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1 Comparison of the inhibition of urokinase-type plasminogen activator (u-PA) activity by monoclonal antibodies specific for u-PA as assessed by different assays
article 1995    
Author: Boheemen, P.A. van · Hoogen, N.M. van den · Koolwijk, N.
Keywords: Biology · monoclonal antibody · urokinase · article · controlled study · enzyme inhibition · fibrinolysis · priority journal
[Abstract]

2 Inhibitors of protein:farnesyl transferase and protein:geranylgeranyl transferase I : Synthesis of homologous diphosphonate analogs of isoprenylated pyrophosphate
article 1998    
Author: Overhand, M. · Stuivenberg, H.R. · Pieterman, E. · Cohen, L.H. · Leeuwen, R.E.W. van · Valentijn, A.R.P.M. · Overkleeft, H.S. · Marel, G.A. van der · Boom, J.H. van
Keywords: Health · bisphosphonic acid derivative · enzyme inhibitor · geranyltransferase · protein farnesyltransferase · article · enzyme activity · enzyme inhibition · enzyme specificity · phosphate metabolism · priority journal
[Abstract]

3 A generic model for glucose production from various cellulose sources by a commercial cellulase complex
article 2007    
Author: Drissen, R.E.T. · Maas, R.H.W. · Maarel, M.J.E.C. van der · Kabel, M.A. · Schols, H.A. · Tramper, J. · Beeftink, H.H.
Keywords: Health · Cellulose · Glucose · Model · Adsorption · Cellulose · Enzyme inhibition · Hydrolysis · Mathematical models · Oligomers · Reaction rates · Cellobiose · Enzyme inactivation · Glucose formation · Glucose · Triticum aestivum
[Abstract]

4 Protein synthesis inhibition by cycloheximide does not affect the acute release of tissue-type plasminogen activator
article 1989    
Author: Tranquille, N. · Emeis, J.J.
Keywords: Health · cycloheximide · plasminogen activator · animal cell · enzyme inhibition · nonhuman · Animal · Cycloheximide · Fibrinolysis · Hindlimb · Lung · Male · Muscles · Perfusion · Protein Synthesis Inhibitors · Rats · Rats, Inbred Strains · Tissue Plasminogen Activator
[Abstract]

5 Inhibition of human glutathione S-transferase P1-1 by the flavonoid quercetin
article 2003    
Author: Zanden, J.J. van · Hamman, O.B. · Iersel, M.L.P.S. van · Boeren, S. · Cnubben, N.H.P. · Lo Bello, M. · Vervoort, J. · Bladeren, P.J. van · Rietjens, I.M.C.M.
Keywords: Biology · Physiological Sciences · Cysteine · Glutathione S-transferase · Inhibition · Quercetin · Quinone · ascorbic acid · cysteine · flavonoid · glutathione · glutathione transferase · isoenzyme · mutant protein · quercetin · article · chemical interaction · concentration response · covalent bond · dimerization · enzyme inhibition · human · incubation time · inhibition kinetics · time · Chromatography, High Pressure Liquid · Dose-Response Relationship, Drug · Glutathione Transferase · Humans · Mass Spectrometry · Molecular Structure · Monophenol Monooxygenase · Mutation · Quercetin
[Abstract]

6 Glutathione conjugation as a bioactivation reaction
article 2000    
Author: Bladeren, P.J. van
Keywords: Nutrition · Bioactivation · Glutathione conjugates · Glutathione S-transferases · Cysteine · Glutathione · Glutathione transferase · Lyase · Catalysis · Chemical binding · Chemical reaction · Chromosomal localization · Conjugation · Covalent bond · Detoxification · Enzyme activation · Enzyme activity · Enzyme induction · Enzyme inhibition · Enzyme mechanism · Gene location · Genetic polymorphism · Human · Nonhuman · Protein expression · Reaction analysis · Reduction · Animals · Biotransformation · Carbon-Sulfur Lyases · Enzyme Induction · Glutathione · Glutathione Transferase · Humans · Metabolic Detoxication, Drug · Oxidation-Reduction · Xenobiotics
[Abstract]

7 Kinetic characteristics of acidic and alkaline ceramidase in human epidermis
article 2007    
Author: Houben, E. · Uchida, Y. · Nieuwenhuizen, W.F. · Paepe, K. de · Vanhaecke, T. · Holleran, W.M. · Rogiers, V.
Keywords: Nutrition · Food technology · Ceramidase · Epidermis · Kinetic parameters · acylsphingosine deacylase · enzyme inhibitor · ethanolamine derivative · isoenzyme · adult · article · enzyme activity · enzyme analysis · enzyme assay · enzyme inhibition · enzyme kinetics · enzyme substrate · enzymology · epidermis · female · human · human tissue · isoenzyme analysis · isotope labeling · normal human · nucleotide sequence · priority journal · zymography · Adult · Amidohydrolases · Enzyme Repression · Epidermis · Female · Humans · Hydrogen-Ion Concentration · Isoenzymes · Kinetics · Middle Aged · Skin Absorption
[Abstract]

