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1 Differential effects of 17α-ethinylestradiol on the neutral and acidic pathways of bile salt synthesis in the rat
article 1999    
Author: Koopen, N.R. · Post, S.M. · Wolters, H. · Havinga, R. · Stellaard, F. · Boverhof, R. · Kuipers, F. · Princen, H.M.G.
Keywords: Δ-<sup>22</sup>-β-muricholate · Bile · Cholestasis · Cholesterol-7α- hydroxylase · Enterohepatic circulation · Estrogens · Sterol-27-hydroxylase · Wistar rat · Animals · Aryl Hydrocarbon Hydroxylases · Bile Acids and Salts · Chenodeoxycholic Acid · Cholates · Cholesterol 7-alpha-Hydroxylase · Cytochrome P-450 CYP27A1 · Cytochrome P-450 Enzyme System · Enterohepatic Circulation · Ethinyl Estradiol · Hydrogen-Ion Concentration · Liver · Male · Rats · Rats, Wistar · RNA, Messenger · Steroid 12-alpha-Hydroxylase · Steroid Hydroxylases
[PDF] [Abstract]

2 Pharmacokinetics of oestriol after repeated oral administration to dogs
article 2003    
Author: Hoeijmakers, M. · Janszen, B. · Coert, A. · Horspool, L.
Keywords: Drugs Chemistry · Physiological Sciences · estriol · incurin · animal experiment · area under the curve · article · blood sampling · calculation · controlled study · dog · dose response · drug accumulation · drug blood level · enterohepatic circulation · female · individualization · nonhuman · radioimmunoassay · statistical analysis · tablet formulation · urine incontinence · Administration, Oral · Animals · Dogs · Estriol · Female · Urinary Incontinence · Animalia · Canidae · Canis familiaris
[Abstract]

3 Heterogeneous expression of cholesterol 7α-hydroxylase and sterol 27- hydroxylase genes in the rat liver lobulus
article 1995    
Author: Twisk, J. · Hoekman, M.F.M. · Mager, W.H. · Moorman, A.F.M. · Boer, P.A.J. de · Scheja, L. · Princen, H.M.G. · Gebhardt, R.
Keywords: Health · 3 hydroxy 3 methylglutaryl coenzyme a · alanine aminotransferase · cholesterol 7alpha monooxygenase · colestipol · glutamate ammonia ligase · glyceraldehyde 3 phosphate dehydrogenase · messenger rna · pyruvate kinase · sterol 27 hydroxylase · unclassified drug · animal cell · animal experiment · bile acid synthesis · controlled study · enterohepatic circulation · enzyme isolation · enzyme localization · gene expression · in situ hybridization · liver metabolism · sterol analysis · Animal · Biological Markers · Blotting, Northern · Cell Separation · Cholesterol 7-alpha-Hydroxylase · Colestipol · Cytochrome P-450 Enzyme System · Gene Expression Regulation, Enzymologic · In Situ Hybridization · Liver · Male · Rats · Rats, Sprague-Dawley · RNA, Messenger · Steroid Hydroxylases · Support, Non-U.S. Gov't · Tissue Distribution · Transcription, Genetic
[Abstract]

4 Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling.
article 2014    
Author: Bosgra, S. · Steeg, E. van de · Vlaming, M.L. · Verhoeckx, K.C. · Huisman, M.T. · Verwei, M. · Wortelboer, H.M.
Keywords: Biology · Transporter · Hepatic disposition · Transfected cell-lines · Protein abundance · LC–MS · Hepatic disposition · OATP · PBPK model · Polymorphisms · Protein abundance · Transfected cell-lines · Drug carrier · Organic anion transporter B · Rosuvastatin · Solute carrier organic anion transporter 1B1 · Solute carrier organic anion transporter 1B3 · Controlled study · Drug clearance · Drug disposition · Drug transport · Enterohepatic circulation · Gene overexpression · Genetic transfection · Genetic variability · HEK293 cell line cell tissue · In vitro study · In vivo study · Intrinsic clearance · Liquid chromatography · Liver · Liver cell · Model · Outer membrane · Physiology based pharmacokinetic model · Prediction · Protein analysis · Simulation · Single drug dose · Tandem mass spectrometry · Food and Nutrition · Healthy Living · Life · RAPID - Risk Assessment Products in Development MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

