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1 Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs
article 2018    
Author: Notenboom, S. · Weigand, K.M. · Proost, J.H. · Lipzig, M.M.H. van · Steeg, E. van de · Broek, P.H.H. van den · Greupink, R. · Russel, F.G.M. · Groothuis, G.M.M.
Keywords: Biology · Bile acid handling · Biokinetic model · BSEP · Cholestasis · Human · In silico · NTCP · Biomedical Innovation · Healthy Living · Life Triskelion BV · MSB - Microbiology and Systems Biology ADME - ADME/DMPK · ELSS - Earth, Life and Social Sciences TNO Bedrijven
[PDF] [Abstract]

2 Prediction of in vivo developmental toxicity of all‑trans‑retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling
article 2014    
Author: Louisse, J. · Bosgra, S. · Blaauboer, B.J. · Rietjens, Y.M.C.M. · Verwei, M.
Keywords: Toxicology · All-trans-retinoic acid · Developmental toxicity · In vitro-in vivo extrapolation · Physiologically based kinetic modeling · Reverse dosimetry · Solid phase microextraction · Food and Nutrition · Healthy Living · Life Triskelion BV · RAPID - Risk Assessment Products in Developmentv ARF - Analytical Research (Food) · ELSS - Earth, Life and Social Sciences TNO Bedrijven

3 Metabolic Profiling Reveals Differences in Plasma Concentrations of Arabinose and Xylose after Consumption of Fiber-Rich Pasta and Wheat Bread with Differential Rates of Systemic Appearance of Exogenous Glucose in Healthy Men
article 2017    
Author: Pantophlet, A.J. · Wopereis, S. · Eelderink, C. · Vonk, R.J. · Stroeve, J.H. · Bijlsma, S. · Stee, L. van · Bobeldijk, I. · Priebe, M.G.
Keywords: Nutrition · Pasta · Bread · Wheat bran · Arabinoxylan · Starch digestion · Postprandial metabolomics · Healthy men · Food and Nutrition · Healthy Living · Life Triskelion BV · MSB - Microbiology and Systems Biology RAPID - Risk Analysis for Products in Development MHR - Metabolic Health Research ARF - Analytical Research (Food) · ELSS - Earth, Life and Social Sciences TNO Bedrijven
[Abstract]

4 Microdosing of a Carbon-14 Labeled Protein in Healthy Volunteers Accurately Predicts Its Pharmacokinetics at Therapeutic Dosages
article 2015    
Author: Vlaming, M.L. · Duijn, E. van · Dillingh, M.R. · Brands, R. · Windhorst, A.D. · Hendrikse, N.H. · Bosgra, S. · Burggraaf, J. · Koning, M.C. de · Fidder, A. · Mocking, J.A. · Sandman, H. · Ligt, R.A. de · Fabriek, B.O. · Pasman, W.J. · Seinen, W. · Alves, T. · Carrondo, M. · Peixoto, C. · Peeters, P.A. · Vaes, W.H.
Keywords: Biology · Alkaline phosphatase, placental · Carbon · Glycosylphosphatidylinositol anchored protein · Isoenzyme · Recombinant protein · Area under the curve · Biological model · Clinical trial · Controlled study · Dose calculation · Double blind procedure · Half life time · Intravenous drug administration · Phase 1 clinical trial · Procedures · Randomized controlled trial · Statistical model · Administration, Intravenous · Adolescent · Adult · Alkaline Phosphatase · Area Under Curve · Carbon Radioisotopes · Double-Blind Method · Drug Dosage Calculations · GPI-Linked Proteins · Half-Life · Healthy Volunteers · Humans · Isoenzymes · Linear Models · Male · Mass Spectrometry · Metabolic Clearance Rate · Models, Biological · Netherlands · Recombinant Proteins · Young Adult · Biomedical Innovation · Healthy Living · Life Triskelion BV · MSB - Microbiology and Systems Biology ARPC - Analytical Research (Pharm & Chemistry) · ELSS - Earth, Life and Social Sciences TNO Bedrijven
[Abstract]

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