8 Low level nose-only exposure to the nerve agent soman: Toxicokinetics of soman stereoisomers and cholinesterase inhibition in atropinized guinea pigs
article 1998    
Author: Benschop, H.P. · Trap, H.C. · Spruit, H.E.T. · Wiel, H.J. van der · Langenberg, J.P. · Jong, L.P.A. de
Keywords: Perception · Atropine · Carboxylesterase · Cholinesterase · Animal cell · Blood level · Enzyme inhibition · Exposure · Guinea pig · Inhalation · Male · Neurotoxicity · Nonhuman · Stereoisomerism · Toxicokinetics · Administration, Inhalation · Animals · Carboxylic ester hydrolases · Chemical warfare agents · Dose-response relationship · Drugs · Erythrocytes · Soman · Stereoisomerism · Time factors · Atropine, 51-55-8 · Carboxylesterase, EC 3.1.1.1 · Carboxylic ester hydrolases, EC 3.1.1.- · Soman, 96-64-0
[Abstract]

9 Inhibition of glutathione S-transferase activity in human melanoma cells by alfa, beta-unsaturated carbonyl derivatives : effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal
article 1996    
Author: Iersel, M.L.P.S. van · Ploemen, J.P.H.T.M. · Struik, I. · Amersfoort, C. van · Keyzer, A.E. · Schefferlie, J.G. · Bladeren, P.J. van
Keywords: Health · Cells · Glutathione S-transferases · Inhibition · Ketones · 2 hexenal · Cinnamaldehyde · Citral · Crotonaldehyde · Controlled study · Enzyme activity · Enzyme inhibition · High performance liquid chromatography · Human · Human cell · Melanoma cell · Acrolein · Aldehydes · Chromatography, High Pressure Liquid · Curcumin · Enzyme Inhibitors · Ethacrynic Acid · Glutathione · Glutathione Transferase · Humans · Melanoma · Monoterpenes · Skin Neoplasms · Terpenes · Tumor Cells, Cultured
[Abstract]

10 Verification of exposure to organophosphates: Generic mass spectrometric method for detection of human butyrylcholinesterase adducts
article 2006    
Author: Noort, D. · Fidder, A. · Schans, M.J. van der · Hulst, A.G.
Keywords: Enzyme inhibition · Ethanol · Mass spectrometry · Phosphates · Plasmas · Proteins · Generic mass spectrometric · Human butyrylcholinesterase adducts · Organophosphates · Phosphylated peptides · Biochemistry · Cholinesterase · Cholinesterase inhibitor · Dichlorvos · Methylphosphonothioic acid s (2 diisopropylaminoethyl) o ethyl ester · Nerve gas · Nonapeptide · Organophosphate pesticide · Organophosphorus compound · Pepsin A · Phosphoserine · Procainamide · Proton · Sarin · Soman · Analytic method · Article · Biological monitoring · Chemical warfare · Cholinesterase inhibition · Human · Liquid chromatography · Plasma · Solid phase extraction · Spectrometer · Tandem mass spectrometry · Terrorism · Time of flight mass spectrometry · Butyrylcholinesterase · Chromatography, Liquid · Humans · Phosphoric Acid Esters · Solid Phase Extraction · Tandem Mass Spectrometry
[Abstract]

11 Differential effects of bone morphogenetic protein-2 and transforming growth factor-β1 on gene expression of collagen-modifying enzymes in human adipose tissue-derived mesenchymal stem cells
article 2009    
Author: Knippenberg, M. · Helder, M.N. · Doulabi, B.Z. · Bank, R.A. · Wuisman, P.I.J.M. · Klein-Nulend, J.
Keywords: Biology · Biomedical Research · Adipose tissue · Alkaline phosphatase activity · Bone morphogenetic protein-2 · Bone tissue · Bone tissue engineering · Differential effect · Extracellular matrices · Growth factor · Human adipose tissue · Hydroxylases · Lysyl oxidase · Mesenchymal stem cell · Osteogenic differentiation · Physical and mechanical properties · Post-translational modifications · Procollagen · Transforming growth factors · Type I collagen · Bioactivity · Biomechanics · Bone · Catalysts · Cell culture · Cells · Collagen · Enzyme activity · Enzyme inhibition · Enzymes · Flowcharting · Gene expression · Mechanical properties · Peptides · Tissue engineering
[Abstract]

