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Showing 1 to 7 of 7 found. | Sort by date

1 The role of human glutathione S-transferase isoenzymes in the formation of glutathione conjugates of the alkylating cytostatic drug thiotepa
article 1995    
Author: Dirven, H.A.A.M. · Dictus, E.L.J.T. · Broeders, N.L.H.L. · Ommen, B. van · Bladeren, P.J. van
Keywords: Nutrition · Glutathione · Glutathione reductase · Tepa · Thiotepa · Conformational transition · Drug conformation · Drug conjugation · Drug protein binding · Drug resistance · Enzyme activity · Priority journal · Chromatography, High Pressure Liquid · Female · Glutathione · Glutathione Transferase · Human · Isoenzymes · Kinetics · Liver · Magnetic Resonance Spectroscopy · Placenta · Pregnancy · Support, Non-U.S. Gov't · Thiotepa
[Abstract]

2 Differential binding of methyl benzimidazol 2 yl carbamate to fungal tubulin as a mechanism of resistance to this antimiotic agent in mutant strains of Aspergillus nidulans
article 1977    
Author: Davidse, L.C. · Flach, W.
Keywords: benomyl · carbon 14 · colchicine · fuberidazole · mebendazole · nocodazole · r 17 934 · radioisotope · tiabendazole · aspergillus nidulans · colchicine h 3 · drug binding · drug protein binding · drug resistance · microorganism · mutant · theoretical study · Aspergillus nidulans · Benzimidazoles · Binding, Competitive · Carbamates · Colchicine · Drug Resistance · Glycoproteins · Griseofulvin · Hydrogen-Ion Concentration · Melatonin · Mutation · Podophyllotoxin · Receptors, Drug · Temperature · Tubulin · Vinblastine
[Abstract]

3 Structure of Rhodococcus erythropolis limonene-1,2-epoxide hydrolase reveals a novel active site
article 2003    
Author: Arand, M. · Hallberg, B.M. · Zou, J. · Bergfors, T. · Oesch, F. · Werf, M.J. van der · Bont, J.A.M. de · Jones, T.A. · Mowbray, S.L.
Keywords: Biology · Biotechnology · Crystal structure · Enantioselectivity · Epoxide hydrolase · Mechanism · Monoterpene degradation · bacterial enzyme · limonene 1,2 epoxide hydrolase · selenomethionine · unclassified drug · valpromide · alpha helix · article · beta sheet · catalysis · chemical reaction · crystal structure · detoxification · drug protein binding · enantioselectivity · enzyme active site · enzyme metabolism · enzyme structure · enzyme substrate complex · nonhuman · priority journal · reaction analysis · Rhodococcus erythropolis · site directed mutagenesis · Amino Acid Sequence · Bacterial Proteins · Catalytic Domain · Crystallography, X-Ray · Dimerization · Epoxide Hydrolases · Models, Molecular · Molecular Sequence Data · Mutagenesis, Site-Directed · Protein Subunits · Recombinant Proteins · Rhodococcus · Sequence Homology, Amino Acid · Actinobacteria (class) · Bacteria (microorganisms) · Rhodococcus · Rhodococcus erythropolis · uncultured actinomycete
[Abstract]

4 Liquid chromatography/tandem mass spectrometry detection of covalent binding of acetaminophen to human serum albumin
article 2007    
Author: Damsten, M.C. · Commandeur, J.N.M. · Fidder, A. · Hulst, A.G. · Touw, D. · Noort, D. · Vermeulen, N.P.E.
Keywords: Cytochrome P450 · Paracetamol · Serum albumin · Article · Biological monitoring · Covalent bond · Drug protein binding · Human · Liquid chromatography · Microsome · Priority journal · Tandem mass spectrometry · Acetaminophen · Acetylcysteine · Animals · Benzoquinones · Chromatography, Liquid · Cysteine · Humans · Imines · Microsomes, Liver · Models, Biological · Molecular Structure · Oligopeptides · Protein Binding · Rats · Reproducibility of Results · Serum Albumin · Tandem Mass Spectrometry · Chemicals · CAS: cytochrome P450, 9035-51-2 · Paracetamol, 103-90-2 · Serum albumin, 9048-46-8 · Acetaminophen, 103-90-2 · Acetylcysteine, 616-91-1 · Benzoquinones · Cysteine, 52-90-4 · Imines · N-acetyl-4-benzoquinoneimine, 50700-49-7 · Oligopeptides
[Abstract]

