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1 Mutagenicity testing of urine from vinylchloride (VCM) treated rats using the salmonella test system
article 1977    
Author: Mattern, I.E. · Zwaan, W.B. van der · Willems, M.J.
Keywords: Biology · Soybean oil · Vinyl chloride · Aerosol · Drug screening · Drug urine level · Inhalational drug administration · Mutagenesis · Oral drug administration · Rat · Salmonella
[Abstract]

2 Mechanisms of inactivation of bacteriophage phiX174 and its DNA in aerosols by ozone and ozonized cyclohexene
article 1977    
Author: Mik, G. de · Groot, I. de
Keywords: Biology · Ozone · Radioisotope · Virus dna · Bacteriophage · Cyclohexene · DNA p 32 · Drug interaction · Drug screening · Escherichia coli · In vitro study · Microorganism · Theoretical study · Virus inactivation · Aerosols · Alkenes · Atmosphere · Centrifugation, Density Gradient · Coliphages · DNA Viruses · DNA, Viral · Ozone
[Abstract]

3 Short-term tests in the framework of carcinogen risk assessment to man
article 1983    
Author: Kroes, R.
Keywords: Carcinogen · Mutagenic agent · Chemical carcinogenesis · Etiology · Human · Methodology · Netherlands · Nonhuman · Risk · Short survey · Animal · Article · Bioassay · Biological model · Drug screening · Mutagen testing · Species difference · Animal · Biological Assay · Carcinogens · Drug Evaluation, Preclinical · Models, Biological · Mutagenicity Tests · Mutagens · Risk · Species Specificity
[Abstract]

4 Role of metallothionein in cisplatin sensitivity of germ-cell tumours
article 2000    
Author: Meijer, C. · Timmer, A. · Vries, E.G.E.de · Groten, J.P. · Knol, A. · Zwart, N. · Dam, W.A. · Sleijfer, D.Th. · Mulder, N.H.
Keywords: Nutrition · Cisplatin · Glutathione peroxidase · Metallothionein · Protein p53 · Article · Cellular distribution · Colon carcinoma · Disease association · Drug sensitivity · Germ cell tumor · Human · Human cell · Immunohistochemistry · Priority journal · Protein expression · Testis tumor · Antineoplastic Agents · Cisplatin · Colonic Neoplasms · Drug Screening Assays, Antitumor · Germinoma · Humans · Immunohistochemistry · Male · Metallothionein · Testicular Neoplasms · Tumor Cells, Cultured · Tumor Suppressor Protein p53 · Food and Nutrition · Healthy Living
[Abstract]

5 Short-term tests of estrogenic potential of plant stanols and plant stanol esters
article 1999    
Author: Turnbull, D. · Frankos, V.H. · Leeman, W.R. · Jonker, D.
Keywords: Nutrition · Fatty acid ester · Phytosterol · Sitostanol · Sitosterol · Body weight · Cell proliferation · Chemical structure · Cytotoxicity · Drug activity · Drug screening · Estrogen activity · Food intake · Priority journal · Structure analysis · Analysis of Variance · Animals · Breast · Cell Division · Dihydrotestosterone · Esters · Estrogens, Non-Steroidal · Female · Humans · Isoflavones · Phytoestrogens · Phytosterols · Plant Preparations · Rats · Rats, Wistar · Tumor Cells, Cultured · Uterus
[Abstract]

6 Report of a workshop on bacterial in vitro mutagenicity test systems
article 1978    
Author: Mattern, I.E. · Greim, H.
Keywords: Biology · 2 Aminoanthracene · 2 Nitrofluorene · Aflatoxin · Aroclor 1254 · Benzo[a]pyrene · Clophen a50 · Cyclophosphamide · Diethylnitrosamine · Dimethylnitrosamine · Mesylic acid ethyl ester · Methylnitronitrosoguanidine · Mitomycin c · N (2 fluorenyl)acetamide · Nitrosomorpholine · Polychlorinated biphenyl · Unclassified drug · Vinylidene chloride · 4 Nitroquinoline · Abstract report · Animal experiment · Bacterium · Benzoflavone · Drug activation · Drug metabolism · Drug screening · Hamster · In vitro study · Liver microsome · Methodology · Mouse · Mutagen testing · Mutagenesis · Rat
[Abstract]

