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1 Toxicological evaluation and risk assessment of chemical mixtures
article 1998    
Author: Cassee, F.R. · Groten, J.P. · Bladeren, P.J. van · Feron, V.J.
Keywords: Nutrition · Combination toxicology · Complex mixtures · Isoboles · Physiologically based toxicokinetic modeling · Response surface analysis · Simple mixtures · Weight of evidence approach · Chemical compound · Chemical analysis · Dose response · Drug mechanism · Drug potentiation · Environmental exposure · Review · Risk assessment · Toxin analysis · Animals · Drug Interactions · Drug Synergism · Guidelines · International Cooperation · Male · Models, Biological · Models, Statistical · No-Observed-Adverse-Effect Level · Rats · Risk Assessment · Xenobiotics
[Abstract]

2 Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin
article 2014    
Author: Kühnast, S. · Hoorn, J.W.A. van der · Pieterman, E.J. · Hoek, A.M. van den · Sasiela, W.J. · Gusarova, V. · Peyman, A. · Schäfer, H.L. · Schwahn, U. · Jukema, J.W. · Princen, H.M.G.
Keywords: Biology · 3Leiden.CETP mice · APOE · Atorvastatin · Proprotein convertase subtilisin/kexin type 9 · Alirocumab · Apolipoprotein E · Atorvastatin · Bile acid · Cholesterol · Collagen · Low density lipoprotein receptor · Sterol · Triacylglycerol · Animal experiment · Animal model · Atherosclerosis · Atherosclerotic plaque · Controlled study · Disease severity · Dose response · Drug effect · Drug potentiation · Drug safety · Fat content · Female · Lipid blood level · Monocyte · Monotherapy · Mouse · Nonhuman · Protein degradation · Smooth muscle fiber · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

3 Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-cholesterol, improves lesion stability and adds to the beneficial effects of atorvastatin
article 2015    
Author: Kühnast, S. · Tuin, S.J.L. van der · Hoorn, J.W.A. van der · Klinken, J.B. van · Simic, B. · Pieterman, E. · Havekes, L.M. · Landmesser, U. · Lüscher, T.F. · Dijk, K.W. van · Rensen, P.C.N. · Jukema, J.W. · Princen, H.M.G.
Keywords: Biology · Anacetrapib · Atherosclerosis · Atorvastatin · Cholesteryl ester transfer protein · HDL function · HDL-cholesterol · Non-HDL-cholesterol · Apolipoprotein E3 · Atorvastatin · High density lipoprotein cholesterol · Analysis of covariance · Animal cell · Animal model · Aorta atherosclerosis · Aorta root · Atherosclerotic plaque · Cholesterol blood level · Controlled study · Diet · Disease severity · Drug efficacy · Drug potentiation · Enzyme activity · Female · In vivo study · Mouse · Nonhuman · Risk reduction · Treatment duration · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

4 On the assessment of adverse drug reactions from spontaneous reporting systems: The influence of under-reporting on odds ratios
article 2002    
Author: Heijden, P.G.M. van der · Puijenbroek, E.P. van · Buuren, S. van · Hofstede, J.W. van der
Keywords: Health · Pharmacovigilance · Spontaneous reporting system · Under-reporting · Antifungal agent · Antineoplastic agent · Diclofenac · Diuretic agent · Nonsteroid antiinflammatory agent · Terbinafine · Congestive heart failure · Controlled study · Covariance · Drug hypersensitivity · Drug potentiation · Drug surveillance program · Hair loss · Information processing · Risk assessment · Sex difference · Adverse Drug Reaction Reporting Systems · Anaphylaxis · Anti-Inflammatory Agents, Non-Steroidal · Diclofenac · Diuretics · Drug Interactions · Female · Heart Failure, Congestive · Humans · Male · Middle Aged · Odds Ratio · Product Surveillance, Postmarketing · Sex Factors
[Abstract]

