats · Rats, Wistar · Ritonavir · Saquinavir · Human immunodeficiency virus 1 · Rattus
[Abstract]

19 Recent methodology in the phytochemical analysis of ginseng
article 2008    
Author: Angelova, N. · Kong, H.-W. · Heijden, R. van de · Yang, S.-Y. · Choi, Y.H. · Kim, H.K. · Wang, M. · Hankemeier, T. · Greef, J. van der · Xu, G. · Verpoorte, R.
Keywords: Health · Biomedical Research · Ginsenosides · Mass spectrometry · Metabolomics · Panax ginseng · Ginseng extract · Phenol · Saponin · Analytic method · Antineoplastic activity · Biosensor · Drug absorption · Drug determination · Drug distribution · Drug efficacy · Drug excretion · Drug half life · Drug metabolism · Drug safety · Drug structure · Electrospray mass spectrometry · Enzyme linked immunosorbent assay · Fourier transform mass spectrometry · Ginseng · High performance liquid chromatography · Human · Immunoregulation · Ion cyclotron resonance mass spectrometry · Liquid chromatography · Liver protection · Mass spectrometry · Metabolomics · Near infrared reflectance spectroscopy · Nonhuman · Nuclear magnetic resonance spectroscopy · Plant root · Quality control · Review · Sensitivity analysis · Structure analysis · Systems biology · Drugs, Chinese Herbal · Ginsenosides · Mass Spectrometry · Panax · Spectroscopy, Fourier Transform Infrared · Spectroscopy, Near-Infrared · Panax ginseng
[Abstract]

20 Comparison of coumarin-induced toxicity between sandwich-cultured primary rat hepatocytes and rats in vivo: A toxicogenomics approach
article 2006    
Author: Kienhuis, A.S. · Wortelboer, H.M. · Hoflack, J.C. · Moonen, E.J. · Kleinjans, J.C.S. · Ommen, B. van · Delft, J.H.M. van · Stierum, R.H.
Keywords: Biology · Biomedical Research · beta naphthoflavone · coumarin · cytochrome P450 · dexamethasone · drug metabolite · enzyme inducing agent · phenobarbital · animal cell · animal experiment · animal model · animal tissue · article · controlled study · culture medium · cytotoxicity · drug activation · drug metabolism · enzyme activity · experimental rat · gene expression · histopathology · in vitro study · in vivo study · liver cell · liver toxicity · male · nonhuman · nucleotide sequence · prediction · principal component analysis · priority journal · rat · signal transduction · toxicogenetics · Alanine Transaminase · Animals · Aspartate Aminotransferases · Cell Culture Techniques · Cells, Cultured · Cholesterol · Coumarins · gamma-Glutamyltransferase · Gene Expression Profiling · Hepatocytes · Liver · Male · Oligonucleotide Array Sequence Analysis · Rats · Rats, Wistar · Toxicogenetics
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 28 found. Next | Sort by date