7 Acetyldinaline: A new oral cytostatic drug with impressive differential activity against leukemic cells and normal stem cells - Preclinical studies in a relevant rat model for human acute myelocytic leukemia
article 1993    
Author: El-Beltagi, H.M. · Martens, A.C.M. · Lelieveld, P. · Haroun, E.A. · Hagenbeek, A.
Keywords: Administration, Oral · Animal · Antineoplastic Agents · Bone Marrow · Bone Marrow Cells · Cell Differentiation · Cell Survival · Clone Cells · Comparative Study · Disease Models, Animal · Dose-Response Relationship, Drug · Drug Administration Schedule · Drug Evaluation · Drug Screening Assays, Antitumor · Hematopoietic Stem Cells · Leukemia, Myelocytic, Acute · Male · Phenylenediamines · Rats · Rats, Inbred BN · Support, Non-U.S. Gov't · Tumor Cells, Cultured
[Abstract]

8 Biological evaluation of Tyr6 and Ser7 modified drosocin analogues
article 2005    
Author: Visser, P.C. de · Hooft, P.A.V. van · Vries, A.-M. de · Jong, A. de · Marel, G.A. van der · Overkleeft, H.S. · Noort, D.
Keywords: Antibiotic agent · Amino acid substitution · Amino terminal sequence · Article · Controlled study · Drug screening · Drug stability · Drug synthesis · Nonhuman · Protein degradation · Amino Acid Sequence · Glycopeptides · Humans · Microbial Sensitivity Tests · Molecular Sequence Data · Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization · Chemicals · Drosocin, 179048-25-0 · Serine, 56-45-1, 6898-95-9 · Tyrosine, 16870-43-2, 55520-40-6, 60-18-4 · Drosocin, 149924-99-2 · Glycopeptides · Serine, 56-45-1 · Tyrosine, 55520-40-6
[Abstract]

9 Inhibiting interleukin-1 and tumor necrosis factor-α does not reduce induction of plasminogen activator inhibitor type-1 by endotoxin in rats in vivo
article 1995    
Author: Emeis, J.E. · Hoekzema, R. · Vos, A.F. de
Keywords: Toxicology · corticosterone · dexamethasone · escherichia coli endotoxin · escherichia coli lipopolysaccharide · interleukin 1 · interleukin 1 receptor blocking agent · pentoxifylline · plasminogen activator inhibitor 1 · tissue plasminogen activator · tumor necrosis factor alpha · animal experiment · animal model · article · drug effect · drug screening · endotoxemia · intravenous drug administration · male · nonhuman · priority journal · rat · toxicity testing · toxin analysis · Animal · Dexamethasone · Drug Interactions · Endotoxins · Human · Immune Sera · Interleukin-1 · Male · Mice · Pentoxifylline · Plasminogen Activator Inhibitor 1 · Rats · Rats, Wistar · Receptors, Interleukin-1 · Tissue Plasminogen Activator · Tumor Necrosis Factor
[Abstract]

10 Pharmacodynamics of cisplatin in human head and neck cancer : correlation between platinum content, DNA adduct levels and drug sensitivity in vitro and in vivo
article 1999    
Author: Welters, M.J.P. · Fichtinger-Schepman, A.M.J. · Baan, R.A. · Jacobs-Bergmans, A.J. · Kegel, A. · Vijgh, W.J.F. van der · Braakhuis, B.J.M.
Keywords: Cisplatin · Cisplatin sensitivity · DNA adducts · Head and neck cancer · Platinum accumulation · DNA · phosphorus 32 · platinum · animal experiment · animal tissue · atomic absorption spectrometry · cancer cell culture · controlled study · DNA drug complex · drug sensitivity · human cell · intravenous drug administration · mouse · nonhuman · nude mouse · pharmacodynamics · radioassay · squamous cell carcinoma · tumor xenograft · Animals · Antineoplastic Agents · Carcinoma, Squamous Cell · Drug Screening Assays, Antitumor · Female · Head and Neck Neoplasms · Humans · Mice · Mice, Nude · Neoplasm Transplantation · Tumor Cells, Cultured
[PDF] [Abstract]

11 Tissue culture and neurotoxicology
article 1982    
Author: Hooisma, J.
Keywords: Biology · Acrylamide · Colchicine · Glutathione · Nicotinamide adenine dinucleotide · Animal cell · Brain cell · Central nervous system · Dose response · Drug comparison · Drug mechanism · Drug mixture · Drug response · Drug screening · In vitro study · Intoxication · Methodology · Nervous system · Neurotoxicity · Nonhuman · Rat · Tissue culture · Acrylamide · Acrylamides · Animal · Axons · Colchicine · Female · Ganglia, Spinal · Glutathione · Male · NAD · Nervous System Diseases · Rats · Rats, Inbred Strains · Support, Non-U.S. Gov't · Tissue Culture · Toxicology
[Abstract]