5 The dual PPARα/γ agonist tesaglitazar blocks progression of pre-existing atherosclerosis in APOE*3Leiden.CETP transgenic mice
article 2009    
Author: Hoorn, J.W.A. van der · Jukema, J.W. · Havekes, L.M. · Lundholm, E. · Camejo, G. · Rensen, P.C.N. · Princen, H.M.G.
Keywords: Biology · Biomedical Research · 3Leiden.CETP mice · APOE · Atherogenic triad · Atherosclerosis · PPARα/γ · Tesaglitazar · 2 ethoxy 3 (4 ((4 (methylsulfonyloxy)phenethyl)oxy)phenyl)propanoic acid · Alkanesulfonic acid · High density lipoprotein cholesterol · Peroxisome proliferator activated receptor alpha · Peroxisome proliferator activated receptor gamma · Phenylpropionic acid derivative · Very low density lipoprotein cholesterol · Biosynthesis · Blood · Drug potentiation · Genetics · Inflammation · Metabolism · Mouse · Mutation · Pathology · Transgenic mouse · Alkanesulfonates · Animals · Aortic Valve · Apolipoprotein E3 · Atherosclerosis · Cholesterol Ester Transfer Proteins · Cholesterol, HDL · Cholesterol, VLDL · Female · Humans · Inflammation · Mice · Mice, Transgenic · Mutation · Phenylpropionates · PPAR alpha · PPAR gamma
[Abstract]

6 Atorvastatin accelerates clearance of lipoprotein remnants generated by activated brown fat to further reduce hypercholesterolemia and atherosclerosis
article 2017    
Author: Hoeke, G. · Wang, Y. · Dam, A.D. van · Mol, M. · Gart, E. · Klop, H.G. · Berg, S.M. van den · Pieterman, E.H. · Princen, H.M.G. · Groen, A.K. · Rensen, P.C.N. · Berbée, J.F.P. · Boon, M.R.
Keywords: Biology · Atherosclerosis · Brown adipose tissue · Hypercholesterolemia · Cholesterol metabolism · Lipid and lipoprotein metabolism · 5 [2 [[2 (3 chlorophenyl) 2 hydroxyethyl]amino]propyl] 1,3 benzodioxole 2,2 dicarboxylic acid · Atorvastatin · Cholesterol · Fatty acid · High density lipoprotein cholesterol · Lipoprotein · Proprotein convertase 9 · Triacylglycerol · Animal experiment · Animal model · Animal tissue · Atherosclerosis · Brown adipose tissue · Cholesterol blood level · Controlled study · Drug effect · Drug potentiation · Energy expenditure · Female · Gene expression · Hypercholesterolemia · Lipid composition · Lipid liver level · Lipid metabolism · Lipid oxidation · Lipid transport · Lipoprotein metabolism · Mouse · Nonhuman · Triacylglycerol blood level · Western diet · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

7 CNTO736, a novel glucagon-like peptide-1 receptor agonist, ameliorates insulin resistance and inhibits very low-density lipoprotein production in high-fat-fed mice
article 2009    
Author: Parlevliet, E.T. · Schröder-van der Elst, J.P. · Corssmit, E.P.M. · Picha, K. · O'Neil, K. · Stojanovic-Susulic, V. · Ort, T. · Havekes, L.M. · Romijn, J.A. · Pijl, H.
Keywords: Biology · Biomedical Research · CNTO 736 · exendin 4 · glucagon like peptide 1 derivative · glucagon like peptide 1 receptor · very low density lipoprotein · glucagon like peptide receptor · glucagon receptor · glucagon-like peptide receptor · hybrid protein · triacylglycerol · animal experiment · animal model · chronic drug administration · controlled study · gluconeogenesis · glucose blood level · glucose transport · hyperinsulinemia · lipid diet · lipoprotein metabolism · male · mouse · nonhuman · single drug dose · animal food · blood · C57BL mouse · Cytomegalovirus · Drug effect · Drug potentiation · Fat intake · Genetics · Intravenous drug administration · Metabolism · Molecular cloning · Animal Feed · Animals · Blood Glucose · Cloning, Molecular · Cytomegalovirus · Dietary Fats · Glucose · Glucose Clamp Technique · Hyperinsulinism · Infusions, Intravenous · Insulin · Insulin Resistance · Lipoproteins, VLDL · Liver · Mice · Mice, Inbred C57BL · Promoter Regions, Genetic · Receptors, Glucagon · Recombinant Fusion Proteins · Triglycerides
[Abstract]