12 Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet
article 2011    
Author: Diepen, J.A. van · Vroegrijk, I.O.C.M. · Berbée, J.F.P. · Shoelson, S.E. · Romijn, J.A. · Havekes, L.M. · Rensen, P.C.N. · Voshol, P.J.
Keywords: Biology · Inflammation · Lipid metabolism · Very low-density lipoprotein · acetylsalicylic acid · apolipoprotein C1 · immunoglobulin enhancer binding protein · transcription factor RelA · triacylglycerol · very low density lipoprotein cholesterol · animal experiment · animal model · article · cholesterol blood level · controlled study · drug mechanism · drug targeting · enzyme inhibition · gene expression · hypertriglyceridemia · in vivo study · lipid diet · lipogenesis · lipoprotein blood level · male · metabolic syndrome X · mouse · nonhuman · priority journal · protein expression · risk factor · triacylglycerol blood level · aspirin · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

13 Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm doxycycline selectively depletes aortic wall neutrophils and cytotoxic t cells
article 2009    
Author: Lindeman, J.H.N. · Abdul-Hussien, H. · Bockel, J.H. van · Wolterbeek, R. · Kleemann, R.
Keywords: Health · Aneurysm · Immunology · Inflammation · Molecular biology · Trials · Doxycycline · Gelatinase B · Granulocyte colony stimulating factor receptor · Interleukin 13 · Interleukin 6 · Interleukin 8 · Antiinfective agent · CCAAT enhancer binding protein · Enzyme inhibitor · IL6 protein, human · Transcription factor AP 1 · Transcription factor RelA · Abdominal aorta aneurysm · Aged · Cytotoxic T lymphocyte · Drug effect · Drug megadose · Drug tolerability · Enzyme inhibition · Aortic Aneurysm, Abdominal · CCAAT-Enhancer-Binding Proteins · Doxycycline · Enzyme Inhibitors · Matrix Metalloproteinase 9 · Middle Aged · Neutrophils · T-Lymphocytes, Cytotoxic · Vasculitis
[PDF] [Abstract]

14 Intravenous and inhalation toxicokinetics of sarin stereoisomers in atropinized guinea pigs
article 2000    
Author: Spruit, W.E.T. · Langenberg, J.P. · Trap, H.C. · Wiel, H.J. van der · Helmich, R.B. · Helden, H.P.M. van · Benschop, H.P.
Keywords: Acetylcholinesterase inhibition · Guinea pig · Intravenous bolus · Nose-only exposure · Respiratory parameters · Stereoisomers · Toxicokinetics · Animal experiment · Animal model · Binding site · Chemical warfare · Controlled study · Drug absorption · Drug elimination · Enzyme inhibition · Gas chromatography · Guinea pig · Nonhuman · Nose mucosa · Stereoisomerism · Toxicokinetics · Acetylcholinesterase · Administration, Inhalation · Animals · Area Under Curve · Atropine · Chemical Warfare Agents · Guinea Pigs · Injections, Intravenous · Male · Stereoisomerism · Acetylcholinesterase, EC 3.1.1.7 · Atropine, 51-55-8 · Chemical warfare agents · Sarin, 107-44-8
[Abstract]

15 Genistein reduces tumor necrosis factor α-induced plasminogen activator inhibitor-1 transcription but not urokinase expression in human endothelial cells
article 1994    
Author: Hinsbergh, V.W.M. van · Vermeer, M. · Koolwijk, P. · Grimbergen, J. · Kooistra, T.
Keywords: Health · bacterium lipopolysaccharide · daidzein · genistein · herbimycin a · plasminogen activator · protein tyrosine phosphatase · transcription factor · tumor necrosis factor alpha · tyrphostin · urokinase · vanadic acid · cell migration · endothelium cell · enzyme activation · enzyme inhibition · fibrinolysis · genetic transcription · human cell · mitogenesis · plasminogen activation · priority journal · signal transduction · Cells, Cultured · Endothelium, Vascular · Fibroblast Growth Factor 2 · Genistein · Human · In Vitro · Isoflavones · Plasminogen Activator Inhibitor 1 · Protein-Tyrosine Kinase · Receptors, Tumor Necrosis Factor · Signal Transduction · Support, Non-U.S. Gov't · Tissue Plasminogen Activator · Tumor Necrosis Factor · Urinary Plasminogen Activator
[Abstract]

16 MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis
article 2005    
Author: Tchetverikov, I. · Lohmander, L.S. · Verzijl, N. · Huizinga, T.W.J. · TeKoppele, J.M. · Hanemaaijer, R. · Groot, J. de
Keywords: Biomedical Research · alpha 2 macroglobulin · interstitial collagenase · matrix metalloproteinase · prointerstitial collagenase · prostromelysin · stromelysin · tissue inhibitor of metalloproteinase 3 · unclassified drug · arthritis · controlled study · enzyme activation · enzyme activity · enzyme inhibition · human · immunoassay · joint injury · knee · major clinical study · osteoarthritis · priority journal · protein determination · pseudogout · quantitative analysis · synovial fluid level · Acute Disease · Adult · alpha-Macroglobulins · Arthritis · Chondrocalcinosis · Cross-Sectional Studies · Female · Humans · Knee Injuries · Male · Matrix Metalloproteinases · Middle Aged · Osteoarthritis, Knee · Synovial Fluid · Tissue Inhibitor of Metalloproteinase-1
[Abstract]

