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1 Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay
article 2017    
Author: Colaianna, M. · Ilmjärv, S. · Peterson, H. · Ilse Kern, I. · Julien, S. · Baquié, M. · allocca, G. · Bosgra, S. · Sachinidis, A. · Hengstler, J.G. · Leist, M. · Krause, K.H.
Keywords: Pharmacology · Mouse embryonic stem cells · Neuroactivity · Neurotoxicity · In vitro screening · Neuronal differentiation · Healthy for Life · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

2 Relative developmental toxicity of glycol ether alkoxy acid metabolites in the embryonic stem cell test as compared with the in vivo potency of their parent compounds
article 2009    
Author: Jong, E. de · Louisse, J. · Verwei, M. · Blaauboer, B.J. · Sandt, J.J.M. van de · Woutersen, R.A. · Rietjens, I.M.C.M. · Piersma, A.H.
Keywords: Chemistry · Toxicology and Applied Pharmacology · Alternatives to animal testing · Developmental toxicology · Embryonic stem cells · Glycol ethers · butoxyacetic acid · ethoxyacetic acid · glycol ether alkoxy acid metabolite · methoxyacetic acid · phenoxyacetic acid · toxin · unclassified drug · animal cell · article · cell differentiation · chemical analysis · chemical structure · concentration response · controlled study · cytotoxicity test · developmental disorder · developmental toxicity · embryonic stem cell · embryonic stem cell test · embryotoxicity · heart muscle cell · in vivo study · mouse · nonhuman · sensitivity analysis · toxicokinetics · Animal Testing Alternatives · Animals · Biotransformation · Cell Differentiation · Cell Survival · Dose-Response Relationship, Drug · Embryonic Development · Embryonic Stem Cells · Glycols · Kinetics · Mice · Models, Statistical · Myocytes, Cardiac · Predictive Value of Tests · Reference Standards · Structure-Activity Relationship · Teratogens · Animalia
[Abstract]

3 Decrease of intracellular pH as possible mechanism of embryotoxicity of glycol ether alkoxyacetic acid metabolites
article 2010    
Author: Louisse, J. · Bai, Y. · Verwei, M. · Sandt, J.J.M. van de · Blaauboer, B.J. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · BALB/c-3T3 cells · Embryonic stem cells · Embryotoxicity · Glycol ethers · Intracellular pH · Mechanism · acetazolamide · acetic acid derivative · alkoxyacetic acid glycol ether derivative · amiloride · butoxyacetic acid · ethoxyacetic acid · fluorouracil · methoxyacetic acid · phenoxyacetic acid · retinoic acid · unclassified drug · valproic acid · acidification · animal cell · animal cell culture · article · cell differentiation · cell pH · cell strain 3T3 · controlled study · embryonic stem cell · embryotoxicity · metabolite · mouse · nonhuman · pH measurement · Acetazolamide · Acetic Acids · Animals · BALB 3T3 Cells · Cell Differentiation · Embryo, Mammalian · Embryonic Stem Cells · Ethylene Glycols · Glycolates · Hydrogen-Ion Concentration · Intracellular Fluid · Mice · Teratogens · Valproic Acid
[Abstract]

4 Early gene expression changes during embryonic stem cell differentiation into cardiomyocytes and their modulation by monobutyl phthalate
article 2009    
Author: Dartel, D.A.M. van · Pennings, J.L.A. · Hendriksen, P.J.M. · Schooten, F.J. van · Piersma, A.H.
Keywords: Alternative test method · Differentiation · Embryonic stem cells · Monobutyl phthalate · Transcriptomics · monobutyl phthalic acid · oligonucleotide · phthalic acid · RNA · Unclassified drug · Animal cell · Cell differentiation · Cell proliferation · Controlled study · Embryonic stem cell · Gene control · Heart muscle cell · Mesoderm · Microarray analysis · Modulation · Mouse · Nonhuman · Pluripotent stem cell · Animals · Cell Differentiation · Cell Proliferation · Cells, Cultured · Dose-Response Relationship, Drug · Embryonic Stem Cells · Gene Expression Profiling · Gene Expression Regulation, Developmental · Gene Regulatory Networks · Mice · Muscle Contraction · Myocytes, Cardiac · Oligonucleotide Array Sequence Analysis · Phthalic Acids · Risk Assessment · Time Factors · Toxicity Tests
[Abstract]

5 Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling
article 2006    
Author: Verwei, M. · Burgsteden, J.A. van · Krul, C.A.M. · Sandt, J.J.M. van de · Freidig, A.P.
Keywords: Biology · Biomedical Research · Alternative test method · Developmental toxicity · Embryonic stem cells · PBPK model · 2 ethoxyethanol · 2 methoxyethanol · acetic acid derivative · ethoxyacetic acid · fluorouracil · methotrexate · methoxyacetic acid · retinoic acid · unclassified drug · animal cell · article · computer model · controlled study · embryo · embryo development · embryonic stem cell · embryotoxicity · exposure · metabolism · mouse · nonhuman · prediction · priority journal · risk assessment · rodent · Animal Testing Alternatives · Animals · Cell Line · Cell Survival · Dose-Response Relationship, Drug · Embryo · Mice · Models, Biological · Predictive Value of Tests · Rats · Risk Assessment · Stem Cells · Teratogens · Toxicity Tests · Rodentia
[Abstract]

Search results also available in MS Excel format.

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