12 Nonclinical testing of vaccines: Report from a workshop
article 2009    
Author: Laan, J.W. van der · Forster, R. · Ledwith, B. · Gruber, M. · Gould, S. · Segal, L. · Penninks, A.
Keywords: Health · Adjuvants · Developmental and reproductive toxicology · DNA vaccines · Nonclinical evaluation · Safety testing · Therapeutic vaccines · Vaccines · diphtheria pertussis tetanus vaccine · DNA vaccine · immunological adjuvant · immunomodulating agent · live vaccine · Meningococcus vaccine · pertussis vaccine · vaccine · Wart virus vaccine · conference paper · disease model · drug dose regimen · drug efficacy · drug research · drug safety · drug screening · drug tolerability · electroporation · human · immune response · immunogenicity · male fertility · nonhuman · pharmacodynamics · practice guideline · priority journal · reproductive toxicity · tattooing · toxicity testing · toxicology · vaccination · workshop
[Abstract]

13 REACH, non-testing approaches and the urgent need for a change in mind set
article 2009    
Author: Schaafsma, G. · Kroese, E.D. · Tielemans, E.L.J.P. · Sandt, J.J.M. van de · Leeuwen, C.J. van
Keywords: Chemistry · Food and Chemical Risk Analysis · Intelligent testing strategies · Mind set change · Non-testing · REACH · Uncertainty paradox · chemical agent · acute toxicity · animal testing alternative · article · chronic toxicity · cost · drug screening · environmental exposure · hazard assessment · health care policy · human · human tissue · in vivo study · priority journal · process optimization · public opinion · REACH program · reproductive toxicity · risk assessment · skin toxicity · toxicity testing · uncertainty · Animal Testing Alternatives · Animals · Databases, Factual · Environmental Exposure · Europe · Hazardous Substances · Humans · Registries · Risk Assessment · Toxicity Tests · Animalia
[Abstract]

14 The evaluation of the immunomodulating properties of ERA-63 a pharmaceutical with estrogenic activity
article 2008    
Author: Janssen, G.B. · Penninks, A.H. · Knippels, L.M.J. · Zijverden, M. van · Spanhaak, S.
Keywords: Chemistry · Ethinyl estradiol · Host resistance · Immunotoxicity · Listeria monocytogenes · PFC · Plaque-forming cell assay · T cell-dependent antibody response · bilirubin · era 63 · ethinylestradiol · gamma glutamyltransferase · immunomodulating agent · unclassified drug · animal experiment · antibody response · article · bilirubin blood level · body weight · controlled study · drug dose comparison · drug megadose · drug screening · estrogen activity · female · gamma glutamyl transferase blood level · immunomodulation · Listeria monocytogenes · low drug dose · male · nonhuman · priority journal · qualitative analysis · rat · testis weight · thymus · Animals · Antibody Formation · Body Weight · Estrogens · Ethinyl Estradiol · Female · Hemolytic Plaque Technique · Immunologic Factors · Listeria Infections · Male · Organ Size · Rats · Rats, Sprague-Dawley · Risk Assessment · T-Lymphocytes · Listeria monocytogenes · Rattus
[Abstract]

15 Rescuing drug discovery: In vivo systems pathology and systems pharmacology
article 2005    
Author: Greef, J. van der · McBurney, R.N.
Keywords: Pharmacology Health · Analytical research · 5' methoxyhydnocarpin · berberine · biological marker · ginseng extract · herbaceous agent · Hypericum extract · paroxetine · unclassified drug · article · bioinformatics · cardiovascular disease · clinical trial · cost benefit analysis · cost control · cost effectiveness analysis · data base · depression · drug approval · drug design · drug efficacy · drug indication · drug industry · drug information · drug marketing · drug research · drug response · drug safety · drug screening · drug targeting · growth inhibition · health care · health care cost · health program · human · in vivo study · non insulin dependent diabetes mellitus · nonhuman · patient compliance · prediction · prescription · priority journal · productivity · quantitative analysis · standard · system analysis · validation process · animal · diagnosis · economics · mass communication · review · Animals · Cost-Benefit Analysis · Diagnosis · Diffusion of Innovation · Drug Approval · Drug Design · Drug Evaluation · Drug Evaluation, Preclinical · Drug Industry · Humans
[Abstract]