5 Covalent binding of nitrogen mustards to the cysteine-34 residue in human serum albumin
article 2002    
Author: Noort, D. · Hulst, A.G. · Jansen, R.
Keywords: Toxicology · Adducts · Albumin · Biomonitoring · Chemotherapy · Nitrogen mustards · Tandem mass spectrometry · Chlorambucil · Chlormethine · Chlormethine derivative · Dichlorodiethylamine · Human serum albumin · Phenylalanine · Proline · Pronase · Tripeptide · Amino acid analysis · Controlled study · Covalent bond · Drug protein binding · In vitro study · In vivo study · Liquid chromatography · Tandem mass spectrometry · Binding Sites · Cyclophosphamide · Cysteine · Drug Monitoring · Humans · Mechlorethamine · Melphalan · Nitrogen Mustard Compounds · Protein Binding · Serum Albumin · Mass spectrometry · Matrix-Assisted Laser Desorption-Ionization · Brassicaceae · Chlorambucil, 305-03-3 · Cyclophosphamide, 50-18-0 · Cysteine, 52-90-4 · Mechlorethamine, 51-75-2 · Melphalan, 148-82-3 · Nitrogen Mustard Compounds · Nornitrogen mustard, 334-22-5 · Serum albumin
[Abstract]

6 Inhibition of multidrug resistance proteins MRP1 and MRP2 by a series of α,β-unsaturated carbonyl compounds
article 2005    
Author: Wortelboer, H.M. · Usta, M. · Zanden, J.J. van · Bladeren, P.J. van · Rietjens, I.M.C.M. · Cnubben, N.H.P.
Keywords: Nutrition · Biomedical Research · α,β-Unsaturated carbonyl compounds · Inhibition · MRP1 · MRP2 · 2 hexenal · acrolein · caffeic acid phenethyl ester · calcein · carbonyl derivative · cinnamaldehyde · citral · crotonaldehyde · curcumin · cyclosporin A · demethoxycurcumin · didemethoxycurcumin · drug metabolite · glutathione · multidrug resistance protein 1 · multidrug resistance protein 2 · thiol derivative · unclassified drug · verlukast · animal cell · article · cell isolation · cell metabolism · conjugate · controlled study · dog · drug efficacy · drug metabolism · drug potency · drug protein binding · glutathione metabolism · kidney cell · membrane vesicle · modulation · molecular model · molecular stability · nonhuman · priority journal · protein expression · protein transport · Aldehydes · Animals · Biological Transport · Cell Line · Curcumin · Dogs · Fluoresceins · Humans · Membrane Transport Modulators · Membrane Transport Proteins · Multidrug Resistance-Associated Proteins · Transfection
[Abstract]

7 Generation of Bayesian prediction models for OATP-mediated drug-drug interactions based on inhibition screen of OATP1B1, OATP1B1∗15 and OATP1B3
article 2015    
Author: Steeg, E. van de · Venhorst, J. · Jansen, H.T. · Nooijen, I.H.G. · Degroot, J. · Wortelboer, H.M. · Vlaming, M.L.H.
Keywords: Biology · Bayesian prediction model · Computational modeling · Drugdrug interaction · OATP · Polymorphisms · Transporter · Abamectin · Acemetacin · Atazanavir · Bromocriptine mesilate · Clarithromycin · Clobetasol propionate · Dihydroergocristine methanesulfonate · Dipyridamole · Docetaxel · Estradiol · Fluindostatin · Fosinopril · Losartan · Mifepristone · Nicardipine · Olmesartan · Pranlukast · Pyrantel embonate · Rapamycin · Rifampicin · Rifamycin · Salazosulfapyridine · Solute carrier organic anion transporter 1B1 · Solute carrier organic anion transporter 1B1 15 · Solute carrier organic anion transporter 1B3 · Suramin · Telmisartan · Tibolone · Troglitazone · Unclassified drug · Unindexed drug · Bayesian learning · Controlled study · Drug protein binding · HEK293 cell line · Human cell · Nucleotide sequence · Prediction · Priority journal · Protein expression · Tandem mass spectrometry · Ultra performance liquid chromatography · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 7 of 7 found. | Sort by date