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1 Integrated in vitro-in silico models for predicting in vivo development toxicity: facilitating non-animal based safety asssment
dissertation 2012    
Author: Louisse, J.
Keywords: Toxicology · Embryonale ontwikkeling · Foetale ontwikkeling · In vitro kweek · Toxiciteit · Biomarkers · Computational science · Alternatieven voor dierproeven · Risicoschatting · Embryonic development · Fetal development · In vitro culture · Toxicity · Animal testing alternatives · Risk assessment · Biomedical Innovation · Healthy Living
[PDF]

2 One-generation reproductive toxicity study of DHA-rich oil in rats
article 2007    
Author: Blum, R. · Kiy, T. · Waalkens-Berendsen, I. · Wong, A.W. · Roberts, A.
Keywords: Toxicology · Toxicology and Applied Pharmacology · ω-3 Polyunsaturated fatty acid · DHA · DHA-rich oil · Docosahexaenoic acid · Food ingredient · Reproductive and developmental toxicity · Safety · algal oil · docosahexaenoic acid · lipid · adipose tissue · animal experiment · animal model · animal tissue · article · body weight · controlled study · diet · fat intake · female · fertility · food intake · liver weight · male · mortality · nonhuman · priority journal · rat · reproductive toxicity · spleen weight · toxicity testing · Algae · Animals · Animals, Newborn · Birth Weight · Docosahexaenoic Acids · Dose-Response Relationship, Drug · Eating · Embryonic Development · Female · Fetal Development · Hematopoiesis, Extramedullary · Liver · Male · Oils · Organ Size · Pituitary Gland · Pregnancy · Rats · Rats, Wistar · Reproduction · Spleen · Subcutaneous Fat, Abdominal · Toxicity Tests · Weight Gain · algae · Animalia · Protista · Rattus · Ulkenia sp. · Zea mays
[Abstract]

3 Relative developmental toxicity of glycol ether alkoxy acid metabolites in the embryonic stem cell test as compared with the in vivo potency of their parent compounds
article 2009    
Author: Jong, E. de · Louisse, J. · Verwei, M. · Blaauboer, B.J. · Sandt, J.J.M. van de · Woutersen, R.A. · Rietjens, I.M.C.M. · Piersma, A.H.
Keywords: Chemistry · Toxicology and Applied Pharmacology · Alternatives to animal testing · Developmental toxicology · Embryonic stem cells · Glycol ethers · butoxyacetic acid · ethoxyacetic acid · glycol ether alkoxy acid metabolite · methoxyacetic acid · phenoxyacetic acid · toxin · unclassified drug · animal cell · article · cell differentiation · chemical analysis · chemical structure · concentration response · controlled study · cytotoxicity test · developmental disorder · developmental toxicity · embryonic stem cell · embryonic stem cell test · embryotoxicity · heart muscle cell · in vivo study · mouse · nonhuman · sensitivity analysis · toxicokinetics · Animal Testing Alternatives · Animals · Biotransformation · Cell Differentiation · Cell Survival · Dose-Response Relationship, Drug · Embryonic Development · Embryonic Stem Cells · Glycols · Kinetics · Mice · Models, Statistical · Myocytes, Cardiac · Predictive Value of Tests · Reference Standards · Structure-Activity Relationship · Teratogens · Animalia
[Abstract]

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