16 Food allergy: What do we learn from animal models?
article 2004    
Author: Knippels, L.M.J. · Wijk, F. van · Penninks, A.H.
Keywords: Health · Toxicology and Applied Pharmacology · Allergenicity · Animal models · Food allergy · Therapy · Ara h 1 allergen · Ara h 2 allergen · Ara h 3 allergen · DNA vaccine · food allergen · fungal immunomodulatory protein · fungal protein · immunoglobulin E antibody · protein fip fve · recombinant antigen · recombinant cytokine · recombinant peanut allergen · unclassified drug · allergenicity · antigen specificity · article · bacterium · clinical research · desensitization · dog · dose response · drug activity · drug mechanism · drug research · drug screening · food allergy · genetic susceptibility · health hazard · hypothesis · immunological tolerance · immunopathogenesis · immunoprophylaxis · mouse strain · nonhuman · pathophysiology · prediction · priority journal · protein degradation · protein diet · protein intake · protein structure · publication · rat strain · review · screening test · sensitization · swine · Th1 cell · Th2 cell · Animals · Food Hypersensitivity · Humans · Immunotherapy · Interleukin-10 · Interleukin-4 · Models, Animal · T-Lymphocytes
[Abstract]

17 Modulating angiogenesis: The yin and the yang in ginseng
article 2004    
Author: Sengupta, S. · Toh, S.A. · Sellers, L.A. · Skepper, J.N. · Koolwijk, P. · Leung, H.W. · Yeung, H.W. · Wong, R.N.S. · Sasisekharan, R. · Fan, T.P.D.
Keywords: Biology · Biomedical Research · Angiogenesis · Nitric oxide · ginseng extract · ginseng polysaccharide · herbaceous agent · nitric oxide synthase · Panax notoginseng extract · panax quinquefolium extract · phosphatidylinositol 3 kinase · polymer · protein kinase B · sterol derivative · animal experiment · animal model · antiangiogenic activity · cell invasion · cell proliferation · chemical analysis · chemical composition · controlled study · drug effect · drug identification · drug isolation · drug mechanism · drug screening · drug structure · endothelium cell · herbal medicine · human cell · human tissue · in vitro study · in vivo study · law · mass spectrometry · neovascularization (pathology) · nonhuman · phenotype · protein expression · regulatory mechanism · species differentiation · standardization · wound healing · 1-Phosphatidylinositol 3-Kinase · Americas · Angiogenesis Inducing Agents · Angiogenesis Inhibitors · Animals · Cells, Cultured · China · Drug Implants · Endothelial Cells · Endothelium, Vascular · Enzyme Inhibitors · Ginsenosides · Humans · Korea · Male · Mice · Mice, Inbred C57BL · Molecular Structure · Neovascularization, Pathologic · NG-Nitroarginine Methyl Ester · Panax · Phytotherapy · Signal Transduction · Species Specificity · Spectrometry, Mass, Electrospray Ionization · Surgical Sponges · Umbilical Veins
[Abstract]

18 Synthesis and antimicrobial evaluation of farnesyl diphosphate mimetics
article 2003    
Author: Fairlamb, I.J.S. · Dickinson, J.M. · O'Connor, R. · Cohen, L.H. · Thiel, C.F. van
Keywords: Antimicrobial agents · Copper(I) catalysed tetrahydropyranyl ether displacements · Farnesyl-protein transferase · Inhibitors · Squalene synthase · 10 phenyl 5,9 dimethyldecadienoic acid · 2 (diethoxyphosphinyl) 10 phenyl 5,9 dimethyldecadienoic acid · 2 phosphono 10 phenyl 5,9 dimethyldecadienoic acid · 3,7 dimethyloctadien 1 phenylsulfone · 8 benzoxy 3,7 dimethyloctadien 1 ol · 8 hydroxy 3,7 dimethyloctadien 1 phenylsulfone · antiinfective agent · farnesyl diphosphate · functional group · squalene synthase · unclassified drug · antimicrobial activity · bromination · Candida albicans · controlled study · drug inhibition · drug mechanism · drug potency · drug screening · drug synthesis · nonhuman · oxidation · Saccharomyces cerevisiae · sterol synthesis · structure analysis · Anti-Bacterial Agents · Antifungal Agents · Bacteria · Biomimetic Materials · Cell Division · Polyisoprenyl Phosphates · Species Specificity · Yeasts · Candida albicans · Escherichia coli · Pseudomonas · Pseudomonas aeruginosa · Saccharomyces cerevisiae · Salmonella typhimurium · Typhimurium
[Abstract]