5 Novel non-systemic inhibitor of ileal apical Na+-dependent bile acid transporter reduces serum cholesterol levels in hamsters and monkeys
article 2006    
Author: Kitayama, K. · Nakai, D. · Kono, K. · Hoop, A.G. van der · Kurata, H. · Wit, E.C. de · Cohen, L.H. · Inaba, T. · Kohama, T.
Keywords: Biology · Apical sodium-dependent bile acid transporter · Cholesterol · Enterohepatic circulation · Hamster · Hypocholesterolemic agent · Monkey · Carbon 14 · Cholesterol · High density lipoprotein cholesterol · Ileum apical bile acid transporter inhibitor · Phospholipid · Piperidine derivative · R 146224 · Taurocholic acid · Triacylglycerol · Tritium · Unclassified drug · Bile acid · Carrier protein · Cotransporter · Organic anion transporter · Quinoline derivative · Sodium · Sodium bile acid cotransporter · Sodium-bile acid cotransporter · Absorption · Animal experiment · Animal tissue · Bile duct fistula · Bile flow · Cholesterol blood level · Cholesterol esterification · Concentration response · Controlled study · Diet · Dose response · Drug mechanism · Embryo · Feeding · Human cell · Hypercholesterolemia · Hypolipemia · Inhibition kinetics · Time · Triacylglycerol blood level · Urinary excretion · Biosynthesis · Blood · Cell line · Drug antagonism · Drug effect · Genetics · In vitro study · Macaca · Metabolism · Physiology · Sprague Dawley rat · Syrian hamster · Animals · Anticholesteremic Agents · Bile Acids and Salts · Cell Line · Cholesterol · Cricetinae · Humans · Ileum · Macaca fascicularis · Male · Membrane Transport Proteins · Mesocricetus · Organic Anion Transporters, Sodium-Dependent · Piperidines · Quinolines · Rats · Rats, Sprague-Dawley · Sodium · Symporters · Taurocholic Acid
[Abstract]

6 Determinants of postprandial plasma bile acid kinetics in human volunteers
article 2017    
Author: Fiamoncini, J. · Yiorkas, A.M. · Gedrich, K. · Rundle, M. · Alsters, S.I. · Roeselers, G. · Broek, T.J. van den · Clavel, T. · Lagkouvardos, I. · Wopereis, S. · Frost, G. · Ommen, B. van · Blakemore, A.I. · Daniel, H.
Keywords: Biology · Bile acids · Mixed-meal tolerance test · Oral glucose tolerance test · Postprandial · SLCO1A2 · Chenodeoxycholic acid · Cholic acid · Deoxycholic acid · Genomic DNA · Glycine · Glycochenodeoxycholic acid · Glycocholic acid · Glycodeoxycholic acid · Glycoursodeoxycholic acid · Solute carrier organic anion transporter 1A2 · Taurine · Taurochenodeoxycholic acid · Taurocholic acid · Taurodeoxycholic acid · Taurolitocholic acid · Tauroursodeoxycholic acid · Unclassified drug · Ursodeoxycholic acid · Bile acid blood level · Bile acid synthesis · Clinical trial · Diet restriction · Dietary intake · Enterohepatic circulation · Feces microflora · Gene expression · Genome analysis · Kinetics · Liquid chromatography-mass spectrometry · Oral glucose tolerance test · Phenotype · Postprandial state · Quantitative analysis · Sex difference · Weight reduction · Whole exome sequencing · Blood · Controlled study · Physiology · Randomized controlled trial · Bile Acids and Salts · Fasting · Female · Humans · Male · Metabolic Clearance Rate · Middle Aged · Postprandial Period · Weight Loss · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 6 of 6 found. | Sort by date