8 Metabolomics in the context of systems biology: Bridging Traditional Chinese Medicine and molecular pharmacology
article 2005    
Author: Wang, M. · Lamers, R.J.A.N. · Korthout, H.A.A.J. · Nesselrooij, J.H.J. van · Witkamp, R.F. · Heijden, R. van der · Voshol, P.J. · Havekes, L.M. · Verpoorte, R. · Greef, J. van der
Keywords: Health Pharmacology · Analytical research · Metabolomics · Systems biology · Traditional Chinese Medicine (TCM) · 5' methoxyhdnocarpin · Alanine aminotransferase · Alkaloid · Apolipoprotein E · Berberine · Biflavonoid · Bilobalide · Cannabidiol · Cannabis · Chaconine · Cholesterol · Flavonoid · Ginkgo biloba extract · Ginkgolide · Glucoside · Herbaceous agent · Insulin · Low density lipoprotein · Plant extract · Prodrug · Salicylic acid · Saligenin · Saponin · Solanine · Tetrahydrocannabinol · Triacylglycerol · Unclassified drug · Very low density lipoprotein · Alanine aminotransferase blood level · Animal experiment · Animal model · Atherosclerosis · Bark · Blood flow · Chinese medicine · Clinical pharmacology · Controlled study · Data analysis · DNA microarray · Drug effect · Drug efficacy · Drug potentiation · Drug research · Drug safety · Drug targeting · Female · Ginkgo biloba · Headache · Herbal medicine · High performance liquid chromatography · Human · Human experiment · Insulin resistance · Insulin sensitivity · Ion cyclotron resonance mass spectrometry · Lipid metabolism · Liver function · Male · Mass spectrometry · Medicinal plant · Metabolic syndrome X · Metabolite · Molecular pharmacology · Nonhuman · Nuclear magnetic resonance spectroscopy · Pain · Phytotherapy · Plant leaf · Proton nuclear magnetic resonance · Rat · Thin layer chromatography · Traditional medicine · Willow · Drugs, Chinese Herbal · Humans · Pharmacology · Phytotherapy
[Abstract]

9 Dual PPARα/γ agonist tesaglitazar reduces atherosclerosis in insulin-resistant and hypercholesterolemic ApoE*3Leiden mice
article 2006    
Author: Zadelaar, A.S.M. · Boesten, L.S.M. · Jukema, J.W. · Vlijmen, B.J.M. van · Kooistra, T. · Emeis, J.J. · Lundholm, E. · Camejo, G. · Havekes, L.M.
Keywords: Cholesterol · Inhibitors · Collagen · Immunoglobulin enhancer binding protein · Serum amyloid A · Tesaglitazar · 2 ethoxy 3 (4 ((4 (methylsulfonyloxy)phenethyl)oxy)phenyl)propanoic acid · Alkanesulfonic acid · Apolipoprotein E3 (Leidein) · Biological marker · Lipoprotein · Peroxisome proliferator activated receptor alpha · Peroxisome proliferator activated receptor gamma · Phenylpropionic acid derivative · Animal cell · Animal experiment · Animal model · Animal tissue · Blood vessel wall · Cholesterol blood level · Controlled study · Diet · Enzyme activity · Monocyte · Mouse · Nonhuman · Protein blood level · Transgenic mouse · Blood · Cholesterol intake · Drug potentiation · Fat intake · Metabolism · Pathology · Pathophysiology · Alkanesulfonates · Animals · Apolipoprotein E3 · Apolipoproteins E · Atherosclerosis · Biological Markers · Blood Vessels · Cell Adhesion · Cholesterol · Cholesterol, Dietary · Collagen · Dietary Fats · Female · Hypercholesterolemia · Inflammation · Insulin Resistance · Lipids · Lipoproteins · Macrophages · Mice · Mice, Transgenic · Monocytes · NF-kappa B · Phenylpropionates · PPAR alpha · PPAR gamma
[Abstract]