19 Apolipoprotein E*3-Leiden transgenic mice mode for hypolipidaemic drugs
article 1998    
Author: Vlijmen, B.J.M. van · Pearce, N.J. · Bergö, M. · Staels, B. · Yates, J.W. · Gribble, A.D. · Bond, B.C. · Hofker, M.H. · Havekes, L.M. · Groot, P.H.E.
Keywords: Pharmacology · ±(3R*,5S*)3-Carboxy-11-(2,4-dichlorophenyl)-3,5-dihydroxyundecanoic acid, 5-ring lactone · CAS 154566-12-8 · Gemfibrozil · Hypolipidaemic drugs, testing in transgenic mice · Lovastatin · SB 204990, hypolipidaemic effect · 3 carboxy 11 (2,4 dichlorophenyl) 3,5 dihydroxyundecanoic acid · Antilipemic agent · Apolipoprotein c3 · Apolipoprotein e3 · Cholesterol · Gemfibrozil · High density lipoprotein · Lipoprotein lipase · Low density lipoprotein · Messenger rna · Mevinolin · Sb 204990 · Triacylglycerol · Unclassified drug · Very low density lipoprotein · Anticoagulant agent · Apolipoprotein E · Apolipoprotein E3 · Heparin · Lactone · Lipid · Messenger RNA · SB 204990 · Animal model · Animal tissue · Atherosclerosis · Cholesterol blood level · Controlled study · Dose response · Drug effect · Enzyme activity · Gene expression · Hyperlipidemia · Lipoprotein blood level · Male · Mouse · Nonhuman · Oral drug administration · Transgenic mouse · Animal · Biosynthesis · Blood · C57BL mouse · Drug screening · Genetics · Liver · Metabolism · hysiology · Animals · Anticoagulants · Antilipemic Agents · Apolipoprotein E3 · Apolipoproteins E · Cholesterol · Drug Evaluation, Preclinical · Gemfibrozil · Heparin · Lactones · Lipids · Lipoprotein Lipase · Liver · Lovastatin · Male · Mice · Mice, Inbred C57BL · Mice, Transgenic · RNA, Messenger · Triglycerides
[PDF] [Abstract]

20 Antidotes to organophosphate poisoning. 2. Thiadiazole-5-carboxaldoximes
article 1979    
Author: Benschop, H.P. · Berg, G.R. van den · Hooidonk, C. van · Jong, L.P.A. de · Kientz, C.E. · Berends, F. · Kepner, L.A. · Meeter, E. · Visser, R.P.L.S.
Keywords: Biology · Acetylcholinesterase · Antidote · Atropine · Cholinesterase reactivator · Diacetyl oxime · Enzyme · Obidoxime P · Paraoxon · Sarin · Tri ortho cresyl phosphate · 1,2,3 thiadiazole 5 carboxaldoxime · 2 (hydroximinomethyl) 1 methylpyridinium salt · 2 methyl 1,2,3 thiadiazolium salt carboxaldoxime · 3 methyl 1,2,3 thiadiazolium salt 5 carboxaldoxime · Animal experiment · Blood · Blood and hemopoietic system · Dose response · Drug administration · Drug analysis · Drug blood level · Drug comparison · Drug elimination · Drug half life · Drug interaction · Drug intoxication · Drug metabolism · Drug response · Drug screening · Drug synthesis · Drug tolerance · Drug toxicity · Drug urine level · Goat · Guinea pig · High performance liquid chromatography · Hydroximinoacetone · In vitro study · Intoxication · Intraperitoneal drug administration · Intravenous drug administration · Mouse · Nuclear magnetic resonance · Oral drug administration · Organophosphate intoxication · Pharmacokinetics · Prevention · Prophylaxis · Rabbit · Rat · Subcutaneous drug administration · Theoretical study · Therapy · Thiadiazole 5 carboxaldoxime derivative · Ultraviolet spectrophotometry · Urine · Acetylcholinesterase · Animal · Antidotes · Body Temperature · Cattle · Chemistry · Dose-Response Relationship, Drug · Enzyme Reactivators · Female · Goats · Guinea Pigs · Half-Life · In Vitro · Lethal Dose 50 · Male · Mice · Organophosphorus Compounds · Oximes · Rabbits · Rats · Rats, Inbred Strains · Sarin · Solubility · Structure-Activity Relationship
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 20 found. | Sort by date