17 Therapy of organophosphate poisoning in the rat by direct effects of oximes unrelated to ChE reactivation
article 1991    
Author: Helden, H.P.M. van · Lange, J. de · Busker, R.W. · Melchers, B.P.C.
Keywords: Biology · Acetylcholinesterase · Direct effect · HGG-12 · HI-6 · Obidoxime · Organophosphate poisoning · P2S · 1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · [(3 benzoyl 1 pyridiniomethyl) (2 hydroxyiminomethyl 1 pyridiniomethyl)] ether · Obidoxime · Organophosphate · Oxime · Soman · Animal experiment · Animal tissue · Diaphragm · Enzyme inhibition · Enzyme reactivation · Intravenous drug administration · Male · Nonhuman · Priority journal · Rat · Animal · Antidotes · Blood-Brain Barrier · Cholinesterase Reactivators · Diaphragm · In Vitro · Male · Neuromuscular Junction · Obidoxime Chloride · Organophosphorus Compounds · Oximes · Pralidoxime Compounds · Pyridinium Compounds · Rats · Respiratory Insufficiency · Synaptic Transmission · Animalia
[Abstract]

18 The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential
article 2007    
Author: Zanden, J.J. van · Woude, H. van der · Vaessen, J. · Usta, M. · Wortelboer, H.M. · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biomedical Research · ABC transporters · Flavonoids · MRP1 · MRP2 · Phase II metabolism · Quercetin · ABC transporter · flavonoid · multidrug resistance protein 1 · multidrug resistance protein 2 · quercetin · animal cell · article · cancer cell culture · cancer chemotherapy · chemical structure · controlled study · enzyme activity · enzyme inhibition · glucuronidation · human · human cell · multidrug resistance · nonhuman · priority journal · rat · Animals · Cell Line, Tumor · Humans · Membrane Transport Proteins · Multidrug Resistance-Associated Proteins · Quercetin · Rats
[Abstract]

19 Elevated expression levels of lysyl oxidases protect against aortic aneurysm progression in Marfan syndrome
article 2015    
Author: Busnadiego, O. · Gorbenko del Blanco, D. · González-Santamaría, J. · Habashi, J.P. · Calderon, J.F. · Sandoval, P. · Bedja, D. · Guinea-Viniegra, J. · Lopez-Cabrera, M. · Rosell-Garcia, T. · Snabel, J.M. · Hanemaaijer, R. · Forteza, A. · Dietz, H.C. · Egea, G. · Rodriguez-Pascual, F.
Keywords: Biology · Aneurysm · Collagen · Extracellular matrix · Lysyl oxidases · Marfan syndrome · Transforming growth factor-β · Losartan · Oxidoreductase · Protein LOXL1 · Protein lysine 6 oxidase · Transforming growth factor beta · Unclassified drug · Animal tissue · Aorta aneurysm · Clinical article · Collagen fiber · Controlled study · Disease association · Disease course · Disease severity · Elastic fiber · Enzyme inhibition · Human tissue · Marfan syndrome · Mouse · Mouse model · Nonhuman · Prophylaxis · Protein expression · Signal transduction · Upregulation · Wild type · Animalia · Mus · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

20 In vitro inhibition of rat and human glutathione S-transferase isoenzymes by disulfiram and diethyldithiocarbamate
article 1996    
Author: Ploemen, J.-P.H.T.M. · Iersel, M.L.P.S. van · Wormhoudt, L.W. · Commandeur, J.N.M. · Vermeulen, N.P.E. · Bladeren, P.J. van
Keywords: diethyldithiocarbamate · disulfiram · gl utathion e · glutathione S-transferases · in vitro · inhibition · 1 chloro 2,4 dinitrobenzene · 1,2 epoxy 3 (4 nitrophenoxy)propane · aldehyde dehydrogenase inhibitor · diethyldithiocarbamic acid · disulfiram · dithiothreitol · glutathione transferase · isoenzyme · thiol · unclassified drug · article · controlled study · drug metabolism · enzyme inactivation · enzyme inhibition · enzyme purification · enzyme substrate · human · nonhuman · priority journal · rat · reduction · Animals · Disulfiram · Dithiothreitol · Ditiocarb · Glutathione · Glutathione Transferase · Humans · Isoenzymes · Rats · Spectrophotometry, Ultraviolet · Time Factors
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 39 found. Next | Sort by date