10 LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: Time course and mechanisms
article 2009    
Author: Verschuren, L. · Vries de Weij, J. van der · Zadelaar, A.S.M. · Kleemann, R. · Kooistra, T.
Keywords: Health · Biomedical Research · Atherosclerosis · Inflammation · Liver-X-receptor · Macrophages · ABC transporter A1 · ABC transporter G1 · apolipoprotein E3 · cell adhesion molecule · chemokine receptor CCR7 · cholesterol · endothelial leukocyte adhesion molecule 1 · Hermes antigen · immunoglobulin enhancer binding protein · intercellular adhesion molecule 1 · lipid · liver X receptor agonist · n (2,2,2 trifluoroethyl) n [4 [2,2,2 trifluoro 1 hydroxy 1 (trifluoromethoxy)ethyl]phenyl]benzenesulfonamide · serum amyloid A · triacylglycerol · ABC transporter · ABCG1 protein, mouse · apolipoprotein E3 (Leidein) · cell receptor · DNA binding protein · fluorinated hydrocarbon · hypocholesterolemic agent · lipoprotein · liver X receptor · n (2,2,2 trifluoroethyl) n [4 (2,2,2 trifluoro 1 hydroxy 1 trifluoromethylethyl)phenyl]benzenesulfonamide · sulfonamide · TO-901317 · animal experiment · animal model · atherosclerosis · cell adhesion · cholesterol blood level · cholesterol diet · controlled study · disease course · drug mechanism · drug potency · endothelium · female · immunohistochemistry · macrophage · monocyte · mouse · nonhuman · priority journal · protein expression · remission · triacylglycerol blood level · animal · drug potentiation · genetics · metabolism · pathology · transgenic mouse · Animals · Anticholesteremic Agents · Antigens, CD44 · Apolipoprotein E3 · Atherosclerosis · ATP-Binding Cassette Transporters · DNA-Binding Proteins · E-Selectin · Female · Hydrocarbons, Fluorinated · Intercellular Adhesion Molecule-1 · Lipoproteins · Mice · Mice, Transgenic · Receptors, Cytoplasmic and Nuclear · Serum Amyloid A Protein · Sulfonamides
[PDF] [Abstract]

11 Therapeutic efficacy of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) against organophosphate intoxication
article 2002    
Author: Bueters, T.J.H. · Groen, B. · Danhof, M. · IJzerman, A.P. · Helden, H.P.M. van
Keywords: Biology · Acetylcholine release · Adenosine A1 receptor · N6-Cyclopentyladenosine · Organophosphate · Adenosine A1 receptor agonist · Adenosine receptor stimulating agent · Cyclohexyladenosine · Methylphosphonothioic acid s (2 diisopropylaminoethyl) o ethyl ester · Adenosine receptor · Cholinesterase · Drug derivative · N(6) cyclopentyladenosine · Organophosphate · Phosphorothioic acid derivative · Bioaccumulation · Cholinergic system · Concentration response · Controlled study · Corpus striatum · Crug efficacy · Enzyme activity · Hippocampus · Intoxication · Male · Microdialysis · Nonhuman · Rat · Reduction · Animal · Drug potentiation · Enzymology · Metabolism · Secretion · Wistar rat · Animals · Cholinesterase Inhibitors · Cholinesterases · Corpus Striatum · Male · Microdialysis · Organothiophosphorus Compounds · Parathion · Phosphoric Acid Esters · Rats · Rats, Wistar · Receptors, Purinergic P1 · Sarin · Acetylcholinesterase, 9000-81-1 · Cyclohexyladenosine, 36396-99-3 · Methylphosphonothioic acid s (2 diisopropylaminoethyl) o ethyl ester, 50782-69-9 · Parathion, 3270-86-8, 56-38-2, 597-88-6 · Sarin, 107-44-8; tabun, 77-81-6 · Acetylcholine, 51-84-3 · Adenosine, 58-61-7; · Cholinesterase Inhibitors · Cholinesterases, EC 3.1.1.8 · N(6)-cyclopentyladenosine, 41552-82-3 · Organothiophosphorus Compounds · Parathion, 56-38- · Phosphoric Acid Esters · Receptors, Purinergic P1 · Sarin, 107-44-8 · Tabun, 77-81-6 · VX, 50782-69-9
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 11 of 11 found. | Sort by date